公开(公告)号：US20230321058A1

公开(公告)日：2023-10-12

申请号：US17719078

申请日：2022-04-12

Applicant: Rohto Pharmaceutical Co., Ltd.

Inventor： Yasuko Matsumura

IPC: A61K31/4402 ,  A61K47/22 ,  A61K47/26 ,  A61K47/32 ,  A61K47/08 ,  A61K47/10 ,  A61K31/196 ,  A61K31/436 ,  A61K33/30 ,  A61K47/02 ,  A61K47/38

CPC classification number: A61K31/4402 ,  A61K47/22 ,  A61K47/26 ,  A61K47/32 ,  A61K47/08 ,  A61K47/10 ,  A61K31/196 ,  A61K31/436 ,  A61K33/30 ,  A61K47/02 ,  A61K47/38

Abstract: The first aspect of the present invention relates to an ophthalmic composition comprising (A) one or more kinds selected from the group consisting of terpenoid, a tocopherol, and a benzyl ammonium compound and a salt thereof, wherein the ophthalmic composition is contained in a container in which a portion or the whole of a part coming into contact with the ophthalmic composition is formed from a resin containing a cyclic olefin.
The second aspect of the present invention relates to an ophthalmic composition comprising (A2) a surface active component and (B2) a buffer, wherein the ophthalmic composition is contained in a container in which a portion or the whole of a part coming into contact with the ophthalmic composition is formed from a resin containing a cyclic olefin.

公开(公告)号：US09173945B2

公开(公告)日：2015-11-03

申请号：US14355350

申请日：2012-10-31

Applicant: ROHTO PHARMACEUTICAL CO., LTD.

Inventor： Yasuko Matsumura ,  Chinatsu Furumiya ,  Masashi Itoh

IPC: A61F2/00 ,  A61K47/38 ,  A61K9/08 ,  A61K31/045 ,  A61K31/122 ,  A61K31/125 ,  A61K33/30 ,  A61K9/00 ,  A61K47/10 ,  A61K47/32 ,  A61K47/36

CPC classification number: A61K47/38 ,  A61K9/0048 ,  A61K9/08 ,  A61K31/045 ,  A61K31/122 ,  A61K31/125 ,  A61K33/30 ,  A61K47/10 ,  A61K47/32 ,  A61K47/36 ,  A61K2300/00

Abstract: The present invention provides an aqueous ophthalmic composition containing (A) a terpenoid, (B) zinc chloride, and (C) at least one member selected from the group consisting of cellulose-based polymeric compounds, vinyl-based polymeric compounds, polyethylene glycols and dextran. According to the present invention, an aqueous ophthalmic composition is provided in which adsorption of the terpenoid to a container can be inhibited, thereby making it possible to inhibit the reduction in the terpenoid content for a long period of time, the aqueous ophthalmic composition having some excellent actions such as an inhibitory action for histamine release, and an inhibitory action for discharges from the eyes.

Abstract translation: 本发明提供含有（A）萜类化合物，（B）氯化锌和（C）至少一种选自纤维素基聚合物，乙烯基类聚合物，聚乙二醇和 葡聚糖 根据本发明，提供一种眼科组合物，其中可以抑制萜类化合物对容器的吸附，从而可以长时间抑制萜类化合物含量的降低，眼用组合物具有一些 优良的作用如对组胺释放的抑制作用，以及从眼睛排出的抑制作用。

公开(公告)号：US20140308368A1

公开(公告)日：2014-10-16

申请号：US14355350

申请日：2012-10-31

Applicant: ROHTO PHARMACEUTICAL CO., LTD.

Inventor： Yasuko Matsumura ,  Chinatsu Furumiya ,  Masashi Itoh

IPC: A61K47/38 ,  A61K31/122 ,  A61K47/36 ,  A61K33/30 ,  A61K47/32 ,  A61K47/10 ,  A61K31/045 ,  A61K31/125

CPC classification number: A61K47/38 ,  A61K9/0048 ,  A61K9/08 ,  A61K31/045 ,  A61K31/122 ,  A61K31/125 ,  A61K33/30 ,  A61K47/10 ,  A61K47/32 ,  A61K47/36 ,  A61K2300/00

Abstract: The present invention provides an aqueous ophthalmic composition containing (A) a terpenoid, (B) zinc chloride, and (C) at least one member selected from the group consisting of cellulose-based polymeric compounds, vinyl-based polymeric compounds, polyethylene glycols and dextran. According to the present invention, an aqueous ophthalmic composition is provided in which adsorption of the terpenoid to a container can be inhibited, thereby making it possible to inhibit the reduction in the terpenoid content for a long period of time, the aqueous ophthalmic composition having some excellent actions such as an inhibitory action for histamine release, and an inhibitory action for discharges from the eyes.

Abstract translation: 本发明提供含有（A）萜类化合物，（B）氯化锌和（C）至少一种选自纤维素基聚合物，乙烯基类聚合物，聚乙二醇和 葡聚糖 根据本发明，提供一种眼科组合物，其中可以抑制萜类化合物对容器的吸附，从而可以长时间抑制萜类化合物含量的降低，眼用组合物具有一些 优良的作用如对组胺释放的抑制作用，以及从眼睛排出的抑制作用。

公开(公告)号：US20170105934A1

公开(公告)日：2017-04-20

申请号：US15317851

申请日：2015-06-09

Applicant: ROHTO Pharmaceutical Co., Ltd.

Inventor： Yoko Mizutare ,  Yasuko Matsumura

IPC: A61K9/08 ,  A61K47/12 ,  A61K47/10 ,  A61K47/18 ,  A61K47/02 ,  A61K9/00 ,  A61K47/26

CPC classification number: A61K9/08 ,  A61K9/0048 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/18 ,  A61K47/26

Abstract: An aqueous ophthalmic composition is provided comprising at least one component which is selected from the group consisting of a polysaccharide, a monosaccharide, at least one vitamin component selected from the group consisting of vitamin B12, vitamin B2, vitamin A and panthenol, at least one oil component selected from the group consisting of a plant oil, an animal oil and a mineral oil, at least one surfactant selected from the group consisting of polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil, polyoxyethylene polyoxypropylene glycol and polyoxyl stearate, an anti-allergic component, a preservative, a thickening component, a polyhydric alcohol, an anti-inflammatory component, an anti-bacterial agent and a cooling and/or refreshing agent; and (B) a buffering agent. When the composition is brought into contact with a polybutylene terephthalate-containing resin container, the container can be prevented from weight change, deterioration and wetting and can be improved in a liquid cutting property.

公开(公告)号：US20140296348A1

公开(公告)日：2014-10-02

申请号：US14355383

申请日：2012-10-31

Applicant: ROHTO PHARMACEUTICAL CO., LTD.

Inventor： Yasuko Matsumura ,  Chinatsu Furumiya ,  Masashi Itoh

IPC: A61K47/02 ,  A61K31/045

CPC classification number: A61K47/02 ,  A61K9/0048 ,  A61K9/08 ,  A61K31/045 ,  A61K31/122 ,  A61K31/125 ,  A61K33/30 ,  A61K2300/00

Abstract: The present invention provides an aqueous ophthalmic composition having a pH of 7 or more, containing a terpenoid and zinc chloride. According to the present invention, an aqueous ophthalmic composition is provided in which adsorption of the terpenoid to a container can be inhibited, thereby making it possible to inhibit the reduction in the terpenoid content for a long period of time, the aqueous ophthalmic composition having some excellent actions such as an inhibitory action for histamine release, and an inhibitory action for discharges from the eyes.

Abstract translation: 本发明提供了含有萜类化合物和氯化锌的pH为7以上的水性眼用组合物。 根据本发明，提供一种眼科组合物，其中可以抑制萜类化合物对容器的吸附，从而可以长时间抑制萜类化合物含量的降低，眼用组合物具有一些 优良的作用如对组胺释放的抑制作用，以及从眼睛排出的抑制作用。

公开(公告)号：US08754029B2

公开(公告)日：2014-06-17

申请号：US13678064

申请日：2012-11-15

Applicant: Rohto Pharmaceutical Co., Ltd.

Inventor： Yasuko Matsumura ,  Kazuhiro Fukushima

IPC: A61K31/00

CPC classification number: A61K31/045 ,  A61F9/0061 ,  A61K9/0046 ,  A61K31/125 ,  A61K31/717 ,  A61K31/721 ,  A61K31/74

Abstract: The present invention provides an ophthalmic composition which stabilizes the tear film during wearing contact lens, prevents eye dryness, imparts a favorable sensation in using, is highly convenient with no risk of misuse and shows a high efficiency in the course from manufacturing to sales. More specifically, the present invention provides a wetting solution—eye drops for contact lenses comprising (A) one or more member(s) selected from the group consisting of a cellulose-based polymer, a vinyl-based polymer, polyethylene glycol and dextran; and (B) a terpenoid.

Abstract translation: 本发明提供了一种眼用组合物，其在佩戴隐形眼镜期间稳定了泪膜，防止眼睛干涩，赋予使用感觉，非常方便，没有被误用的风险，并且在制造过程中显示出高效率。 更具体地说，本发明提供一种用于隐形眼镜的润湿溶液 - 滴眼剂，其包括（A）一种或多种选自纤维素基聚合物，乙烯基类聚合物，聚乙二醇和葡聚糖的成员; 和（B）萜类化合物。

公开(公告)号：US20180161438A1

公开(公告)日：2018-06-14

申请号：US15577560

申请日：2016-05-24

Applicant: ROHTO PHARMACEUTICAL CO., LTD.

Inventor： Yasuko Matsumura

IPC: A61K47/44 ,  A61K9/08 ,  A61K9/00 ,  A61K9/06 ,  A61K47/32 ,  A61K47/38 ,  A61K47/02 ,  A61K47/10 ,  A61K47/36 ,  A61K47/18 ,  A61K47/22 ,  A61K31/27 ,  A61K31/4164 ,  A61K31/4174 ,  A61K31/635 ,  A61K47/34 ,  A61K47/26 ,  A61K47/20 ,  A61K47/12

CPC classification number: A61K47/44 ,  A61K9/0048 ,  A61K9/06 ,  A61K9/08 ,  A61K31/27 ,  A61K31/4164 ,  A61K31/4174 ,  A61K31/635 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/18 ,  A61K47/186 ,  A61K47/20 ,  A61K47/22 ,  A61K47/26 ,  A61K47/32 ,  A61K47/34 ,  A61K47/36 ,  A61K47/38

Abstract: The present invention relates to an aqueous ophthalmic composition that contains (A) vaseline and (B) at least one selected from the group consisting of a vinyl-based polymer compound, a saccharide, an amino acid, polyalcohol, a preservative, a sulfa drug, a vitamin, an inorganic salt compound, an ocular muscle modulator component, a vasoconstrictor, a stabilizer, polyoxyethylene polyoxypropylene glycol, and a vegetable oil.

公开(公告)号：US11331390B2

公开(公告)日：2022-05-17

申请号：US16094919

申请日：2017-04-21

Applicant: Rohto Pharmaceutical Co., Ltd.

Inventor： Yasuko Matsumura

IPC: A61K47/26 ,  A61K9/00 ,  A61K31/045 ,  A61K31/14 ,  A61K31/355 ,  A61K47/44 ,  A61K47/10 ,  C08J5/00 ,  A61K47/18 ,  A61K47/12 ,  A61K47/02 ,  A61K47/22

Abstract: The first aspect of the present invention relates to an ophthalmic composition comprising (A) one or more kinds selected from the group consisting of terpenoid, a tocopherol, and a benzyl ammonium compound and a salt thereof, wherein the ophthalmic composition is contained in a container in which a portion or the whole of a part coming into contact with the ophthalmic composition is formed from a resin containing a cyclic olefin.
The second aspect of the present invention relates to an ophthalmic composition comprising (A2) a surface active component and (B2) a buffer, wherein the ophthalmic composition is contained in a container in which a portion or the whole of a part coming into contact with the ophthalmic composition is formed from a resin containing a cyclic olefin.

公开(公告)号：US20190125877A1

公开(公告)日：2019-05-02

申请号：US16094919

申请日：2017-04-21

Applicant: Rohto Pharmaceutical Co., Ltd.

Inventor： Yasuko Matsumura

IPC: A61K47/26 ,  A61K9/00 ,  A61K31/045 ,  A61K31/14 ,  A61K31/355 ,  A61K47/44 ,  A61K47/10 ,  C08J5/00

Abstract: The first aspect of the present invention relates to an ophthalmic composition comprising (A) one or more kinds selected from the group consisting of terpenoid, a tocopherol, and a benzyl ammonium compound and a salt thereof, wherein the ophthalmic composition is contained in a container in which a portion or the whole of a part coming into contact with the ophthalmic composition is formed from a resin containing a cyclic olefin.The second aspect of the present invention relates to an ophthalmic composition comprising (A2) a surface active component and (B2) a buffer, wherein the ophthalmic composition is contained in a container in which a portion or the whole of a part coming into contact with the ophthalmic composition is formed from a resin containing a cyclic olefin.