公开(公告)号：US12078596B2

公开(公告)日：2024-09-03

申请号：US16043651

申请日：2018-07-24

Applicant: Quantum-Si Incorporated

Inventor： Jonathan M. Rothberg ,  Benjamin Cipriany ,  Todd Rearick ,  Paul E. Glenn ,  Faisal R. Ahmad ,  Todd Roswech ,  Brittany Lathrop ,  Thomas Connolly

IPC: G01N21/64 ,  H01S5/00 ,  H01S5/02253 ,  H01S5/024 ,  H01S5/026

CPC classification number: G01N21/6486 ,  G01N21/6402 ,  G01N21/6408 ,  G01N21/6454 ,  H01S5/0071 ,  H01S5/02253 ,  H01S5/02461 ,  H01S5/0262 ,  G01N21/648 ,  G01N2021/6482 ,  G01N2201/0221 ,  G01N2201/0873

Abstract: A hand-held bioanalytic instrument is described that can perform massively parallel sample analysis including single-molecule gene sequencing. The instrument includes a pulsed optical source that produces ultrashort excitation pulses and a compact beam-steering assembly. The beam-steering assembly provides automated alignment of excitation pulses to an interchangeable bio-optoelectronic chip that contains tens of thousands of reaction chambers or more. The optical source, beam-steering assembly, bio-optoelectronic chip, and coupling optics register to an alignment structure in the instrument that can form at least one wall of an enclosure and dissipate heat.

公开(公告)号：US20190025214A1

公开(公告)日：2019-01-24

申请号：US16043651

申请日：2018-07-24

Applicant: Quantum-Si Incorporated

Inventor： Jonathan M. Rothberg ,  Benjamin Cipriany ,  Todd Rearick ,  Paul E. Glenn ,  Faisal R. Ahmad ,  Todd Roswech ,  Brittany Lathrop ,  Thomas Connolly

IPC: G01N21/64 ,  H01S5/00 ,  H01S5/026 ,  H01S5/022 ,  H01S5/024

Abstract: A hand-held bioanalytic instrument is described that can perform massively parallel sample analysis including single-molecule gene sequencing. The instrument includes a pulsed optical source that produces ultrashort excitation pulses and a compact beam-steering assembly. The beam-steering assembly provides automated alignment of excitation pulses to an interchangeable bio-optoelectronic chip that contains tens of thousands of reaction chambers or more. The optical source, beam-steering assembly, bio-optoelectronic chip, and coupling optics register to an alignment structure in the instrument that can form at least one wall of an enclosure and dissipate heat.