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公开(公告)号：US06897297B1
公开(公告)日：2005-05-24
申请号：US09579680
申请日：2000-05-26
申请人： R. Blake Pepinsky , Chenhui Zeng , Darren P. Baker , Dingyi Wen , Kevin P. Williams , Ellen A. Garber , Kathryn L. Strauch , Frederick R. Taylor , Paul H. Weinreb , Russell C. Petter , Alphonse Galdes , Jeffrey Porter
发明人： R. Blake Pepinsky , Chenhui Zeng , Darren P. Baker , Dingyi Wen , Kevin P. Williams , Ellen A. Garber , Kathryn L. Strauch , Frederick R. Taylor , Paul H. Weinreb , Russell C. Petter , Alphonse Galdes , Jeffrey Porter
IPC分类号： A61K38/00 , A61K38/17 , C07K14/46 , C07K14/435 , C07K1/107
CPC分类号： C07K14/46 , A61K38/1709 , C07K2319/00
摘要： Hydrophobically-modified proteins and methods of making them are described. A hydrophobic moiety is attached to a surface amino acid residue of the protein. The hydrophobic moiety can be a lipid or a peptide. Alternatively, the protein can be derivatized by a wide variety of chemical reactions that append a hydrophobic structure to the protein. The preferred protein is of mammalian origin and is selected from the group consisting of Sonic, Indian, and Desert hedgehog. The hydrophobic moiety is used as a convenient tether to which may be attached a vesicle such as a cell membrane, liposome, or micelle.
摘要翻译： 描述了疏水性修饰的蛋白质及其制备方法。 疏水部分连接到蛋白质的表面氨基酸残基。 疏水部分可以是脂质或肽。 或者，蛋白质可以通过向蛋白质附加疏水结构的各种化学反应衍生化。 优选的蛋白质是哺乳动物来源的，并且选自Sonic，Indian和Desert hedgehog。 疏水部分用作方便的系链，其可以连接囊泡，例如细胞膜，脂质体或胶束。
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公开(公告)号：US20090054632A1
公开(公告)日：2009-02-26
申请号：US11894745
申请日：2007-08-20
申请人： R. Blake Pepinsky , Alphonse Galdes , Ellen A. Garber , Darren P. Baker , Jeffery A. Porter , Frederick R. Taylor , Kevin P. Williams , Russell C. Petter , Kathryn Strauch , Paul H. Weinreb , Dingyi Wen , Chenhui Zeng
发明人： R. Blake Pepinsky , Alphonse Galdes , Ellen A. Garber , Darren P. Baker , Jeffery A. Porter , Frederick R. Taylor , Kevin P. Williams , Russell C. Petter , Kathryn Strauch , Paul H. Weinreb , Dingyi Wen , Chenhui Zeng
CPC分类号： C07K14/46 , A61K38/1709 , C07K2319/00
摘要： Hydrophobically-modified proteins and methods of making them are described. A hydrophobic moiety is attached to a surface amino acid residue of the protein. The hydrophobic moiety can be a lipid or a peptide. Alternatively, the protein can be derivatized by a wide variety of chemical reactions that append a hydrophobic structure to the protein. The preferred protein is of mammalian origin and is selected from the group consisting of Sonic, Indian, and Desert hedgehog. The hydrophobic moiety is used as a convenient tether to which may be attached a vesicle such as a cell membrane, liposome, or micelle.
摘要翻译： 描述了疏水性修饰的蛋白质及其制备方法。 疏水部分连接到蛋白质的表面氨基酸残基。 疏水部分可以是脂质或肽。 或者，蛋白质可以通过向蛋白质附加疏水结构的各种化学反应衍生化。 优选的蛋白质是哺乳动物来源的，并且选自Sonic，Indian和Desert hedgehog。 疏水部分用作方便的系链，其可以连接囊泡，例如细胞膜，脂质体或胶束。
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公开(公告)号：US06444793B1
公开(公告)日：2002-09-03
申请号：US09325256
申请日：1999-06-03
申请人： R. Blake Pepinsky , Darren P. Baker , Dingyi Wen , Kevin P. Williams , Ellen A. Garber , Frederick R. Taylor , Alphonse Galdes , Jeffrey Porter
发明人： R. Blake Pepinsky , Darren P. Baker , Dingyi Wen , Kevin P. Williams , Ellen A. Garber , Frederick R. Taylor , Alphonse Galdes , Jeffrey Porter
IPC分类号： C07K14435
CPC分类号： A61K38/1709 , C07K1/1077 , C07K14/46 , C07K2319/00
摘要： Hydrophobically-modified proteins and methods of making them are described. A hydrophobic moiety is attached to a surface amino acid residue of the protein. The hydrophobic moiety can be a lipid or a peptide. Alternatively, the protein can be derivatized by a wide variety of chemical reactions that append a hydrophobic structure to the protein. The preferred protein is of mammalian origin and is selected from the group consisting of Sonic, Indian, and Desert hedgehog. The hydrophobic moiety is used as a convenient tether to which may be attached a vesicle such as a cell membrane, liposome, or micelle.
摘要翻译： 描述了疏水性修饰的蛋白质及其制备方法。 疏水部分连接到蛋白质的表面氨基酸残基。 疏水部分可以是脂质或肽。 或者，蛋白质可以通过向蛋白质附加疏水结构的各种化学反应衍生化。 优选的蛋白质是哺乳动物来源的，并且选自Sonic，Indian和Desert hedgehog。 疏水部分用作方便的系链，其可以连接囊泡，例如细胞膜，脂质体或胶束。
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公开(公告)号：US08524660B2
公开(公告)日：2013-09-03
申请号：US13230080
申请日：2011-09-12
申请人： KoChung Lin , R. Blake Pepinsky , Ling Ling Chen , Donna M. Hess , Edward Y. Lin , Russell C. Petter , Darren P. Baker
发明人： KoChung Lin , R. Blake Pepinsky , Ling Ling Chen , Donna M. Hess , Edward Y. Lin , Russell C. Petter , Darren P. Baker
IPC分类号： A61K47/48 , C08G65/329 , A61K38/00 , C07K17/08 , A61K31/00 , A61K38/21 , C07K14/565 , C12N15/22
CPC分类号： C08G65/329 , A61K47/60 , C08L2203/02
摘要： The invention relates to novel polyalkylene glycol compounds and methods of using them. In particular, compounds comprising a novel polyethylene glycol conjugate are used alone, or in combination with antiviral agents to treat a viral infection, such as chronic hepatitis C.
摘要翻译： 本发明涉及新型聚亚烷基二醇化合物及其使用方法。 特别地，包含新型聚乙二醇缀合物的化合物单独使用或与抗病毒剂组合用于治疗病毒感染，例如慢性丙型肝炎。
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公开(公告)号：US08017733B2
公开(公告)日：2011-09-13
申请号：US10892830
申请日：2004-07-16
申请人： KoChung Lin , R. Blake Pepinsky , Ling Ling Chen , Donna M. Hess , Edward Y. Lin , Russell C. Petter , Darren P. Baker
发明人： KoChung Lin , R. Blake Pepinsky , Ling Ling Chen , Donna M. Hess , Edward Y. Lin , Russell C. Petter , Darren P. Baker
CPC分类号： C08G65/329 , A61K47/60 , C08L2203/02
摘要： The invention relates to novel polyalkylene glycol compounds and methods of using them. In particular, compounds comprising a novel polyethylene glycol conjugate are used alone, or in combination with antiviral agents to treat a viral infection, such as chronic hepatitis C.
摘要翻译： 本发明涉及新型聚亚烷基二醇化合物及其使用方法。 特别地，包含新型聚乙二醇缀合物的化合物单独使用或与抗病毒剂组合用于治疗病毒感染，例如慢性丙型肝炎。
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公开(公告)号：US20120014916A1
公开(公告)日：2012-01-19
申请号：US13230080
申请日：2011-09-12
申请人： KoChung Lin , R. Blake Pepinsky , Ling Ling Chen , Donna M. Hess , Edward Y. Lin , Russell C. Petter , Darren P. Baker
发明人： KoChung Lin , R. Blake Pepinsky , Ling Ling Chen , Donna M. Hess , Edward Y. Lin , Russell C. Petter , Darren P. Baker
CPC分类号： C08G65/329 , A61K47/60 , C08L2203/02
摘要： The invention relates to novel polyalkylene glycol compounds and methods of using them. In particular, compounds comprising a novel polyethylene glycol conjugate are used alone, or in combination with antiviral agents to treat a viral infection, such as chronic hepatitis C.
摘要翻译： 本发明涉及新型聚亚烷基二醇化合物及其使用方法。 特别地，包含新型聚乙二醇缀合物的化合物单独使用或与抗病毒剂组合用于治疗病毒感染，例如慢性丙型肝炎。
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7.发明申请INTERFERON-BETA FOR USE AS MONOTHERAPY OR IN COMBINATION WITH OTHER CANCER THERAPIES 审中-公开干扰素作为单独使用或与其他癌症治疗组合使用公开(公告)号：US20120082647A1
公开(公告)日：2012-04-05
申请号：US13247556
申请日：2011-09-28
CPC分类号： A61K38/215 , A61K31/166 , A61K31/337 , A61K31/4188 , A61K31/436 , A61K31/44 , A61K39/3955 , A61K45/06 , A61K47/60 , A61K2039/505 , A61K2300/00 , C07K16/22 , C07K2317/24 , C07K2317/76
摘要： This description relates to the use of a polymer-conjugated interferon-beta as monotherapy or in combination with other cancer therapies.
摘要翻译： 该描述涉及聚合物缀合的干扰素-β作为单一疗法或与其它癌症治疗组合的用途。
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公开(公告)号：US20100279316A1
公开(公告)日：2010-11-04
申请号：US12523681
申请日：2008-01-09
申请人： Leonid Gorelik , Darren P. Baker , Catherine A. Hession , Karyn Van De Mark , Robert M. Arduini , Craig Wildes
发明人： Leonid Gorelik , Darren P. Baker , Catherine A. Hession , Karyn Van De Mark , Robert M. Arduini , Craig Wildes
IPC分类号： G01N33/567 , C07K16/40 , C12N5/12 , G01N33/566
CPC分类号： C07K16/40 , C07K16/44 , G01N33/573 , G01N2333/9121 , G01N2500/02 , G01N2500/10
摘要： The present invention relates to antibodies that bind phosphorylated forms of IRAK4, methods of using such antibodies to detect IRAK4 biological activity, and methods for the detection, diagnosis, and prognostication of pathological conditions related to IRAK4 biological activity. ERAK4 is one member of a small family of highly conserved cytoplasmic signal transduction proteins characterized by the presence of an N-terminal “death domain” and a C-terminal serine-threonine kinase domain. IRAK4 functions in cytoplasmic signal transduction pathways by interacting with membrane spanning proteins which play, inter alia, critical roles in vertebrate immune system function.
摘要翻译： 本发明涉及结合IRAK4的磷酸化形式的抗体，使用这种抗体检测IRAK4生物活性的方法，以及用于检测，诊断和预测与IRAK4生物活性有关的病理学病症的方法。 ERAK4是一种高度保守的细胞质信号转导蛋白家族的成员，其特征在于存在N末端“死亡结构域”和C末端丝氨酸 - 苏氨酸激酶结构域。 IRAK4通过与膜跨膜蛋白相互作用而在细胞质信号转导途径中起作用，尤其是在脊椎动物免疫系统功能中起关键作用。
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