公开(公告)号：US20060040906A1

公开(公告)日：2006-02-23

申请号：US10526178

申请日：2003-09-05

申请人： Raman Bakshi ,  Ravi Nargund ,  Brenda Palucki ,  Min Park ,  Zhixiong Ye

发明人： Raman Bakshi ,  Ravi Nargund ,  Brenda Palucki ,  Min Park ,  Zhixiong Ye

IPC分类号： A61K31/551 ,  A61K31/496 ,  C07D403/02

CPC分类号： C07D401/12 ,  C07D211/18 ,  C07D211/22 ,  C07D211/62 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D487/08

摘要： Certain novel piperazine urea derivatives are agonists of the human melanocortin-4 receptor (MC-4R) and, in particular, are receptor-subtype selective agonists of MC-4R. They are useful for the treatment, control, or prevention of diseases and disorders responsive to the activation of MC-4R, such as obesity and diabetes.

摘要翻译： 某些新型哌嗪脲衍生物是人类黑皮质素-4受体（MC-4R）的激动剂，特别是MC-4R的受体亚型选择性激动剂。 它们可用于治疗，控制或预防对MC-4R活化反应的疾病和病症，例如肥胖症和糖尿病。

公开(公告)号：US20050119261A1

公开(公告)日：2005-06-02

申请号：US10799230

申请日：2004-03-12

申请人： Prasun Chakravarty ,  Michael Fisher ,  Jeffrey Fisher ,  Brenda Palucki ,  Min Park ,  William Parsons ,  Bishan Zhou ,  James Carey ,  Douglas Frantz ,  Michael Kress ,  Damian Weaver

发明人： Prasun Chakravarty ,  Michael Fisher ,  Jeffrey Fisher ,  Brenda Palucki ,  Min Park ,  William Parsons ,  Bishan Zhou ,  James Carey ,  Douglas Frantz ,  Michael Kress ,  Damian Weaver

IPC分类号： A61K31/4196 ,  A61P25/00 ,  C07D249/08 ,  C07D249/10 ,  C07D413/02 ,  A61K31/496 ,  A61K31/506 ,  A61K31/5377 ,  C07D417/02 ,  C07D43/02

CPC分类号： C07D249/08 ,  C07D249/10

摘要： Biaryl substituted triazole compounds represented by Formula I, II or III, or pharmaceutically acceptable salts thereof, and a process for making such compounds and salts thereof. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier. Methods of treating conditions associated with, or caused by, sodium channel activity, including, for example, acute pain, chronic pain, visceral pain, inflammatory pain, neuropathic pain, epilepsy, irritable bowel syndrome, depression, anxiety, multiple sclerosis, and bipolar disorder, comprise administering an effective amount of the present compounds, either alone, or in combination with one or more other therapeutically active compounds. A method of administering local anesthesia comprises administering an effective amount of a compound of the instant invention, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier.

摘要翻译： 由式I，II或III表示的二芳基取代的三唑化合物或其药学上可接受的盐，以及其制备方法。 药物组合物包含单独的或与一种或多种其它治疗活性化合物组合的有效量的本发明化合物和药学上可接受的载体。 治疗与钠通道活性相关或由其引起的疾病的方法，包括例如急性疼痛，慢性疼痛，内脏痛，炎性疼痛，神经性疼痛，癫痫，肠易激综合征，抑郁症，焦虑症，多发性硬化症和双相 包括单独施用有效量的本发明化合物或与一种或多种其它治疗活性化合物组合施用。 施用局部麻醉的方法包括单独施用有效量的本发明化合物或与一种或多种其它治疗活性化合物和药学上可接受的载体组合施用。

公开(公告)号：US20060183897A1

公开(公告)日：2006-08-17

申请号：US10549790

申请日：2004-03-12

申请人： Prasun Chakravarty ,  Michael Fisher ,  Brenda Palucki ,  Min Park ,  William Parsons ,  Bishan Zhou ,  James Carey ,  Douglas Frantz ,  Michael Kress ,  Damian Weaver

发明人： Prasun Chakravarty ,  Michael Fisher ,  Brenda Palucki ,  Min Park ,  William Parsons ,  Bishan Zhou ,  James Carey ,  Douglas Frantz ,  Michael Kress ,  Damian Weaver

IPC分类号： C07D417/02 ,  C07D403/02 ,  C07D413/02

CPC分类号： C07D249/08 ,  C07D249/10

摘要： Biaryl substituted triazole compounds represented by Formula I, II or III, or pharmaceutically acceptable salts thereof, and a process for making such compounds and salts thereof. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier. Methods of treating conditions associated with, or caused by, sodium channel activity, including, for example, acute pain, chronic pain, visceral pain, inflammatory pain, neuropathic pain, epilepsy, irritable bowel syndrome, depression, anxiety, multiple sclerosis, and bipolar disorder, comprise administering an effective amount of the present compounds, either alone, or in combination with one or more other therapeutically active compounds. A method of administering local anesthesia comprises administering an effective amount of a compound of the instant invention, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier.

公开(公告)号：US20060020006A1

公开(公告)日：2006-01-26

申请号：US10985592

申请日：2004-11-10

申请人： Min Park ,  Prasun Chakravarty ,  Bishan Zhou ,  Edward Gonzalez ,  Hyun Ok ,  Brenda Palucki ,  William Parsons ,  Rosemary Sisco ,  Michael Fisher ,  Louis Zuegner

发明人： Min Park ,  Prasun Chakravarty ,  Bishan Zhou ,  Edward Gonzalez ,  Hyun Ok ,  Brenda Palucki ,  William Parsons ,  Rosemary Sisco ,  Michael Fisher ,  Louis Zuegner

IPC分类号： A61K31/4196 ,  C07D403/02

CPC分类号： C07D249/10 ,  C07D403/10

摘要： Substituted triazole compounds represented by Formula I, II or III, or pharmaceutically acceptable salts thereof. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier. Methods of treating conditions associated with, or caused by, sodium channel activity, including, for example, acute pain, chronic pain, visceral pain, inflammatory pain, neuropathic pain, migraine, headache pain, migraine headache, epilepsy, irritable bowel syndrome, diabetic neuropathy, multiple sclerosis, manic depression and bipolar disorder, comprise administering an effective amount of the present compounds, either alone, or in combination with one or more other therapeutically active compounds. A method of administering local anesthesia comprises administering an effective amount of a compound of the instant invention, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier.

摘要翻译： 由式I，II或III表示的取代的三唑化合物或其药学上可接受的盐。 药物组合物包含单独的或与一种或多种其它治疗活性化合物组合的有效量的本发明化合物和药学上可接受的载体。 治疗与钠通道活性相关或由其引起的疾病的方法，包括例如急性疼痛，慢性疼痛，内脏痛，炎性疼痛，神经性疼痛，偏头痛，头痛，偏头痛，癫痫，肠易激综合征，糖尿病 神经病，多发性硬化症，躁狂抑郁症和双相性精神障碍，包括单独施用有效量的本发明化合物或与一种或多种其它治疗活性化合物组合施用。 施用局部麻醉的方法包括单独施用有效量的本发明化合物或与一种或多种其它治疗活性化合物和药学上可接受的载体组合施用。

公开(公告)号：US20090074890A1

公开(公告)日：2009-03-19

申请号：US10578950

申请日：2004-11-05

申请人： Min K. Park ,  Prasun K. Chakravarty ,  Bishan Zhou ,  Edward Gonzalez ,  Hyun Ok ,  Brenda Palucki ,  William H. Parsons ,  Rosemary Sisco ,  Michael H. Fisher ,  Louis L. Zuegner, III

发明人： Min K. Park ,  Prasun K. Chakravarty ,  Bishan Zhou ,  Edward Gonzalez ,  Hyun Ok ,  Brenda Palucki ,  William H. Parsons ,  Rosemary Sisco ,  Michael H. Fisher ,  Louis L. Zuegner, III

IPC分类号： C07D249/08 ,  A61P29/00 ,  A61P9/00 ,  A61P25/00 ,  A61K33/00 ,  A61K31/4196 ,  A61P1/00 ,  A61P31/12 ,  A61P37/00

CPC分类号： C07D249/10 ,  C07D403/10

摘要： Substituted triazole compounds represented by Formula I, II or III, or pharmaceutically acceptable salts thereof. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier. Methods of treating conditions associated with, or caused by, sodium channel activity, including, for example, acute pain, chronic pain, visceral pain, inflammatory pain, neuropathic pain, migraine, headache pain, migraine headache, epilepsy, irritable bowel syndrome, diabetic neuropathy, multiple sclerosis, manic depression and bipolar disorder, comprise administering an effective amount of the present compounds, either alone, or in combination with one or more other therapeutically active compounds. A method of administering local anesthesia comprises administering an effective amount of a compound of the instant invention, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier (I), (II), (III).

摘要翻译： 由式I，II或III表示的取代的三唑化合物或其药学上可接受的盐。 药物组合物包含单独的或与一种或多种其它治疗活性化合物组合的有效量的本发明化合物和药学上可接受的载体。 治疗与钠通道活性相关或由其引起的疾病的方法，包括例如急性疼痛，慢性疼痛，内脏痛，炎性疼痛，神经性疼痛，偏头痛，头痛，偏头痛，癫痫，肠易激综合征，糖尿病 神经病，多发性硬化症，躁狂抑郁症和双相性精神障碍，包括单独施用有效量的本发明化合物或与一种或多种其它治疗活性化合物组合施用。 施用局部麻醉的方法包括单独施用有效量的本发明化合物或与一种或多种其它治疗活性化合物和药学上可接受的载体（I），（II），（III） 。

公开(公告)号：US20080171777A1

公开(公告)日：2008-07-17

申请号：US12011967

申请日：2008-01-30

申请人： Prasun K. Chakravarty ,  Michael H. Fisher ,  Louis L. Zuegner ,  William H. Parsons ,  Brenda Palucki ,  Bishan Zhou ,  Min K. Park

发明人： Prasun K. Chakravarty ,  Michael H. Fisher ,  Louis L. Zuegner ,  William H. Parsons ,  Brenda Palucki ,  Bishan Zhou ,  Min K. Park

IPC分类号： A61K31/4196 ,  C07D249/08 ,  A61P23/02 ,  A61P25/04

CPC分类号： C07D249/08 ,  C07D249/10

摘要： Biaryl substituted triazole compounds represented by Formula I, II or III, or pharmaceutically acceptable salts thereof, and a process for making such compounds and salts thereof. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier. Methods of treating conditions associated with, or caused by, sodium channel activity, including, for example, acute pain, chronic pain, visceral pain, inflammatory pain, neuropathic pain, epilepsy, irritable bowel syndrome, depression, anxiety, multiple sclerosis, and bipolar disorder, comprise administering an effective amount of the present compounds, either alone, or in combination with one or more other therapeutically active compounds. A method of administering local anesthesia comprises administering an effective amount of a compound of the instant invention, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier.