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    DEPTH-RESOLVED MID-INFRARED PHOTOTHERMAL IMAGING OF LIVING CELLS AND ORGANISMS WITH SUB-MICRON SPATIAL RESOLUTION
    2.
    发明申请
    DEPTH-RESOLVED MID-INFRARED PHOTOTHERMAL IMAGING OF LIVING CELLS AND ORGANISMS WITH SUB-MICRON SPATIAL RESOLUTION 有权

    公开(公告)号：US20220349818A1

    公开(公告)日：2022-11-03

    申请号：US17698215

    申请日：2022-03-18

    Applicant: Purdue Research Foundation

    Inventor： Delong Zhang ,  Ji-Xin Cheng

    IPC: G01N21/3563 ,  G01N21/17 ,  C12Q1/02 ,  G01J5/22

    Abstract: Systems and methods for sensing vibrational absorption induced photothermal effect via a visible light source. A Mid-infrared photothermal probe (MI-PTP, or MIP) approach achieves 10 mM detection sensitivity and sub-micron lateral spatial resolution. Such performance exceeds the diffraction limit of infrared microscopy and allows label-free three-dimensional chemical imaging of live cells and organisms. Distributions of endogenous lipid and exogenous drug inside single cells can be visualized. MIP imaging technology may enable applications from monitoring metabolic activities to high-resolution mapping of drug molecules in living systems, which are beyond the reach of current infrared microscopy.

    SYSTEMS AND METHODS FOR BOND-SELECTIVE TRANSIENT PHASE IMAGING
    3.
    发明申请
    SYSTEMS AND METHODS FOR BOND-SELECTIVE TRANSIENT PHASE IMAGING 审中-公开

    公开(公告)号：US20200348182A1

    公开(公告)日：2020-11-05

    申请号：US16865082

    申请日：2020-05-01

    Applicant: Trustees of Boston University ,  Purdue Research Foundation

    Inventor： Ji-Xin Cheng ,  Delong Zhang ,  Lu Lan

    IPC: G01J5/08 ,  H01S3/094 ,  G02F1/125

    Abstract: A method includes directing a first plurality of probe laser pulses through a sample, dividing each of the first plurality of probe laser pulses to generate a first interferogram, and generating first image data reproducible as a first phase image of the sample. A plurality of pump laser bursts are directed onto the sample to heat the sample. A second plurality of probe laser pulses are directed through the sample at a predetermined time delay. Each of the second plurality of probe laser pulses are divided to generate a second interferogram. Second image data is generated that is reproducible as a second phase image of the sample. A transient phase shift is determined in the second phase image relative to the first phase image. A vibrational spectroscopy property is determined of the sample based on the transient phase shift, thereby allowing an identification of chemical bond information of within the sample.

    Ultrafast chemical imaging by widefield photothermal sensing of infrared absorption
    8.
    发明授权
    Ultrafast chemical imaging by widefield photothermal sensing of infrared absorption 有权

    公开(公告)号：US11867620B2

    公开(公告)日：2024-01-09

    申请号：US17600438

    申请日：2019-12-10

    Applicant: Purdue Research Foundation

    Inventor： Ji-Xin Cheng ,  Yeran Bai ,  Delong Zhang ,  Ali Shakouri ,  D. Kerry Maize

    IPC: G01N21/3577

    CPC classification number: G01N21/3577 ,  G01N2201/06113

    Abstract: Systems and methods for detecting photothermal effect in a sample are described herein. In these systems and methods, a pump source is configured to generate a pump pulse train, a probe source is configured to generate a probe pulse train and is synchronized with the pump pulse train, and a camera collects the resulting data. The camera is configured to collect a first signal corresponding to a hot frame, wherein the hot frame includes visible probe beam as modified by a pump beam and a second signal corresponding to a cold frame, wherein the cold frame includes visible probe beam that has not been modified by a pump beam. A processor can subtract the second signal from the first signal to detect the photothermal effect.

    Systems and methods for bond-selective transient phase imaging
    10.
    发明授权
    Systems and methods for bond-selective transient phase imaging 有权

    公开(公告)号：US11199453B2

    公开(公告)日：2021-12-14

    申请号：US17067345

    申请日：2020-10-09

    Applicant: Trustees of Boston University ,  Purdue Research Foundation

    Inventor： Ji-Xin Cheng ,  Delong Zhang ,  Lu Lan

    IPC: G01J5/08 ,  G02F1/125 ,  H01S3/094 ,  G01J5/00

    Abstract: A method includes directing a first plurality of probe laser pulses through a sample, dividing each of the first plurality of probe laser pulses to generate a first interferogram, and generating first image data reproducible as a first phase image of the sample. A plurality of pump laser bursts are directed onto the sample to heat the sample. A second plurality of probe laser pulses are directed through the sample at a predetermined time delay. Each of the second plurality of probe laser pulses are divided to generate a second interferogram. Second image data is generated that is reproducible as a second phase image of the sample. A transient phase shift is determined in the second phase image relative to the first phase image. A vibrational spectroscopy property is determined of the sample based on the transient phase shift, thereby allowing an identification of chemical bond information of within the sample.

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