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    Polysaccharide conjugates of biomolecules
    1.
    发明申请
    Polysaccharide conjugates of biomolecules 审中-公开
    生物分子的多糖共轭物

    公开(公告)号：US20050281833A1

    公开(公告)日：2005-12-22

    申请号：US11180245

    申请日：2005-07-13

    申请人： Rajendra Singh ,  Harshvardhan Mehta

    发明人： Rajendra Singh ,  Harshvardhan Mehta

    IPC分类号： A01N43/16 ,  G01N33/564 ,  A61K39/00 ,  C07K14/705 ,  C07K16/46

    CPC分类号： C08B37/0021 ,  A01N43/16 ,  C08H1/00 ,  G01N33/564 ,  G01N2333/988

    摘要： Compounds that are modified polysaccharides having pendant aldehyde functionalities are disclosed. Each of the aldehyde functionalities is attached through a linker to a position corresponding to a hydrogen atom of a different hydroxyl group of unmodified polysaccharide. Also disclosed is a method fore introducing an amine-reactive functionality into a dextran. The method comprises (a) reacting the dextran with an alkylating agent having a functionality that reacts with an hydroxyl group of the dextran thereby forming an alkylated dextran wherein the alkylating agent has an olefin group and (b) treating the alkylated dextran to convert the olefin group to an amine-reactive functionality. A polysaccharide can be conjugated to a biomolecule by carrying out the above method and reacting the amine-reactive functionality with an amine functionality on the biomolecule to produce polysaccharide conjugated to the biomolecule.

    摘要翻译： 公开了具有侧醛官能团的改性多糖的化合物。 每个醛官能团通过接头连接到对应于未修饰多糖的不同羟基的氢原子的位置。 还公开了将胺反应性功能引入葡聚糖的方法。 该方法包括（a）使葡聚糖与具有与葡聚糖羟基反应的官能团的烷基化剂反应，从而形成烷基化葡聚糖，其中烷基化剂具有烯烃基团，和（b）处理烷基化葡聚糖以转化烯烃 与胺反应性官能团。 通过进行上述方法并使胺反应性官能团与胺官能团在生物分子上反应以产生与生物分子缀合的多糖，可以将多糖与生物分子缀合。

    Polysaccharide conjugates of biomolecules
    2.
    发明授权
    Polysaccharide conjugates of biomolecules 有权
    生物分子的多糖共轭物

    公开(公告)号：US06949524B2

    公开(公告)日：2005-09-27

    申请号：US10188578

    申请日：2002-07-02

    申请人： Rajendra Singh ,  Harshvardhan Mehta

    发明人： Rajendra Singh ,  Harshvardhan Mehta

    IPC分类号： A01N43/16 ,  G01N33/564 ,  A61K31/715 ,  C08B37/00

    CPC分类号： C08B37/0021 ,  A01N43/16 ,  C08H1/00 ,  G01N33/564 ,  G01N2333/988

    摘要： Compounds that are modified polysaccharides having pendant aldehyde functionalities are disclosed. Each of the aldehyde functionalities is attached through a linker to a position corresponding to a hydrogen atom of a different hydroxyl group of unmodified polysaccharide. Also disclosed is a method for introducing an amine-reactive functionality into a dextran. The method comprises (a) reacting the dextran with an alkylating agent having a functionality that reacts with an hydroxyl group of the dextran thereby forming an alkylated dextran wherein the alkylating agent has an olefin group and (b) treating the alkylated dextran to convert the olefin group to an amine-reactive functionality. A polysaccharide can be conjugated to a biomolecule by carrying out the above method and reacting the amine-reactive functionality with an amine functionality on the biomolecule to produce polysaccharide conjugated to the biomolecule.

    摘要翻译： 公开了具有侧醛官能团的改性多糖的化合物。 每个醛官能团通过接头连接到对应于未修饰多糖的不同羟基的氢原子的位置。 还公开了将胺反应性功能引入葡聚糖的方法。 该方法包括（a）使葡聚糖与具有与葡聚糖羟基反应的官能团的烷基化剂反应，从而形成烷基化葡聚糖，其中烷基化剂具有烯烃基团，和（b）处理烷基化葡聚糖以转化烯烃 与胺反应性官能团。 通过进行上述方法并使胺反应性官能团与胺官能团在生物分子上反应以产生与生物分子缀合的多糖，可以将多糖与生物分子缀合。

    Polysaccharide conjugates of biomolecules
    3.
    发明授权
    Polysaccharide conjugates of biomolecules 有权
    生物分子的多糖共轭物

    公开(公告)号：US06489309B1

    公开(公告)日：2002-12-03

    申请号：US09314055

    申请日：1999-05-18

    申请人： Rajendra Singh ,  Harshvardhan Mehta

    发明人： Rajendra Singh ,  Harshvardhan Mehta

    IPC分类号： A01N4304

    CPC分类号： C08B37/0021 ,  A01N43/16 ,  C08H1/00 ,  G01N33/564 ,  G01N2333/988

    摘要： Compounds that are modified polysaccharides having pendant aldehyde functionalities are disclosed. Each of the aldehyde functionalities is attached through a linker to a position corresponding to a hydrogen atom of a different hydroxyl group of unmodified polysaccharide. Also disclosed is a method for introducing an amine-reactive functionality into a dextran. The method comprises (a) reacting the dextran with an alkylating agent having a functionality that reacts with an hydroxyl group of the dextran thereby forming an alkylated dextran wherein the alkylating agent has an olefin group and (b) treating the alkylated dextran to convert the olefin group to an amine-reactive functionality. A polysaccharide can be conjugated to a biomolecule by carrying out the above method and reacting the amine-reactive functionality with an amine functionality on the biomolecule to produce polysaccharide conjugated to the biomolecule.

    摘要翻译： 公开了具有侧醛官能团的改性多糖的化合物。 每个醛官能团通过接头连接到对应于未修饰多糖的不同羟基的氢原子的位置。 还公开了将胺反应性功能引入葡聚糖的方法。 该方法包括（a）使葡聚糖与具有与葡聚糖羟基反应的官能团的烷基化剂反应，从而形成烷基化葡聚糖，其中烷基化剂具有烯烃基团，和（b）处理烷基化葡聚糖以转化烯烃 与胺反应性官能团。 通过进行上述方法并使胺反应性官能团与胺官能团在生物分子上反应以产生与生物分子缀合的多糖，可以将多糖与生物分子缀合。

    Polysaccharide conjugates of biomolecules
    4.
    发明授权
    Polysaccharide conjugates of biomolecules 失效

    公开(公告)号：US5929049A

    公开(公告)日：1999-07-27

    申请号：US907842

    申请日：1997-08-08

    申请人： Rajendra Singh ,  Harshvardhan Mehta

    发明人： Rajendra Singh ,  Harshvardhan Mehta

    IPC分类号： A01N43/16 ,  G01N33/564 ,  A01N43/04

    CPC分类号： C08B37/0021 ,  A01N43/16 ,  C08H1/00 ,  G01N33/564 ,  G01N2333/988

    摘要： Compounds that are modified polysaccharides having pendant aldehyde functionalities are disclosed. Each of the aldehyde functionalities is attached through a linker to a position corresponding to a hydrogen atom of a different hydroxyl group of unmodified polysaccharide. Also disclosed is a method for introducing an amine-reactive functionality into a dextran. The method comprises (a) reacting the dextran with an alkylating agent having a functionality that reacts with an hydroxyl group of the dextran thereby forming an alkylated dextran wherein the alkylating agent has an olefin group and (b) treating the alkylated dextran to convert the olefin group to an amine-reactive functionality. A polysaccharide can be conjugated to a biomolecule by carrying out the above method and reacting the amine-reactive functionality with an amine functionality on the biomolecule to produce polysaccharide conjugated to the biomolecule.