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    Preparation for the production of 1,2,4-triazolylmethyl-oxiranes
    1.
    发明授权
    Preparation for the production of 1,2,4-triazolylmethyl-oxiranes 失效
    制备1,2,4-三唑基甲基环氧乙烷

    公开(公告)号：US07368464B2

    公开(公告)日：2008-05-06

    申请号：US10516727

    申请日：2003-06-06

    申请人： Rainer Noack ,  Michael Sander ,  Michael Henningsen

    发明人： Rainer Noack ,  Michael Sander ,  Michael Henningsen

    IPC分类号： A61K31/41 ,  C07D249/08

    CPC分类号： C07D249/08 ,  C07D231/12 ,  C07D233/56

    摘要： The present invention relates to a process for the preparation of 1,2,4-triazol-1-ylmethyloxiranes of the formula I in which A and B are identical or different and, independently of one another, are C1-C4-alkyl, phenyl-C1-C2-alkyl, C3-C6-cycloalkyl, C3-C6-cycloalkenyl, tetrahydropyranyl, tetrahydrofuranyl, dioxanyl or phenyl, where the phenyl radical can carry one to three substituents chosen from the group: halogen, nitro, C1-C4-alkyl, Cl-C4-alkyloxy, phenoxy, amino, C1-C2-haloalkyl or phenylsulfonyl, which comprises reacting a) an oxirane of the formula II in which A and B have the meanings given above and L is a nucleophilically substitutable leaving group, with 4-amino-1,2,4-triazole of the formula III to give 4-amino-1,2,4-triazolium salts of the formula IV and b) deaminating the 4-amino-1,2,4-triazolium salts IV with alkali metal nitrites and acid or organic nitrites to give 1,2,4-triazol-1-ylmethyloxiranes of the formula I, and to 4-aminotriazolium salts of the formula IV as intermediates.

    摘要翻译： 本发明涉及制备式I的1,2,4-三唑-1-基甲基环氧烷的方法，其中A和B相同或不同，且彼此独立地为C 1〜 C 1 -C 4 - 亚烷基，苯基-C 1 -C 2 - 烷基，C 3 -C C 6 -C 6 - 环烷基，C 3 -C 6 - 环烯基，四氢吡喃基，四氢呋喃基，二烷基或苯基，其中苯基可以携带一至三个 选自以下的取代基：卤素，硝基，C 1 -C 4 - 烷基，C 1 -C 4 - 烷氧基，苯氧基，氨基，C 1 -C 2 - 卤代烷基或苯基磺酰基，其包括使a）式A的环氧乙烷与A和B具有式 L是具有式III的4-氨基-1,2,4-三唑的亲核可取代的离去基团，得到式IV的4-氨基-1,2,4-三唑鎓盐，和b）脱氨基 具有碱金属元素的4-氨基-1,2,4-三唑鎓盐IV l亚硝酸盐和酸或有机亚硝酸盐，得到式I的1,2,4-三唑-1-基甲基环氧乙烷和作为中间体的式IV的4-氨基三唑鎓盐。

    Preparation for the production of 1,2,4-triazolymethyl-oxiranes
    2.
    发明申请
    Preparation for the production of 1,2,4-triazolymethyl-oxiranes 失效
    制备1,2,4-三唑甲基环氧乙烷

    公开(公告)号：US20050176967A1

    公开(公告)日：2005-08-11

    申请号：US10516727

    申请日：2003-06-06

    申请人： Rainer Noack ,  Michael Sander ,  Michael Henningsen

    发明人： Rainer Noack ,  Michael Sander ,  Michael Henningsen

    IPC分类号： C07D405/06 ,  C07D521/00 ,  C07D45/02

    CPC分类号： C07D249/08 ,  C07D231/12 ,  C07D233/56

    摘要： The present invention relates to a process for the preparation of 1,2,4-triazol-1-ylmethyloxiranes of the formula I in which A and B are identical or different and, independently of one another, are C1-C4-alkyl, phenyl-C1-C2-alkyl, C3-C6-cycloalkyl, C3-C6-cycloalkenyl, tetrahydropyranyl, tetrahydrofuranyl, dioxanyl or phenyl, where the phenyl radical can carry one to three substituents chosen from the group: halogen, nitro, C1-C4-alkyl, Cl-C4-alkyloxy, phenoxy, amino, C1-C2-haloalkyl or phenylsulfonyl, which comprises reacting a) an oxirane of the formula II in which A and B have the meanings given above and L is a nucleophilically substitutable leaving group, with 4-amino-1,2,4-triazole of the formula III to give 4-amino-1,2,4-triazolium salts of the formula IV and b) deaminating the 4-amino-1,2,4-triazolium salts IV with alkali metal nitrites and acid or organic nitrites to give 1,2,4-triazol-1-ylmethyloxiranes of the formula I, and to 4-aminotriazolium salts of the formula IV as intermediates.

    摘要翻译： 本发明涉及制备式I的1,2,4-三唑-1-基甲基环氧烷的方法，其中A和B相同或不同，且彼此独立地为C 1〜 C 1 -C 4 - 亚烷基，苯基-C 1 -C 2 - 烷基，C 3 -C C 6 -C 6 - 环烷基，C 3 -C 6 - 环烯基，四氢吡喃基，四氢呋喃基，二烷基或苯基，其中苯基可以携带一至三个 选自以下的取代基：卤素，硝基，C 1 -C 4 - 烷基，C 1 -C 4 - 烷氧基，苯氧基，氨基，C 1 -C 2 - 卤代烷基或苯基磺酰基，其包括使a）式A的环氧乙烷与A和B具有式 L是具有式III的4-氨基-1,2,4-三唑的亲核可取代的离去基团，得到式IV的4-氨基-1,2,4-三唑鎓盐，和b）脱氨基 具有碱金属元素的4-氨基-1,2,4-三唑鎓盐IV l亚硝酸盐和酸或有机亚硝酸盐，得到式I的1,2,4-三唑-1-基甲基环氧乙烷和作为中间体的式IV的4-氨基三唑鎓盐。

    HTS cryomagnet and magnetization method
    5.
    发明授权
    HTS cryomagnet and magnetization method 失效
    HTS低磁铁磁化法

    公开(公告)号：US06762664B2

    公开(公告)日：2004-07-13

    申请号：US10280824

    申请日：2002-10-25

    申请人： Michael Sander

    发明人： Michael Sander

    IPC分类号： H01F600

    CPC分类号： H01F13/00 ,  H01F6/06

    摘要： In a method and a kryomagnet for the pulsed magnetization of the kryomagnet which comprises discs stacked on top of one another, with each disc including concentric annular conductor elements arranged in axially spaced relationship and each conductor element having two contact points forming two arms between the contact points for their energization, a transport current impulse is applied to each conductor element which pulse is divided in each conductor element into first and second partial currents I1 and I2 to flow through the two arms from one of the contact points in an opposite sense to the other contact point, wherein one arm has a length of maximally 35% of the circumference of the conductor element, the transport current having a polarity such that the larger partial current flowing through the shorter arm while the transport current is increasing flows in all the conductor elements in the same direction.

    摘要翻译： 在用于克隆磁体的脉冲磁化的方法和克隆磁体中，其包括彼此堆叠的盘，其中每个盘包括以轴向间隔开的关系布置的同心环形导体元件，并且每个导体元件具有两个接触点， 对于它们通电的点，传输电流脉冲被施加到每个导体元件，该脉冲被分成每个导体元件中的第一和第二部分电流I1和I2，以便以相反的方式从一个接触点流过两个臂 其他接触点，其中一个臂的长度最大为导体元件周长的35％，传输电流具有极性，使得在传输电流增加时流过较短臂的较大的部分电流在所有导体中流动 元素在同一个方向。

    Intermediates of 1-O-acyl-2-deoxy-2-fluoro-4-thio-beta-D-arabinofuranoses
    6.
    发明授权
    Intermediates of 1-O-acyl-2-deoxy-2-fluoro-4-thio-beta-D-arabinofuranoses 有权
    1-O-酰基-2-脱氧-2-氟-4-硫代-β-D-阿拉伯呋喃糖苷的中间体

    公开(公告)号：US08420831B2

    公开(公告)日：2013-04-16

    申请号：US13606746

    申请日：2012-09-07

    申请人： David Voigtländer ,  Michael Sander ,  Michael Harre

    发明人： David Voigtländer ,  Michael Sander ,  Michael Harre

    IPC分类号： C07D495/06

    CPC分类号： C07D333/32 ,  C07H13/04

    摘要： The present invention relates to a process for preparing 1-O-acyl-2-deoxy-2-fluoro-4-thio-β-D-arabinofuranoses having formula I and intermediates thereof: wherein R1 represents —C(O)—C1-C6-alkyl or —C(O)-aryl; and R2 represents C1-C6-alkyl, C1-C4-perfluoroalkyl or aryl.

    摘要翻译： 本发明涉及一种制备具有式I的1-O-酰基-2-脱氧-2-氟-4-硫代-β-阿拉伯呋喃糖的方法及其中间体：其中R1表示-C（O）-C1 -C 1-6 - 烷基或-C（O） - 芳基; 并且R 2表示C 1 -C 6烷基，C 1 -C 4全氟烷基或芳基。

    METHODS FOR RECEIVING GPS INDOORS WITH HIGH PRECISION AND DEVICES THEREOF
    7.
    发明申请
    METHODS FOR RECEIVING GPS INDOORS WITH HIGH PRECISION AND DEVICES THEREOF 审中-公开
    用于接收具有高精度的GPS室的方法及其装置

    公开(公告)号：US20130033397A1

    公开(公告)日：2013-02-07

    申请号：US13567688

    申请日：2012-08-06

    申请人： John Fischer ,  Gilles Boime ,  Denis Reilly ,  Michael Sander ,  David Sohn

    发明人： John Fischer ,  Gilles Boime ,  Denis Reilly ,  Michael Sander ,  David Sohn

    IPC分类号： G01S19/48 ,  G01S19/05

    CPC分类号： G01S19/14 ,  G01S19/246 ,  G01S19/25

    摘要： A method, non-transitory computer readable medium, and apparatus that determines a GPS location includes obtaining assisted GPS data of locations of a plurality of GPS satellites, current time, and initial location data of the receiver computing device. A GPS signal from one or more of the plurality of GPS satellites within a frequency range and time range is acquired based on the obtained assisted GPS data, current time, and initial location data of the receiver computing device. The one or more acquired GPS signals are integrated over a frame period of two or more seconds. A GPS location for the receiver computing device is determined based on the one or more integrated GPS signals.

    摘要翻译： 确定GPS位置的方法，非暂时计算机可读介质和装置包括获得多个GPS卫星的位置的辅助GPS数据，当前时间和接收机计算设备的初始位置数据。 基于所获得的辅助GPS数据，当前时间和接收机计算设备的初始位置数据，获取在频率范围和时间范围内来自多个GPS卫星中的一个或多个GPS卫星的GPS信号。 一个或多个获取的GPS信号在两秒或更多秒的帧周期内被积分。 基于一个或多个集成GPS信号来确定用于接收机计算设备的GPS位置。

    Wound spray
    10.
    发明授权
    Wound spray 有权

    公开(公告)号：US10646613B2

    公开(公告)日：2020-05-12

    申请号：US14131022

    申请日：2012-07-23

    申请人： Michael Sander ,  Harald Potzschke

    发明人： Michael Sander ,  Harald Potzschke

    IPC分类号： A61L26/00 ,  A61M1/34 ,  A61K38/42 ,  A61M35/00 ,  C07K14/805

    摘要： The present invention refers to a composition, comprising hemoglobin or myoglobin, wherein in at least 40% of said hemoglobin or myoglobin the oxygen binding site is charged by a non-O2 ligand, and at least one further ingredient, a method for preparing said composition and the use of hemoglobin or myoglobin charged with a non-oxygen ligand for external treatment of wounds.