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1.发明授权Process for the production of 16alpha 17alpha-dihydroxy-19-nor-progesterone 失效生产16ALPHA 17ALPHA-DIHYDROX-19-NOR-PROGESTERONE的方法
公开(公告)号：US3637770A
公开(公告)日：1972-01-25
申请号：US3637770D
申请日：1969-12-31
Applicant: ROUSSEL UCLAF
Inventor： WARNANT JULIEN , JOLLY JEAN , JOLY ROBERT
Abstract: A PROCESS FOR THE PRODUCTION OF 16A,17A-DIHYDROXY-19NOR-PROGESTERONE FROM A 3,5-IKETAL OF 4,5-SECO-ESTRANE3,5,17-TRIONE BY 17-CYANATION, 16-DEHYDRATION, METHYLATION, HYDROLYSIS OF THE KETALS, CYCLIZATION OF THE A RING AND HYDROXYLATION OF THE $16 BOND. THE INTERMEDIATES ARE ALSO PART OF THE DISCLOURE.
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公开(公告)号：US3424745A
公开(公告)日：1969-01-28
申请号：US45841665
申请日：1965-05-24
Applicant: ROUSSEL UCLAF
Inventor： JOLY ROBERT , WARNANT JULIEN , JOLLY JEAN , PROST-MARECHAL JACQUES , BUCOURT ROBERT , TESSIER JEAN
IPC: A61K31/565 , A61K31/566 , A61K31/567 , A61K31/57 , C07D295/04 , C07J1/00 , C07J5/00 , C07J7/00 , C07J41/00 , C07J75/00 , F16B35/06 , C07C173/10 , C07C169/10 , C07C169/34
CPC classification number: C07D295/04 , A61K31/565 , A61K31/566 , A61K31/567 , A61K31/57 , C07J1/00 , C07J5/00 , C07J7/00 , C07J41/00 , C07J75/00 , F16B35/06
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3.发明授权3,5-diketals of 4,5 - seco-gonane-3,5,17-triones and process of preparation 失效4,5-SEON-GONANE-3,5,17-TRIONES的3,5-二硬脂酸酯和制备方法
公开(公告)号：US3591606A
公开(公告)日：1971-07-06
申请号：US3591606D
申请日：1967-05-23
Applicant: ROUSSEL UCLAF
Inventor： WARNANT JULIEN , JOLLY JEAN , JOLY ROBERT
Abstract: WHEREIN R" IS LOWER ALKYL AND R"'' IS SELECTED FROM THE GROUP CONSISTING OF LOWER ALKYLENE AND SUBSTITUTED LOWER ALKYLENE; AND A IS SELECTED FROM THE GROUP CONSISTING OF TWO HYDROGENS AND A DOUBLE BOND THESE COMPOUNDS ARE USEFUL AS INTERMEDIATES IN THE TOTAL SYNTHESIS OF STEROIDS, PARTICULARLY THOSE HAVING SUBSTITUENTS ON THE 17 CARBON ATOM.
=C(-O-R")2 AND =C
WHREIN R'' REPRESENTS AN ALKYL HAVING FROM 1 TO 4 CARBON ATOMS; X REPRESENTS A MEMBER SELECTED FROM THE GROUP CONSISTING OF
X AND THE 9,11-POSITION IS A
3-(X=),13-R''-GON-4-EN-17-ONE WHERE C-4 IS REPLACED BY
THE PRESENT INVENTON RELATES TO 3,5-DIKETALS OF 4,5SECO-GONANE-3,517-TRIONES OF THE FORMULA-
4.发明授权Acetonides of alpha-monoglycerides of 4 - (2'-carboxyphenylamino)-chloroquinolines 失效4 - （2'-羧基苯基） - 氯代喹啉的单羟酸酯的乙酸酯
公开(公告)号：US3502682A
公开(公告)日：1970-03-24
申请号：US3502682D
申请日：1969-05-15
Applicant: ROUSSEL UCLAF
Inventor： ALLAIS ANDRE , GIRAULT PIERRE , JOLY ROBERT , WARNANT JULIEN , GOFFINET BERNARD
IPC: A61K31/00 , A61K31/395 , C07D215/44 , C07D33/52
CPC classification number: A61K31/00 , A61K31/395 , C07D215/44
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公开(公告)号：US3567732A
公开(公告)日：1971-03-02
申请号：US3567732D
申请日：1968-01-08
Applicant: ROUSSEL UCLAF
Inventor： JOLY ROBERT , WARNANT JULIEN , GOFFINET BERNARD
IPC: C07D215/18 , C07D215/22 , C07D215/233 , C07D33/14
CPC classification number: C07D215/233 , C07D215/18
Abstract: THIS INVENTION RELATES TO A PROCESS FOR THE PREPARATION OF CHLORINATED QUINOLINES OF THE FORMULA
4-CL,CL-QUINOLINE
WHEREIN THE CHLORINE ATTACHED TO THE BENZENE NUCLEUS IS IN A POSITION SELECTED FROM THE GROUP CONSISTING OF THE 5, 6, 7 AND 8 POSITIONS. THE SAID PROCESS INVOLVES REACTING A 2, 3 OR 4-CHLOROANILINE WITH A COMPOUND SELECTED FROM THE GROUP CONSISTING OF B-PROPIOLACTONE AND A COMPOUND OF THE FORMULA
CH2=CH-COOR
WHEREIN R IS SELECTED FROM THE GROUP CONSISTING OF HYDROGEN AND LOWER ALKYL, CYCLIZING THE 3-(CHLOROANILINO)PROPIONIC ACID FORMED WITH POLYPHOSPHORIC ACID, CHLORINATING THE RESULTING 5, 6, 7 OR 8-CHLORO-4-OXO-1,2,3,4TETRAHYDROQUINOLINE WITH PHOSPHORUS OXYCHLORIDE AND RECOVERING SAID CHLORINATED QUINOLINE. THE DICHLOROQUINOLINES ARE KNOWN PRODUCTS USEFUL AS INTERMEDIATES IN THE PRODUCTION OF KNOWN COMPOUNDS HAVING THERAPEUTIC ACTIVITY.-
Patent Agency Ranking6.发明授权Therapeutic compositions and method for the treatment of disorders due to insufficient corpus luteum secretion 失效治疗组合物和治疗由于不合理的分泌物分泌引起的疾病的方法
公开(公告)号：US3557286A
公开(公告)日：1971-01-19
申请号：US3557286D
申请日：1966-12-21
Applicant: ROUSSEL UCLAF
Inventor： JOLY ROBERT , WARNANT JULIEN , FARCILLI ANDRE
CPC classification number: A61K31/57 , A61K9/0019 , A61K9/0031 , A61K9/02 , A61K9/08 , A61K9/10 , A61K9/2018 , A61K9/2059 , A61K47/44
Abstract: THERAPEUTIC COMPOSITIONS AND METHOD FOR THE TREATMENT OF DISORDERS DUE TO AN INSUFFICIENT SECRETION OF THE CORPUS LUTEUM.
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7.发明授权
公开(公告)号：US3518296A
公开(公告)日：1970-06-30
申请号：US3518296D
申请日：1964-04-22
Applicant: ROUSSEL UCLAF
Inventor： BUCOURT ROBERT , PIERDET ANDRE , COSTEROUSSE GERMAIN , HAINAUT DANIEL , JOLY ROBERT , WARNANT JULIEN , GOFFINET BERNARD
CPC classification number: C07C45/676
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公开(公告)号：US3499913A
公开(公告)日：1970-03-10
申请号：US3499913D
申请日：1968-01-03
Applicant: ROUSSEL UCLAF
Inventor： JOLY ROBERT , WARNANT JULIEN , JOLLY JEAN
IPC: C07J73/00 , C07D101/00 , C07C167/02 , C07C169/10
CPC classification number: C07J73/003
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公开(公告)号：US3547959A
公开(公告)日：1970-12-15
申请号：US3547959D
申请日：1969-01-31
Applicant: ROUSSEL UCLAF
Inventor： JOLY ROBERT , WARNANT JULIEN , FARCILLI ANDRE
IPC: C07J1/00 , C07J63/00 , C07J75/00 , D04H11/00 , C07C169/34
CPC classification number: C07J1/00 , C07J63/008 , C07J75/00
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10.发明授权Novel process for the preparation of 3-oxo-delta**4,9,11-trienic steroids 失效3-OXO-DELTA ** 4,9,11-三硝基苯甲酸酯的制备方法
公开(公告)号：US3453267A
公开(公告)日：1969-07-01
申请号：US3453267D
申请日：1965-12-28
Applicant: ROUSSEL UCLAF
Inventor： VIGNAU MICHEL , BUCOURT ROBERT , TESSIER JEAN , COSTEROUSSE GERMAIN , NEDELEC LUCIEN , GASC JEAN-CLAUDE , JOLY ROBERT , WARNANT JULIEN , GOFFINET BERNARD
IPC: C07J1/00 , C07J63/00 , C07J75/00 , C07C167/14 , C07C169/10 , C07C173/00
CPC classification number: C07J1/00 , C07J63/008 , C07J75/00
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