公开(公告)号：US20160326477A1

公开(公告)日：2016-11-10

申请号：US15105388

申请日：2014-12-19

申请人： Jose FERNANDEZ-ALCON ,  Norman WEN ,  Richard NOVAK ,  PRESIDENT AND FELLOWS OF HARVARD COLLEGE

发明人： Jose Fernandez-Alcon ,  Norman Wen ,  Richard Novak ,  Donald E. Ingber ,  Geraldine A. Hamilton ,  Christopher Hinojosa ,  Karel Domansky ,  Daniel Levner ,  Guy Thompson, II ,  Kambez Hajipouran Benam ,  Remi Villenave ,  Thomas Umundum ,  Alfred Paris ,  Georg Bauer

IPC分类号： C12M3/06 ,  C12M1/12 ,  C12M1/00 ,  C12M1/42 ,  C12M1/34

CPC分类号： C12M23/16 ,  C12M21/08 ,  C12M23/26 ,  C12M25/02 ,  C12M35/04 ,  C12M41/00 ,  C12M41/46

摘要： An organomimetic device includes a microfluidic device that can be used to culture cells in its microfluidic channels. The organomimetic device can be part of dynamic system that can apply mechanical forces to the cells by modulating the microfluidic device and the flow of fluid through the microfluidic channels. The membrane in the organomimetic device can be modulated mechanically via pneumatic means and/or mechanical means. The organomimetic device can be manufactured by the fabrication of individual components separately, for example, as individual layers that can be subsequently laminated together.

摘要翻译： 有机模拟装置包括可用于在其微流体通道中培养细胞的微流体装置。 有机模拟装置可以是动态系统的一部分，其可以通过调节微流体装置和通过微流体通道的流体流而将机械力施加到细胞。 有机模拟装置中的膜可以通过气动装置和/或机械装置机械调节。 有机模拟装置可以通过单独制造各个组件来制造，例如，作为随后层压在一起的各个层。

公开(公告)号：US20170327781A1

公开(公告)日：2017-11-16

申请号：US15601430

申请日：2017-05-22

申请人： President and Fellows of Harvard College

发明人： Jose Fernandez-Alcon ,  Norman Wen ,  Richard Novak ,  Donald E. Ingber ,  Geraldine A. Hamilton ,  Christopher Hinojosa ,  Karel Domansky ,  Daniel Levner ,  Guy Thompson ,  Kambez Hajipouran Benam ,  Remi Villenave ,  Thomas Umundum ,  Alfred Paris ,  Georg Bauer

IPC分类号： C12M3/06 ,  C12M1/42 ,  C12M1/00 ,  C12M1/12 ,  C12M1/34

CPC分类号： C12M23/16 ,  C12M21/08 ,  C12M23/26 ,  C12M25/02 ,  C12M35/04 ,  C12M41/00 ,  C12M41/46

摘要： An organomimetic device includes a microfluidic device that can be used to culture cells in its microfluidic channels. The organomimetic device can be part of dynamic system that can apply mechanical forces to the cells by modulating the microfluidic device and the flow of fluid through the microfluidic channels. The membrane in the organomimetic device can be modulated mechanically via pneumatic means and/or mechanical means. The organomimetic device can be manufactured by the fabrication of individual components separately, for example, as individual layers that can be subsequently laminated together.

公开(公告)号：US20240084235A1

公开(公告)日：2024-03-14

申请号：US18470404

申请日：2023-09-19

申请人： President and Fellows of Harvard College

发明人： Jose Fernandez-Alcon ,  Norman Wen ,  Richard Novak ,  Donald E. Ingber ,  Geraldine A. Hamilton ,  Christopher Hinojosa ,  Karel Domansky ,  Daniel Levner ,  Guy Thompson, II ,  Kambez Hajipouran Benam ,  Remi Villenave ,  Thomas Umundum ,  Alfred Paris ,  Georg Bauer

IPC分类号： C12M3/06 ,  B01D61/18 ,  B01D63/08 ,  B01D67/00 ,  B01L3/00 ,  C12M1/00 ,  C12M1/12 ,  C12M1/34 ,  C12M1/42 ,  C12M3/00

CPC分类号： C12M23/16 ,  B01D61/18 ,  B01D63/081 ,  B01D67/0023 ,  B01L3/5027 ,  B01L3/502753 ,  C12M21/08 ,  C12M23/26 ,  C12M25/02 ,  C12M35/04 ,  C12M41/00 ,  C12M41/46 ,  B01L2200/0647 ,  B01L2200/12 ,  B01L2300/0645 ,  B01L2300/0887 ,  B01L2400/0487

摘要： An organomimetic device includes a microfluidic device that can be used to culture cells in its microfluidic channels. The organomimetic device can be part of dynamic system that can apply mechanical forces to the cells by modulating the microfluidic device and the flow of fluid through the microfluidic channels. The membrane in the organomimetic device can be modulated mechanically via pneumatic means and/or mechanical means. The organomimetic device can be manufactured by the fabrication of individual components separately, for example, as individual layers that can be subsequently laminated together.