公开(公告)号：US20210371906A1

公开(公告)日：2021-12-02

申请号：US17400168

申请日：2021-08-12

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Yuval EBENSTEIN ,  Micha FRIDMAN

IPC: C12Q1/6806 ,  C12P19/30

Abstract: Methodologies for labeling the epigenetic modification 5-hydroxymethyl-cytosine (5hmC) along a DNA molecule, and for determining a presence or a level of this epigenetic modification based on a ratio of fluorescence intensity of a labeled DNA sample to absorption intensity of the DNA sample at 260 nm are disclosed. Related compositions and reagents, and methods of preparing same are also disclosed.

公开(公告)号：US20190316178A1

公开(公告)日：2019-10-17

申请号：US16424523

申请日：2019-05-29

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Yuval EBENSTEIN ,  Micha FRIDMAN

IPC: C12Q1/6806 ,  C12P19/30 ,  C12Q1/6827

Abstract: Methodologies for labeling the epigenetic modification 5-hydroxymethyl-cytosine (5hmC) along a DNA molecule, and for imaging this epigenetic modification along a DNA molecule are disclosed. Related compositions and reagents, and methods of preparing same are also disclosed.

公开(公告)号：US20230173018A1

公开(公告)日：2023-06-08

申请号：US18106009

申请日：2023-02-06

Applicant: RAMOT AT TEL AVIV UNIVERSITY LTD.

Inventor： Micha FRIDMAN ,  Qais Z JABER ,  Judith BERMAN

IPC: A61K38/12 ,  A61P31/10 ,  C12Q1/18

CPC classification number: A61K38/12 ,  A61P31/10 ,  C12Q1/18

Abstract: Provided herein are caspofungin derivatives having anti-fungal activity and methods of using same for treating fungal infection. Further provided are methods and kits for determining responsiveness to an anti-fungal activity of an echinocandin compound.

公开(公告)号：US20160115525A1

公开(公告)日：2016-04-28

申请号：US14894350

申请日：2014-01-05

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Yuval EBENSTEIN ,  Micha FRIDMAN

IPC: C12Q1/68

CPC classification number: C12Q1/6806 ,  C12P19/305 ,  C12Q1/6827 ,  G01N21/6428 ,  G01N21/6458 ,  C12Q2537/164

Abstract: Methodologies for labeling the epigenetic modification 5-hydroxymethyl-cytosine (5hmC) along a DNA molecule, and for imaging this epigenetic modification along a DNA molecule are disclosed. Related compositions and reagents, and methods of preparing same are also disclosed.

Abstract translation: 公开了沿着DNA分子标记表观遗传修饰5-羟甲基 - 胞嘧啶（5hmC）并沿着DNA分子对该表观遗传修饰进行成像的方法。 还公开了相关的组合物和试剂及其制备方法。