公开(公告)号：US06308705B1

公开(公告)日：2001-10-30

申请号：US09467881

申请日：1999-12-21

申请人： Thomas Rupprecht ,  Rainer Kuth

发明人： Thomas Rupprecht ,  Rainer Kuth

IPC分类号： A61M1600

CPC分类号： A61M16/10 ,  A61B5/055 ,  A61M2202/02 ,  A61M2230/205

摘要： In a lung therapy method, hyperpolarized gas is administered for one breath to a subject, and a magnetic resonance scan of at least one lung of the subject is conducted. The data obtained from the scan are evaluated, specifically to determine the extent and distribution of infusion of hyperpolarized gas in the lung, as an indication of the alveolae in the lung which are open. Based on the evaluation of the data obtained in the magnetic resonance scan, a determination is made as to whether administration of a surfactant is necessary in order to improve opening of the lung. If a surfactant is administered, the procedure can be repeated to obtain an updated dataset, which can be evaluated to determine whether the administered surfactant has been effective.

摘要翻译： 在肺部治疗方法中，对受试者进行一次呼吸的超极化气体，并进行受试者的至少一个肺的磁共振扫描。 评估从扫描获得的数据，特别是确定肺中超极化气体输注的程度和分布，作为开放的肺中的肺泡的指示。 基于对磁共振扫描中获得的数据的评估，确定为了改善肺的开放是否需要施用表面活性剂。 如果施用表面活性剂，则可以重复该过程以获得更新的数据集，其可以被评估以确定所施用的表面活性剂是否有效。

公开(公告)号：US08447380B2

公开(公告)日：2013-05-21

申请号：US11597078

申请日：2004-05-17

申请人： Rainer Kuth ,  Sabine Rupprecht ,  Thomas Rupprecht ,  Maren Zapke

发明人： Rainer Kuth ,  Sabine Rupprecht ,  Thomas Rupprecht ,  Maren Zapke

IPC分类号： A61B5/08

CPC分类号： A61B5/411 ,  A61B5/055 ,  A61B5/08 ,  A61B6/03 ,  A61B6/507

摘要： In a method for diagnosing functional lung illnesses, image exposures of the lungs are obtained at various phase points in time of the respiration of a subject, such as at maximum inhalation and maximum expiration, and the image exposures are segmented and at least two of the image exposures are compared on a segment-by-segment basis to identify a change in tissue density between the compared segments, as an indicator of lung functioning.

摘要翻译： 在用于诊断功能性肺部疾病的方法中，在受试者的呼吸时间（例如在最大吸入和最大呼吸期间）的各个相位点处获得肺的图像曝光，并且图像曝光被分割，并且至少两个 将图像曝光在逐段进行比较，以识别比较的片段之间的组织密度的变化，作为肺功能的指标。

公开(公告)号：US06519489B2

公开(公告)日：2003-02-11

申请号：US09844108

申请日：2001-04-27

申请人： Rainer Kuth ,  Thomas Rupprecht

发明人： Rainer Kuth ,  Thomas Rupprecht

IPC分类号： A61B5055

CPC分类号： G01R33/563 ,  G01R33/281

摘要： In a method for analyzing cerebrospinal fluid perfusion by magnetic resonance imaging, a contrast agent is directing injected into volumes containing cerebrospinal fluid and a magnetic resonance image of those volumes is obtained. After a suitable waiting time, at least one further magnetic resonance image of the volumes is obtained. The (at least) two magnetic resonance images of the volumes are then compared and the degree of perfusion of the contrast agent is identified as an indicator of the perfusion and/or flow of cerebrospinal fluid in the volumes.

公开(公告)号：US06611703B2

公开(公告)日：2003-08-26

申请号：US09770008

申请日：2001-01-25

申请人： Rainer Kuth ,  Thomas Rupprecht

发明人： Rainer Kuth ,  Thomas Rupprecht

IPC分类号： A61B505

CPC分类号： A61B5/0555

摘要： An apparatus for examining contrast agent movement in the body of a patient under the effect of gravity has an MR scanner with a patient support system which can be tilted around the longitudinal axis and/or transverse center axis for placing the patient in an oblique position within the magnet.

摘要翻译： 用于在重力作用下检查患者体内造影剂运动的装置具有MR扫描仪，患者支撑系统可围绕纵向轴线和/或横向中心轴线倾斜，以将患者置于内侧的倾斜位置 磁铁。

公开(公告)号：US20060200065A1

公开(公告)日：2006-09-07

申请号：US11391150

申请日：2006-03-27

申请人： Rainer Kuth ,  Thomas Rupprecht

发明人： Rainer Kuth ,  Thomas Rupprecht

IPC分类号： A61F2/04

CPC分类号： A61M27/006

摘要： An implantable fluid valve for the adjustable limitation of the fluid pressure in the brain of a patient has all valve component parts composed of non-magnetic material, thereby making the valve MR-compatible.

摘要翻译： 用于可调节限制患者脑中流体压力的可植入流体阀具有由非磁性材料组成的所有阀组成部分，从而使得MR兼容。

公开(公告)号：US06411088B1

公开(公告)日：2002-06-25

申请号：US09522419

申请日：2000-03-09

申请人： Rainer Kuth ,  Sabine Rupprecht ,  Thomas Rupprecht

发明人： Rainer Kuth ,  Sabine Rupprecht ,  Thomas Rupprecht

IPC分类号： G01V300

CPC分类号： G01R33/4833

摘要： For purposes of producing a transparency image in a transparency direction, a magnetic resonance device includes a basic field magnetic system for generating a basic magnetic field that exhibits a high homogeneity and a low flux density in at least one imaging volume, and an arrangement for executing a refocused gradient echo sequence, wherein two gradient fields, respectively oriented perpendicularly to the transparency direction, can be switched without slice selection, or for executing a refocused gradient echo sequence with a large slice thickness in the transparency direction.

摘要翻译： 为了在透明方向上制造透明度图像，磁共振装置包括用于产生在至少一个成像体积中表现出高均匀性和低通量密度的基本磁场的基本磁场系统，以及用于执行 重新聚焦的梯度回波序列，其中分别垂直于透明度方向的两个梯度场可以在没有切片选择的情况下切换，或者用于在透明方向上执行具有大切片厚度的重新聚焦的梯度回波序列。

公开(公告)号：US06338836B1

公开(公告)日：2002-01-15

申请号：US09406372

申请日：1999-09-28

申请人： Rainer Kuth ,  Thomas Rupprecht

发明人： Rainer Kuth ,  Thomas Rupprecht

IPC分类号： A61K4900

CPC分类号： A61K49/1815 ,  A61K49/0004 ,  Y10T436/24

摘要： In an integrated asthma analysis and therapy determination method, a patient is administered hyperpolarized gas and an magnetic resonance (MR) scan is conducted to obtain a first MR image set, and the patient is then administered an allergen provoker and is again administered hyperpolarized gas and another MR scan is conducted, to obtain a second MR image set. This is followed by administering asthma therapeutics and again administering hyperpolarized gas to the subject, and another MR scan is conducted to obtain a third image data set. The first, second and third image data sets are compared among each other in order to determine the effect of the allergen provoker and the effect of the asthma therapeutics, in order to determine an appropriate medication dosage for the subject.

摘要翻译： 在综合哮喘分析和治疗测定方法中，给予患者超极化气体并进行磁共振（MR）扫描以获得第一MR图像组，然后向患者施用过敏原检疫者，并再次施用超极化气体和 进行另一MR扫描，以获得第二MR图像集。 随后施用哮喘治疗剂并再次对受试者施用超极化气体，并进行另一MR扫描以获得第三图像数据集。 将第一，第二和第三图像数据集彼此进行比较，以便确定过敏原检疫者的效果和哮喘治疗剂的作用，以确定受试者的适当药物剂量。

公开(公告)号：US06334066B1

公开(公告)日：2001-12-25

申请号：US09467884

申请日：1999-12-21

申请人： Thomas Rupprecht ,  Rainer Kuth

发明人： Thomas Rupprecht ,  Rainer Kuth

IPC分类号： A61B5055

CPC分类号： G06F19/3481 ,  G06F19/00

摘要： In a method for monitoring growth disorder therapy, a magnetic resonance image of a skeletal body portion, such as a hand, of a candidate for growth disorder therapy is obtained using an open magnetic resonance scanner and using an imaging sequence to produce a tomogram having a slice thickness which approximates the thickness of the hand. The number of visible wrist bones and the width of epiphysis joints in the magnetic resonance image is evaluated to obtain osteo age data, and the osteo age data, in conjunction with an atlas of compiled osteo age data, are used to determine the osteo age of the candidate for growth disorder therapy. The relationship between the osteo age of the candidate and the chronological age of the candidate is used to determine whether growth disorder therapy is required. If growth disorder therapy is administered, such as by administering a hormone, the above procedure is repeated after a predetermined time, and the status of the therapy is again evaluated.

摘要翻译： 在用于监测生长障碍治疗的方法中，使用开放磁共振扫描仪获得用于生长障碍治疗的候选者的诸如手的骨骼体部分的磁共振图像，并且使用成像序列产生具有 切片厚度近似于手的厚度。 评估磁共振图像中可见腕骨的数量和骨ysis关节的宽度，以获得骨龄数据，并将骨龄数据与编制骨龄数据的图集一起用于确定骨形态 生长障碍治疗的候选人。 候选人的骨龄与候选人的年龄之间的关系用于确定是否需要生长障碍治疗。 如果施用生长障碍治疗，例如通过施用激素，则在预定时间后重复上述过程，并再次评估治疗的状态。

公开(公告)号：US08187166B2

公开(公告)日：2012-05-29

申请号：US10231311

申请日：2002-08-29

申请人： Rainer Kuth ,  Thomas Rupprecht ,  Maren Wagner

发明人： Rainer Kuth ,  Thomas Rupprecht ,  Maren Wagner

IPC分类号： A61B1/00

CPC分类号： A61B1/041 ,  A61B1/00087 ,  A61B1/00158 ,  A61B5/06 ,  A61B5/062 ,  A61B5/4839 ,  A61B10/0275 ,  A61B34/73 ,  A61B2034/732

摘要： A system for the implementation of minimally invasive diagnoses and interventions in the inside of the body of a patient has an endo-robot that has a linear magnet and carries measurement instruments and/or instruments for taking specimens and/or for treatment. The endo-robot is freely mobile within the body of a patient. A magnet system accepts the examination region of the patient and generates a 3D gradient field for remotely-controls movement and orientation of the endo-robot in the patient's body by interaction with the linear magnet.

摘要翻译： 用于在患者体内实施微创诊断和干预的系统具有内线机器人，其具有线性磁体并且携带用于取样和/或治疗的测量仪器和/或仪器。 内窥镜机器人在患者体内自由移动。 磁体系统接受患者的检查区域并产生3D梯度场，用于通过与线性磁体的相互作用来远程控制内窥镜机器人在患者体内的移动和取向。

公开(公告)号：US20080269592A1

公开(公告)日：2008-10-30

申请号：US11597078

申请日：2004-05-17

申请人： Rainer Kuth ,  Sabine Rupprecht ,  Thomas Rupprecht ,  Maren Zapke

发明人： Rainer Kuth ,  Sabine Rupprecht ,  Thomas Rupprecht ,  Maren Zapke

IPC分类号： A61B5/08 ,  A61B5/05

CPC分类号： A61B5/411 ,  A61B5/055 ,  A61B5/08 ,  A61B6/03 ,  A61B6/507

摘要： In a method for diagnosing functional lung illnesses, image exposures of the lungs are obtained at various phase points in time of the respiration of a subject, such as at maximum inhalation and maximum expiration, and the image exposures are segmented and at least two of the image exposures are compared on a segment-by-segment basis to identify a change in tissue density between the compared segments, as an indicator of lung functioning.

摘要翻译： 在用于诊断功能性肺部疾病的方法中，在受试者的呼吸时间（例如在最大吸入和最大呼吸期间）的各个相位点处获得肺的图像曝光，并且图像曝光被分割，并且至少两个 将图像曝光在逐段进行比较，以识别比较的片段之间的组织密度的变化，作为肺功能的指标。