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1.发明申请公开(公告)号：US20180072756A1
公开(公告)日：2018-03-15
申请号：US15468467
申请日：2017-03-24
申请人： Rajinder Singh , Ankush Argade , Hui Li , Somasekhar Bhamidipati , David Carroll , Catherine Sylvain , Jeffrey Clough , Holger Keim
发明人： Rajinder Singh , Ankush Argade , Hui Li , Somasekhar Bhamidipati , David Carroll , Catherine Sylvain , Jeffrey Clough , Holger Keim
IPC分类号： C07D498/04 , C07D498/06 , C07D417/14 , C07D417/12 , C07D413/14 , A61K31/506 , C07D405/14 , C07D405/12 , C07D403/12 , A61K31/541 , C07D413/12
CPC分类号： C07D498/04 , A61K31/506 , A61K31/538 , A61K31/541 , A61P19/02 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D498/02 , C07D498/06
摘要： The present invention provides methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds, as well as methods of treating, preventing or ameliorating symptoms associated with such diseases. Specific examples of autoimmune diseases that can be treated or prevented with the compounds include rheumatoid arthritis and/or its associated symptoms, systemic lupus erythematosis and/or its associated symptoms and multiple sclerosis and/or its associated symptoms.
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公开(公告)号：US08415365B2
公开(公告)日：2013-04-09
申请号：US12030031
申请日：2008-02-12
申请人： Hui Li , Sambaiah Thota , David Carroll , Ankush Argade , Kin Tso , Arvinder Sran , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Vanessa Taylor , Robin Cooper , Rajinder Singh , Brian Wong
发明人： Hui Li , Sambaiah Thota , David Carroll , Ankush Argade , Kin Tso , Arvinder Sran , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Vanessa Taylor , Robin Cooper , Rajinder Singh , Brian Wong
IPC分类号： C07D239/48 , A61K31/505
CPC分类号： C07D413/12 , A61K31/343 , A61K31/436 , A61K31/505 , A61K31/506 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/541 , A61K31/695 , A61K38/13 , A61K39/3955 , A61K45/06 , C07D239/42 , C07D239/48 , C07D285/22 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D413/14 , C07D417/12 , C07D498/04 , C07F7/0812 , C07F7/10
摘要： The invention encompasses compounds having formula I-V and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, may be therapeutically useful.
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公开(公告)号：US08399472B2
公开(公告)日：2013-03-19
申请号：US12193627
申请日：2008-08-18
申请人： Hui Li , Sambaiah Thota , David Carroll , Ankush Argade , Kin Tso , Arvinder Sran , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Vanessa Taylor , Robin Cooper , Rajinder Singh , Brian Wong
发明人： Hui Li , Sambaiah Thota , David Carroll , Ankush Argade , Kin Tso , Arvinder Sran , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Vanessa Taylor , Robin Cooper , Rajinder Singh , Brian Wong
IPC分类号： C07D239/48 , A61K31/506
CPC分类号： C07D413/12 , A61K31/343 , A61K31/436 , A61K31/505 , A61K31/506 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/541 , A61K31/695 , A61K38/13 , A61K39/3955 , A61K45/06 , C07D239/42 , C07D239/48 , C07D285/22 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D413/14 , C07D417/12 , C07D498/04 , C07F7/0812 , C07F7/10
摘要： The invention encompasses compounds having formula I-V and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, may be therapeutically useful.
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4.发明申请PYRIMIDINE-2-AMINE COMPOUNDS AND THEIR USE AS INHIBITORS OF JAK KINASES 有权吡嗪-2-胺化合物及其作为JAK KINASES的抑制剂的用途公开(公告)号：US20130018041A1
公开(公告)日：2013-01-17
申请号：US13619843
申请日：2012-09-14
申请人： Somasekhar Bhamidipati , Jeffrey Clough , Ankush Argade , Rajinder Singh , Vadim Markovtosov , Pingyu Ding , Jiaxin Yu , Andy Atuegbu , Hui Hong , Ihab Darwish , Sambaiah Thota
发明人： Somasekhar Bhamidipati , Jeffrey Clough , Ankush Argade , Rajinder Singh , Vadim Markovtosov , Pingyu Ding , Jiaxin Yu , Andy Atuegbu , Hui Hong , Ihab Darwish , Sambaiah Thota
IPC分类号： A61K31/506 , A61K31/5377 , A61K31/5386 , A61K31/538 , A61K31/551 , A61K31/553 , A61K31/541 , A61K31/5415 , A61K31/55 , A61P35/02 , A61P35/00 , A61P37/06 , A61P29/00 , A61P7/00 , A61K31/5383
CPC分类号： C07D487/08 , C07D451/00 , C07D451/04 , C07D491/08 , C07D519/00
摘要： This invention is directed to compounds of formula (I): where n, m, Y, R1, R2, R3, R4 and R5 are disclosed herein, as isolated stereoisomers or mixtures thereof, or pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising the compounds of formula (I); and methods of using the compounds and the pharmaceutical compositions in treating diseases or conditions associated with JAK2 activity.
摘要翻译： 本发明涉及式（I）的化合物：其中n，m，Y，R 1，R 2，R 3，R 4和R 5在本文中公开，作为其分离的立体异构体或其混合物或其药学上可接受的盐; 包含式（I）化合物的药物组合物; 以及使用化合物和药物组合物治疗与JAK2活性相关的疾病或病症的方法。
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5.发明申请Methods of Treating or Preventing Autoimmune Diseases With 2,4-Pyrimidinediamine Compounds 有权用2,4-嘧啶二胺化合物治疗或预防自身免疫性疾病的方法公开(公告)号：US20120230984A1
公开(公告)日：2012-09-13
申请号：US13418696
申请日：2012-03-13
申请人： Rajinder Singh , Ankush Argade , Donald G. Payan , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Catherine Sylvain , Hui Li
发明人： Rajinder Singh , Ankush Argade , Donald G. Payan , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Catherine Sylvain , Hui Li
IPC分类号： A61K31/506 , A61K31/5383 , A61K31/56 , A61K31/616 , A61K31/519 , A61P37/06 , A61P37/08 , A61K39/395 , A61P7/06 , A61P25/00 , A61P7/00 , A61P27/02 , A61P21/04 , A61P1/16 , A61P13/12 , A61P29/00 , A61P19/02 , A61P19/04 , A61K31/538
CPC分类号： A61K31/506 , A61K31/519 , C07D401/12 , C07D403/12 , C07D405/12 , C07D407/12 , C07D413/12 , C07D413/14 , C07D471/04 , C07D498/04 , Y10S514/825 , Y10S514/903
摘要： The present invention provides methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds, as well as methods of treating, preventing or ameliorating symptoms associated with such diseases. Specific examples of autoimmune diseases that can be treated or prevented with the compounds include rheumatoid arthritis and/or its associated symptoms, systemic lups erythematosis and/or its associated symptoms and multiple sclerosis and/or its associated symptoms.
摘要翻译： 本发明提供了用2,4-嘧啶二胺化合物治疗或预防自身免疫疾病的方法，以及治疗，预防或改善与这些疾病相关的症状的方法。 可以用化合物治疗或预防的自身免疫性疾病的具体实例包括类风湿性关节炎和/或其相关症状，系统性红斑狼疮病和/或其相关症状和多发性硬化症和/或其相关症状。
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6.发明授权Methods of treating or preventing autoimmune diseases with 2, 4-pyrimidinediamine compounds 有权用2,4-嘧啶二胺化合物治疗或预防自身免疫性疾病的方法公开(公告)号：US08178671B2
公开(公告)日：2012-05-15
申请号：US10903263
申请日：2004-07-30
申请人： Rajinder Singh , Ankush Argade , Hui Li , Somasekhar Bhamidipati , David Carroll , Catherine Sylvain , Jeffrey Clough , Holger Keim
发明人： Rajinder Singh , Ankush Argade , Hui Li , Somasekhar Bhamidipati , David Carroll , Catherine Sylvain , Jeffrey Clough , Holger Keim
IPC分类号： C07D239/48 , C07D403/12 , C07D403/14 , C07D413/12 , C07D417/12 , A61K31/506 , A61K31/498 , A61K31/5375 , A61K31/5383 , A61K31/5415 , A61P19/02
CPC分类号： C07D498/04 , A61K31/506 , A61K31/541 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D498/06
摘要： The present invention provides methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds, as well as methods of treating, preventing or ameliorating symptoms associated with such diseases. Specific examples of autoimmune diseases that can be treated or prevented with the compounds include rheumatoid arthritis and/or its associated symptoms, systemic lups erythematosis and/or its associated symptoms and multiple sclerosis and/or its associated symptoms.
摘要翻译： 本发明提供了用2,4-嘧啶二胺化合物治疗或预防自身免疫疾病的方法，以及治疗，预防或改善与这些疾病相关的症状的方法。 可以用化合物治疗或预防的自身免疫性疾病的具体实例包括类风湿性关节炎和/或其相关症状，系统性红斑狼疮和/或其相关症状和多发性硬化症和/或其相关症状。
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7.发明授权Methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds 有权用2,4-嘧啶二胺化合物治疗或预防自身免疫性疾病的方法公开(公告)号：US08158621B2
公开(公告)日：2012-04-17
申请号：US12691657
申请日：2010-01-21
申请人： Rajinder Singh , Ankush Argade , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Catherine Sylvain , Hui Li
发明人： Rajinder Singh , Ankush Argade , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Catherine Sylvain , Hui Li
IPC分类号： C07D498/04 , A61K31/538
CPC分类号： A61K31/506 , A61K31/519 , C07D401/12 , C07D403/12 , C07D405/12 , C07D407/12 , C07D413/12 , C07D413/14 , C07D471/04 , C07D498/04 , Y10S514/825 , Y10S514/903
摘要： The present invention provides methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds, as well as methods of treating, preventing or ameliorating symptoms associated with such diseases. Specific examples of autoimmune diseases that can be treated or prevented with the compounds include rheumatoid arthritis and/or its associated symptoms, systemic lups erythematosis and/or its associated symptoms and multiple sclerosis and/or its associated symptoms.
摘要翻译： 本发明提供了用2,4-嘧啶二胺化合物治疗或预防自身免疫疾病的方法，以及治疗，预防或改善与这些疾病相关的症状的方法。 可以用化合物治疗或预防的自身免疫性疾病的具体实例包括类风湿性关节炎和/或其相关症状，系统性红斑狼疮病和/或其相关症状和多发性硬化症和/或其相关症状。
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公开(公告)号：US20110124599A1
公开(公告)日：2011-05-26
申请号：US12950612
申请日：2010-11-19
IPC分类号： A61K31/5383 , C07D498/04 , A61P29/00 , A61P17/02 , A61P37/06 , A61K31/675 , C12N9/99 , C12N5/071
CPC分类号： C07D498/04 , C07F9/6561
摘要： The present disclosure provides biologically active 2,4-pyrimidinediamine compounds of formulae (I)-(III): and salts thereof, compositions comprising these compounds, and methods of using these compounds in a variety of applications.
摘要翻译： 本公开提供式（I） - （III）的生物活性2,4-嘧啶二胺化合物及其盐，包含这些化合物的组合物，以及在各种应用中使用这些化合物的方法。
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9.发明申请Deuterated 2, 4-Pyrimidinediamine Compounds and Prodrugs Thereof and Their Uses 审中-公开氘代2,4-嘧啶二胺化合物及其前体药物及其用途公开(公告)号：US20110015155A1
公开(公告)日：2011-01-20
申请号：US12838224
申请日：2010-07-16
IPC分类号： A61K31/675 , C07D498/04 , C07F9/09 , A61K31/5383 , A61P37/08 , A61P17/02 , A61P29/00 , A61P19/02 , A61P37/00 , A61P21/04 , A61P1/04
CPC分类号： C07D498/04 , C07B59/002 , C07F9/6561 , C07F9/65742
摘要： The present disclosure provides biologically active deuterated 2,4-pyrimidinediamine compounds and prodrugs thereof, compositions comprising the deuterated compounds, intermediates and methods for synthesizing the deuterated compounds and methods of using the deuterated compounds in a variety of applications.
摘要翻译： 本公开提供了生物活性的氘代2,4-嘧啶二胺化合物及其前药，包含氘代化合物的组合物，用于合成氘代化合物的中间体和方法以及在各种应用中使用氘代化合物的方法。
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公开(公告)号：US07825116B2
公开(公告)日：2010-11-02
申请号：US11539101
申请日：2006-10-05
申请人： Rajinder Singh , Ankush Argade , Donald G. Payan , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Catherine Sylvain , Hui Li
发明人： Rajinder Singh , Ankush Argade , Donald G. Payan , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Catherine Sylvain , Hui Li
IPC分类号： C07D239/48 , C07D403/12 , A61K31/506
CPC分类号： A61K31/506 , A61K31/519 , C07D401/12 , C07D403/12 , C07D405/12 , C07D407/12 , C07D413/12 , C07D413/14 , C07D471/04 , C07D498/04 , Y10S514/825 , Y10S514/903
摘要： The present invention provides methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds, as well as methods of treating, preventing or ameliorating symptoms associated with such diseases. Specific examples of autoimmune diseases that can be treated or prevented with the compounds include rheumatoid arthritis and/or its associated symptoms, systemic lups erythematosis and/or its associated symptoms and multiple sclerosis and/or its associated symptoms.
摘要翻译： 本发明提供了用2,4-嘧啶二胺化合物治疗或预防自身免疫疾病的方法，以及治疗，预防或改善与这些疾病相关的症状的方法。 可以用化合物治疗或预防的自身免疫性疾病的具体实例包括类风湿性关节炎和/或其相关症状，系统性红斑狼疮病和/或其相关症状和多发性硬化症和/或其相关症状。
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