公开(公告)号：US10168312B2

公开(公告)日：2019-01-01

申请号：US15649763

申请日：2017-07-14

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Christina Ramires Ferreira ,  Tiago Sobreira

IPC: H01J49/42 ,  G01N33/48 ,  G01N33/487 ,  G06F17/30 ,  H01J49/00 ,  H01J49/16 ,  H04L1/00 ,  G06F19/00

Abstract: The invention generally relates to systems methods for screening a sample based on multiple reaction monitoring mass spectrometry. In certain embodiments, the invention provides methods for screening a sample that involve ionizing a sample. Mass spectrometry is then used in order to monitor specific transitions connecting one or more ion pairs within the sample in order to generate a multidimensional chemical profile of the sample. Then, the multidimensional chemical profile of the sample is compared to a database of reference multidimensional chemical profiles, thereby screening the sample. Each reference multidimensional chemical profile is produced from a training set of data.

公开(公告)号：US20180024108A1

公开(公告)日：2018-01-25

申请号：US15649763

申请日：2017-07-14

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Christina Ramires Ferreira ,  Tiago Sobreira

IPC: G01N33/487 ,  G06F17/30 ,  H01J49/42 ,  H01J49/00 ,  H01J49/16

CPC classification number: G01N33/487 ,  G01N2560/00 ,  G01N2570/00 ,  G01N2800/2835 ,  G06F17/30592 ,  G06F19/324 ,  H01J49/0036 ,  H01J49/005 ,  H01J49/165 ,  H01J49/424 ,  H04L1/0072

Abstract: The invention generally relates to systems methods for screening a sample based on multiple reaction monitoring mass spectrometry. In certain embodiments, the invention provides methods for screening a sample that involve ionizing a sample. Mass spectrometry is then used in order to monitor specific transitions connecting one or more ion pairs within the sample in order to generate a multidimensional chemical profile of the sample. Then, the multidimensional chemical profile of the sample is compared to a database of reference multidimensional chemical profiles, thereby screening the sample. Each reference multidimensional chemical profile is produced from a training set of data.