公开(公告)号：US10751685B2

公开(公告)日：2020-08-25

申请号：US16094091

申请日：2017-04-24

Applicant: Purdue Research Foundation

Inventor： Andy Koswara ,  Zoltan Kalman Nagy ,  Conor Douglas Parks

IPC: B01J19/00 ,  C07C213/06 ,  C07D207/16

Abstract: The invention generally provides systems and methods for producing a chemical product. In certain embodiments, the invention provides systems that include a chemical product production unit. The chemical production unit includes a plurality of microfluidic modules configured to be fluidically coupled to each other in an arrangement that produces a chemical product from an input of a plurality of starting reagents that react with each other due to conditions within the plurality of microfluidic modules through which the starting reagents flow. The system also includes a droplet dispenser fluidically coupled to the chemical product production unit that forms and dispenses droplets of the chemical product.

公开(公告)号：US10766014B2

公开(公告)日：2020-09-08

申请号：US15496355

申请日：2017-04-25

Applicant: Purdue Research Foundation

Inventor： Andy Koswara ,  Zoltan Kalman Nagy

IPC: C30B29/54 ,  B01J19/00 ,  C07C227/42 ,  C07C231/24 ,  B08B7/00 ,  B08B17/00 ,  C30B7/08 ,  B01D9/00

Abstract: The invention generally relates to systems with anti-fouling control and methods for controlling fouling within a channel of a plug flow crystallizer. In certain aspects, the invention provides a system that includes a plug flow crystallizer having a channel, one or more heating/cooling elements, each operably associated with a different segment of the channel, and a controller. The controller is operably coupled to the one or more heating/cooling elements and configured to implement a temperature profile within the channel of the plug flow crystallizer that grows crystals in a plug of fluid that flows through a first segment of the channel and dissolves encrust in a second segment of the channel while having minimal impact on crystal growth in the plug of fluid in the second segment of the channel. In certain embodiments, these segments may be cyclically alternated, in that the segment in which crystal grows in one cycle becomes the segment in which crystal dissolves in the next cycle and vice versa, to realize a fully continuous crystallization process.

公开(公告)号：US20190176122A1

公开(公告)日：2019-06-13

申请号：US16094091

申请日：2017-04-24

Applicant: Purdue Research Foundation

Inventor： Andy Koswara ,  Zoltan Kalman Nagy ,  Conor Douglas Parks

IPC: B01J19/00 ,  C07D207/16 ,  C07C213/06

CPC classification number: B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00792 ,  B01J2219/0081 ,  B01J2219/00813 ,  B01J2219/00867 ,  B01J2219/00873 ,  B01J2219/0088 ,  B01J2219/00891 ,  B01J2219/00905 ,  B01J2219/00909 ,  B01J2219/00916 ,  B01J2219/00954 ,  B01J2219/00959 ,  B01J2219/00968 ,  B01J2219/0097 ,  B01J2219/00986 ,  B01J2219/00995 ,  B01J2219/00997 ,  C07C213/06 ,  C07D207/16

Abstract: The invention generally provides systems and methods for producing a chemical product. In certain embodiments, the invention provides systems that include a chemical product production unit. The chemical production unit includes a plurality of microfluidic modules configured to be fluidically coupled to each other in an arrangement that produces a chemical product from an input of a plurality of starting reagents that react with each other due to conditions within the plurality of microfluidic modules through which the starting reagents flow. The system also includes a droplet dispenser fluidically coupled to the chemical product production unit that forms and dispenses droplets of the chemical product.

公开(公告)号：US20170312795A1

公开(公告)日：2017-11-02

申请号：US15496355

申请日：2017-04-25

Applicant: Purdue Research Foundation

Inventor： Andy Koswara ,  Zoltan Kalman Nagy

IPC: B08B7/00 ,  C30B7/14 ,  C07C231/24 ,  B01J19/06 ,  B01J19/00 ,  B08B17/02 ,  C01F11/46 ,  C30B29/54 ,  C07C227/42

CPC classification number: B01J19/0013 ,  B01D9/0013 ,  B01D9/0036 ,  B01D9/0054 ,  B01D9/0059 ,  B01D9/0063 ,  B01D9/0072 ,  B01D9/0077 ,  B08B7/0064 ,  B08B17/00 ,  C07C227/42 ,  C07C231/24 ,  C30B7/08 ,  C30B29/54

Abstract: The invention generally relates to systems with anti-fouling control and methods for controlling fouling within a channel of a plug flow crystallizer. In certain aspects, the invention provides a system that includes a plug flow crystallizer having a channel, one or more heating/cooling elements, each operably associated with a different segment of the channel, and a controller. The controller is operably coupled to the one or more heating/cooling elements and configured to implement a temperature profile within the channel of the plug flow crystallizer that grows crystals in a plug of fluid that flows through a first segment of the channel and dissolves encrust in a second segment of the channel while having minimal impact on crystal growth in the plug of fluid in the second segment of the channel. In certain embodiments, these segments may be cyclically alternated, in that the segment in which crystal grows in one cycle becomes the segment in which crystal dissolves in the next cycle and vice versa, to realize a fully continuous crystallization process.