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公开(公告)号：US20240181397A1
公开(公告)日：2024-06-06
申请号：US18282976
申请日：2022-03-18
申请人： ProLynx LLC
发明人： Jeffrey C. HENISE , Brian YAO
CPC分类号： B01D63/06 , B01D69/04 , B01D71/5222 , B01D2325/38
摘要： The present disclosure is related to high-throughput membranes for preparation of microdroplet emulsions and microparticle suspensions and apparatus and systems comprising the same. Also provided are methods of preparing microdroplet emulsions and microparticle suspensions.
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公开(公告)号：US20220265873A1
公开(公告)日：2022-08-25
申请号：US17631325
申请日：2020-08-07
申请人： ProLynx LLC
发明人： Jeffrey C. HENISE , Gary W. ASHLEY , Brian YAO
IPC分类号： A61L2/07 , A61L2/00 , C08J3/075 , A61K47/69 , C08K5/3475
摘要： Methods for the steam sterilization of hydrogels crosslinked with a beta-eliminative linker without the drawback of significant degradation are provided.
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公开(公告)号：US20190209691A1
公开(公告)日：2019-07-11
申请号：US16248537
申请日：2019-01-15
申请人： ProLynx LLC
IPC分类号： A61K47/34 , A61L27/52 , C07C317/18 , A61L15/26 , C07C271/08 , A61L27/18 , C08J3/075 , A61K47/60 , A61K47/61 , A61L15/64 , A61L15/60 , A61L15/44 , A61L27/58 , A61L27/54 , A61K47/69
CPC分类号： A61K47/34 , A61K47/60 , A61K47/61 , A61K47/6903 , A61L15/26 , A61L15/44 , A61L15/60 , A61L15/64 , A61L27/18 , A61L27/52 , A61L27/54 , A61L27/58 , C07C271/08 , C07C317/18 , C08G2650/30 , C08J3/075 , C08J2300/16 , C08J2305/08 , C08J2371/02
摘要： Hydrogels that degrade under appropriate conditions of pH and temperature by virtue of crosslinking compounds that cleave through an elimination reaction are described. The hydrogels may be used for delivery of various agents, such as pharmaceuticals.
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公开(公告)号：US20230135347A1
公开(公告)日：2023-05-04
申请号：US17930381
申请日：2022-09-07
申请人： ProLynx LLC
IPC分类号： A61K47/34 , A61K47/61 , A61K47/69 , A61K47/60 , A61L15/44 , A61L15/60 , A61L15/64 , A61L27/54 , A61L27/58 , C07C317/18 , C08J3/075 , G02F1/361 , C09B23/01 , A61K47/50 , A61K9/06 , A61K47/30 , A61L15/26 , A61L27/18 , A61L27/52 , C07C271/08
摘要： Hydrogels that degrade under appropriate conditions of pH and temperature by virtue of crosslinking compounds that cleave through an elimination reaction are described. The hydrogels may be used for delivery of various agents, such as pharmaceuticals.
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公开(公告)号：US20170312368A1
公开(公告)日：2017-11-02
申请号：US15486215
申请日：2017-04-12
申请人： ProLynx LLC
IPC分类号： A61K47/34 , A61L27/18 , A61L15/26 , A61L27/52 , C07C271/08
CPC分类号： A61K47/34 , A61K47/60 , A61K47/61 , A61K47/6903 , A61L15/26 , A61L15/44 , A61L15/60 , A61L15/64 , A61L27/18 , A61L27/52 , A61L27/54 , A61L27/58 , C07C271/08 , C07C317/18 , C08G2650/30 , C08J3/075 , C08J2300/16 , C08J2305/08 , C08J2371/02
摘要： Hydrogels that degrade under appropriate conditions of pH and temperature by virtue of crosslinking compounds that cleave through an elimination reaction are described. The hydrogels may be used for delivery of various agents, such as pharmaceuticals.
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公开(公告)号：US20150352246A1
公开(公告)日：2015-12-10
申请号：US14762424
申请日：2014-01-22
申请人： PROLYNX LLC
CPC分类号： A61L26/0019 , A61L24/0015 , A61L24/0031 , A61L24/0036 , A61L24/0042 , A61L24/043 , A61L24/06 , A61L24/10 , A61L26/0066 , A61L26/008 , A61L26/0085 , A61L26/009 , A61L2300/216 , A61L2300/604 , C09B11/24 , C09B57/02
摘要： The invention provides sealants wherein biodegradable hydrogels that do not otherwise comprise protein-reactive groups for binding to membranes or tissue are provided said groups optionally through a linker. The linker may be biodegradable and may be biodegradable by an elimination reaction. The invention also provides multilayer gels for drug delivery wherein a porous gel in contact with a tissue or organ to which the drug is to be delivered is protected by a microporous layer from the surrounding bodily fluid.
摘要翻译： 本发明提供了密封剂，其中任选地通过连接体为所述基团提供其中不另外包含用于结合膜或组织的蛋白质反应性基团的可生物降解的水凝胶。 接头可以是可生物降解的并且可以通过消除反应生物降解。 本发明还提供用于药物递送的多层凝胶，其中与药物将被递送的组织或器官接触的多孔凝胶被来自周围体液的微孔层保护。
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公开(公告)号：US20200164083A1
公开(公告)日：2020-05-28
申请号：US16085139
申请日：2017-03-16
申请人： ProLynx LLC
摘要： Extended-release conjugates of stabilized GLP-1 agonists balance agonist stability with release rates to provide long lasting administration to treat diabetes and related conditions on once-a-month or less frequent dosing schedules.
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公开(公告)号：US20200054756A1
公开(公告)日：2020-02-20
申请号：US16557243
申请日：2019-08-30
申请人： ProLynx LLC
IPC分类号： A61K47/34 , C09B23/01 , G02F1/361 , C07C271/08 , A61L27/52 , A61L27/18 , A61L15/26 , C08J3/075 , C07C317/18 , A61L27/58 , A61L27/54 , A61L15/64 , A61L15/60 , A61L15/44 , A61K47/60 , A61K47/69 , A61K47/61
摘要： Hydrogels that degrade under appropriate conditions of pH and temperature by virtue of crosslinking compounds that cleave through an elimination reaction are described. The hydrogels may be used for delivery of various agents, such as pharmaceuticals.
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公开(公告)号：US20190209692A1
公开(公告)日：2019-07-11
申请号：US16248589
申请日：2019-01-15
申请人： ProLynx LLC
IPC分类号： A61K47/34 , A61L27/52 , C07C317/18 , A61L15/26 , C07C271/08 , A61L27/18 , C08J3/075 , A61K47/60 , A61K47/61 , A61L15/64 , A61L15/60 , A61L15/44 , A61L27/58 , A61L27/54 , A61K47/69
CPC分类号： A61K47/34 , A61K47/60 , A61K47/61 , A61K47/6903 , A61L15/26 , A61L15/44 , A61L15/60 , A61L15/64 , A61L27/18 , A61L27/52 , A61L27/54 , A61L27/58 , C07C271/08 , C07C317/18 , C08G2650/30 , C08J3/075 , C08J2300/16 , C08J2305/08 , C08J2371/02
摘要： Hydrogels that degrade under appropriate conditions of pH and temperature by virtue of crosslinking compounds that cleave through an elimination reaction are described. The hydrogels may be used for delivery of various agents, such as pharmaceuticals.
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