公开(公告)号：US20240269636A1

公开(公告)日：2024-08-15

申请号：US18569403

申请日：2022-06-14

Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

Inventor： Daeyeon LEE ,  David Aaron ISSADORE ,  Jingyu WU ,  Sagar Prasad YADAVALI

IPC: B01J13/00 ,  B01J19/00 ,  C08F2/48

CPC classification number: B01J13/0052 ,  B01J19/0093 ,  C08F2/48 ,  B01J2219/00792 ,  B01J2219/00936

Abstract: Hydrogel particles (microgels) generated using microfluidic methods have superb properties such as high size uniformity and precise control over degradation and release profiles, making them useful for applications in wound healing and injectable drug delivery. However, the throughput of microfluidics is constrained by the physics governing the flow of immiscible fluids confined within microchannels. This throughput tends to be several orders of magnitude lower than what would be necessary for commercial and clinical applications. Here, we demonstrate the scaling up of on-chip synthesis of microgels by parallelizing the microfluidic channels. Taking advantage of the established fabrication technologies developed by the semiconductor industry and a high flow control system, a 4-inch silicon microfluidic chip integrating more than 4,000 microfluidic devices is developed. By incorporating a high energy flood UV source, this chip allows the synthesis of poly (ethylene glycol) diacrylate microgel particles with diameter down to 30 m at a throughput above Ikg/hr. By using photomasks that enable milli-second scale control of the UV exposure, the stiffness of microgels can be varied.

公开(公告)号：US20170297017A1

公开(公告)日：2017-10-19

申请号：US15132751

申请日：2016-04-19

Applicant: General Electric Company

Inventor： Philipp Lang ,  Ruben Julian Salvamoser ,  Victor Donald Samper ,  Christian Friedrich Peter Rensch

IPC: B01L3/00 ,  B01J19/24

CPC classification number: B01J19/24 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00792 ,  B01J2219/00795 ,  B01J2219/00858 ,  B01J2219/00891 ,  B01J2219/009 ,  B01J2219/00963 ,  B67D7/0266 ,  G01F11/28 ,  G01F13/00

Abstract: Fluid transport approaches are described that operate without the need for precise displacement of an actuator and with little or no sensing in the flow path. In certain implementations, a gas phase in a fluid reservoir is compressed by a pressure source such that releasing the pressure, such as by opening a valve to an intermediary conduit, displaces fluid to the intermediary chamber. Closing that fluid path and opening a different fluid path to a chamber at ambient temperature causes the fluid to be displaced to the chamber.

公开(公告)号：US20170246634A1

公开(公告)日：2017-08-31

申请号：US15320408

申请日：2015-06-25

Applicant: President and Fellows of Harvard College ,  The University Court of the University of Glasgow

Inventor： David A. Weitz ,  Thomas Franke

IPC: B01L3/00 ,  B01F3/08 ,  B01F13/00 ,  B01J19/00 ,  B01F15/02

CPC classification number: B01L3/502784 ,  B01F3/0819 ,  B01F5/0471 ,  B01F13/0071 ,  B01F15/0241 ,  B01F15/0263 ,  B01F2215/0037 ,  B01F2215/0463 ,  B01J19/0093 ,  B01J2219/00792 ,  B01J2219/00833 ,  B01J2219/00932 ,  B01L3/502776 ,  B01L2200/0647 ,  B01L2200/16 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2400/0436 ,  B01L2400/0439 ,  B01L2400/0487 ,  C07K14/415 ,  C12N15/8222 ,  C12N15/8243 ,  C12N15/8261 ,  Y02A40/146

Abstract: The present invention generally relates to the manipulation of fluids using acoustic waves such as surface acoustic waves. In some aspects, one fluid may be introduced into another fluid via application of suitable acoustic waves. For example, a fluid may be added or injected into another fluid by applying acoustic waves where, in the absence of the acoustic waves, the fluid cannot be added or injected, e.g., due to the interface or surface tension between the fluids. Thus, for example, a fluid may be injected into a droplet of another fluid. Other embodiments of the invention are generally directed to systems and methods for making or using such systems, kits involving such systems, or the like.

公开(公告)号：US20170057937A1

公开(公告)日：2017-03-02

申请号：US14837500

申请日：2015-08-27

Applicant: MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.

Inventor： Camille A. Correia ,  Kerry Gilmore ,  David Tyler McQuade ,  Peter H. Seeberger

IPC: C07D265/18 ,  B01J19/00 ,  C07C33/50 ,  C07C29/00 ,  C07C29/68 ,  C07C45/00 ,  C07C265/12 ,  C07F1/08

CPC classification number: C07D265/18 ,  B01J19/0093 ,  B01J2219/00792 ,  B01J2219/00795 ,  B01J2219/0081 ,  B01J2219/00813 ,  B01J2219/00833 ,  B01J2219/00835 ,  B01J2219/0086 ,  B01J2219/00867 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00894 ,  B01J2219/00963 ,  C07C29/00 ,  C07C29/42 ,  C07C29/68 ,  C07C33/50 ,  C07C45/00 ,  C07C45/46 ,  C07C265/12 ,  C07C2601/02 ,  C07F1/08 ,  C07C49/80

Abstract: The invention relates to a process for the preparation of Efavirenz via an efficient transition metal catalyzed cyclization, to a device suitable to perform such process as well as to novel intermediates.

Abstract translation: 本发明涉及通过有效的过渡金属催化环化制备依法韦仑的方法，涉及适用于进行这种方法的装置以及新型中间体。

公开(公告)号：US09534062B2

公开(公告)日：2017-01-03

申请号：US14721298

申请日：2015-05-26

Applicant: Corning Incorporated

Inventor： Mingqian He ,  Clemens Rudolf Horn ,  Jieyu Hu ,  Patrick Jean ,  Weijun Niu ,  David Neal Schissel ,  Michael James Winningham

IPC: C08F2/01 ,  C08F4/04 ,  B01J19/00 ,  C08F220/18 ,  B01F13/00 ,  C08F220/12 ,  B01F13/10

CPC classification number: C08F2/01 ,  B01F13/0059 ,  B01F13/1016 ,  B01J19/0093 ,  B01J2219/00792 ,  B01J2219/0086 ,  B01J2219/00873 ,  B01J2219/00889 ,  C08F4/04 ,  C08F220/12 ,  C08F220/18 ,  C08F220/56 ,  C08F2220/1825

Abstract: An improved process for synthesizing acrylic polymers, which is highly controllable to achieve high molecular weight, high conversion rate, and low polydispersity involves continuously introducing initiator(s), acrylic monomer(s), and optionally other monomers capable of polymerizing with the acrylic monomer(s), into a microchannel of a microreactor having an integral micromixer and an integral heat exchanger.

Abstract translation: 用于合成丙烯酸聚合物的改进方法，其高度可控以实现高分子量，高转化率和低多分散性，包括连续引入引发剂，丙烯酸单体和任选的能够与丙烯酸单体聚合的其它单体 进入具有整体微型混合器和整体式热交换器的微反应器的微通道中。

公开(公告)号：US09464029B2

公开(公告)日：2016-10-11

申请号：US14768391

申请日：2014-04-25

Applicant: BASF SE

Inventor： Ralf Boehling ,  Michael Hayer ,  Alwin Rehfinger ,  Michael Schelper ,  Johann-Peter Melder ,  Martin Ernst ,  Joaquim Henrique Teles

IPC: C07C205/00 ,  C07C201/08 ,  B01J19/00

CPC classification number: C07C201/08 ,  B01J19/0093 ,  B01J2219/00792 ,  B01J2219/00795 ,  B01J2219/00824 ,  B01J2219/00826 ,  B01J2219/00831 ,  B01J2219/00835 ,  B01J2219/00842 ,  B01J2219/0086 ,  B01J2219/00867 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00891 ,  Y02P20/582 ,  C07C205/02

Abstract: The invention relates to a process for preparing nitroalkanes by reaction of at least one alkane with at least one nitrating agent in the gas phase, wherein the nitration is carried out in a microstructured reaction zone having parallel channels having hydraulic diameters of less than 2.5 mm and a total specific internal surface area of more than 1600 m2/m3 and the alkane and the nitrating agent are conveyed under a pressure of from 1 bar to 20 bar through the reaction zone and reacted at a temperature of from 150° C. to 650° C. and the reaction products are cooled downstream of the reaction zone and discharged and the at least one nitrating agent is introduced over from two to ten introduction points along the reaction zone.

Abstract translation: 本发明涉及通过在气相中至少一种烷烃与至少一种硝化剂反应来制备硝基烷烃的方法，其中硝化在具有水力直径小于2.5mm的平行通道的微结构反应区中进行，以及 超过1600m 2 / m 3的总比表面积和烷烃和硝化剂在1巴-20巴的压力下通过反应区输送，并在150℃至650℃的温度下反应 并且反应产物在反应区的下游冷却并排出，并且将至少一种硝化剂沿着反应区引入二至十个引入点。

公开(公告)号：US09415374B2

公开(公告)日：2016-08-16

申请号：US14395150

申请日：2013-04-17

Applicant: DSM IP ASSETS B.V.

Inventor： Werner Bonrath

IPC: C07C33/02 ,  B01J19/24 ,  B01J23/44 ,  B01J10/00 ,  B01J12/00 ,  B01J19/00 ,  B01J19/02 ,  B01J35/00 ,  B01J35/04 ,  C07C29/17 ,  C10G45/40 ,  B01J23/889 ,  B01J23/883 ,  B01J23/885 ,  B01J23/887 ,  B01J23/89 ,  B01J37/02 ,  C07C67/283 ,  C10G3/00 ,  B01J23/60 ,  B01J21/04 ,  B01J23/06

CPC classification number: B01J23/44 ,  B01J10/007 ,  B01J12/007 ,  B01J19/0093 ,  B01J19/02 ,  B01J19/2415 ,  B01J19/2485 ,  B01J21/04 ,  B01J23/06 ,  B01J23/60 ,  B01J23/883 ,  B01J23/885 ,  B01J23/8876 ,  B01J23/8878 ,  B01J23/8892 ,  B01J23/8993 ,  B01J35/0006 ,  B01J35/006 ,  B01J35/04 ,  B01J37/0201 ,  B01J2219/00094 ,  B01J2219/00792 ,  B01J2219/00822 ,  B01J2219/00824 ,  B01J2219/00835 ,  B01J2219/0086 ,  B01J2219/00873 ,  B01J2219/0277 ,  B01J2219/2403 ,  B01J2219/2411 ,  B01J2219/2428 ,  B01J2219/2435 ,  B01J2219/2437 ,  B01J2219/2444 ,  C07C29/17 ,  C07C67/283 ,  C10G3/47 ,  C10G3/50 ,  C10G45/40 ,  Y02P30/20 ,  C07C33/03 ,  C07C33/02 ,  C07C69/145

Abstract: The present invention relates to a device for treatment of material transported through the device comprising at least one porous element consisting of specific solid metallic structure which allows cross-flow of the material through the porous element and wherein the porous element is coated by a non-acidic metal oxide which is impregnated by palladium (Pd).

Abstract translation: 本发明涉及一种用于处理通过该装置输送的材料的装置，包括至少一个由特定固体金属结构组成的多孔元件，该多孔元件允许材料跨过多孔元件的交叉流动，并且其中多孔元件被非金属结构涂覆， 用钯（Pd）浸渍的酸性金属氧化物。

公开(公告)号：US20150290623A1

公开(公告)日：2015-10-15

申请号：US14436433

申请日：2013-09-26

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO

Inventor： Staci A. Van Norman ,  Victoria J. Aston ,  Alan W. Weimer

IPC: B01J23/30 ,  B01J31/06 ,  B01J23/89 ,  C23C16/455 ,  B01J23/652 ,  B01J23/34 ,  B01J37/02 ,  B01J37/08 ,  B01J19/00 ,  B01J23/888

CPC classification number: B01J23/30 ,  B01J19/0093 ,  B01J23/22 ,  B01J23/34 ,  B01J23/44 ,  B01J23/462 ,  B01J23/464 ,  B01J23/466 ,  B01J23/6527 ,  B01J23/745 ,  B01J23/75 ,  B01J23/755 ,  B01J23/888 ,  B01J23/892 ,  B01J23/8993 ,  B01J31/06 ,  B01J35/006 ,  B01J37/0225 ,  B01J37/0244 ,  B01J37/08 ,  B01J37/349 ,  B01J2219/00792 ,  B01J2219/00822 ,  B01J2219/00835 ,  B01J2219/0086 ,  B01J2219/00873 ,  C10G2/332 ,  C10G2/333 ,  C10G2/341 ,  C23C16/45555

Abstract: Structures, catalysts, and reactors suitable for use for a variety of applications, including gasto-liquid and coal-to-liquid processes and methods of forming the structures, catalysts, and reactors are disclosed. The catalyst material can be deposited onto an inner wall of a microtubular reactor and/or onto porous tungsten support structures using atomic layer deposition techniques.

Abstract translation: 公开了适用于各种应用的结构，催化剂和反应器，包括气液和煤 - 液方法以及形成结构，催化剂和反应器的方法。 可以使用原子层沉积技术将催化剂材料沉积到微管反应器的内壁和/或多孔钨支撑结构上。

公开(公告)号：US20140353207A1

公开(公告)日：2014-12-04

申请号：US14464635

申请日：2014-08-20

Applicant: BATTELLE MEMORIAL INSTITUTE

Inventor： James J. Strohm ,  Benjamin Q. Roberts ,  Tricia D. Smurthwaite ,  Theresa M. Bergsman ,  Mark D. Bearden

IPC: C10G15/08

CPC classification number: C10G15/08 ,  B01J19/0093 ,  B01J19/088 ,  B01J19/126 ,  B01J2219/00792 ,  B01J2219/00822 ,  B01J2219/00826 ,  B01J2219/00835 ,  B01J2219/0086 ,  B01J2219/00941 ,  B01J2219/0894 ,  B01J2219/1215 ,  B01J2219/1227 ,  B01J2219/1239 ,  B01J2219/1245 ,  B01J2219/1269 ,  B01J2219/1272 ,  C10G1/002 ,  C10G29/205 ,  C10G2300/1033 ,  C10G2400/02 ,  C10G2400/04 ,  C10G2400/08 ,  H05H1/46 ,  H05H2001/4622

Abstract: Conversion of heavy fossil hydrocarbons (HFH) to a variety of value-added chemicals and/or fuels can be enhanced using microwave (MW) and/or radio-frequency (RF) energy. Variations of reactants, process parameters, and reactor design can significantly influence the relative distribution of chemicals and fuels generated as the product. In one example, a system for flash microwave conversion of HFH includes a source concentrating microwave or RF energy in a reaction zone having a pressure greater than 0.9 atm, a continuous feed having HFH and a process gas passing through the reaction zone, a HFH-to-liquids catalyst contacting the HFH in at least the reaction zone, and dielectric discharges within the reaction zone. The HFH and the catalyst have a residence time in the reaction zone of less than 30 seconds. In some instances, a plasma can form in or near the reaction zone.

Abstract translation: 可以使用微波（MW）和/或射频（RF）能量将重质化石碳氢化合物（HFH）转化为各种增值化学品和/或燃料。 反应物的变化，工艺参数和反应器设计可以显着影响作为产品生成的化学品和燃料的相对分布。 在一个实例中，用于HFH的闪速微波转换的系统包括在具有大于0.9atm的压力的反应区中的源集中微波或RF能量，具有HFH的连续进料和通过反应区的处理气体，HFH- 至少在反应区中与HFH接触的液体催化剂和反应区内的介质放电。 HFH和催化剂在反应区中的停留时间小于30秒。 在一些情况下，等离子体可以形成在反应区或其附近。

公开(公告)号：US08835690B2

公开(公告)日：2014-09-16

申请号：US13984500

申请日：2012-02-09

Applicant: Freddy Tjosas

Inventor： Freddy Tjosas

IPC: C07C213/04 ,  C07C213/02 ,  B01J19/00

CPC classification number: C07C213/04 ,  B01J19/0093 ,  B01J2219/00792 ,  C07C215/10

Abstract: The present invention relates to a process for the manufacture of APD and N-alkyl-APD wherein 1-CPD is reacted with aqueous ammonium or aqueous alkyl-amine under alkaline conditions and where the process is conducted in a continuous manner in a reactor comprising a tubular reactor wherein at least two reaction zones are established.

Abstract translation: 本发明涉及制备APD和N-烷基-APD的方法，其中1-CPD在碱性条件下与铵水溶液或烷基胺水溶液反应，并且其中该方法以连续的方式在含有 管式反应器，其中建立至少两个反应区。