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1.发明授权公开(公告)号：US07231075B2
公开(公告)日：2007-06-12
申请号：US11063662
申请日：2005-02-23
申请人： Raghu Raghavan , Timothy Poston , John Kucharczyk
发明人： Raghu Raghavan , Timothy Poston , John Kucharczyk
IPC分类号： G06K9/00
CPC分类号： G06F19/3481 , A61B5/055 , A61B6/03 , G06F19/00 , G06F19/3456 , G16H50/50
摘要： A method supplies a dynamic vector map of properties within a region or a unified suite of quantification functionality for property functions, such as density functions, conduction functions (e.g., thermal conduction, electrical conduction, atomic or subatomic mass conduction, macromolecular mass conduction), defined on, defined in or defining a three-dimensional space, which functions may optionally vary in time. At least two services assisting in the definition of the map or suite, even in a dynamic modality, are selected from: (a) computation of the volume of the region where the density lies above or below a specified threshold, or between two specified values; (b) computation of the integral of the density; (c) estimation of the rate of change of the density with respect to time, optionally restricted to a specified region; (d) estimation of the local or global failure of conservation represented by changes with time in the density; (e) estimation of the local or global rate at which material with a changing density is passing through a specified surface (e.g., boundary); and (f) separation of the density of a material with a changing density, given an implemented transport model, into “free” and “bound” densities.
摘要翻译： 一种方法提供属性功能范围内的属性的动态向量图或属性函数的统一的量化功能，例如密度函数，传导函数（例如，热传导，导电，原子或亚原子质量传导，大分子质量传导） 定义在，定义或定义三维空间，哪些功能可以可选地在时间上变化。 即使在动态模式中，帮助定义地图或套件的至少两个服务可从以下选项中选择：（a）计算密度高于或低于指定阈值或两个指定值之间的区域的体积 ; （b）密度积分的计算; （c）可选地限制在特定区域内的密度相对于时间的变化率的估计; （d）以密度随时间变化而表示的地方或全球保护失效的估计; （e）估计具有变化密度的材料通过指定表面（例如边界）的局部或全局速率; （f）将已实施的运输模式，以密度变化的材料密度分离为“自由”和“限制”密度。
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2.发明申请公开(公告)号：US20050265589A1
公开(公告)日：2005-12-01
申请号：US11063662
申请日：2005-02-23
申请人： Raghu Raghavan , Timothy Poston , John Kucharczyk
发明人： Raghu Raghavan , Timothy Poston , John Kucharczyk
CPC分类号： G06F19/3481 , A61B5/055 , A61B6/03 , G06F19/00 , G06F19/3456 , G16H50/50
摘要： A method supplies a dynamic vector map of properties within a region or a unified suite of quantification functionality for property functions, such as density functions, conduction functions (e.g., thermal conduction, electrical conduction, atomic or subatomic mass conduction, macromolecular mass conduction), defined on, defined in or defining a three-dimensional space, which functions may optionally vary in time. At least two services assisting in the definition of the map or suite, even in a dynamic modality, are selected from: (a) computation of the volume of the region where the density lies above or below a specified threshold, or between two specified values; (b) computation of the integral of the density; (c) estimation of the rate of change of the density with respect to time, optionally restricted to a specified region; (d) estimation of the local or global failure of conservation represented by changes with time in the density; (e) estimation of the local or global rate at which material with a changing density is passing through a specified surface (e.g., boundary); and (f) separation of the density of a material with a changing density, given an implemented transport model, into “free” and “bound” densities.
摘要翻译： 一种方法提供属性功能范围内的属性的动态向量图或属性函数的统一的量化功能，例如密度函数，传导函数（例如，热传导，导电，原子或亚原子质量传导，大分子质量传导） 定义在，定义或定义三维空间，哪些功能可以可选地在时间上变化。 即使在动态模式中，帮助定义地图或套件的至少两个服务可从以下选项中选择：（a）计算密度高于或低于指定阈值或两个指定值之间的区域的体积 ; （b）密度积分的计算; （c）可选地限制在特定区域内的密度相对于时间的变化率的估计; （d）以密度随时间变化而表示的地方或全球保护失效的估计; （e）估计具有变化密度的材料通过指定表面（例如边界）的局部或全局速率; （f）将已实施的运输模式，以密度变化的材料密度分离为“自由”和“限制”密度。
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公开(公告)号：US20220054153A1
公开(公告)日：2022-02-24
申请号：US17460210
申请日：2021-08-28
IPC分类号： A61B17/221
摘要： An intravascular thrombus retraction device and method utilizing wires compressible into a compact form within a catheter and are self-expandable into a wire mesh web with fluid-penetrable openings in the wire mesh small enough to filter clot particles. A base of the wire mesh web is connected to a radially ring-shaped structure supporting and maintaining an opening in the base of the wire mesh and forming a thrombus capture volume. The ring-shaped structure is compressible into the catheter and is self-expandable when free of compressive forces within the catheter to open up into the open, expanded ring-shaped structure, maintaining the opening in the opening in the base of the wire mesh.
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公开(公告)号：US20110230909A1
公开(公告)日：2011-09-22
申请号：US13152004
申请日：2011-06-02
IPC分类号： A61F2/01
CPC分类号： A61F2/01 , A61B17/12022 , A61B17/12145 , A61B17/1215 , A61B17/1219 , A61B17/221 , A61B17/32056 , A61B2017/22034 , A61B2017/2212 , A61F2002/016 , A61F2230/0078 , A61F2230/0091
摘要： A device capable of capturing and facilitating the removal of a thrombus in blood vessels (or stones in biliary or urinary ducts, or foreign bodies) uses a soft coil mesh with the aid of a pull wire or string to engage the surface of a thrombus, and remove the captured thrombus. The soft coil mesh is formed by an elongated microcoil element that forms the helical elements of a macrocoil element. The microcoil element provides a relatively elastic effect to the helical elements forming the macrocoil and allows for control of gripping forces on the thrombus while reducing non-rigid contact of the device with arterial walls. The use of multiple coil mesh elements, delivered through a single lumen or multiple lumens, preferably with separate control of at least one end of each coil, provides a firm grasp on a distal side of a thrombus, assisting in non-disruptive or minimally disrupted removal of the thrombus upon withdrawal of the device.
摘要翻译： 能够捕获和促进血管（或胆管或泌尿道或异物中的石块）的去除的装置使用软线圈网，借助于拉丝或绳子来接合血栓的表面， 并取出捕获的血栓。 软线圈网由形成大量线圈元件的螺旋元件的细长的微线圈元件形成。 微线圈元件对形成大螺线管的螺旋元件提供相对弹性的效果，并且允许控制血栓上的夹持力，同时减少装置与动脉壁的非刚性接触。 使用通过单个腔或多个流明递送的多个线圈网状元件，优选地具有每个线圈的至少一个端部的单独控制，在血栓的远端侧提供牢固的抓握，辅助非破坏性或最小程度的破坏 取出装置时取出血栓。
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公开(公告)号：US07048716B1
公开(公告)日：2006-05-23
申请号：US09448720
申请日：1999-11-24
CPC分类号： A61M25/0043 , A61M25/0108 , A61M25/0127 , G01R33/285
摘要： A catheter is used for medical treatments within an organism. The catheter comprises at least one lumen. Within the at least one lumen are at least two microcatheters, with at least one of the at least two microcatheters being connected to a source of liquid material to be delivered to the organism and another of the at least two microcatheters being connected to a system capable of effecting a medical treatment other than delivery of the liquid.
摘要翻译： 导管用于生物体内的医疗治疗。 导管包括至少一个内腔。 所述至少一个腔内至少有两个微导管，所述至少两个微导管中的至少一个微小导管连接到待传递给所述生物的液体材料源，并且所述至少两个微导管中的另一个连接到能够 除了输送液体之外进行医疗。
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公开(公告)号：US06626902B1
公开(公告)日：2003-09-30
申请号：US09548110
申请日：2000-04-12
申请人： John Kucharczyk , George T. Gillies
发明人： John Kucharczyk , George T. Gillies
IPC分类号： A61B1818
CPC分类号： A61B5/14503 , A61B5/14539 , A61B5/411 , A61B5/416 , A61B2562/17 , A61M2025/0036 , A61M2025/004
摘要： A multi-lumen, multi-functional catheter system comprising a plurality of axial lumens, at least one lumen supporting a functionality other than material delivery and material removal.
摘要翻译： 一种多腔多功能导管系统，包括多个轴向内腔，至少一个内腔，其支撑材料输送和材料移除以外的功能。
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公开(公告)号：US06463317B1
公开(公告)日：2002-10-08
申请号：US09081319
申请日：1998-05-19
申请人： John Kucharczyk , Richard Latchaw
发明人： John Kucharczyk , Richard Latchaw
IPC分类号： A61B5055
CPC分类号： A61F2/958 , A61B5/02014 , A61B5/055 , A61B5/411 , A61B5/4839 , A61B17/12022 , A61B17/12113 , A61B17/12136 , A61B17/1214 , A61B17/1219 , A61B2090/374
摘要： This invention provides a method and a device for treating hemodynamically significant aneurysms especially in the intracranial and extracranial circulation regions using either X-ray fluoroscopy or real-time magnetic resonance (MR) imaging guidance. An MR-visible parachute-shaped occlusion device, e.g., containing multiple elongated filamentary loops made of a memory metal, elastomeric hydrogel or other expansile material, is deployed into the aneurysm by radial expansion of the expansile material outwardly into contact with the interior aneurysm surface. The device is firmly positioned against the interior aneurysm surface using a coating which adheres to that interior aneurysm surface. The device may be filled with a hardenable polymer for permanent and complete aneurysm occlusion. Wide-neck aneurysms may be treated with the same device, with the addition of a temporary balloon expanded in the parent vessel to allow expansion of the occluding device within the aneurysm, instillation of the polymer into the device, and detachment of the device from the transporting catheter. Detachment of the aneurysm occlusion device from a transport catheter is achieved by mechanical, electrical and/or chemical decoupling. A coating applied to the surface of the parachute device may induce thrombotic occlusion of the aneurysm by timed delivery of biologic modifier drugs which promote collagen formation, fibroblast growth, and endothelial ingrowth within the aneurysm. The catheter systems may have attached microcoils or may be impregnated with MR-visible agents to permit visualization in MR imaging systems.
摘要翻译： 本发明提供一种用于使用X射线荧光透视或实时磁共振（MR）成像指导，特别是在颅内和颅外循环区域中治疗血液动力学显着的动脉瘤的方法和装置。 MR记录的降落伞形闭塞装置，例如包含由记忆金属，弹性体水凝胶或其它可膨胀材料制成的多个细长丝状环，通过向外膨胀膨胀材料径向膨胀而与内部动脉瘤表面接触而部署到动脉瘤中 。 该装置使用粘附于内部动脉瘤表面的涂层牢固地抵靠内部动脉瘤表面定位。 该装置可以填充用于永久和完全动脉瘤闭塞的可硬化聚合物。 可以使用相同的装置处理宽颈动脉瘤，同时在母体血管中添加临时囊扩张，以允许阻塞装置在动脉瘤内膨胀，将聚合物滴入装置中，并将装置从 运输导管。 通过机械，电和/或化学去耦实现动脉瘤闭塞装置从运输导管的分离。 施加到降落伞装置的表面上的涂层可以通过定时递送促进胶原形成，成纤维细胞生长和动脉内皮内向内生长的生物修饰剂药物来引起动脉瘤的血栓闭塞。 导管系统可以具有附接的微线圈或可以用MR-可见剂浸渍以允许MR成像系统中的可视化。
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公开(公告)号：US08480697B2
公开(公告)日：2013-07-09
申请号：US13152004
申请日：2011-06-02
IPC分类号： A61B17/22
CPC分类号： A61F2/01 , A61B17/12022 , A61B17/12145 , A61B17/1215 , A61B17/1219 , A61B17/221 , A61B17/32056 , A61B2017/22034 , A61B2017/2212 , A61F2002/016 , A61F2230/0078 , A61F2230/0091
摘要： A device capable of capturing and facilitating the removal of a thrombus in blood vessels (or stones in biliary or urinary ducts, or foreign bodies) uses a soft coil mesh with the aid of a pull wire or string to engage the surface of a thrombus, and remove the captured thrombus. The soft coil mesh is formed by an elongated microcoil element that forms the helical elements of a macrocoil element. The microcoil element provides a relatively elastic effect to the helical elements forming the macrocoil and allows for control of gripping forces on the thrombus while reducing non-rigid contact of the device with arterial walls. The use of multiple coil mesh elements, delivered through a single lumen or multiple lumens, preferably with separate control of at least one end of each coil, provides a firm grasp on a distal side of a thrombus, assisting in non-disruptive or minimally disrupted removal of the thrombus upon withdrawal of the device.
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公开(公告)号：US07670327B2
公开(公告)日：2010-03-02
申请号：US11105166
申请日：2005-04-13
申请人： John Kucharczyk , George T. Gillies
发明人： John Kucharczyk , George T. Gillies
IPC分类号： A61M31/00
CPC分类号： A61M25/003 , A61M25/0032 , A61M25/007 , A61M2025/0004 , A61M2025/0039
摘要： A method is disclosed for the delivery of therapeutic agents into tissues, blood vessels, and body ducts of the human body. A novel catheter enables controlled directing of emitted drug delivery to assist control of drug dwell time in targeted areas. One coaxial catheter embodiment provides capability for locating an outer lumen of the system into the target region, with localization of said outer lumen carried out by use of appropriate medical imaging modalities. In one embodiment, an inner lumen of the catheter means is primed with the agent to be delivered, and recirculated flow of the agent through pluralities of appropriately positioned port holes on the two lumens then occurs via one or more active and/or passive flow driving and guiding techniques intrinsic to the design of the coaxial catheter system. Another coaxial catheter embodiment carries and emits agent in an outer cannula and recaptures agent plus liquid or fluids in the body (such as blood, bile, serum, stable (non-flowing) liquid or kinetic liquid) in an inner cannula.
摘要翻译： 公开了用于将治疗剂递送到人体的组织，血管和体导管中的方法。 一种新型的导管能够控制引导排出的药物输送以帮助控制目标区域中的药物停留时间。 一个同轴导管实施例提供了将系统的外腔定位到目标区域中的能力，通过使用适当的医学成像模式对所述外腔进行定位。 在一个实施例中，导管装置的内腔用待传递的药剂引发，并且药剂的再循环流动通过两个流明上的多个适当定位的孔口然后经由一个或多个主动和/或被动流动驱动 以及设计同轴导管系统固有的指导技术。 另一个同轴导管实施例在外插管中携带并发射试剂，并在内套管中重新捕获剂体内加液体或液体（例如血液，胆汁，血清，稳定（非流动）液体或动力学液体）。
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公开(公告)号：US20090209831A1
公开(公告)日：2009-08-20
申请号：US12321139
申请日：2009-01-15
申请人： John Kucharczyk , Mark A. Litman
发明人： John Kucharczyk , Mark A. Litman
摘要： A method is provided herein for indicating viability of cells grown on a rejection inert tissue cytoarchitecture or scaffolding with a medical device that supports at least one sensing function comprising: non-destructively observing a region of a patient to where cells have been transplanted; guiding the medical device to said region of a patient using the non-destructive observation; positioning said medical device within said region of a patient using the non-destructive observation to assist in the positioning; sensing a property within said region of a patient that is indicative of cell viability or nonviability; and using data from sensing said property within said region to indicate cell viability from a transplant with the region. Magnetic Resonance Imaging is a particularly useful format for non-destructive observation of the region.
摘要翻译： 本文提供了一种用于指示在具有支持至少一种感测功能的医疗装置的排斥惰性组织细胞结构或脚手架上生长的细胞的活力的方法，包括：非破坏性地观察患者移植细胞的区域; 使用非破坏性观察将医疗装置引导到患者的所述区域; 使用非破坏性观察将所述医疗装置定位在患者的所述区域内以辅助定位; 感测指示细胞活力或不可行性的患者的所述区域内的性质; 以及使用来自所述区域内的所述属性的数据来表示来自所述区域的移植的细胞活力。 磁共振成像是对该区域进行非破坏性观察的特别有用的形式。
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