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    Benzofuran derivatives and antiulcerogenic agents containing same
    1.
    发明授权
    Benzofuran derivatives and antiulcerogenic agents containing same 失效
    含有苯并呋喃衍生物和含有其的抗致癌剂

    公开(公告)号：US4845096A

    公开(公告)日：1989-07-04

    申请号：US170321

    申请日：1988-03-18

    申请人： Rainer Schlecker ,  Klaus Ruebsamen

    发明人： Rainer Schlecker ,  Klaus Ruebsamen

    IPC分类号： A61K31/38 ,  A61K31/41 ,  A61K31/415 ,  A61K31/42 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/445 ,  A61K31/50 ,  A61P1/04 ,  C07D307/86 ,  C07D405/06 ,  C07D409/06 ,  C07D413/06

    CPC分类号： C07D405/06 ,  C07D307/86 ,  C07D409/06 ,  C07D413/06

    摘要： Benzofuran derivatives of the general formula I ##STR1## where R.sup.1 and R.sup.2 are each hydrogen, alkyl or phenylalkyl, where alkyl in each case is of 1 to 4 carbon atoms, R.sup.3 and R.sup.4 are identical or different and are each hydrogen or C.sub.1 -C.sub.4 -alkyl or together form a 3-membered to 5-membered chain which may be interrupted by an oxygen atom or an NR.sup.1 group, X is --CO--CH.dbd.CH--, --CO--CH.sub.2 --CH.sub.2 --or --CHOH--CH.sub.2 --CH.sub.2 --, n is 2 or 3 and Het is an aromatic 5-membered or 6-membered ring which contains a hetero atom from the group consisting of N, O and S and may additionally contain a (further) N atom, in which the ring may be substituted by C.sub.1 -C.sub.4 -alkyl, fluorine, chlorine, bromine, NH.sub.2 or NR.sup.1 R.sup.2, where R.sup.1 and R.sup.2 have the abovementioned meanings, the use of these benzofuran derivatives for the preparation of pharmaceutical, in particular antiulcerogenic, agents, and these agents themselves are described.

    摘要翻译： 通式I的苯并呋喃衍生物其中R 1和R 2各自为氢，烷基或苯基烷基，其中每种情况下的烷基为1至4个碳原子，R 3和R 4相同或不同，各自为氢或C1- C4烷基或一起形成可被氧原子或NR1基团间隔的3元至5元环，X为-CO-CH = CH-，-CO-CH2-CH2-或-CHOH-CH2 -CH 2 - ，n为2或3，Het为包含来自N，O和S的杂原子的芳香族5元或6元环，并且可以另外含有（进一步）N原子，其中 该环可以被C1-C4-烷基，氟，氯，溴，NH2或NR1R2取代，其中R1和R2具有上述含义，这些苯并呋喃衍生物用于制备药物，特别是抗致癌剂，以及 这些代理人自己被描述。