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公开(公告)号：US20090054632A1
公开(公告)日：2009-02-26
申请号：US11894745
申请日：2007-08-20
申请人： R. Blake Pepinsky , Alphonse Galdes , Ellen A. Garber , Darren P. Baker , Jeffery A. Porter , Frederick R. Taylor , Kevin P. Williams , Russell C. Petter , Kathryn Strauch , Paul H. Weinreb , Dingyi Wen , Chenhui Zeng
发明人： R. Blake Pepinsky , Alphonse Galdes , Ellen A. Garber , Darren P. Baker , Jeffery A. Porter , Frederick R. Taylor , Kevin P. Williams , Russell C. Petter , Kathryn Strauch , Paul H. Weinreb , Dingyi Wen , Chenhui Zeng
CPC分类号： C07K14/46 , A61K38/1709 , C07K2319/00
摘要： Hydrophobically-modified proteins and methods of making them are described. A hydrophobic moiety is attached to a surface amino acid residue of the protein. The hydrophobic moiety can be a lipid or a peptide. Alternatively, the protein can be derivatized by a wide variety of chemical reactions that append a hydrophobic structure to the protein. The preferred protein is of mammalian origin and is selected from the group consisting of Sonic, Indian, and Desert hedgehog. The hydrophobic moiety is used as a convenient tether to which may be attached a vesicle such as a cell membrane, liposome, or micelle.
摘要翻译： 描述了疏水性修饰的蛋白质及其制备方法。 疏水部分连接到蛋白质的表面氨基酸残基。 疏水部分可以是脂质或肽。 或者，蛋白质可以通过向蛋白质附加疏水结构的各种化学反应衍生化。 优选的蛋白质是哺乳动物来源的，并且选自Sonic，Indian和Desert hedgehog。 疏水部分用作方便的系链，其可以连接囊泡，例如细胞膜，脂质体或胶束。
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公开(公告)号：US06897297B1
公开(公告)日：2005-05-24
申请号：US09579680
申请日：2000-05-26
申请人： R. Blake Pepinsky , Chenhui Zeng , Darren P. Baker , Dingyi Wen , Kevin P. Williams , Ellen A. Garber , Kathryn L. Strauch , Frederick R. Taylor , Paul H. Weinreb , Russell C. Petter , Alphonse Galdes , Jeffrey Porter
发明人： R. Blake Pepinsky , Chenhui Zeng , Darren P. Baker , Dingyi Wen , Kevin P. Williams , Ellen A. Garber , Kathryn L. Strauch , Frederick R. Taylor , Paul H. Weinreb , Russell C. Petter , Alphonse Galdes , Jeffrey Porter
IPC分类号： A61K38/00 , A61K38/17 , C07K14/46 , C07K14/435 , C07K1/107
CPC分类号： C07K14/46 , A61K38/1709 , C07K2319/00
摘要： Hydrophobically-modified proteins and methods of making them are described. A hydrophobic moiety is attached to a surface amino acid residue of the protein. The hydrophobic moiety can be a lipid or a peptide. Alternatively, the protein can be derivatized by a wide variety of chemical reactions that append a hydrophobic structure to the protein. The preferred protein is of mammalian origin and is selected from the group consisting of Sonic, Indian, and Desert hedgehog. The hydrophobic moiety is used as a convenient tether to which may be attached a vesicle such as a cell membrane, liposome, or micelle.
摘要翻译： 描述了疏水性修饰的蛋白质及其制备方法。 疏水部分连接到蛋白质的表面氨基酸残基。 疏水部分可以是脂质或肽。 或者，蛋白质可以通过向蛋白质附加疏水结构的各种化学反应衍生化。 优选的蛋白质是哺乳动物来源的，并且选自Sonic，Indian和Desert hedgehog。 疏水部分用作方便的系链，其可以连接囊泡，例如细胞膜，脂质体或胶束。
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公开(公告)号：US06444793B1
公开(公告)日：2002-09-03
申请号：US09325256
申请日：1999-06-03
申请人： R. Blake Pepinsky , Darren P. Baker , Dingyi Wen , Kevin P. Williams , Ellen A. Garber , Frederick R. Taylor , Alphonse Galdes , Jeffrey Porter
发明人： R. Blake Pepinsky , Darren P. Baker , Dingyi Wen , Kevin P. Williams , Ellen A. Garber , Frederick R. Taylor , Alphonse Galdes , Jeffrey Porter
IPC分类号： C07K14435
CPC分类号： A61K38/1709 , C07K1/1077 , C07K14/46 , C07K2319/00
摘要： Hydrophobically-modified proteins and methods of making them are described. A hydrophobic moiety is attached to a surface amino acid residue of the protein. The hydrophobic moiety can be a lipid or a peptide. Alternatively, the protein can be derivatized by a wide variety of chemical reactions that append a hydrophobic structure to the protein. The preferred protein is of mammalian origin and is selected from the group consisting of Sonic, Indian, and Desert hedgehog. The hydrophobic moiety is used as a convenient tether to which may be attached a vesicle such as a cell membrane, liposome, or micelle.
摘要翻译： 描述了疏水性修饰的蛋白质及其制备方法。 疏水部分连接到蛋白质的表面氨基酸残基。 疏水部分可以是脂质或肽。 或者，蛋白质可以通过向蛋白质附加疏水结构的各种化学反应衍生化。 优选的蛋白质是哺乳动物来源的，并且选自Sonic，Indian和Desert hedgehog。 疏水部分用作方便的系链，其可以连接囊泡，例如细胞膜，脂质体或胶束。
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公开(公告)号：US08669345B2
公开(公告)日：2014-03-11
申请号：US12162256
申请日：2007-01-26
申请人： Daniel H. S. Lee , Dingyi Wen , R. Blake Pepinsky , Jane K. Relton , Xinzhong Wang , Alexey Lugovskoy , Werner Meier , Ellen A. Garber , Laura Silvian , Paul H. Weinreb
发明人： Daniel H. S. Lee , Dingyi Wen , R. Blake Pepinsky , Jane K. Relton , Xinzhong Wang , Alexey Lugovskoy , Werner Meier , Ellen A. Garber , Laura Silvian , Paul H. Weinreb
IPC分类号： A61K38/00 , C07K2/00 , C07K4/00 , C07K5/00 , C07K7/00 , C07K14/00 , C07K16/00 , C07K17/00 , A61K51/00
CPC分类号： C07K14/705 , A01K67/027 , A01K67/0275 , A01K2217/058 , A01K2227/105 , A01K2267/0356 , A61K38/179 , A61K39/3955 , A61K48/00 , A61K2039/505 , C07K16/28 , C07K16/2863 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/76 , C07K2319/30 , C07K2319/32 , C07K2319/33 , C07K2319/74 , C12N15/1136 , C12N15/1138 , C12N15/8509 , C12N2310/111 , C12N2310/14 , C12N2310/53
摘要： Disclosed are immunogenic Nogo receptor-1 polypeptides, Nogo receptor-1 antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof and nucleic acids encoding the same. Also disclosed are Nogo receptor antagonist polynucleotides. Also disclosed are compositions comprising, and methods for making and using, such Nogo receptor antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof, nucleic acids encoding the same and antagonist polynucleotides.
摘要翻译： 公开了免疫原性Nogo受体-1多肽，Nogo受体-1抗体，其抗原结合片段，可溶性Nogo受体及其融合蛋白和编码其的核酸。 还公开了Nogo受体拮抗剂多核苷酸。 还公开了包含这样的Nogo受体抗体，其抗原结合片段，可溶性Nogo受体及其融合蛋白，编码相同的核苷酸和拮抗剂多核苷酸的制备和使用方法。
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公开(公告)号：US20090099078A1
公开(公告)日：2009-04-16
申请号：US12162256
申请日：2007-01-26
申请人： Daniel H.S. Lee , Dingyi Wen , R. Blake Pepinsky , Jane K. Relton , Xinzhong Wang , Alexey Lugovskoy , Werner Meier , Ellen A. Garber , Laura Silvian , Paul H. Weinreb
发明人： Daniel H.S. Lee , Dingyi Wen , R. Blake Pepinsky , Jane K. Relton , Xinzhong Wang , Alexey Lugovskoy , Werner Meier , Ellen A. Garber , Laura Silvian , Paul H. Weinreb
CPC分类号： C07K14/705 , A01K67/027 , A01K67/0275 , A01K2217/058 , A01K2227/105 , A01K2267/0356 , A61K38/179 , A61K39/3955 , A61K48/00 , A61K2039/505 , C07K16/28 , C07K16/2863 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/76 , C07K2319/30 , C07K2319/32 , C07K2319/33 , C07K2319/74 , C12N15/1136 , C12N15/1138 , C12N15/8509 , C12N2310/111 , C12N2310/14 , C12N2310/53
摘要： Disclosed are immunogenic Nogo receptor-1 polypeptides, Nogo receptor-1 antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof and nucleic acids encoding the same. Also disclosed are Nogo receptor antagonist polynucleotides. Also disclosed are compositions comprising, and methods for making and using, such Nogo receptor antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof, nucleic acids encoding the same and antagonist polynucleotides.
摘要翻译： 公开了免疫原性Nogo受体-1多肽，Nogo受体-1抗体，其抗原结合片段，可溶性Nogo受体及其融合蛋白和编码其的核酸。 还公开了Nogo受体拮抗剂多核苷酸。 还公开了包含这样的Nogo受体抗体，其抗原结合片段，可溶性Nogo受体及其融合蛋白，编码相同的核苷酸和拮抗剂多核苷酸的制备和使用方法。
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公开(公告)号：US20120014916A1
公开(公告)日：2012-01-19
申请号：US13230080
申请日：2011-09-12
申请人： KoChung Lin , R. Blake Pepinsky , Ling Ling Chen , Donna M. Hess , Edward Y. Lin , Russell C. Petter , Darren P. Baker
发明人： KoChung Lin , R. Blake Pepinsky , Ling Ling Chen , Donna M. Hess , Edward Y. Lin , Russell C. Petter , Darren P. Baker
CPC分类号： C08G65/329 , A61K47/60 , C08L2203/02
摘要： The invention relates to novel polyalkylene glycol compounds and methods of using them. In particular, compounds comprising a novel polyethylene glycol conjugate are used alone, or in combination with antiviral agents to treat a viral infection, such as chronic hepatitis C.
摘要翻译： 本发明涉及新型聚亚烷基二醇化合物及其使用方法。 特别地，包含新型聚乙二醇缀合物的化合物单独使用或与抗病毒剂组合用于治疗病毒感染，例如慢性丙型肝炎。
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公开(公告)号：US08524660B2
公开(公告)日：2013-09-03
申请号：US13230080
申请日：2011-09-12
申请人： KoChung Lin , R. Blake Pepinsky , Ling Ling Chen , Donna M. Hess , Edward Y. Lin , Russell C. Petter , Darren P. Baker
发明人： KoChung Lin , R. Blake Pepinsky , Ling Ling Chen , Donna M. Hess , Edward Y. Lin , Russell C. Petter , Darren P. Baker
IPC分类号： A61K47/48 , C08G65/329 , A61K38/00 , C07K17/08 , A61K31/00 , A61K38/21 , C07K14/565 , C12N15/22
CPC分类号： C08G65/329 , A61K47/60 , C08L2203/02
摘要： The invention relates to novel polyalkylene glycol compounds and methods of using them. In particular, compounds comprising a novel polyethylene glycol conjugate are used alone, or in combination with antiviral agents to treat a viral infection, such as chronic hepatitis C.
摘要翻译： 本发明涉及新型聚亚烷基二醇化合物及其使用方法。 特别地，包含新型聚乙二醇缀合物的化合物单独使用或与抗病毒剂组合用于治疗病毒感染，例如慢性丙型肝炎。
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公开(公告)号：US08017733B2
公开(公告)日：2011-09-13
申请号：US10892830
申请日：2004-07-16
申请人： KoChung Lin , R. Blake Pepinsky , Ling Ling Chen , Donna M. Hess , Edward Y. Lin , Russell C. Petter , Darren P. Baker
发明人： KoChung Lin , R. Blake Pepinsky , Ling Ling Chen , Donna M. Hess , Edward Y. Lin , Russell C. Petter , Darren P. Baker
CPC分类号： C08G65/329 , A61K47/60 , C08L2203/02
摘要： The invention relates to novel polyalkylene glycol compounds and methods of using them. In particular, compounds comprising a novel polyethylene glycol conjugate are used alone, or in combination with antiviral agents to treat a viral infection, such as chronic hepatitis C.
摘要翻译： 本发明涉及新型聚亚烷基二醇化合物及其使用方法。 特别地，包含新型聚乙二醇缀合物的化合物单独使用或与抗病毒剂组合用于治疗病毒感染，例如慢性丙型肝炎。
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公开(公告)号：US08609407B2
公开(公告)日：2013-12-17
申请号：US13356413
申请日：2012-01-23
申请人： Sha Mi , R. Blake Pepinsky , Zhaohui Shao , Ellen A. Garber , Steven D. Miklasz , Christilyn Graff
发明人： Sha Mi , R. Blake Pepinsky , Zhaohui Shao , Ellen A. Garber , Steven D. Miklasz , Christilyn Graff
CPC分类号： C07K16/2803 , A61K2039/505 , C07K16/28 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/41 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： Endogenous Sp35 is a negative regulator for neuronal survival, axon regeneration, oligodendrocyte differentiation and myelination. Molecules that block endogenous Sp35 function, such anti-Sp35 antibodies can be used as therapeutics for the treatment of neuron and oligodendrocyte dysfunction. The present invention provides antibodies specific for Sp35, and methods of using such antibodies as antagonists of endogenous Sp35 function. The invention further provides specific hybridoma and phage library-derived monoclonal antibodies, nucleic acids encoding these antibodies, and vectors and host cells comprising these antibodies. The invention further provides methods of promoting oligodendrocyte survival and myelination in a vertebrate, comprising administering to a vertebrate in need of such treatment an effective amount of an anti-Sp35 antibody.
摘要翻译： 内源性Sp35是神经元存活，轴突再生，少突胶质细胞分化和髓鞘形成的负调节因子。 阻断内源性Sp35功能的分子，这种抗Sp35抗体可以用作治疗神经元和少突胶质细胞功能障碍的治疗剂。 本发明提供对Sp35特异性的抗体，以及使用抗体作为内源性Sp35功能拮抗剂的方法。 本发明还提供特异性杂交瘤和源自噬菌体文库的单克隆抗体，编码这些抗体的核酸，以及包含这些抗体的载体和宿主细胞。 本发明还提供了在脊椎动物中促进少突胶质细胞存活和髓鞘形成的方法，其包括对需要这种治疗的脊椎动物施用有效量的抗Sp35抗体。
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公开(公告)号：US20090252748A1
公开(公告)日：2009-10-08
申请号：US12410181
申请日：2009-03-24
申请人： Sha MI , R. Blake Pepinsky , Zhaohui Shao , Ellen A. Garber , Steven D. Miklasz
发明人： Sha MI , R. Blake Pepinsky , Zhaohui Shao , Ellen A. Garber , Steven D. Miklasz
CPC分类号： C07K16/2803 , A61K2039/505 , C07K16/28 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/41 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： Endogenous Sp35 is a negative regulator for neuronal survival, axon regeneration, oligodendrocyte differentiation and myelination. Molecules that block endogenous Sp35 function, such anti-Sp35 antibodies can be used as therapeutics for the treatment of neuron and oligodendrocyte dysfunction. The present invention provides antibodies specific for Sp35, and methods of using such antibodies as antagonists of endogenous Sp35 function. The invention further provides specific hybridoma and phage library-derived monoclonal antibodies, nucleic acids encoding these antibodies, and vectors and host cells comprising these antibodies. The invention further provides methods of promoting oligodendrocyte survival and myelination in a vertebrate, comprising administering to a vertebrate in need of such treatment an effective amount of an anti-Sp35 antibody.
摘要翻译： 内源性Sp35是神经元存活，轴突再生，少突胶质细胞分化和髓鞘形成的负调节因子。 阻断内源性Sp35功能的分子，这种抗Sp35抗体可以用作治疗神经元和少突胶质细胞功能障碍的治疗剂。 本发明提供对Sp35特异性的抗体，以及使用抗体作为内源性Sp35功能拮抗剂的方法。 本发明还提供特异性杂交瘤和源自噬菌体文库的单克隆抗体，编码这些抗体的核酸，以及包含这些抗体的载体和宿主细胞。 本发明还提供了在脊椎动物中促进少突胶质细胞存活和髓鞘形成的方法，其包括对需要这种治疗的脊椎动物施用有效量的抗Sp35抗体。
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