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公开(公告)号：US20100130486A1
公开(公告)日：2010-05-27
申请号：US12175441
申请日：2008-07-17
申请人： Rajinder Singh , Hui Li , Haoran Zhao , Donald Payan , Rao Kolluri , Kin Tso , John Ramphal , Shihai Gu
发明人： Rajinder Singh , Hui Li , Haoran Zhao , Donald Payan , Rao Kolluri , Kin Tso , John Ramphal , Shihai Gu
IPC分类号： A61K31/5383 , C07D401/14 , C07D403/14 , C07D265/38 , C07D413/14 , A61K31/497 , A61K31/506 , A61K31/5377 , A61P35/00
CPC分类号： C07D401/12 , C07D239/48 , C07D401/14 , C07D407/14 , C07D413/14 , C07D417/14 , C07D498/04
摘要： The invention encompasses compounds having formula I or II and the compositions and methods using these compounds in the treatment of conditions in which inhibition of PKC and PKD is therapeutically useful.
摘要翻译： 本发明包括具有式I或II的化合物以及使用这些化合物治疗PKC和PKD的抑制在治疗上有用的条件的组合物和方法。
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公开(公告)号：US08993585B2
公开(公告)日：2015-03-31
申请号：US12175441
申请日：2008-07-17
申请人： Rajinder Singh , Hui Li , Haoran Zhao , Donald Payan , Rao Kolluri , Kin Tso , John Ramphal , Shihai Gu
发明人： Rajinder Singh , Hui Li , Haoran Zhao , Donald Payan , Rao Kolluri , Kin Tso , John Ramphal , Shihai Gu
IPC分类号： C07D401/12 , C07D239/48 , C07D401/14 , C07D407/14 , C07D413/14 , C07D417/14 , C07D498/04
CPC分类号： C07D401/12 , C07D239/48 , C07D401/14 , C07D407/14 , C07D413/14 , C07D417/14 , C07D498/04
摘要： The invention encompasses compounds having formula I or II and the compositions and methods using these compounds in the treatment of conditions in which inhibition of PKC and PKD is therapeutically useful.
摘要翻译： 本发明包括具有式I或II的化合物以及使用这些化合物治疗PKC和PKD的抑制在治疗上有用的条件的组合物和方法。
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公开(公告)号：US20100204208A1
公开(公告)日：2010-08-12
申请号：US12691607
申请日：2010-01-21
申请人： Rajinder Singh , Hui Li , Haoran Zhao , Rao Kolluri , Kin Tso , John Ramphal , Shihai Gu , Carlos Valdez , Jing Zhang , Emily Stauffer , Matthew Duncton , Salvador Alvarez
发明人： Rajinder Singh , Hui Li , Haoran Zhao , Rao Kolluri , Kin Tso , John Ramphal , Shihai Gu , Carlos Valdez , Jing Zhang , Emily Stauffer , Matthew Duncton , Salvador Alvarez
IPC分类号： A61K31/55 , C07D401/14 , A61K31/496 , A61K31/506 , C07D413/14 , A61K31/5377 , C07D403/14 , A61P1/00 , A61P27/02 , A61P37/00 , A61P29/00 , A61P17/06 , A61P25/28 , C12Q1/48
CPC分类号： A61K31/506 , A61K31/5377 , A61K31/538 , A61K31/55 , C07D401/12 , C07D401/14 , C07D413/12
摘要： This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
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公开(公告)号：US08377924B2
公开(公告)日：2013-02-19
申请号：US12691607
申请日：2010-01-21
申请人： Rajinder Singh , Huí Li , Haoran Zhao , Rao Kolluri , Kin Tso , John Ramphal , Shihai Gu , Carlos Valdez , Jing Zhang , Emily Stauffer , Matthew Duncton , Salvador Alvarez
发明人： Rajinder Singh , Huí Li , Haoran Zhao , Rao Kolluri , Kin Tso , John Ramphal , Shihai Gu , Carlos Valdez , Jing Zhang , Emily Stauffer , Matthew Duncton , Salvador Alvarez
IPC分类号： A61K31/55 , A61K31/497 , A61K31/535 , A61K31/505 , C07D403/10 , C07D413/12 , C07D401/12
CPC分类号： A61K31/506 , A61K31/5377 , A61K31/538 , A61K31/55 , C07D401/12 , C07D401/14 , C07D413/12
摘要： This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
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公开(公告)号：US20100184755A1
公开(公告)日：2010-07-22
申请号：US12687054
申请日：2010-01-13
申请人： Haoran Zhao , Rao Kolluri , Carlos Valdez , Kin Tso , Rajinder Singh , John Ramphal
发明人： Haoran Zhao , Rao Kolluri , Carlos Valdez , Kin Tso , Rajinder Singh , John Ramphal
IPC分类号： A61K31/5383 , C07D498/04 , C07D498/10 , A61P37/00 , A61P29/00 , A61P27/02 , C12N9/99
CPC分类号： C07D498/04 , A61K31/5383 , C07D498/14
摘要： This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译： 本公开涉及可用作蛋白激酶C（PKC）的抑制剂的化合物，因此可用于治疗通过PKC的活性介导或维持的多种疾病和病症。 本公开还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。
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公开(公告)号：US08394951B2
公开(公告)日：2013-03-12
申请号：US12687054
申请日：2010-01-13
申请人： Haoran Zhao , Rao Kolluri , Carlos Valdez , Kin Tso , Rajinder Singh , John Ramphal
发明人： Haoran Zhao , Rao Kolluri , Carlos Valdez , Kin Tso , Rajinder Singh , John Ramphal
IPC分类号： C07D345/00 , C07D517/00
CPC分类号： C07D498/04 , A61K31/5383 , C07D498/14
摘要： This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
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公开(公告)号：US20110130415A1
公开(公告)日：2011-06-02
申请号：US12958284
申请日：2010-12-01
申请人： Rajinder Singh , Kin Tso , Jing Zhang , Matthew Duncton , Salvador Alvarez , Rao Kolluri , John Ramphal , Sacha Holland
发明人： Rajinder Singh , Kin Tso , Jing Zhang , Matthew Duncton , Salvador Alvarez , Rao Kolluri , John Ramphal , Sacha Holland
IPC分类号： A61K31/506 , C07D401/14 , C07D405/14 , A61P29/00 , A61P17/00 , A61P17/06 , A61P37/08 , A61P1/16 , A61P11/00 , A61P9/10 , A61P25/00 , A61P31/18 , A61P9/12 , A61P3/04 , A61P37/06 , C12N9/99 , C12Q1/48
CPC分类号： C07D405/14 , A61K31/41 , A61K31/506 , C07D401/14
摘要： This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译： 本公开涉及可用作蛋白激酶C（PKC）的抑制剂的化合物，因此可用于治疗通过PKC的活性介导或维持的多种疾病和病症。 本公开还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。
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公开(公告)号：US07776847B2
公开(公告)日：2010-08-17
申请号：US11362553
申请日：2006-02-24
申请人： Hui Hong , Eileen Goldstein , Emily Stauffer , Dane Goff , Rao Kolluri , Ihab Darwish , Rajinder Singh , Henry Lu
发明人： Hui Hong , Eileen Goldstein , Emily Stauffer , Dane Goff , Rao Kolluri , Ihab Darwish , Rajinder Singh , Henry Lu
IPC分类号： A61K31/33
CPC分类号： C07D275/04 , C07D417/12 , C07D513/04
摘要： The present invention relates to benzisothiazoles and pharmaceutical compositions thereof that inhibit replication and/or proliferation of HCV virus. The present invention also relates to the use of the benzisothiazoles and pharmaceutical compositions comprising the compounds to treat or prevent HCV infections.
摘要翻译： 本发明涉及抑制HCV病毒复制和/或增殖的苯并异噻唑及其药物组合物。 本发明还涉及包含该化合物的苯并异噻唑和药物组合物用于治疗或预防HCV感染的用途。
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公开(公告)号：US20060229294A1
公开(公告)日：2006-10-12
申请号：US11362553
申请日：2006-02-24
申请人： Hui Hong , Eileen Goldstein , Emily Stauffer , Dane Goff , Rao Kolluri , Ihab Darwish , Rajinder Singh , Henry Lu
发明人： Hui Hong , Eileen Goldstein , Emily Stauffer , Dane Goff , Rao Kolluri , Ihab Darwish , Rajinder Singh , Henry Lu
IPC分类号： C07D417/02 , C07D471/02 , C07D473/02 , A61K31/52 , A61K31/506 , A61K31/4745 , A61K31/4709 , A61K31/454 , A61K31/4439 , A61K31/42
CPC分类号： C07D275/04 , C07D417/12 , C07D513/04
摘要： The present invention relates to benzisothiazoles and pharmaceutical compositions thereof that inhibit replication and/or proliferation of HCV virus. The present invention also relates to the use of the benzisothiazoles and pharmaceutical compositions comprising the compounds to treat or prevent HCV infections.
摘要翻译： 本发明涉及抑制HCV病毒复制和/或增殖的苯并异噻唑及其药物组合物。 本发明还涉及包含该化合物的苯并异噻唑和药物组合物用于治疗或预防HCV感染的用途。
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公开(公告)号：US20050215614A1
公开(公告)日：2005-09-29
申请号：US10530767
申请日：2003-10-15
申请人： Rajinder Singh , Ihab Darwish , Rao Kolluri , Sambaiah Thota , Henry Lu
发明人： Rajinder Singh , Ihab Darwish , Rao Kolluri , Sambaiah Thota , Henry Lu
IPC分类号： C07D209/08 , C07D209/18 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12 , A61K31/4439 , A61K31/405 , C07D209/04 , C07D43/02 , C07D49/02
CPC分类号： C07D401/04 , C07D209/08 , C07D209/18 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12
摘要： The present invention comprises indole-derivatives that are inhibitors of HCV. Composition comprising the compounds in combination with a pharmaceutically acceptable carrier are also disclosed, as are methods of using the compounds and compositions to inhibit HCV infection of a cell, particular in the form of treating HCV infection in a mammal.
摘要翻译： 本发明包括作为HCV抑制剂的吲哚衍生物。 还公开了包含与药学上可接受的载体组合的化合物的组合物，以及使用化合物和组合物抑制细胞的HCV感染的方法，特别是以哺乳动物治疗HCV感染的形式。
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