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公开(公告)号：US08128682B2
公开(公告)日：2012-03-06
申请号：US12777947
申请日：2010-05-11
IPC分类号： A61F2/82
CPC分类号： A61F2/2418 , A61F2/07 , A61F2/2475 , A61F2/86 , A61F2/90 , A61F2002/075 , A61F2210/0004 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2220/0075 , A61F2230/0071 , A61F2250/0018 , A61F2250/0031 , A61F2250/0071
摘要： Medical devices for implantation in a body vessel, and methods of using and making the same, are provided. A medical device includes a support frame having struts and a weakened frame portion, and a remodelable material tensionably attached to the support frame. The weakened frame portion has a first configuration in which the support frame has a first outward radial force and a second configuration in which the support frame has a second, lesser outward radial force. The remodelable material restricts expansion of the frame from a radially compressed configuration to a radially expanded configuration when the weakened frame portion is in the first configuration. The remodelable material can form one or more valve leaflets adapted to regulate fluid flow in a body vessel, such as a vein.
摘要翻译： 提供了用于植入体内的医疗装置及其使用和制造方法。 医疗装置包括具有支柱和弱化框架部分的支撑框架和可张紧地附接到支撑框架的可重塑材料。 弱化的框架部分具有第一构造，其中支撑框架具有第一向外径向力和第二构造，其中支撑框架具有第二较小的向外径向力。 当变弱的框架部分处于第一构型时，可重塑材料将框架从径向压缩构型扩展到径向扩张构型。 可重塑材料可以形成适于调节诸如静脉的体内血管中的流体流动的一个或多个瓣膜小叶。
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公开(公告)号：US08382822B2
公开(公告)日：2013-02-26
申请号：US12574870
申请日：2009-10-07
申请人： Dusan Pavcnik , Brian C. Case , Jacob A. Flagle , Michael Garrison , Andrew K. Hoffa , Raymond B. Leonard, II , Thomas A. Osborne , Ram H. Paul, Jr. , Darin G. Schaeffer , Richard B Sisken
发明人： Dusan Pavcnik , Brian C. Case , Jacob A. Flagle , Michael Garrison , Andrew K. Hoffa , Raymond B. Leonard, II , Thomas A. Osborne , Ram H. Paul, Jr. , Darin G. Schaeffer , Richard B Sisken
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2002/825 , A61F2002/8483 , A61F2220/0016 , A61F2230/0008 , A61F2230/001 , A61F2230/0017 , A61F2230/0021 , A61F2230/0026 , A61F2230/0054 , A61F2230/0058 , A61F2230/0095
摘要： A valve prosthesis, such as an artificial venous valve, having a support frame and leaf structure comprising one or more leaflets in which the outer edge of each leaflet engages the inner circumference of the bodily passageway along a serpentine path urged against the passageway by an expandable frame, while the inner edges move in response to fluid to restrict retrograde flow. Optionally, one or more elements can extend from the support frame/leaf structure to provide centering support and/or protection from the leaflet adhering to the vessel wall. In one embodiment, the centering support structure comprises a second or third expandable frames attached to and extending from the proximal and/or distal ends of main valve structure and support frame. In another embodiment, one or more support elements extend outward from the valve support frame to engage the vessel wall to provide greater longitudinal stability.
摘要翻译： 一种阀门假体，例如人造静脉瓣，其具有支撑框架和叶片结构，其包括一个或多个小叶，每个小叶的外边缘沿着沿着通过可扩张的第二通道推动抵靠通道的蛇形路径接合身体通道的内周 框架，而内边缘响应流体移动以限制逆行流。 任选地，一个或多个元件可以从支撑框架/叶结构延伸，以提供定位支撑和/或防止附着在血管壁上的小叶的保护。 在一个实施例中，定心支撑结构包括附接到主阀结构和支撑框架的近端和/或远端的第二或第三可膨胀框架。 在另一个实施例中，一个或多个支撑元件从阀支撑框架向外延伸以接合血管壁以提供更大的纵向稳定性。
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公开(公告)号：US08066733B2
公开(公告)日：2011-11-29
申请号：US12338731
申请日：2008-12-18
申请人： Ram H. Paul , Brian C. Case , Jacob A. Flagle
发明人： Ram H. Paul , Brian C. Case , Jacob A. Flagle
IPC分类号： A61M29/00
CPC分类号： A61B17/00008 , A61B17/12022 , A61B17/12109 , A61B17/12136 , A61B17/12181 , A61B2017/1205
摘要： Described are devices, methods and systems useful for achieving occlusion of vascular vessels. Percutaneous procedures can be used to occlude and obliterate the greater saphenous vein, for example in the treatment of varicose vein condition caused by venous reflux. Certain embodiments encompass the percutaneous delivery of an occlusion device inverted within a cannula, its deployment and filling, so as to occlude or obliterate a portion of a vascular vessel.
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公开(公告)号：US20090216321A1
公开(公告)日：2009-08-27
申请号：US12437731
申请日：2009-05-08
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2220/0016 , A61F2230/0026 , A61F2230/0067 , A61F2230/008 , A61F2230/0095 , A61F2250/0067
摘要： A prosthetic valve includes a support frame, a leaflet attached to the support frame, and a bioactive agent associated with the leaflet. A first free edge of the leaflet permits fluid flow through a body vessel in a first direction and substantially prevents fluid flow through the body vessel in a second, opposite direction. A second free edge of the leaflet at least partially defines an opening for permitting a controlled amount of fluid flow through the body vessel.
摘要翻译： 假体瓣膜包括支撑框架，附接到支撑框架的小叶以及与小叶相关联的生物活性剂。 小叶的第一自由边允许流体沿着第一方向流过身体容器，并且基本上防止流体沿第二相反方向流过身体血管。 叶片的第二自由边缘至少部分地限定了允许受控量的流体流过身体容器的开口。
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公开(公告)号：US20090099589A1
公开(公告)日：2009-04-16
申请号：US12338731
申请日：2008-12-18
申请人： Ram H. Paul , Brian C. Case , Jacob A. Flagle
发明人： Ram H. Paul , Brian C. Case , Jacob A. Flagle
CPC分类号： A61B17/00008 , A61B17/12022 , A61B17/12109 , A61B17/12136 , A61B17/12181 , A61B2017/1205
摘要： Described are devices, methods and systems useful for achieving occlusion of vascular vessels. Percutaneous procedures can be used to occlude and obliterate the greater saphenous vein, for example in the treatment of varicose vein condition caused by venous reflux. Certain embodiments encompass the percutaneous delivery of an occlusion device inverted within a cannula, its deployment and filling, so as to occlude or obliterate a portion of a vascular vessel.
摘要翻译： 描述了用于实现血管血管阻塞的装置，方法和系统。 经皮手术可用于闭塞和闭塞较大的隐静脉，例如用于治疗由静脉回流引起的静脉曲张病变。 某些实施方案包括在插管内反转的闭塞装置的经皮递送，其展开和填充，以封闭或消除血管容器的一部分。
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公开(公告)号：US20090069838A1
公开(公告)日：2009-03-12
申请号：US12271401
申请日：2008-11-14
申请人： Ram H. Paul , Jacob A. Flagle , Brian C. Case
发明人： Ram H. Paul , Jacob A. Flagle , Brian C. Case
IPC分类号： A61M29/02
CPC分类号： A61L29/005 , A61B17/12109 , A61B17/12136 , A61B17/1219 , A61B2017/1205
摘要： Described are devices, methods and systems useful for achieving occlusion of vascular vessels. Percutaneous procedures can be used to occlude and obliterate the greater saphenous vein, for example in the treatment of varicose vein condition caused by venous reflux. Certain embodiments encompass the deployment and filling of an inflatable occlusion device via a percutaneous procedure, so as to occlude or obliterate a portion of a vascular vessel.
摘要翻译： 描述了用于实现血管血管阻塞的装置，方法和系统。 经皮手术可用于闭塞和闭塞较大的隐静脉，例如用于治疗由静脉回流引起的静脉曲张病变。 某些实施方案包括经由经皮程序展开和填充可充气闭塞装置，从而封闭或消除血管容器的一部分。
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7.发明授权公开(公告)号：US09307995B2
公开(公告)日：2016-04-12
申请号：US11763773
申请日：2007-06-15
申请人： Ram H. Paul , Brian C. Case , Jacob A. Flagle
发明人： Ram H. Paul , Brian C. Case , Jacob A. Flagle
CPC分类号： A61B17/12031 , A61B17/12022 , A61B17/12109 , A61B17/12181 , A61B17/1219 , A61B2017/00778 , A61B2017/00867 , A61B2017/00898 , A61B2017/1205 , A61B2017/22038
摘要： Described are devices, methods, and systems for achieving occlusion of vascular vessels. Further described are certain reduced or low profile procedures and devices for the percutaneous occlusion of the saphenous vein, such as in the treatment of a varicose vein condition caused by venous reflux. Devices and procedures can involve an endoluminal delivery device having an atraumatic distal end, that is advancable through a vascular vessel, and an occlusion device received on the endoluminal delivery device. The endoluminal delivery device can have one or more adaptations for releasably receiving the occlusion device. The occlusion device can include a sponge form material. The occlusion device can include a remodelable material or a synthetic material. The occlusion device can include an anchor.
摘要翻译： 描述了用于实现血管血管闭塞的装置，方法和系统。 进一步描述了用于经皮闭塞隐静脉的某些缩减或低调程序和装置，例如用于治疗由静脉回流引起的静脉曲张病症。 装置和程序可以包括具有无创损伤远端的腔内输送装置，其可通过血管容器和通过内腔输送装置接收的闭塞装置。 腔内输送装置可具有用于可释放地接收闭塞装置的一种或多种适应。 闭塞装置可以包括海绵形式的材料。 闭塞装置可包括可重塑材料或合成材料。 遮挡装置可以包括锚固件。
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公开(公告)号：US08398663B2
公开(公告)日：2013-03-19
申请号：US12781300
申请日：2010-05-17
申请人： Ram H. Paul, Jr. , Brian C. Case , Jacob A. Flagle
发明人： Ram H. Paul, Jr. , Brian C. Case , Jacob A. Flagle
IPC分类号： A61B17/22
CPC分类号： A61B17/3207 , A61B17/320725 , A61B2017/22097
摘要： Valvulotome devices and methods are provided. Valvulotome devices include one or more valvulotome arms that have a u-shaped curved body with opposing arms and a base portion that extends between the arms. The valvulotome arm defines a notch open at one end on one of the arms and extending into the base portion of the u-shaped curved body. The notch defines an angled surface that provides a cutting edge. Methods of making valvulotome devices are also described.
摘要翻译： 提供瓣膜切除装置和方法。 瓣膜切开装置包括一个或多个瓣膜切开臂，其具有带相对臂的u形弯曲体和在臂之间延伸的基部。 瓣膜切开臂限定了在一个臂上的一端处开口并且延伸到U形弯曲体的基部中的凹口。 切口限定了提供切削刃的成角度的表面。 还描述了制造瓣膜切开术装置的方法。
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公开(公告)号：US20100286719A1
公开(公告)日：2010-11-11
申请号：US12781300
申请日：2010-05-17
申请人： Ram H. Paul , Brian C. Case , Jacob A. Flagle
发明人： Ram H. Paul , Brian C. Case , Jacob A. Flagle
IPC分类号： A61B17/22
CPC分类号： A61B17/3207 , A61B17/320725 , A61B2017/22097
摘要： Valvulotome devices and methods are provided. Valvulotome devices include one or more valvulotome arms that have a u-shaped curved body with opposing arms and a base portion that extends between the arms. The valvulotome arm defines a notch open at one end on one of the arms and extending into the base portion of the u-shaped curved body. The notch defines an angled surface that provides a cutting edge. Methods of making valvulotome devices are also described.
摘要翻译： 提供瓣膜切除装置和方法。 瓣膜切开装置包括一个或多个瓣膜切开臂，其具有带相对臂的u形弯曲体和在臂之间延伸的基部。 瓣膜切开臂限定了在一个臂上的一端处开口并且延伸到U形弯曲体的基部中的凹口。 切口限定了提供切削刃的成角度的表面。 还描述了制造瓣膜切开术装置的方法。
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公开(公告)号：US20100280586A1
公开(公告)日：2010-11-04
申请号：US12777947
申请日：2010-05-11
IPC分类号： A61F2/82
CPC分类号： A61F2/2418 , A61F2/07 , A61F2/2475 , A61F2/86 , A61F2/90 , A61F2002/075 , A61F2210/0004 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2220/0075 , A61F2230/0071 , A61F2250/0018 , A61F2250/0031 , A61F2250/0071
摘要： Medical devices for implantation in a body vessel, and methods of using and making the same, are provided. A medical device includes a support frame having struts and a weakened frame portion, and a remodelable material tensionably attached to the support frame. The weakened frame portion has a first configuration in which the support frame has a first outward radial force and a second configuration in which the support frame has a second, lesser outward radial force. The remodellable material restricts expansion of the frame from a radially compressed configuration to a radially expanded configuration when the weakened frame portion is in the first configuration. The remodelable material can form one or more valve leaflets adapted to regulate fluid flow in a body vessel, such as a vein.
摘要翻译： 提供了用于植入体内的医疗装置及其使用和制造方法。 医疗装置包括具有支柱和弱化框架部分的支撑框架和可张紧地附接到支撑框架的可重塑材料。 弱化的框架部分具有第一构造，其中支撑框架具有第一向外径向力和第二构造，其中支撑框架具有第二较小的向外径向力。 当减弱的框架部分处于第一构造时，可重构材料限制框架从径向压缩构型到径向膨胀构型的膨胀。 可重塑材料可以形成适于调节诸如静脉的体内血管中的流体流动的一个或多个瓣膜小叶。
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