公开(公告)号：US20050265589A1

公开(公告)日：2005-12-01

申请号：US11063662

申请日：2005-02-23

Applicant: Raghu Raghavan ,  Timothy Poston ,  John Kucharczyk

Inventor： Raghu Raghavan ,  Timothy Poston ,  John Kucharczyk

IPC: A61B5/055 ,  A61B6/03 ,  G06F19/00 ,  G06K9/00 ,  G06K9/34 ,  A61B5/05

CPC classification number: G06F19/3481 ,  A61B5/055 ,  A61B6/03 ,  G06F19/00 ,  G06F19/3456 ,  G16H50/50

Abstract: A method supplies a dynamic vector map of properties within a region or a unified suite of quantification functionality for property functions, such as density functions, conduction functions (e.g., thermal conduction, electrical conduction, atomic or subatomic mass conduction, macromolecular mass conduction), defined on, defined in or defining a three-dimensional space, which functions may optionally vary in time. At least two services assisting in the definition of the map or suite, even in a dynamic modality, are selected from: (a) computation of the volume of the region where the density lies above or below a specified threshold, or between two specified values; (b) computation of the integral of the density; (c) estimation of the rate of change of the density with respect to time, optionally restricted to a specified region; (d) estimation of the local or global failure of conservation represented by changes with time in the density; (e) estimation of the local or global rate at which material with a changing density is passing through a specified surface (e.g., boundary); and (f) separation of the density of a material with a changing density, given an implemented transport model, into “free” and “bound” densities.

Abstract translation: 一种方法提供属性功能范围内的属性的动态向量图或属性函数的统一的量化功能，例如密度函数，传导函数（例如，热传导，导电，原子或亚原子质量传导，大分子质量传导） 定义在，定义或定义三维空间，哪些功能可以可选地在时间上变化。 即使在动态模式中，帮助定义地图或套件的至少两个服务可从以下选项中选择：（a）计算密度高于或低于指定阈值或两个指定值之间的区域的体积 ; （b）密度积分的计算; （c）可选地限制在特定区域内的密度相对于时间的变化率的估计; （d）以密度随时间变化而表示的地方或全球保护失效的估计; （e）估计具有变化密度的材料通过指定表面（例如边界）的局部或全局速率; （f）将已实施的运输模式，以密度变化的材料密度分离为“自由”和“限制”密度。

公开(公告)号：US20050186544A1

公开(公告)日：2005-08-25

申请号：US10771545

申请日：2004-02-05

Applicant: Raghu Raghavan ,  Timothy Poston

Inventor： Raghu Raghavan ,  Timothy Poston

IPC: G09B23/28 ,  G09B23/30

CPC classification number: G09B23/30 ,  G06F17/5018

Abstract: A method and system for mapping anatomical connection and signaling across a multiplicity of channels, channel contents, and channel speed. In particular, the anatomical connection and signaling is mapped in relation to the human brain. Constructs a three-dimensional, dynamically structured, active model, for general or individual patterns. Uses for the present invention include: risk reduction in surgery to significant channels; planning cell insertion at sites where they can be expected to migrate to a less reachable target site; guiding searches for metastatic tumors; indirectly localizing brain structures; constructing models of disease in which multiple sites are involved in the deficit and any proposed repair; and building simulation of normal processes which require the sequential interaction of multiple sites.

Abstract translation: 用于在多个信道，信道内容和信道速度上映射解剖连接和信令的方法和系统。 特别地，解剖学连接和信号被映射到与人的大脑相关联。 构建一个三维，动态结构化的活动模型，用于一般或单个模式。 本发明的用途包括：手术对重要通道的风险降低; 在可以预期迁移到较少可达目标站点的地点规划单元插入; 指导性搜索转移性肿瘤; 间接定位脑结构; 构建多个地点涉及赤字和任何拟议修复的疾病模式; 并构建需要多个站点顺序交互的正常进程的模拟。

公开(公告)号：US08438180B2

公开(公告)日：2013-05-07

申请号：US12694905

申请日：2010-01-27

Applicant: Timothy Poston ,  Raghu Raghavan ,  Michael Fenton ,  David Poston

Inventor： Timothy Poston ,  Raghu Raghavan ,  Michael Fenton ,  David Poston

IPC: G06F17/30

CPC classification number: G06F17/30554 ,  G06F17/30424 ,  G06F17/3053 ,  G06F17/3087 ,  G06F17/30873 ,  Y10S707/956 ,  Y10S707/99931 ,  Y10S707/99933 ,  Y10S707/99943

Abstract: A contents display and search system for navigating and searching and exploring a collection of objects includes a database of Attributes; each of the Attributes being associated with one or more objects, and a database of Kinds, each Kind being associated with one or more Attributes. When a user enters a search query including at least one Attribute, an object is tested to determine whether it has Attributes of the Kind corresponding to the Kind of the at least one specified Attribute before function testing is performed. Search and contents investigation results are presented in a hierarchical format in which Kinds and Attributes rather than objects, are displayed until the search or content type is further specified by selecting additional Kinds and/or Attributes such that the number of objects satisfying the specified search is below a threshold. User interaction modifies the hierarchical order of Kinds and Attributes in the display.

Abstract translation: 用于导航和搜索和搜索对象集合的内容显示和搜索系统包括属性数据库; 每个属性与一个或多个对象相关联，以及一个种类的数据库，每个属性与一个或多个属性相关联。 当用户输入包括至少一个属性的搜索查询时，测试对象以在执行功能测试之前确定其是否具有与所述至少一个指定属性的类型相对应的种类的属性。 搜索和内容调查结果以分层格式呈现，其中显示种类和属性而不是对象，直到通过选择附加种类和/或属性进一步指定搜索或内容类型，使得满足指定搜索的对象的数量为 低于门槛。 用户交互在显示中修改种类和属性的层次顺序。

公开(公告)号：US07231075B2

公开(公告)日：2007-06-12

申请号：US11063662

申请日：2005-02-23

Applicant: Raghu Raghavan ,  Timothy Poston ,  John Kucharczyk

Inventor： Raghu Raghavan ,  Timothy Poston ,  John Kucharczyk

IPC: G06K9/00

CPC classification number: G06F19/3481 ,  A61B5/055 ,  A61B6/03 ,  G06F19/00 ,  G06F19/3456 ,  G16H50/50

Abstract: A method supplies a dynamic vector map of properties within a region or a unified suite of quantification functionality for property functions, such as density functions, conduction functions (e.g., thermal conduction, electrical conduction, atomic or subatomic mass conduction, macromolecular mass conduction), defined on, defined in or defining a three-dimensional space, which functions may optionally vary in time. At least two services assisting in the definition of the map or suite, even in a dynamic modality, are selected from: (a) computation of the volume of the region where the density lies above or below a specified threshold, or between two specified values; (b) computation of the integral of the density; (c) estimation of the rate of change of the density with respect to time, optionally restricted to a specified region; (d) estimation of the local or global failure of conservation represented by changes with time in the density; (e) estimation of the local or global rate at which material with a changing density is passing through a specified surface (e.g., boundary); and (f) separation of the density of a material with a changing density, given an implemented transport model, into “free” and “bound” densities.

Abstract translation: 一种方法提供属性功能范围内的属性的动态向量图或属性函数的统一的量化功能，例如密度函数，传导函数（例如，热传导，导电，原子或亚原子质量传导，大分子质量传导） 定义在，定义或定义三维空间，哪些功能可以可选地在时间上变化。 即使在动态模式中，帮助定义地图或套件的至少两个服务可从以下选项中选择：（a）计算密度高于或低于指定阈值或两个指定值之间的区域的体积 ; （b）密度积分的计算; （c）可选地限制在特定区域内的密度相对于时间的变化率的估计; （d）以密度随时间变化而表示的地方或全球保护失效的估计; （e）估计具有变化密度的材料通过指定表面（例如边界）的局部或全局速率; （f）将已实施的运输模式，以密度变化的材料密度分离为“自由”和“限制”密度。

公开(公告)号：US06549803B1

公开(公告)日：2003-04-15

申请号：US09566478

申请日：2000-05-08

Applicant: Raghu Raghavan ,  Timothy Poston ,  Raju R. Viswanathan

Inventor： Raghu Raghavan ,  Timothy Poston ,  Raju R. Viswanathan

IPC: A61B600

CPC classification number: A61M5/14 ,  A61M2005/14208 ,  A61M2005/14292 ,  G06F19/00

Abstract: Movement of material in an organism, such as a drug injected into a brain, is modeled by a uniformly structured field of static constants governing transport by moving fluid and diffusion within the fluid. This supports planning of material introduction, (e.g., infusion, perfusion, retroperfusion, injections, etc.) to achieve a desired distribution of the material, continuing real-time feedback as to whether imaged material is moving as planned and will be distributed as desired, and real-time plan modification to improve results.

Abstract translation: 通过均匀结构化的静态常数场，通过移动流体和流体内的扩散来控制运输的生物体中的物质的运动，例如注射到脑中的药物。 这支持材料介绍（例如输液，灌注，灌注，注射等）的规划，以实现材料的所需分布，持续实时反馈成像材料是否按计划移动，并将根据需要分布 ，并实时计划修改，以提高结果。

公开(公告)号：US20230017291A1

公开(公告)日：2023-01-19

申请号：US17932168

申请日：2022-09-14

Applicant: Raghu Raghavan ,  Timothy Poston

Inventor： Raghu Raghavan ,  Timothy Poston

IPC: A61B8/00 ,  G16H40/67 ,  G06T7/00 ,  A61B8/08 ,  G16H30/20 ,  G16H30/00 ,  G09B23/28 ,  G16H30/40 ,  G16H40/63 ,  G16Z99/00 ,  G16H40/00

Abstract: Methods for acquiring ultrasonic data from a scanner constructed for B-mode scans are disclosed. An image-acquiring system is provided. A three-dimensional target region is selected. A model of the target region comprising a plurality of target locations representing a plurality of planned locations in the target region at which ultrasonic data is to be acquired is created, and a visual representation of the model comprising a plurality of graphical elements is displayed. Ultrasonic data at each of the planned locations is acquired. A transformation of the visual representation is executed, comprising: performing a data quality test at each target location; for any target location that fails the data quality test, altering a graphical element corresponding to the failed target location to indicate failure of the data quality test at that location; and displaying a transformed visual representation comprising updated graphical elements on the visual display

公开(公告)号：US20190021698A1

公开(公告)日：2019-01-24

申请号：US16144536

申请日：2018-09-27

Applicant: Raghu Raghavan ,  Timothy Poston

Inventor： Raghu Raghavan ,  Timothy Poston

IPC: A61B8/00 ,  G09B23/28 ,  G06T7/00 ,  G06F19/00 ,  A61B8/08 ,  G16H40/67 ,  G16H30/40 ,  G16H30/00 ,  G16H30/20 ,  G16H40/00

Abstract: Methods for acquiring ultrasonic data are disclosed. An image-acquiring system is provided. A three-dimensional target region is selected. A plurality of fiducial positions corresponding to anatomical features in the target region are calculated. A model of the target region comprising a plurality of target locations representing a plurality of planned locations in the target region at which ultrasonic data is to be acquired is created, and a visual representation of the model comprising a plurality of graphical elements is displayed. Ultrasonic data at each of the planned locations is acquired. A transformation of the visual representation is executed, comprising: performing a data quality test at each target location; for any target location that fails the data quality test, altering a graphical element corresponding to the failed target location to indicate failure of the data quality test at that location; and displaying a transformed visual representation comprising updated graphical elements on the visual display.

公开(公告)号：US08249813B2

公开(公告)日：2012-08-21

申请号：US10442989

申请日：2003-05-22

Applicant: Raghu Raghavan ,  Timothy Poston

Inventor： Raghu Raghavan ,  Timothy Poston

IPC: G01N33/48 ,  G01N33/50 ,  G01N31/00 ,  G06F7/60 ,  C12Q1/00

CPC classification number: A61M5/14

Abstract: A computer-implemented system and method for determining an optimal manner of introducing and moving an introduced entity from an introduction site to a target tissue region. The method comprises: calculating a modeling value at the introduction site, the pathway to the target tissue region, and the target tissue region; calculating a diffusion value representing a concentration gradient of the introduced entity as it moves through the introduction site, the pathway, and the target tissue region; calculating a flow value representing how the introduced entity is transported through the introduction site, the pathway, and the target tissue region; and determining a time, location, and method for introducing and moving the introduced entity based on the modeling value, the diffusion value, and the flow value.

Abstract translation: 一种计算机实现的系统和方法，用于确定将引入的实体从引入位点引入和移动到目标组织区域的最佳方式。 该方法包括：计算引入位点的模拟值，到目标组织区域的路径和目标组织区域; 计算表示所引入实体在通过引入位点，途径和目标组织区域移动时的浓度梯度的扩散值; 计算表示引入实体如何通过引入位点，途径和目标组织区域传送的流量值; 以及基于建模值，扩散值和流量值确定用于引入和移动引入的实体的时间，位置和方法。

公开(公告)号：US06749833B2

公开(公告)日：2004-06-15

申请号：US09866524

申请日：2001-05-25

Applicant: Raghu Raghavan ,  Timothy Poston

Inventor： Raghu Raghavan ,  Timothy Poston

IPC: A61K4900

CPC classification number: A61K49/00

Abstract: The present invention includes a method for evaluating the acceptability of a device for the delivery of cells in a cell implantation therapy comprising: determining a first rate of cell survival in a stable environment, evaluating a second rate of survival during a procedure using a device that manipulates cells, and comparing the first and second rates of survival to determine the effect of the device used during the procedure on cell survival rates to establish a base line effect of the manipulative procedure on cell survivability. That method may be practiced wherein after determining the second survival rate, modifying the design of the device, evaluating a third rate of survival after modifying the design of the device to determine if the change has increased the rate of survival during the procedure. The method is particularly effective where the procedure is selected from the group consisting of cell harvesting, cell transport, cell implantation, and cell delivery. The procedure may include, for example, a peristalsis process for movement of cells during the procedure or a bolus flow of cells for movement of cells during the procedure.

Abstract translation: 本发明包括用于评估细胞注射疗法中用于递送细胞的装置的可接受性的方法，包括：在稳定环境中确定细胞存活的第一速率，在使用装置期间评估在手术期间的第二生存率 操纵细胞，并比较第一和第二生存率，以确定在手术期间使用的装置对细胞存活率的影响，以建立操纵程序对细胞存活率的基线效应。 可以实施该方法，其中在确定第二存活率之后，修改装置的设计，在修改装置的设计之后评估第三生存率，以确定改变是否在手术过程中增加了存活率。 该方法特别有效，其中该方法选自细胞收集，细胞转运，细胞移植和细胞递送。 该程序可以包括例如用于在手术期间移动细胞的蠕动过程或用于细胞在手术过程中移动的细胞的推注流。

公开(公告)号：US06697661B2

公开(公告)日：2004-02-24

申请号：US10043323

申请日：2002-01-14

Applicant: Raghu Raghavan ,  Timothy Poston ,  Raju R. Viswanathan

Inventor： Raghu Raghavan ,  Timothy Poston ,  Raju R. Viswanathan

IPC: A61B5055

CPC classification number: G01R33/285 ,  G01R33/583

Abstract: An apparatus, system and method for calibrating a movable receiver coil with spatially varying signal reception profile in a magnetic resonance imaging environment is described. The method of the invention calibrates the movable receiver coil with spatially varying signal reception profile by dividing the receiver coil into parts and determining electromagnetic interactions of the parts in the environment. The method further includes (1) estimating orientation and position information corresponding to the receiver coil and (2) associating electromagnetic interaction data with records such as (a) responses of the receiver coil in various tissue environments to emissions caused by stimuli from external magnetic resonance coils, (b) high-resolution external receiver coil records of emissions from same environments, and (c) measurements of self-interactions and mutual interactions among the parts of the receiver coil.

Abstract translation: 描述了用于在磁共振成像环境中校准具有空间变化的信号接收简档的可移动接收器线圈的装置，系统和方法。 本发明的方法通过将接收器线圈分成部分并确定环境中部件的电磁相互作用来校准具有空间变化的信号接收轮廓的可移动接收器线圈。 该方法还包括（1）估计与接收器线圈对应的取向和位置信息，以及（2）将电磁相互作用数据与诸如（a）接收器线圈在各种组织环境中的响应与来自外部磁共振的刺激引起的发射相关联的记录 线圈，（b）来自相同环境的高分辨率外部接收器线圈记录，以及（c）接收器线圈部分之间的自相互作用和相互作用的测量。