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公开(公告)号:US4775757A
公开(公告)日:1988-10-04
申请号:US909817
申请日:1986-09-22
IPC分类号: C07D495/04 , C07D401/14 , C07D495/02
CPC分类号: C07D495/04
摘要: The synthesis of thienopyridine derivatives is described. The novel thienopyridine derivatives are cardiotonic agents and renal vasodilating agents. The compounds are useful as cardiovascular agents.
摘要翻译: 描述了噻吩并吡啶衍生物的合成。 新型噻吩并吡啶衍生物是强心剂和肾血管舒张剂。 这些化合物可用作心血管药。
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公开(公告)号:US5378713A
公开(公告)日:1995-01-03
申请号:US787705
申请日:1991-11-04
IPC分类号: C07D333/32 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/445 , A61K31/455 , A61P3/00 , A61P9/12 , C07D495/04 , C07D401/14
CPC分类号: C07D495/04
摘要: Substituted thienopyrans and processes for preparing the thienopyrans are disclosed. The thienopyrans are useful as antihypertensive agents; antianginals are peripheral antivasoconstrictive agents.
摘要翻译: 公开了取代的噻吩吡喃和制备噻吩并吡喃的方法。 噻吩普兰作为抗高血压药物是有用的; 抗衰老药是外周抗感染药。
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公开(公告)号:US4992435A
公开(公告)日:1991-02-12
申请号:US249043
申请日:1988-09-23
IPC分类号: C07D495/04
CPC分类号: C07D495/04
摘要: Substituted thienopyrans and processes for preparing the thienopyrans are disclosed. The thienopyrans are useful as antihypertensive agents; antianginals are peripheral antivasoconstrictive agents.
摘要翻译: 公开了取代的噻吩吡喃和制备噻吩并吡喃的方法。 噻吩普兰作为抗高血压药物是有用的; 抗衰老药是外周抗感染药。
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公开(公告)号:US5284857A
公开(公告)日:1994-02-08
申请号:US631593
申请日:1990-12-21
IPC分类号: C07D333/32 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/445 , A61K31/455 , A61P3/00 , A61P9/12 , C07D495/04 , C07D497/04
CPC分类号: C07D495/04
摘要: Substituted thienopyrans and processes for preparing the thienopyrans are disclosed. The thienopyrans are useful as antihypertensive agents; antianginals are peripheral antivasoconstrictive agents.
摘要翻译: 公开了取代的噻吩吡喃和制备噻吩并吡喃的方法。 噻吩普兰作为抗高血压药物是有用的; 抗衰老药是外周抗感染药。
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公开(公告)号:US5030736A
公开(公告)日:1991-07-09
申请号:US609493
申请日:1990-11-05
IPC分类号: C07D495/04
CPC分类号: C07D495/04
摘要: Substituted thienopyrans and processes for preparing the thienopyrans are disclosed. The thienopyrans are useful as antihypertensive agents; antianginals are peripheral antivasoconstrictive agents.
摘要翻译: 公开了取代的噻吩吡喃和制备噻吩并吡喃的方法。 噻吩普兰作为抗高血压药物是有用的; 抗衰老药是外周抗感染药。
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公开(公告)号:US08350041B2
公开(公告)日:2013-01-08
申请号:US13334374
申请日:2011-12-22
申请人: John R. Carson , Ellen Codd , Christine M. Razler , Andrea Works , Mark McDonnell , James J. McNally
发明人: John R. Carson , Ellen Codd , Christine M. Razler , Andrea Works , Mark McDonnell , James J. McNally
IPC分类号: A61K31/4535 , C07D409/04
CPC分类号: C07D405/04 , C07D405/14 , C07D409/14 , C07D471/08
摘要: The invention is directed to delta opioid receptor modulators. More specifically, the invention relates to tricyclic δ-opioid modulators. Pharmaceutical and veterinary compositions and methods of treating mild to severe pain and various diseases using compounds of the invention are also described.
摘要翻译: 本发明涉及Δ阿片样物质受体调节剂。 更具体地,本发明涉及三环δ-阿片样物质调节剂。 还描述了使用本发明的化合物治疗轻度至重度疼痛和各种疾病的药物和兽医组合物和方法。
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公开(公告)号:US08106207B2
公开(公告)日:2012-01-31
申请号:US13157846
申请日:2011-06-10
申请人: John R. Carson , Ellen Codd , Christine M. Razler , Andrea Works , Mark McDonnell , James J. McNally
发明人: John R. Carson , Ellen Codd , Christine M. Razler , Andrea Works , Mark McDonnell , James J. McNally
IPC分类号: A61K31/453 , C07D405/04
CPC分类号: C07D405/04 , C07D405/14 , C07D409/14 , C07D471/08
摘要: The invention is directed to delta opioid receptor modulators. More specifically, the invention relates to tricyclic δ-opioid modulators. Pharmaceutical and veterinary compositions and methods of treating mild to severe pain and various diseases using compounds of the invention are also described.
摘要翻译: 本发明涉及Δ阿片样物质受体调节剂。 更具体地,本发明涉及三环δ-阿片样物质调节剂。 还描述了使用本发明的化合物治疗轻度至重度疼痛和各种疾病的药物和兽医组合物和方法。
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公开(公告)号:US20100160289A1
公开(公告)日:2010-06-24
申请号:US12638550
申请日:2009-12-15
申请人: Mark J. Macielag , James J. McNally
发明人: Mark J. Macielag , James J. McNally
IPC分类号: A61K31/381 , C07D333/66 , A61K31/4535 , C07D409/12 , A61K31/496 , A61K31/541 , C07D417/12 , A61K31/4025 , A61K31/551 , C07D413/12 , A61K31/5377 , A61K31/397 , A61K31/4725 , C07C311/32 , A61K31/18 , A61K31/5375 , C07D295/16 , A61K31/54 , C07D211/30 , A61K31/451 , A61K31/472 , C07D217/04 , C07D205/04 , A61K31/495 , A61P29/00
CPC分类号: C07D333/66 , C07C311/32 , C07D205/04 , C07D211/14 , C07D217/04 , C07D295/10 , C07D295/18 , C07D409/12 , C07D413/12 , C07D417/12
摘要: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) and Formula (II) as follows: wherein Y, R1, R2, R3, R4, RA, and RB are defined herein.
摘要翻译: 公开了用于治疗各种疾病,综合征,病症和障碍(包括疼痛)的化合物,组合物和方法。 这样的化合物由式(I)和式(II)表示如下:其中Y,R 1,R 2,R 3,R 4,RA和RB在本文中定义。
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公开(公告)号:US20100093709A1
公开(公告)日:2010-04-15
申请号:US12622548
申请日:2009-11-20
申请人: Steven J. Coats , Scott L. Dax , Bart DeCorte , Li Liu , Mark McDonnell , James J. McNally
发明人: Steven J. Coats , Scott L. Dax , Bart DeCorte , Li Liu , Mark McDonnell , James J. McNally
IPC分类号: A61K31/5415 , C07D413/02 , C07D413/14 , C07D417/14 , A61K31/538
CPC分类号: C07D451/04
摘要: The invention is directed to delta opioid receptor modulators. More specifically, the invention relates to tricyclic δ-opioid modulators. Pharmaceutical and veterinary compositions and methods of treating mild to severe pain and various diseases using compounds of the invention are also described.
摘要翻译: 本发明涉及Δ阿片样物质受体调节剂。 更具体地,本发明涉及三环δ-阿片样物质调节剂。 还描述了使用本发明的化合物治疗轻度至重度疼痛和各种疾病的药物和兽医组合物和方法。
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公开(公告)号:US20090264474A1
公开(公告)日:2009-10-22
申请号:US12175740
申请日:2008-07-18
申请人: Shawn T. Branum , Raymond W. Colburn , Scott L. Dax , Christopher M. Flores , Michele C. Jetter , Yi Liu , Donald Ludovici , Mark J. Macielag , Jay M. Matthews , James J. McNally , Laura M. Reaney , Ronald K. Russell , Ning Qin , Christopher Teleha , Kenneth M. Wells , Scott C. Youells , Mark A. Youngman
发明人: Shawn T. Branum , Raymond W. Colburn , Scott L. Dax , Christopher M. Flores , Michele C. Jetter , Yi Liu , Donald Ludovici , Mark J. Macielag , Jay M. Matthews , James J. McNally , Laura M. Reaney , Ronald K. Russell , Ning Qin , Christopher Teleha , Kenneth M. Wells , Scott C. Youells , Mark A. Youngman
IPC分类号: A61K31/4439 , C07D333/66 , A61K31/381 , C07D417/12 , C07D409/12 , A61K31/4196 , A61K31/427 , C07D401/14
CPC分类号: C07D333/66 , C07D333/36 , C07D409/12 , C07D409/14 , C07D417/12 , C07D495/04
摘要: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein A, B, G, Y, R1, R2, R3, and R4 are defined herein.
摘要翻译: 公开了用于治疗各种疾病,综合征,病症和障碍(包括疼痛)的化合物,组合物和方法。 这样的化合物由式I表示如下:其中A,B,G,Y,R 1,R 2,R 3和R 4在本文中定义。
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