公开(公告)号：US11994465B2

公开(公告)日：2024-05-28

申请号：US17849395

申请日：2022-06-24

Applicant: ABB Schweiz AG

Inventor： François Tanguay ,  Kyle Owen ,  John Brian Leen ,  Axel Meunier ,  Bertrand Simon Lanher

IPC: G01N21/39 ,  G01N21/03

CPC classification number: G01N21/39 ,  G01N21/031 ,  G01N2021/399 ,  G01N2201/0612 ,  G01N2201/0636

Abstract: A laser absorption spectrometry system for gas measurement is provided. The system includes an integrated cavity output spectroscopy (ICOS) assembly. The assembly includes a gas cell including a cell body defining an optical cavity, one or more tunable diode lasers having one or more nominal wavelengths, and a reflective collimation mirror positioned in an optical path between the one or more tunable diode lasers and the gas cell.

公开(公告)号：US20230417656A1

公开(公告)日：2023-12-28

申请号：US17849360

申请日：2022-06-24

Applicant: ABB Schweiz AG

Inventor： Raphaël Desbiens ,  John Brian Leen ,  Kyle Owen

IPC: G01N21/31 ,  G01N33/00

CPC classification number: G01N21/31 ,  G01N33/0044 ,  G01N33/004 ,  G01N2201/0612

Abstract: The present disclosure relates to measuring chemical constituents and associated properties of hydrocarbon fuel mixtures, and further relates to tunable diode laser absorption spectrometry gas analyzers having improved chemometric models. Methods described herein include setting gas concentration fit coefficients to a chemometric model for the measured gas concentration data for each of one or more background; wherein the chemometric model employs a broadband offset basis to a final basis set spectrum for the one or more gaseous target components; applying an iterative mathematical model to the measured light absorption data by iteratively adjusting target component fit coefficients until the measured light absorption data matches the chemometric model; and, determining a calculated amount of the one or more target components within the sample gas mixture by applying the gas concentration fit coefficients and the target component fit coefficients to the measured light absorption data and to the measured gas concentration data.

公开(公告)号：US20230408410A1

公开(公告)日：2023-12-21

申请号：US18115382

申请日：2023-02-28

Applicant: Electronics and Telecommunications Research Institute

Inventor： Hong-Seok SEO ,  Dong Hoon SONG ,  Jeong Won PARK ,  CHUL HUH

IPC: G01N21/64

CPC classification number: G01N21/6428 ,  G01N2021/6439 ,  G01N2201/08 ,  G01N2201/0612 ,  G01N2201/0697

Abstract: Disclosed is a PCR diagnosis apparatus. This apparatus includes a PCR chip configured to store a PCR sample, a light source part configured to generate laser light to be provided to the PCR sample, an optical modulator provided between the light source part and the PCR chip and configured to selectively provide the laser light to the PCR sample according to a code, a sensor configured to detect fluorescent light generated in the PCR sample by the laser light, and a code generator connected between the optical modulator and the sensor and configured to transmit an orthogonal code to the optical modulator and the sensor.

公开(公告)号：US11795504B2

公开(公告)日：2023-10-24

申请号：US17574416

申请日：2022-01-12

Applicant: Element Biosciences, Inc.

Inventor： Steve Xiangling Chen ,  Minghao Guo ,  Michael Previte ,  Chunhong Zhou ,  Derek Fuller

IPC: C12Q1/6869 ,  G01N21/64 ,  G01N15/14 ,  C12N15/10 ,  C12Q1/6806

CPC classification number: C12Q1/6869 ,  C12N15/1006 ,  C12Q1/6806 ,  G01N15/147 ,  G01N15/1436 ,  G01N15/1484 ,  G01N21/6402 ,  G01N21/6428 ,  G01N21/6456 ,  G01N21/6458 ,  G01N21/6486 ,  G01N2015/144 ,  G01N2021/6439 ,  G01N2021/6441 ,  G01N2021/6463 ,  G01N2201/0612

Abstract: Fluorescence imaging system designs are described that provide larger fields-of-view, increased spatial resolution, improved modulation transfer and image quality, higher spatial sampling frequency, faster transitions between image capture when repositioning the sample plane to capture a series of images (e.g., of different fields-of-view), and improved imaging system duty cycle, and thus enable higher throughput image acquisition and analysis for genomics and other imaging applications.

公开(公告)号：US11788967B2

公开(公告)日：2023-10-17

申请号：US16963679

申请日：2019-01-23

Applicant: DANMARKS TEKNISKE UNIVERSITET

Inventor： Oleksii Ilchenko ,  Tomas Rindzevicius ,  Anja Boisen ,  Roman Slipets

IPC: G01J3/02 ,  G01J3/44 ,  G01N21/65

CPC classification number: G01N21/65 ,  G01J3/0229 ,  G01J3/0297 ,  G01J3/44 ,  G01N2201/0612 ,  G01N2201/0631 ,  G01N2201/0633 ,  G01N2201/0635

Abstract: An apparatus for carrying out Raman spectroscopy on a sample includes a light source for providing a beam of excitation radiation, and an optical system including a spectrograph. The spectrograph includes a grating that divides a beam of scattered light into a spectrum of spatially separated wavelength components and to direct a portion of the spectrum to a detector. The spectrograph includes: 1) a first lens system for focusing the portion of the spectrum onto the detector and 2) a second lens system-configured to provide a focal plane with focal point in the optical path for focusing the beam of excitation radiation and/or the beam of scattered radiation at the focal point. The apparatus including a reference sample arranged in the focal plane, in particular at the focal point, for obtaining a reference spectrum from the reference sample.

公开(公告)号：US11703453B2

公开(公告)日：2023-07-18

申请号：US17407230

申请日：2021-08-20

Applicant: The Government of the United States of America, as represented by the Secretary of the Navy

Inventor： Jerry R. Meyer ,  Igor Vurgaftman ,  Chadwick Lawrence Canedy ,  William W. Bewley ,  Chul Soo Kim ,  Charles D. Merritt ,  Michael V. Warren ,  R. Joseph Weiblen ,  Mijin Kim

IPC: G01N21/59 ,  H01S5/028 ,  H01S5/10 ,  H01S5/125 ,  H01S5/34 ,  H01S5/343 ,  H01S5/042 ,  H01S5/20 ,  H01S5/02 ,  H01S5/026 ,  G02B6/10 ,  G01N21/27 ,  G01N21/25 ,  G01J3/18 ,  G01J3/28 ,  H01S5/22 ,  H01S5/06 ,  H01S5/062

CPC classification number: G01N21/59 ,  G01J3/1895 ,  G01J3/2803 ,  G01N21/255 ,  G01N21/27 ,  G02B6/102 ,  H01S5/0215 ,  H01S5/0262 ,  H01S5/0287 ,  H01S5/0421 ,  H01S5/101 ,  H01S5/125 ,  H01S5/2063 ,  H01S5/2206 ,  H01S5/3402 ,  H01S5/343 ,  G01N2201/0612 ,  H01S5/062 ,  H01S5/0612

Abstract: Building blocks are provided for on-chip chemical sensors and other highly-compact photonic integrated circuits combining interband or quantum cascade lasers and detectors with passive waveguides and other components integrated on a III-V or silicon. A MWIR or LWIR laser source is evanescently coupled into a passive extended or resonant-cavity waveguide that provides evanescent coupling to a sample gas (or liquid) for spectroscopic chemical sensing. In the case of an ICL, the uppermost layer of this passive waveguide has a relatively high index of refraction that enables it to form the core of the waveguide, while the ambient air, consisting of the sample gas, functions as the top cladding layer. A fraction of the propagating light beam is absorbed by the sample gas if it contains a chemical species having a fingerprint absorption feature within the spectral linewidth of the laser emission.

公开(公告)号：US20230181091A1

公开(公告)日：2023-06-15

申请号：US18061500

申请日：2022-12-05

Applicant: THE HONG KONG POLYTECHNIC UNIVERSITY

Inventor： Jung Sun YOO ,  Ngai Nick Alex WONG

IPC: A61B5/00 ,  G01N21/27 ,  G01N21/64

CPC classification number: A61B5/4041 ,  A61B5/0082 ,  G01N21/27 ,  G01N21/6428 ,  G01N2201/062 ,  G01N2201/0612 ,  G01N2021/6439

Abstract: Methods and systems useful for machine learning assisted imaging and detection of peripheral nerves comprising reflectance imaging spectroscopy. The method can be conducted label-free and in real-time.

公开(公告)号：US11674897B2

公开(公告)日：2023-06-13

申请号：US17698215

申请日：2022-03-18

Applicant: Purdue Research Foundation

Inventor： Delong Zhang ,  Ji-Xin Cheng

IPC: G01N21/3563 ,  G01N21/17 ,  C12Q1/02 ,  G01J5/22 ,  G01J5/00 ,  G02B21/02 ,  G02B21/06 ,  G02B21/18 ,  H01S5/34

CPC classification number: G01N21/3563 ,  C12Q1/02 ,  G01J5/22 ,  G01N21/171 ,  G01J2005/0077 ,  G01N2021/1712 ,  G01N2201/0612 ,  G01N2201/0697 ,  G02B21/02 ,  G02B21/06 ,  G02B21/18 ,  H01S5/3401

Abstract: Systems and methods for sensing vibrational absorption induced photothermal effect via a visible light source. A Mid-infrared photothermal probe (MI-PTP, or MIP) approach achieves 10 mM detection sensitivity and sub-micron lateral spatial resolution. Such performance exceeds the diffraction limit of infrared microscopy and allows label-free three-dimensional chemical imaging of live cells and organisms. Distributions of endogenous lipid and exogenous drug inside single cells can be visualized. MIP imaging technology may enable applications from monitoring metabolic activities to high-resolution mapping of drug molecules in living systems, which are beyond the reach of current infrared microscopy.

公开(公告)号：US20190234931A1

公开(公告)日：2019-08-01

申请号：US16383427

申请日：2019-04-12

Applicant: Instrumentation Laboratory Company

Inventor： Ethan Schonbrun ,  Gert Blankenstein ,  Josef Kerimo ,  Hansong Zeng

IPC: G01N33/49 ,  G01N21/25 ,  G01N21/05 ,  G01N21/552 ,  G01N21/03 ,  B01L3/00

CPC classification number: G01N33/49 ,  B01L3/502 ,  B01L2300/0654 ,  B01L2300/168 ,  G01N21/0303 ,  G01N21/05 ,  G01N21/25 ,  G01N21/552 ,  G01N2201/0612

Abstract: Analyte content in a cell free portion of a body fluid, such as blood, is optically determined without centrifugation or other preliminary steps for separating the cell free portion from the body fluid. A channel is configured for containing a flowing sample of the body fluid along an optical boundary. The channel is configured so that a cell free layer of the fluid naturally forms along the boundary of the channel which coincides with the optical boundary. A light source is directed onto the optical boundary at an angle selected to generate total reflection from the boundary and to generate an evanescent field across the boundary in the cell free layer of fluid. A light detector is configured to detect absorption of the light in the evanescent field. The light source and light detector are matched to the wavelength range of an absorption peak of the analyte being detected.

公开(公告)号：US20190187043A1

公开(公告)日：2019-06-20

申请号：US16282903

申请日：2019-02-22

Applicant: 1087 Systems, Inc.

Inventor： Matthias Wagner ,  John Heanue

IPC: G01N15/14 ,  G01N21/3563 ,  B07C5/34 ,  G01N29/24 ,  G01N21/17 ,  C12N5/071 ,  B01L3/00

CPC classification number: G01N15/1436 ,  B01L3/502761 ,  B01L2200/0652 ,  B01L2300/0627 ,  B01L2300/0864 ,  B07C5/34 ,  C12N5/0612 ,  G01N15/14 ,  G01N15/1427 ,  G01N15/1429 ,  G01N15/1434 ,  G01N15/1459 ,  G01N15/1463 ,  G01N15/147 ,  G01N15/1484 ,  G01N21/1702 ,  G01N21/3563 ,  G01N29/2418 ,  G01N2015/0065 ,  G01N2015/1006 ,  G01N2015/149 ,  G01N2015/1497 ,  G01N2201/0612

Abstract: This disclosure concerns a cytometry system including a handling system that enables presentation of single cells to at least one laser source. The laser source is configured to deliver light to a cell within the cells in order to induce bond vibrations in the cellular DNA. The system further includes a detection facility that detects the signature of the bond vibrations, wherein the bond vibration signature is used to determine the folding or packing of the DNA.