公开(公告)号：US11932628B2

公开(公告)日：2024-03-19

申请号：US17567201

申请日：2022-01-03

申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA ,  TORREY PINES INSTITUTE FOR MOLECULAR STUDIES

发明人： Carrie Haskell-Luevano ,  Skye Ross Doering ,  Marcello A. Giulianotti ,  Clemencia Pinilla ,  Radleigh G. Santos ,  Richard A. Houghten

IPC分类号： C07D403/14 ,  A61K9/20 ,  A61K9/48 ,  A61P3/04

CPC分类号： C07D403/14 ,  A61K9/2013 ,  A61K9/2027 ,  A61K9/2054 ,  A61K9/2059 ,  A61K9/485 ,  A61K9/4858 ,  A61K9/4866 ,  A61P3/04

摘要： The invention provides compounds having the general formula I:




and salts thereof, wherein the variables R1, R2, R3 and R4 have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

公开(公告)号：US20170342107A1

公开(公告)日：2017-11-30

申请号：US15605213

申请日：2017-05-25

申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA ,  TORREY PINES INSTITUTE FOR MOLECULAR STUDIES

发明人： Carrie Haskell-Luevano ,  Skye Ross Doering ,  Jon R. Appel ,  Marc A. Giulianotti ,  Richard A. Houghten ,  Clemencia Pinilla ,  Radleigh G. Santos

IPC分类号： C07K5/10 ,  A61K38/00

CPC分类号： C07K5/1027 ,  A61K38/00

摘要： Certain embodiments of the invention provide a compound of formula (I): R1—C(═O)—W—X—Y—Z—N(R2)2   (I) or a salt thereof, wherein R1, R2, W, X, Y and Z are as defined herein, as well as methods of use thereof.

公开(公告)号：US10899793B2

公开(公告)日：2021-01-26

申请号：US15605213

申请日：2017-05-25

申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA ,  TORREY PINES INSTITUTE FOR MOLECULAR STUDIES

发明人： Carrie Haskell-Luevano ,  Skye Ross Doering ,  Jon R. Appel ,  Marc A. Giulianotti ,  Richard A. Houghten ,  Clemencia Pinilla ,  Radleigh G. Santos

IPC分类号： C07K5/10 ,  A61K38/00 ,  A61K38/07 ,  C07K14/575

摘要： Certain embodiments of the invention provide a compound of formula (I): R1—C(═O)—W—X—Y—Z—N(R2)2  (I) or a salt thereof, wherein R1, R2, W, X, Y and Z are as defined herein, as well as methods of use thereof.

公开(公告)号：US20220213068A1

公开(公告)日：2022-07-07

申请号：US17567201

申请日：2022-01-03

申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA ,  TORREY PINES INSTITUTE FOR MOLECULAR STUDIES

发明人： Carrie Haskell-Luevano ,  Skye Ross Doering ,  Marcello A. Giulianotti ,  Clemencia Pinilla ,  Radleigh G. Santos ,  Richard A. Houghten

IPC分类号： C07D403/14 ,  A61P3/04 ,  A61K9/20 ,  A61K9/48

摘要： The invention provides compounds having the general formula I: and salts thereof, wherein the variables R1, R2, R3 and R4 have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

公开(公告)号：US20240002438A1

公开(公告)日：2024-01-04

申请号：US17944574

申请日：2022-09-14

申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA ,  FLORIDA INTERNATIONAL UNIVERSITY ,  NOVA SOUTHEASTERN UNIVERSITY

发明人： Carrie Haskell-Luevano ,  Mark David Ericson ,  Richard A. Houghten ,  Clemencia Pinilla ,  Marcello Angelo Giulianotti ,  Radleigh G. Santos

IPC分类号： C07K5/117 ,  C07K5/107

CPC分类号： C07K5/1024 ,  C07K5/1016 ,  A61K38/00

摘要： Certain embodiments of the invention provide a compound of formula (I) or a compound of formula (II):


R1—A1—A2—A3—A4—N(R2)2   (I)



R3—A5—A6—A7—A8—N(R4)2   (II)

or a salt thereof, wherein R1, R2, R3, R4, A1, A2, A3, A4, A5, A6, A7, and A8 are as defined herein, as well as methods of use thereof.