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公开(公告)号：US07947698B2
公开(公告)日：2011-05-24
申请号：US12053382
申请日：2008-03-21
申请人： Andy Atuegbu , Vadim Markovtsov , Somasekhar Bhamidipati , Rajinder Singh , Vanessa Taylor , Sambaiah Thota , Jeffrey Wayne Clough , David Carroll , Hui Li , Robin Cooper
发明人： Andy Atuegbu , Vadim Markovtsov , Somasekhar Bhamidipati , Rajinder Singh , Vanessa Taylor , Sambaiah Thota , Jeffrey Wayne Clough , David Carroll , Hui Li , Robin Cooper
IPC分类号： C07D239/02 , A01N43/54
CPC分类号： C07D239/48
摘要： The invention encompasses compounds having formula I and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, are therapeutically useful.
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公开(公告)号：US08304422B2
公开(公告)日：2012-11-06
申请号：US12966839
申请日：2010-12-13
申请人： Andy Atuegbu , Vadim Markovtsov , Somasekhar Bhamidipati , Rajinder Singh , Vanessa Taylor , Sambaiah Thota , Jeffrey Wayne Clough , David Carroll , Hui Li , Robin Cooper
发明人： Andy Atuegbu , Vadim Markovtsov , Somasekhar Bhamidipati , Rajinder Singh , Vanessa Taylor , Sambaiah Thota , Jeffrey Wayne Clough , David Carroll , Hui Li , Robin Cooper
IPC分类号： C07D239/02 , A01N43/54
CPC分类号： C07D239/48
摘要： The invention encompasses compounds having formula I and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, are therapeutically useful.
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公开(公告)号：US20110082146A1
公开(公告)日：2011-04-07
申请号：US12966839
申请日：2010-12-13
申请人： Andy Atuegbu , Vadim Markovtsov , Somasekhar Bhamidipati , Rajinder Singh , Vanessa Taylor , Sambaiah Thota , Jeffrey Wayne Clough , David Carroll , Hui Li , Robin Cooper
发明人： Andy Atuegbu , Vadim Markovtsov , Somasekhar Bhamidipati , Rajinder Singh , Vanessa Taylor , Sambaiah Thota , Jeffrey Wayne Clough , David Carroll , Hui Li , Robin Cooper
IPC分类号： A61K31/5377 , A61K31/505 , C07D239/48 , C07D403/02 , A61K31/496 , C07D401/14 , C07D413/02 , A61P37/06 , C12N9/99
CPC分类号： C07D239/48
摘要： The invention encompasses compounds having formula I and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, are therapeutically useful.
摘要翻译： 本发明包括具有式I的化合物和使用这些化合物的组合物和方法用于治疗JAK途径的调节或JAK激酶，特别是JAK3的抑制在治疗上有用的条件。
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公开(公告)号：US20110027856A1
公开(公告)日：2011-02-03
申请号：US12902052
申请日：2010-10-11
申请人： Hui Li , Vanessa Taylor , Somasekhar Bhamidipati , John Ramphal , Kin Tso , Arvinder Sran , Holger Keim , Vadim Markovtsov , David Carroll , Sambaiah Thota , Ankush Argade , Jeffrey Wayne Clough , Rajinder Singh , Robin Cooper
发明人： Hui Li , Vanessa Taylor , Somasekhar Bhamidipati , John Ramphal , Kin Tso , Arvinder Sran , Holger Keim , Vadim Markovtsov , David Carroll , Sambaiah Thota , Ankush Argade , Jeffrey Wayne Clough , Rajinder Singh , Robin Cooper
IPC分类号： C12N9/99
CPC分类号： A61K31/506 , A61K31/5375 , A61K31/538 , A61K31/5383 , C07D239/48 , C07D239/49 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D491/04 , C07D498/04
摘要： The invention encompasses compounds having formula I and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, are therapeutically useful.
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公开(公告)号：US07834024B2
公开(公告)日：2010-11-16
申请号：US12053438
申请日：2008-03-21
申请人： Hui Li , Vanessa Taylor , Somasekhar Bhamidipati , John Ramphal , Kin Tso , Avinder Sran , Holger Keim , Vadim Markovtsov , David Carroll , Sambaiah Thota , Ankush Argade , Jeffrey Wayne Clough , Rajinder Singh , Robin Cooper
发明人： Hui Li , Vanessa Taylor , Somasekhar Bhamidipati , John Ramphal , Kin Tso , Avinder Sran , Holger Keim , Vadim Markovtsov , David Carroll , Sambaiah Thota , Ankush Argade , Jeffrey Wayne Clough , Rajinder Singh , Robin Cooper
IPC分类号： A61K31/505
CPC分类号： A61K31/506 , A61K31/5375 , A61K31/538 , A61K31/5383 , C07D239/48 , C07D239/49 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D491/04 , C07D498/04
摘要： The invention encompasses compounds having formula I and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, are therapeutically useful.
摘要翻译： 本发明包括具有式I的化合物和使用这些化合物的组合物和方法用于治疗JAK途径的调节或JAK激酶，特别是JAK3的抑制在治疗上有用的条件。
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公开(公告)号：US08846908B2
公开(公告)日：2014-09-30
申请号：US13119950
申请日：2009-09-23
IPC分类号： C07D239/48 , C07D265/36 , C07D263/62 , C07D413/14 , A61K31/506 , A61K31/538 , A61K31/5383 , A61K31/423 , A61P35/00 , C07D413/12
CPC分类号： C07D417/14 , A61K31/423 , A61K31/506 , A61K31/538 , A61K31/5383 , A61K31/5415 , A61K45/06 , C07D239/48 , C07D263/62 , C07D265/36 , C07D413/12 , C07D413/14
摘要： The present disclosure relates to 2,4-pyrimidinediamines substituted with tricyclic carbamates and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, such as JAK2 or JAK3, is therapeutically useful.
摘要翻译： 本公开涉及用三环氨基甲酸酯取代的2,4-嘧啶基和使用这些化合物的组合物和方法，用于治疗JAK途径的调节或JAK激酶（例如JAK2或JAK3）的抑制在治疗上有用的条件。
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公开(公告)号：US20110269749A1
公开(公告)日：2011-11-03
申请号：US13119950
申请日：2009-09-23
IPC分类号： A61K31/5415 , C07D413/14 , C07D417/14 , A61K31/506 , A61P3/00 , A61P35/00 , A61P35/02 , A61P37/06 , A61P29/00 , C07D413/12 , A61K31/538
CPC分类号： C07D417/14 , A61K31/423 , A61K31/506 , A61K31/538 , A61K31/5383 , A61K31/5415 , A61K45/06 , C07D239/48 , C07D263/62 , C07D265/36 , C07D413/12 , C07D413/14
摘要： The present disclosure relates to 2,4-pyrimidinediamines substituted with tricyclic carbamates and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, such as JAK2 or JAK3, is therapeutically useful.
摘要翻译： 本公开涉及用三环氨基甲酸酯取代的2,4-嘧啶基和使用这些化合物的组合物和方法，用于治疗JAK途径的调节或JAK激酶（例如JAK2或JAK3）的抑制在治疗上有用的条件。
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公开(公告)号：US08299087B2
公开(公告)日：2012-10-30
申请号：US12902052
申请日：2010-10-11
申请人： Hui Li , Vanessa Taylor , Somasekhar Bhamidipati , John Ramphal , Kin Tso , Arvinder Sran , Holger Keim , Vadim Markovtsov , David Carroll , Sambaiah Thota , Ankush Argade , Jeffrey Wayne Clough , Rajinder Singh , Robin Cooper
发明人： Hui Li , Vanessa Taylor , Somasekhar Bhamidipati , John Ramphal , Kin Tso , Arvinder Sran , Holger Keim , Vadim Markovtsov , David Carroll , Sambaiah Thota , Ankush Argade , Jeffrey Wayne Clough , Rajinder Singh , Robin Cooper
IPC分类号： A61K31/505
CPC分类号： A61K31/506 , A61K31/5375 , A61K31/538 , A61K31/5383 , C07D239/48 , C07D239/49 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D491/04 , C07D498/04
摘要： The invention encompasses compounds having formula I and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, are therapeutically useful.
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公开(公告)号：US20080279867A1
公开(公告)日：2008-11-13
申请号：US12053382
申请日：2008-03-21
申请人： Andy Atuegbu , Vadim Markovtsov , Somasekhar Bhamidipati , Rajinder Singh , Vanessa Taylor , Sambaiah Thota , Jeffrey Wayne Clough , David Carroll , Hui Li , Robin Cooper
发明人： Andy Atuegbu , Vadim Markovtsov , Somasekhar Bhamidipati , Rajinder Singh , Vanessa Taylor , Sambaiah Thota , Jeffrey Wayne Clough , David Carroll , Hui Li , Robin Cooper
IPC分类号： A61K39/395 , C07D413/12 , C12N9/99 , A61K31/538 , C07D239/48 , A61K31/505 , C12N5/06 , A61K31/506 , C07D403/12 , A61P37/00 , A61P37/06
CPC分类号： C07D239/48
摘要： The invention encompasses compounds having formula I and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, are therapeutically useful.
摘要翻译： 本发明包括具有式I的化合物和使用这些化合物的组合物和方法用于治疗JAK途径的调节或JAK激酶，特别是JAK3的抑制在治疗上有用的条件。
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公开(公告)号：US20080260754A1
公开(公告)日：2008-10-23
申请号：US12053438
申请日：2008-03-21
申请人： Hui Li , Vanessa Taylor , Somasekhar Bhamidipati , John Ramphal , Kin Tso , Avinder Sran , Holger Keim , Vadim Markovtsov , David Carroll , Sambaiah Thota , Ankush Argade , Jeffrey Wayne Clough , Rajinder Singh , Robin Cooper
发明人： Hui Li , Vanessa Taylor , Somasekhar Bhamidipati , John Ramphal , Kin Tso , Avinder Sran , Holger Keim , Vadim Markovtsov , David Carroll , Sambaiah Thota , Ankush Argade , Jeffrey Wayne Clough , Rajinder Singh , Robin Cooper
IPC分类号： A61K39/395 , C12N9/12 , C07D239/24 , A61K31/505 , C07D295/00 , A61K31/5377 , C07D498/02 , C12N5/00 , A61P37/00 , A61K31/5383 , C07D403/02 , A61K31/496 , C07D279/16 , A61K31/5415 , A61K38/13
CPC分类号： A61K31/506 , A61K31/5375 , A61K31/538 , A61K31/5383 , C07D239/48 , C07D239/49 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D491/04 , C07D498/04
摘要： The invention encompasses compounds having formula I and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, are therapeutically useful.
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