-
公开(公告)号：US20160326477A1
公开(公告)日：2016-11-10
申请号：US15105388
申请日：2014-12-19
发明人： Jose Fernandez-Alcon , Norman Wen , Richard Novak , Donald E. Ingber , Geraldine A. Hamilton , Christopher Hinojosa , Karel Domansky , Daniel Levner , Guy Thompson, II , Kambez Hajipouran Benam , Remi Villenave , Thomas Umundum , Alfred Paris , Georg Bauer
摘要： An organomimetic device includes a microfluidic device that can be used to culture cells in its microfluidic channels. The organomimetic device can be part of dynamic system that can apply mechanical forces to the cells by modulating the microfluidic device and the flow of fluid through the microfluidic channels. The membrane in the organomimetic device can be modulated mechanically via pneumatic means and/or mechanical means. The organomimetic device can be manufactured by the fabrication of individual components separately, for example, as individual layers that can be subsequently laminated together.
摘要翻译： 有机模拟装置包括可用于在其微流体通道中培养细胞的微流体装置。 有机模拟装置可以是动态系统的一部分，其可以通过调节微流体装置和通过微流体通道的流体流而将机械力施加到细胞。 有机模拟装置中的膜可以通过气动装置和/或机械装置机械调节。 有机模拟装置可以通过单独制造各个组件来制造，例如，作为随后层压在一起的各个层。
-
公开(公告)号：US11940441B2
公开(公告)日：2024-03-26
申请号：US17019102
申请日：2020-09-11
发明人： Donald E. Ingber , Kambez Hajipouran Benam , Remi Villenave , Geraldine A. Hamilton , Bryan Hassell , Christopher D. Hinojosa , Carolina Lucchesi
CPC分类号： G01N33/5044 , C12M21/08 , C12M23/16 , C12M25/02 , C12M35/04 , C12M41/46 , G01N2800/122
摘要： Provided herein relates to systems and methods for producing and using a body having a central channel separated by one or more membranes. The membrane(s) are configured to divide the central channel into at least one mesochannel and at least one microchannel. The height of the mesochannel is substantially greater than the height of the microchannel. A gaseous fluid can be applied through the mesochannel while a liquid fluid flowing through the microchannel. The systems and methods described herein can be used for various applications, including, e.g., growth and differentiation of primary cells such as human lung cells, as well as any other cells requiring low shear and/also stratified structures, or simulation of a microenvironment in living tissues and/or organs (to model physiology or disease states, and/or to identify therapeutic agents and/or vaccines). The systems and methods can also permit co-culture with one or more different cell types.
-
公开(公告)号：US20210003561A1
公开(公告)日：2021-01-07
申请号：US17019102
申请日：2020-09-11
发明人： Donald E. Ingber , Kambez Hajipouran Benam , Remi Villenave , Geraldine A. Hamilton , Bryan Hassell , Christopher D. Hinojosa , Carolina Lucchesi
摘要： Provided herein relates to systems and methods for producing and using a body having a central channel separated by one or more membranes. The membrane(s) are configured to divide the central channel into at least one mesochannel and at least one microchannel. The height of the mesochannel is substantially greater than the height of the microchannel. A gaseous fluid can be applied through the mesochannel while a liquid fluid flowing through the microchannel. The systems and methods described herein can be used for various applications, including, e.g., growth and differentiation of primary cells such as human lung cells, as well as any other cells requiring low shear and/also stratified structures, or simulation of a microenvironment in living tissues and/or organs (to model physiology or disease states, and/or to identify therapeutic agents and/or vaccines). The systems and methods can also permit co-culture with one or more different cell types.
-
公开(公告)号：US20170327781A1
公开(公告)日：2017-11-16
申请号：US15601430
申请日：2017-05-22
发明人： Jose Fernandez-Alcon , Norman Wen , Richard Novak , Donald E. Ingber , Geraldine A. Hamilton , Christopher Hinojosa , Karel Domansky , Daniel Levner , Guy Thompson , Kambez Hajipouran Benam , Remi Villenave , Thomas Umundum , Alfred Paris , Georg Bauer
摘要： An organomimetic device includes a microfluidic device that can be used to culture cells in its microfluidic channels. The organomimetic device can be part of dynamic system that can apply mechanical forces to the cells by modulating the microfluidic device and the flow of fluid through the microfluidic channels. The membrane in the organomimetic device can be modulated mechanically via pneumatic means and/or mechanical means. The organomimetic device can be manufactured by the fabrication of individual components separately, for example, as individual layers that can be subsequently laminated together.
-
5.发明申请公开(公告)号：US20160313306A1
公开(公告)日：2016-10-27
申请号：US15105962
申请日：2014-12-19
发明人： Donald E. Ingber , Kambez Hajipouran Benam , Remi Villenave , Geraldine A. Hamilton , Bryan Hassell , Christopher D. Hinojosa
CPC分类号： G01N33/5044 , B01L3/5027 , C12M21/08 , C12M23/16 , C12M25/02 , C12M35/04 , C12M41/46 , G01N2800/122
摘要： Provided herein relates to systems and methods for producing and using a body having a central channel separated by one or more membranes. The membrane(s) are configured to divide the central channel into at least one mesochannel and at least one microchannel. The height of the mesochannel is substantially greater than the height of the microchannel. A gaseous fluid can be applied through the mesochannel while a liquid fluid flowing through the microchannel. The systems and methods described herein can be used for various applications, including, e.g., growth and differentiation of primary cells such as human lung cells, as well as any other cells requiring low shear and/also stratified structures, or simulation of a microenvironment in living tissues and/or organs (to model physiology or disease states, and/or to identify therapeutic agents and/or vaccines). The systems and methods can also permit co-culture with one or more different cell types.
摘要翻译： 本文涉及用于生产和使用具有由一个或多个隔膜分隔的中心通道的主体的系统和方法。 膜被配置为将中心通道分成至少一个中间通道和至少一个微通道。 中间通道的高度明显大于微通道的高度。 气体流体可以通过中间通道施加，同时液体流体流过微通道。 本文描述的系统和方法可用于各种应用，包括例如原代细胞如人肺细胞的生长和分化以及需要低剪切和/或分层结构的任何其它细胞，或微环境的模拟 活组织和/或器官（用于模拟生理学或疾病状态，和/或鉴定治疗剂和/或疫苗）。 系统和方法还可以允许与一种或多种不同细胞类型的共培养。
-
公开(公告)号：US20240248077A1
公开(公告)日：2024-07-25
申请号：US18436701
申请日：2024-02-08
发明人： Donald E. Ingber , Kambez Hajipouran Benam , Remi Villenave , Geraldine A. Hamilton , Bryan Hassell , Christopher D. Hinojosa , Carolina Lucchesi
CPC分类号： G01N33/5044 , C12M21/08 , C12M23/16 , C12M25/02 , C12M35/04 , C12M41/46 , G01N2800/122
摘要： Provided herein relates to systems and methods for producing and using a body having a central channel separated by one or more membranes. The membrane(s) are configured to divide the central channel into at least one mesochannel and at least one microchannel. The height of the mesochannel is substantially greater than the height of the microchannel. A gaseous fluid can be applied through the mesochannel while a liquid fluid flowing through the microchannel. The systems and methods described herein can be used for various applications, including, e.g., growth and differentiation of primary cells such as human lung cells, as well as any other cells requiring low shear and/also stratified structures, or simulation of a microenvironment in living tissues and/or organs (to model physiology or disease states, and/or to identify therapeutic agents and/or vaccines). The systems and methods can also permit co-culture with one or more different cell types.
-
公开(公告)号：US20240084235A1
公开(公告)日：2024-03-14
申请号：US18470404
申请日：2023-09-19
发明人： Jose Fernandez-Alcon , Norman Wen , Richard Novak , Donald E. Ingber , Geraldine A. Hamilton , Christopher Hinojosa , Karel Domansky , Daniel Levner , Guy Thompson, II , Kambez Hajipouran Benam , Remi Villenave , Thomas Umundum , Alfred Paris , Georg Bauer
IPC分类号： C12M3/06 , B01D61/18 , B01D63/08 , B01D67/00 , B01L3/00 , C12M1/00 , C12M1/12 , C12M1/34 , C12M1/42 , C12M3/00
CPC分类号： C12M23/16 , B01D61/18 , B01D63/081 , B01D67/0023 , B01L3/5027 , B01L3/502753 , C12M21/08 , C12M23/26 , C12M25/02 , C12M35/04 , C12M41/00 , C12M41/46 , B01L2200/0647 , B01L2200/12 , B01L2300/0645 , B01L2300/0887 , B01L2400/0487
摘要： An organomimetic device includes a microfluidic device that can be used to culture cells in its microfluidic channels. The organomimetic device can be part of dynamic system that can apply mechanical forces to the cells by modulating the microfluidic device and the flow of fluid through the microfluidic channels. The membrane in the organomimetic device can be modulated mechanically via pneumatic means and/or mechanical means. The organomimetic device can be manufactured by the fabrication of individual components separately, for example, as individual layers that can be subsequently laminated together.
-
公开(公告)号：US11119093B2
公开(公告)日：2021-09-14
申请号：US15105962
申请日：2014-12-19
发明人： Donald E. Ingber , Kambez Hajipouran Benam , Remi Villenave , Geraldine A. Hamilton , Bryan Hassell , Christopher D. Hinojosa , Carolina Lucchesi
摘要： Provided herein relates to systems and methods for producing and using a body having a central channel separated by one or more membranes. The membrane(s) are configured to divide the central channel into at least one mesochannel and at least one microchannel. The height of the mesochannel is substantially greater than the height of the microchannel. A gaseous fluid can be applied through the mesochannel while a liquid fluid flowing through the microchannel. The systems and methods described herein can be used for various applications, including, e.g., growth and differentiation of primary cells such as human lung cells, as well as any other cells requiring low shear and/also stratified structures, or simulation of a microenvironment in living tissues and/or organs (to model physiology or disease states, and/or to identify therapeutic agents and/or vaccines). The systems and methods can also permit co-culture with one or more different cell types.
-
-
-
-
-
-
-
搜索结果
8 条记录 (耗时 0.038 秒)
