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公开(公告)号：US20240271105A1
公开(公告)日：2024-08-15
申请号：US18692146
申请日：2022-09-16
Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA
Inventor： Timothy D. O'Brien , Beth Lindborg , Amanda Vegoe , Yi Wen Chai , Manci Li
CPC classification number: C12N5/0697 , A61K35/32 , A61P19/02 , C12N2500/30 , C12N2506/45
Abstract: A method for producing a multi-tissue organoid generally includes obtaining pluripotent stem cells (PSCs) and inducing growth of the multi-tissue organoid by culturing the harvested PSCs in suspension in a culture vessel. Another method for producing a multi-tissue organoid generally includes introducing a pluripotent stem cell into a cell culture medium comprising hyaluronic acid, transferring the pluripotent stem cell to a cell culture device that does not include a three-dimensional matrix, culturing the pluripotent stem cell in the cell culture device for at least 1 week, and producing a multi-tissue organoid comprising cartilage, bone, fibrous connective tissue, brain tissue, or epithelial tissue, or a combination thereof.
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Patent Agency Ranking
公开(公告)号：US12139722B2
公开(公告)日：2024-11-12
申请号：US17344064
申请日：2021-06-10
Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA
Inventor： Timothy D. O'Brien , Beth Lindborg , Amanda Vegoe
Abstract: This disclosure describes methods for organoid generation including, for example, for generation of a multi-tissue organoid. The multi-tissue organoid may include cartilage, bone, epithelium, and/or fibrous connective tissue. This disclosure further describes methods for isolating cells from the organoids and methods of using the organoids and cells of the organoids.
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公开(公告)号：US20200248139A1
公开(公告)日：2020-08-06
申请号：US16637450
申请日：2018-08-08
Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA
Inventor： Timothy D. O'Brien , Beth A. Lindborg , Amanda Vegoe , Jakub Tolar
Abstract: This disclosure describes methods for organoid generation including, for example, for generation of a mid-brain organoid including an A9 neuron. Specifically, the methods comprising: introducing an input cell into a cell culture medium comprising hyaluronic acid, wherein the input cell comprises an embryonic stem cell, an induced pluripotent stem cell, or a neural progenitor cell; transferring the input cell to a cell culture device; and culturing the cell in the cell culture device for at least 7 days. This disclosure further describes methods for using the organoids.
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公开(公告)号：US20210108172A1
公开(公告)日：2021-04-15
申请号：US17070368
申请日：2020-10-14
Applicant: Regents of the University of Minnesota
Inventor： Timothy D. O'Brien , John H. Brekke , Aubie Shaw
Abstract: Fully dissolved, aqueous solutions of polycationic macromolecules and polyanionic macromolecules with a cell suspension are mixed to form a three dimensional hydrogel, useful for clinical, diagnostic, and therapeutic applications.
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公开(公告)号：US20250066719A1
公开(公告)日：2025-02-27
申请号：US18915826
申请日：2024-10-15
Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA
Inventor： Timothy D. O'Brien , Beth Lindborg , Amanda Vegoe
Abstract: This disclosure describes methods for organoid generation including, for example, for generation of a multi-tissue organoid. The multi-tissue organoid may include cartilage, bone, epithelium, and/or fibrous connective tissue. This disclosure further describes methods for isolating cells from the organoids and methods of using the organoids and cells of the organoids.
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公开(公告)号：US20210301251A1
公开(公告)日：2021-09-30
申请号：US17344064
申请日：2021-06-10
Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA
Inventor： Timothy D. O'Brien , Beth Lindborg , Amanda Vegoe
Abstract: This disclosure describes methods for organoid generation including, for example, for generation of a multi-tissue organoid. The multi-tissue organoid may include cartilage, bone, epithelium, and/or fibrous connective tissue. This disclosure further describes methods for isolating cells from the organoids and methods of using the organoids and cells of the organoids.
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