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公开(公告)号：US20170158738A1
公开(公告)日：2017-06-08
申请号：US15317693
申请日：2015-06-11
发明人： Kenichi MASUDA , Yasuyuki ISHII , Toshihiro TSUKUI
IPC分类号： C07K7/08 , A61K39/395 , C07K16/18
CPC分类号： C07K7/08 , A61K39/00 , A61K39/39 , A61K39/3955 , A61K2039/55522 , C07K16/18 , C07K16/42 , C07K17/02 , C07K2317/34
摘要： The present invention provides a synthetic peptide capable of inducing an antibody to an autoantigen, and specifically, provides: a multiplexed same type-antigenic peptide having a dendritic core and B-cell recognition peptides, wherein the multiplexed same type-antigenic peptide comprises 4 to 8 B-cell recognition peptides of the same type that are bound to the terminal ends of the dendritic core directly or via a spacer, and each B-cell recognition peptide is bound to the terminal end of the dendritic core directly or via a spacer; an antibody production-inducing agent having the peptides; and a method for producing the peptide.
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2.发明申请ANTI-DOG IgE MONOCLONAL ANTIBODY, AND LIGHT-CHAIN VARIABLE REGION AND HEAVY-CHAIN VARIABLE REGION OF ANTI-DOG IgE MONOCLONAL ANTIBODY 有权抗IgE单克隆抗体，抗链可变区和抗链IgE单克隆抗体的重链可变区公开(公告)号：US20160272728A1
公开(公告)日：2016-09-22
申请号：US14778452
申请日：2014-03-17
申请人： Kazusa DNA Research Institute , Animal Allergy Clinical Laboratories Inc. , Nippon Zenyaku Kogyo Co., Ltd.
发明人： Osamu OHARA , Takahiro NAGASE , Yoshihiro YAMAGUCHI , Reiko OHARA , Kenichi MASUDA , Toshihiro TSUKUI
IPC分类号： C07K16/42 , G01N33/68 , G01N33/577 , C12N15/85
CPC分类号： C07K16/4291 , A01K2217/052 , A01K2227/706 , A01K2267/01 , C07K2317/14 , C07K2317/52 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/624 , C07K2317/626 , C07K2319/21 , C12N15/8509 , C12N2015/8518 , G01N33/577 , G01N33/6854
摘要： Problem to be Solved: The present invention is intended to provide a polynucleotide encoding the light-chain variable region and the heavy-chain variable region of an anti-dog IgE antibody; and an anti-dog IgE antibody containing these variable regions.Solution: The present invention is DNA encoding a heavy-chain variable region consisting of the amino acid sequence represented by SEQ ID NO: 2 or 6 and DNA encoding a light-chain variable region consisting of the amino acid sequence represented by SEQ ID NO: 4 or 8, and an anti-dog IgE monoclonal antibody which binds to dog IgE, containing these variable regions or a functional fragment thereof which binds to dog IgE.
摘要翻译： 解决方案：本发明是编码由SEQ ID NO：2或6所示的氨基酸序列组成的重链可变区的DNA和编码由SEQ ID NO：2或6所示氨基酸序列组成的轻链可变区的DNA。 4或8，以及结合狗IgE的抗狗IgE单克隆抗体，其含有这些可变区或其与狗IgE结合的功能片段。
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3.发明公开公开(公告)号：US20230218742A1
公开(公告)日：2023-07-13
申请号：US17926975
申请日：2021-05-21
发明人： Kenichi MASUDA , Takashi SAITO
IPC分类号： A61K39/215 , C07K14/005 , A61P31/14
CPC分类号： A61K39/215 , C07K14/005 , A61P31/14 , A61K2039/70
摘要： The present invention provides a vaccine against a coronavirus. According to the present invention, there is provided a peptide consisting of the amino acid sequence set forth in SEQ ID NO: 1 or a partial peptide of a coronavirus spike protein consisting of the amino acid sequence corresponding to the amino acid sequence of SEQ ID NO: 1 and a multiple antigen peptide containing a plurality of any of these peptides.
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公开(公告)号：US20190337989A1
公开(公告)日：2019-11-07
申请号：US16345599
申请日：2017-11-02
发明人： Kenichi MASUDA , Takashi SAITO , Yasuyuki ISHII , Ayato TAKADA , Manabu IGARASHI , Junki MARUYAMA , Yusuke SAITO , Takuya NARA
IPC分类号： C07K14/005 , A61K39/145 , A61K39/39 , A61P31/16 , C12N7/00
摘要： This application relates to an useful drug for prevention or treatment of avian influenza virus infection, and specifically provides a multiple antigen peptide comprising a dendritic core and 4-8 antigen peptides, wherein each of the antigen peptides is bound to a terminus of the dendritic core directly or through a spacer, and is a peptide consisting of 7-12 consecutive amino acids in the amino acid sequence of SEQ ID NO: 4, the multiple antigen peptide inducing the production of IgG antibodies in mammalian animals or birds, and further provides an immunity inducer comprising the multiple antigen peptide.
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公开(公告)号：US20210355237A1
公开(公告)日：2021-11-18
申请号：US17278164
申请日：2019-09-20
发明人： Kenichi MASUDA , Takashi SAITO
摘要： The present invention provides an antibody specific to IgE antibody-producing B cells or an antibody binding fragment thereof. More specifically, the present invention provides an isolated monoclonal antibody or an antigen binding fragment thereof that binds to a peptide having a sequence consisting of an amino acid sequence set forth in SEQ ID NO: 1 or 18, and (1) binds to IgE antibody on a B cell surface and/or (2) binds to IgE antibody heated at 56° C.
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公开(公告)号：US20190276495A1
公开(公告)日：2019-09-12
申请号：US16336894
申请日：2017-09-27
发明人： Kenichi MASUDA , Takashi SAITO , Yasuyuki ISHII , Ayato TAKADA , Manabu IGARASHI , Junki MARUYAMA , Yusuke SAITO , Takuya NARA
摘要： This application provides: a multiple antigen peptide comprising a dendritic core and 4-8 antigen peptides, wherein each of the antigen peptides is bound to a terminus of the dendritic core directly or through a spacer and is a peptide consisting of 7-15 consecutive amino acids in the amino acid sequence of SEQ ID NO: 1, or a peptide which is the same as the peptide except that 1-3 amino acids are substituted; and an immune inducer comprising the multiple antigen peptide(s), wherein the multiple antigen peptide and the immune inducer are both useful for prevention or treatment of Ebola virus infection.
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