公开(公告)号：US3518296A

公开(公告)日：1970-06-30

申请号：US3518296D

申请日：1964-04-22

Applicant: ROUSSEL UCLAF

Inventor： BUCOURT ROBERT ,  PIERDET ANDRE ,  COSTEROUSSE GERMAIN ,  HAINAUT DANIEL ,  JOLY ROBERT ,  WARNANT JULIEN ,  GOFFINET BERNARD

IPC: C07C45/67 ,  C07C69/74

CPC classification number: C07C45/676

公开(公告)号：US3567732A

公开(公告)日：1971-03-02

申请号：US3567732D

申请日：1968-01-08

Applicant: ROUSSEL UCLAF

Inventor： JOLY ROBERT ,  WARNANT JULIEN ,  GOFFINET BERNARD

IPC: C07D215/18 ,  C07D215/22 ,  C07D215/233 ,  C07D33/14

CPC classification number: C07D215/233 ,  C07D215/18

Abstract: THIS INVENTION RELATES TO A PROCESS FOR THE PREPARATION OF CHLORINATED QUINOLINES OF THE FORMULA

4-CL,CL-QUINOLINE

WHEREIN THE CHLORINE ATTACHED TO THE BENZENE NUCLEUS IS IN A POSITION SELECTED FROM THE GROUP CONSISTING OF THE 5, 6, 7 AND 8 POSITIONS. THE SAID PROCESS INVOLVES REACTING A 2, 3 OR 4-CHLOROANILINE WITH A COMPOUND SELECTED FROM THE GROUP CONSISTING OF B-PROPIOLACTONE AND A COMPOUND OF THE FORMULA

CH2=CH-COOR

WHEREIN R IS SELECTED FROM THE GROUP CONSISTING OF HYDROGEN AND LOWER ALKYL, CYCLIZING THE 3-(CHLOROANILINO)PROPIONIC ACID FORMED WITH POLYPHOSPHORIC ACID, CHLORINATING THE RESULTING 5, 6, 7 OR 8-CHLORO-4-OXO-1,2,3,4TETRAHYDROQUINOLINE WITH PHOSPHORUS OXYCHLORIDE AND RECOVERING SAID CHLORINATED QUINOLINE. THE DICHLOROQUINOLINES ARE KNOWN PRODUCTS USEFUL AS INTERMEDIATES IN THE PRODUCTION OF KNOWN COMPOUNDS HAVING THERAPEUTIC ACTIVITY.

公开(公告)号：US3453267A

公开(公告)日：1969-07-01

申请号：US3453267D

申请日：1965-12-28

Applicant: ROUSSEL UCLAF

Inventor： VIGNAU MICHEL ,  BUCOURT ROBERT ,  TESSIER JEAN ,  COSTEROUSSE GERMAIN ,  NEDELEC LUCIEN ,  GASC JEAN-CLAUDE ,  JOLY ROBERT ,  WARNANT JULIEN ,  GOFFINET BERNARD

IPC: C07J1/00 ,  C07J63/00 ,  C07J75/00 ,  C07C167/14 ,  C07C169/10 ,  C07C173/00

CPC classification number: C07J1/00 ,  C07J63/008 ,  C07J75/00

公开(公告)号：US3646118A

公开(公告)日：1972-02-29

申请号：US3646118D

申请日：1968-07-05

Applicant: ROUSSEL UCLAF

Inventor： GOFFINET BERNARD ,  LOCATELLI ANTOINE

IPC: C07C61/37 ,  C07B31/00 ,  C07B57/00 ,  C07C51/00 ,  C07C51/487 ,  C07C67/00 ,  C07C51/42 ,  C07C61/16

CPC classification number: C07C51/487 ,  C07C61/37

Abstract: A PROCESS FOR THE RECOVERY OF D-TRANS-CHRYSANTHEMIC ACID FROM A MIXTURE OF DL-TRANS-CIS-CHRYSANTHEMIC ACID WITH D(-)-THREO-1-P-NITROPHENYL-2-DIMETHYLAMINO-PROPANE1,3-DIOL.

公开(公告)号：US3502682A

公开(公告)日：1970-03-24

申请号：US3502682D

申请日：1969-05-15

Applicant: ROUSSEL UCLAF

Inventor： ALLAIS ANDRE ,  GIRAULT PIERRE ,  JOLY ROBERT ,  WARNANT JULIEN ,  GOFFINET BERNARD

IPC: A61K31/00 ,  A61K31/395 ,  C07D215/44 ,  C07D33/52

CPC classification number: A61K31/00 ,  A61K31/395 ,  C07D215/44