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公开(公告)号：US11111481B2
公开(公告)日：2021-09-07
申请号：US15764691
申请日：2016-09-29
发明人： Tamir Tuller , Eli Goz , Shimshi Atar , Hadas Zur
摘要： Attenuated viruses and methods of designing them are disclosed. In one embodiment, there is disclosed an attenuated form of a virulent virus comprising an RNA encoding a viral protein or a nucleic acid sequence transcribable to said RNA, wherein the folding energy or structure of the RNA is changed at positions of evolutionarily conserved RNA structures with respect to that of said RNA encoding said viral protein in the virulent virus so as to bring about attenuation of the virus.
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公开(公告)号：US11795440B2
公开(公告)日：2023-10-24
申请号：US17467265
申请日：2021-09-05
发明人： Tamir Tuller , Eli Goz , Shimshi Atar , Hadas Zur
CPC分类号： C12N7/00 , A61K39/12 , C12N7/04 , G16B15/10 , G16B99/00 , A61K35/76 , A61K2039/5254 , C12N2770/24121 , C12N2770/24162 , Y02A50/30
摘要： Attenuated viruses and methods of designing them are disclosed. In one embodiment, there is disclosed an attenuated form of a virulent virus comprising an RNA encoding a viral protein or a nucleic acid sequence transcribable to said RNA, wherein the folding energy or structure of the RNA is changed at positions of evolutionarily conserved RNA structures with respect to that of said RNA encoding said viral protein in the virulent virus so as to bring about attenuation of the virus.
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公开(公告)号：US11610650B2
公开(公告)日：2023-03-21
申请号：US14723875
申请日：2015-05-28
发明人： Tamir Tuller , Hadas Zur
IPC分类号： C12N15/79 , G16B30/00 , G16B35/00 , G16C20/60 , C12N15/10 , G06F17/00 , G06F17/10 , G06F17/15 , G06F17/17
摘要： Methods of designing a polynucleotide sequence for expressing a polypeptide-of-interest in a cell are provided. Also provided are artificial transcript sequences generated according to the present teachings. Further provided are methods of estimating the adaptiveness of a transcript sequence encoding a polypeptide-of-interest to a gene expression machinery in a cell.
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公开(公告)号：US11236344B2
公开(公告)日：2022-02-01
申请号：US15985082
申请日：2018-05-21
发明人： Tamir Tuller , Hadas Zur , Rachel Cohen-Kupiec
IPC分类号： C12N15/67 , C12Q1/6809 , C12N15/79
摘要： Genetically modified cells with at least one codon substituted to a synonymous codon, and with modified replicative fitness as compared to the unmodified cell, wherein a slower translating synonymous codon increases replicative fitness and a faster translating codon decreased replicative fitness are provided. Further, vaccine composition comprising those cells as well as methods for modifying replicative fitness of a cell are provided.
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公开(公告)号：US20180334679A1
公开(公告)日：2018-11-22
申请号：US15985082
申请日：2018-05-21
发明人： Tamir Tuller , Hadas Zur , Rachel Cohen-Kupiec
IPC分类号： C12N15/67 , C12N15/79 , C12Q1/6809
CPC分类号： C12N15/67 , C12N15/79 , C12N2800/22 , C12Q1/6809
摘要： Genetically modified cells with at least one codon substituted to a synonymous codon, and with modified replicative fitness as compared to the unmodified cell, wherein a slower translating synonymous codon increases replicative fitness and a faster translating codon decreased replicative fitness are provided. Further, vaccine composition comprising those cells as well as methods for modifying replicative fitness of a cell are provided.
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6.发明申请METHOD AND SYSTEM FOR DESIGNING POLYNUCLEOTIDE SEQUENCES AND POLYNUCLEOTIDE SEQUENCES OBTAINED THEREBY 审中-公开设计多核苷酸序列的方法和系统及其获得的多核苷酸序列公开(公告)号：US20150347677A1
公开(公告)日：2015-12-03
申请号：US14723875
申请日：2015-05-28
发明人： Tamir Tuller , Hadas Zur
CPC分类号： G16B30/00 , C12N15/1089 , G16B35/00 , G16C20/60
摘要： Methods of designing a polynucleotide sequence for expressing a polypeptide-of-interest in a cell are provided. Also provided are artificial transcript sequences generated according to the present teachings. Further provided are methods of estimating the adaptiveness of a transcript sequence encoding a polypeptide-of-interest to a gene expression machinery in a cell.
摘要翻译： 提供了设计用于在细胞中表达感兴趣的多肽的多核苷酸序列的方法。 还提供了根据本教导产生的人工转录物序列。 还提供了估计编码感兴趣多肽的转录本序列与细胞中的基因表达机制的适应性的方法。
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公开(公告)号：US12065651B2
公开(公告)日：2024-08-20
申请号：US16480671
申请日：2018-01-25
申请人： SYNVACCINE LTD.
发明人： Tamir Tuller , Eli Goz , Oriah Mioduser , Alon Diament
CPC分类号： C12N15/67 , C12N7/00 , G16B25/10 , C12N2710/16621 , C12N2710/16634 , C12N2710/16662 , C12N2770/24121 , C12N2770/24134 , C12N2770/24162 , C12N2795/10321 , C12N2795/10362 , C12N2800/22 , C12N2840/10
摘要： Nucleic acid molecules comprising a coding sequence with at least one codon substituted to a synonymous codon, a modified form of a virus comprising the nucleic acid molecules of the invention, and methods for producing these nucleic acid molecules, and viruses, are provided.
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