公开(公告)号：US3769425A

公开(公告)日：1973-10-30

申请号：US3769425D

申请日：1972-06-07

Applicant: ROUSSEL UCLAF

Inventor： ROUSSEAU G ,  POITTEVIN A

IPC: C07C69/738 ,  A61K31/19 ,  A61K31/215 ,  A61P25/04 ,  A61P29/00 ,  C07C15/20 ,  C07C49/385 ,  C07C51/00 ,  C07C53/08 ,  C07C57/38 ,  C07C57/46 ,  C07C57/50 ,  C07C57/62 ,  C07C59/54 ,  C07C59/86 ,  C07C59/88 ,  C07C67/00 ,  C07C405/00 ,  C07D309/06 ,  C07D309/36 ,  C07D311/04 ,  C07D311/96 ,  C07D335/02 ,  A61K27/00

CPC classification number: C07C57/50 ,  C07C57/46 ,  C07C57/62 ,  C07C59/54 ,  C07C59/86 ,  C07C59/88 ,  C07D309/06 ,  C07D311/04 ,  C07D311/96

Abstract: NOVEL SPIRO BENZOCYCLANE ACETIC ACID COMPOUNDS OF THE FORMULA

(-(CH2)2-Y-(CH2)2-)>C
1,2-PHENYLENE)-)

WHEREIN R IS SELECTED FROM THE GROUP CONSISTING OF HYDROGEN AND LINEAR AND BRANCHED ALKLY OF 1 TO 4 CARBON ATOMS. R1 IS SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, CHLORINE, TRIFLUOROMETHYL AND LOWER ALKOXY, Y IS SELECTED FROM THE GROUP CONSISTING OF METHYLENE, OXYGEN AND SULFUR, N IS 2, 3 OR 4 AND R2 IS SELECTED FROM THE GROUP CONSISTING OF HYDROGEN SUBSTITUTED OR UNSUBSTITUTED ALKYL OF 1 TO 6 CARBON ATOMS AND CATION OF NON-TOXIC, PHARMACEUTICALLY ACCEPTABLE MINERAL AND ORGANIC BASES, PROCESSES FOR THEIR PREPRATION AND NOVEL INTERMEDIATES. THE COMPOUNDS OF FORMULA I HAVE ANALGESIC AND ANTI-INFLAMMATORY PROPERTIES.

公开(公告)号：US3799974A

公开(公告)日：1974-03-26

申请号：US25456872

申请日：1972-05-18

Applicant: ROUSSEL UCLAF

Inventor： ROUSSEAU G ,  ALLAIS A ,  POITTEVIN A

IPC: C07C49/675 ,  C07C49/697 ,  C07C57/46 ,  C07C57/50 ,  C07C57/62 ,  C07C59/54 ,  C07C59/86 ,  C07C59/88 ,  C07C69/157 ,  C07D311/96 ,  C07C63/00 ,  C07C65/20

CPC classification number: C07C59/88 ,  C07C49/675 ,  C07C49/697 ,  C07C57/46 ,  C07C57/50 ,  C07C57/62 ,  C07C59/54 ,  C07C59/86 ,  C07D311/96

Abstract: NOVEL SPRIO BENZOCYCLANE ACETIC ACID COMPOUND OF THE FORMULA
WHEREIN R IS SELECTED FROM THE GROUP CONSISTING OF HYDROGEN AND LINEAR AND BRANCHED ALKYL OF 1 TO 4 CARBON ATOMS R1 IS SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, CHLORINE, TRIFLUOROMETHYL AND LOWER ALKOXY, Y IS SELECTED FROM THE GROUP CONSISTING OF METHYLENE, OXYGEN AND SULFUR, N IS 2,3, OR 4 AND R2 IS SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, SUBSTITUTED OR UNSUBSTITUTED ALKYL OF 1 TO 6 CARBON ATOMS AND CATION OF NONTOXIC, PHARMACEUTICALLY ACCEPTABLE MINERAL AND ORGANIC BASES. PROCESSES FOR THEIR PREPARATION AND NOVEL INTERMEDIATES. THE COMPOUNDS OF FORMULA 1 HAVE ANALGESIC AND ANTI-INFLAMMATORY PROPERTIES.

-)-)BENZENE

1-R1,3-(R2-OOC-CH(-R)-),5,6-(-(CH2)N-C