公开(公告)号：US07038041B2

公开(公告)日：2006-05-02

申请号：US10257081

申请日：2001-04-12

申请人： Rahul Ray ,  Scott C. Mohr ,  Narasimha Swamy

发明人： Rahul Ray ,  Scott C. Mohr ,  Narasimha Swamy

IPC分类号： C07D487/22 ,  C07D209/00 ,  A61K31/555

CPC分类号： C07J43/00 ,  A61K41/0071

摘要： An estrogen/antiestrogen-porphyrin conjugate, their composition and methods for their use are claimed. The active compounds of the invention are conjugates consisting of an estrogen or anti estrogen portion, tether or linker portion and a porphyrin portion. The method of invention exploits an active process that involves strong and specific interactions between nuclear receptor and its cognate ligand.

公开(公告)号：US08853188B2

公开(公告)日：2014-10-07

申请号：US13402023

申请日：2012-02-22

申请人： Narasimha Swamy

发明人： Narasimha Swamy

IPC分类号： A61K31/593 ,  A61K31/695 ,  C07C401/00 ,  A61K31/59

CPC分类号： A61K31/59

摘要： Bromoacetoxycalcidiol (B3CD), which is structurally related to calcidiol, exhibits cytotoxic and apoptotic activity toward cancer cells, including highly aggressive neuroblastoma cells. A series of small molecules designed around the structure of B3CD is expected to have growth inhibitory and apoptogenic activities toward a wide range of malignancies. B3CD shows no apparent toxicity in vivo, indicating potential value as a chemotherapeutic agent which will be particularly useful in treating highly aggressive tumors.

摘要翻译： 与calcidiol结构相关的溴乙酰氧基胆钙二醇（B3CD）对癌细胞（包括高度侵袭性的神经母细胞瘤细胞）表现出细胞毒性和凋亡活性。 围绕B3CD结构设计的一系列小分子预计具有朝向广泛恶性肿瘤的生长抑制和凋亡活性。 B3CD在体内没有明显的毒性，表明作为化学治疗剂的潜在价值，其将特别可用于治疗高度侵袭性的肿瘤。

公开(公告)号：US20120270839A1

公开(公告)日：2012-10-25

申请号：US13402023

申请日：2012-02-22

申请人： Narasimha Swamy ,  Hema Malini K. Sundaresha

发明人： Narasimha Swamy ,  Hema Malini K. Sundaresha

IPC分类号： A61K31/593 ,  A61P35/02 ,  C07D495/04 ,  C07C401/00 ,  C07F7/18 ,  C12N5/09 ,  A61P35/00 ,  A61K31/695

CPC分类号： A61K31/59

摘要： Bromoacetoxycalcidiol (B3CD), which is structurally related to calcidiol, exhibits cytotoxic and apoptotic activity toward cancer cells, including highly aggressive neuroblastoma cells. A series of small molecules designed around the structure of B3CD is expected to have growth inhibitory and apoptogenic activities toward a wide range of malignancies. B3CD shows no apparent toxicity in vivo, indicating potential value as a chemotherapeutic agent which will be particularly useful in treating highly aggressive tumors.

摘要翻译： 与calcidiol结构相关的溴乙酰氧基胆钙二醇（B3CD）对癌细胞（包括高度侵袭性的神经母细胞瘤细胞）表现出细胞毒性和凋亡活性。 围绕B3CD结构设计的一系列小分子预计具有朝向广泛恶性肿瘤的生长抑制和凋亡活性。 B3CD在体内没有明显的毒性，表明作为化学治疗剂的潜在价值，其将特别可用于治疗高度侵袭性的肿瘤。

公开(公告)号：US20100144671A1

公开(公告)日：2010-06-10

申请号：US11885606

申请日：2006-03-03

申请人： Narasimha Swamy ,  Hema Malini K. Sundaresha

发明人： Narasimha Swamy ,  Hema Malini K. Sundaresha

IPC分类号： A61K31/695 ,  C12N5/09 ,  A61K31/047 ,  A61K31/215 ,  A61K31/4188 ,  C07C69/533 ,  C07C69/608 ,  C07C211/25 ,  C07C43/18 ,  C07C323/15 ,  C07F7/08 ,  A61P35/00

CPC分类号： A61K31/59

摘要： Bromoacetoxycalcidiol (B3CD), which is structurally related to calcidiol, exhibits cytotoxic and apoptotic activity toward cancer cells, including highly aggressive neuroblastoma cells. A series of small molecules designed around the structure of B3CD is expected to have growth inhibitory and apoptogenic activities toward a wide range of malignancies. B3CD shows no apparent toxicity in vivo, indicating potential value as a chemotherapeutic agent which will be particularly useful in treating highly aggressive tumors.

摘要翻译： 与calcidiol结构相关的溴乙酰氧基胆钙二醇（B3CD）对癌细胞（包括高度侵袭性的神经母细胞瘤细胞）表现出细胞毒性和凋亡活性。 围绕B3CD结构设计的一系列小分子预计具有朝向广泛恶性肿瘤的生长抑制和凋亡活性。 B3CD在体内没有明显的毒性，表明作为化学治疗剂的潜在价值，其将特别可用于治疗高度侵袭性的肿瘤。

公开(公告)号：US5783032A

公开(公告)日：1998-07-21

申请号：US725245

申请日：1996-10-04

申请人： John S. O'Callaghan ,  Tomasz Bednarek ,  Metin M. Durum ,  Narasimha Swamy

发明人： John S. O'Callaghan ,  Tomasz Bednarek ,  Metin M. Durum ,  Narasimha Swamy

IPC分类号： B65C1/02 ,  B65C9/18 ,  B32B31/00

CPC分类号： B65C9/1826 ,  B65C1/021 ,  Y10T156/1339 ,  Y10T156/1744

摘要： A linerless label applicator for forming and applying a discrete, pressure sensitive adhesive linerless label to a document is adapted to receive and advance a plurality of documents, one at a time, along a document path through the applicator. The applicator includes a label storage and feed section, a label cutting section and a label application section. The storage and feed section stores the label material in roll form thereon and feeds the material through a feed assembly into the cutting section. The label cutting section includes a label drive assembly, a label guide assembly and a cutting assembly. The drive assembly includes a feed roller and a plasma coated idler roller which contacts the label adhesive and prevents adhesion thereto. The guide assembly includes a fan/vacuum manifold which retains the non-adhesive side of the label material in contact with the cutting assembly surfaces. The cutting assembly includes self-lubricating stationary and moveable blades adapted to coact with one another to cut the label material into predetermined, discrete labels. The moveable blade is mounted to the cutting section by a parallelogram drive linkage which facilitates reciprocating and transverse movement of the blade to effect the label cut. The application section includes a vacuum provided paddle to hold the label in place while being cut and to transfer the label to a passing document. The application section includes a compression mechanism for compressing the label to the document.

摘要翻译： 用于将离散的压敏粘合剂无衬标签形成并应用于文件的无衬标签涂布器适于沿着通过涂布器的文件路径一次一个地接收和推进多个文件。 涂抹器包括标签储存和进料部分，标签切割部分和标签施加部分。 存储和进给部分将标签材料以卷形式存储在其上，并将材料通过进料组件进料到切割部分中。 标签切割部分包括标签驱动组件，标签引导组件和切割组件。 驱动组件包括进给辊和等离子体涂覆的惰辊，其与标签粘合剂接触并防止粘附到其上。 引导组件包括风扇/真空歧管，其保持标签材料的非粘性侧与切割组件表面接触。 切割组件包括自润滑固定和可移动的叶片，其适于彼此共同作用以将标签材料切割成预定的离散标签。 可移动刀片通过平行四边形驱动联动装置安装到切割部分，该驱动联动装置有助于刀片的往复运动和横向移动以实现标签切割。 应用部分包括一个真空提供的桨叶，以便在剪切时将标签保持在适当的位置，并将标签转移到通过的文件。 应用部分包括用于将标签压缩到文档的压缩机构。

公开(公告)号：US20110288080A1

公开(公告)日：2011-11-24

申请号：US12225202

申请日：2007-03-07

申请人： Giselle L Saulnier Sholler ,  Narasimha Swamy ,  Henna Swamy ,  Satyan Kalkunte ,  Rakesh K. Singh ,  Laurent Brard ,  Kyu Kwang Kim

发明人： Giselle L Saulnier Sholler ,  Narasimha Swamy ,  Henna Swamy ,  Satyan Kalkunte ,  Rakesh K. Singh ,  Laurent Brard ,  Kyu Kwang Kim

IPC分类号： C07D279/12 ,  A61P9/00 ,  A61K31/422 ,  A61P35/00 ,  A61K31/541 ,  C07D413/12

CPC分类号： A61K31/541 ,  A61K31/34 ,  A61K31/345 ,  A61K45/06

摘要： The invention is directed to the synthesis and use of nitrofuran compounds, especially Nifurtimox, as medicaments to treat cancer, especially neuroblastoma, and to inhibit angiogenesis. The invention also provides compositions, unit dosage forms, and kits comprising the compounds.

摘要翻译： 本发明涉及硝基呋喃化合物，特别是Nifurtimox的合成和用途，作为治疗癌症，特别是神经母细胞瘤的药物，并且用于抑制血管生成。 本发明还提供组合物，单位剂量形式和包含该化合物的试剂盒。

公开(公告)号：US5143364A

公开(公告)日：1992-09-01

申请号：US638937

申请日：1991-01-09

申请人： Joseph S. Kharzo ,  David W. Grostick ,  Jiann-Shing Liang ,  Narasimha Swamy

发明人： Joseph S. Kharzo ,  David W. Grostick ,  Jiann-Shing Liang ,  Narasimha Swamy

IPC分类号： B41L21/08 ,  B65H3/08

CPC分类号： B41L21/08 ,  B65H3/0891

摘要： A printing or duplicating machine has a suction control system which includes a source of vacuum and a conduit connecting the source of vacuum to a suction feeder. An operator panel is used to set a pattern of relative weight of each sheet in a stack. A controlled bleed valve is operatively associated with any of the suction feeder, source of vacuum or conduit for automatically adjusting vacuum at the suction feeder responsive to relative weight of any given sheet as selected by an operator.

摘要翻译： 打印机或复印机具有抽吸控制系统，该系统包括真空源和将真空源连接到抽吸给料器的导管。 操作面板用于设置堆叠中每张纸张的相对重量的图案。 控制泄放阀可操作地与任何吸入进料器，真空源或管道相关联，用于响应于由操作者选择的任何给定的纸张的相对重量而自动调节吸入进料器处的真空度。