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公开(公告)号：US20120190674A1
公开(公告)日：2012-07-26
申请号：US13407251
申请日：2012-02-28
申请人： Shawn T. Branum , Raymond W. Colburn , Scott L. Dax , Christopher M. Flores , Michele C. Jetter , Yi Liu , Donald Ludovici , Mark J. Macielag , Jay M. Matthews , James J. McNally , Laura M. Reaney , Ronald K. Russell , Ning Qin , Christopher Teleha , Kenneth M. Wells , Scott C. Youells , Mark A. Youngman
发明人： Shawn T. Branum , Raymond W. Colburn , Scott L. Dax , Christopher M. Flores , Michele C. Jetter , Yi Liu , Donald Ludovici , Mark J. Macielag , Jay M. Matthews , James J. McNally , Laura M. Reaney , Ronald K. Russell , Ning Qin , Christopher Teleha , Kenneth M. Wells , Scott C. Youells , Mark A. Youngman
IPC分类号： A61K31/381 , A61K31/4436 , A61K31/4709 , A61K31/4725 , A61K31/5377 , A61P9/12 , A61P25/00 , A61P29/00 , A61P25/22 , A61P25/24 , A61P9/00 , C07D333/66 , A61K31/541
CPC分类号： C07D333/66 , C07D333/36 , C07D409/12 , C07D409/14 , C07D417/12 , C07D495/04
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein A, B, G, Y, R1, R2, R3, and R4 are defined herein.
摘要翻译： 公开了用于治疗各种疾病，综合征，病症和障碍（包括疼痛）的化合物，组合物和方法。 这样的化合物由式I表示如下：其中A，B，G，Y，R 1，R 2，R 3和R 4在本文中定义。
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公开(公告)号：US08809327B2
公开(公告)日：2014-08-19
申请号：US13407251
申请日：2012-02-28
申请人： Shawn T. Branum , Raymond W. Colburn , Scott L. Dax , Christopher M. Flores , Michele C. Jetter , Yi Liu , Donald Ludovici , Mark J. Macielag , Jay M. Matthews , James J. McNally , Laura M. Reaney , Ronald K. Russell , Ning Qin , Christopher Teleha , Kenneth M. Wells , Scott C. Youells , Mark A. Youngman
发明人： Shawn T. Branum , Raymond W. Colburn , Scott L. Dax , Christopher M. Flores , Michele C. Jetter , Yi Liu , Donald Ludovici , Mark J. Macielag , Jay M. Matthews , James J. McNally , Laura M. Reaney , Ronald K. Russell , Ning Qin , Christopher Teleha , Kenneth M. Wells , Scott C. Youells , Mark A. Youngman
IPC分类号： A61K31/381 , A61K31/541 , A61K31/4709 , A61K31/5377 , A61P29/02
CPC分类号： C07D333/66 , C07D333/36 , C07D409/12 , C07D409/14 , C07D417/12 , C07D495/04
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein A, B, G, Y, R1, R2, R3, and R4 are defined herein.
摘要翻译： 公开了用于治疗各种疾病，综合征，病症和障碍（包括疼痛）的化合物，组合物和方法。 这样的化合物由式I表示如下：其中A，B，G，Y，R 1，R 2，R 3和R 4在本文中定义。
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![Imidazo[1,2-α]pyridine sulfonamides as TRPM8 modulators](/abs-image/US/2013/12/31/US08618150B2/abs.jpg.150x150.jpg)
公开(公告)号：US08618150B2
公开(公告)日：2013-12-31
申请号：US13316031
申请日：2011-12-09
IPC分类号： A61K31/415 , C07D235/02
CPC分类号： C07D471/04 , A61K31/415 , C07D235/02
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein Y, R1, R2, and are defined herein.
摘要翻译： 公开了用于治疗各种疾病，综合征，病症和障碍（包括疼痛）的化合物，组合物和方法。 这样的化合物由式I表示如下：其中Y，R 1，R 2，并且在本文中定义。
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![IMIDAZO[1,2-a]PYRIDINE SULFONAMIDES AS TRPM8 MODULATORS](/abs-image/US/2012/06/14/US20120149699A1/abs.jpg.150x150.jpg)
公开(公告)号：US20120149699A1
公开(公告)日：2012-06-14
申请号：US13316031
申请日：2011-12-09
IPC分类号： A61K31/5377 , A61P25/02 , A61P25/00 , A61P25/04 , C07D471/04 , A61K31/437
CPC分类号： C07D471/04 , A61K31/415 , C07D235/02
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein Y, R1, R2, and are defined herein.
摘要翻译： 公开了用于治疗各种疾病，综合征，病症和障碍（包括疼痛）的化合物，组合物和方法。 这样的化合物由式I表示如下：其中Y，R 1，R 2，并且在本文中定义。
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公开(公告)号：US08153682B2
公开(公告)日：2012-04-10
申请号：US12175740
申请日：2008-07-18
申请人： Shawn T. Branum , Raymond W. Colburn , Scott L. Dax , Christopher M. Flores , Michele C. Jetter , Yi Liu , Donald Ludovici , Mark J. Macielag , Jay M. Matthews , James J. McNally , Laura M. Reaney , Ronald K. Russell , Ning Qin , Christopher Teleha , Kenneth M. Wells , Scott C. Youells , Mark A. Youngman
发明人： Shawn T. Branum , Raymond W. Colburn , Scott L. Dax , Christopher M. Flores , Michele C. Jetter , Yi Liu , Donald Ludovici , Mark J. Macielag , Jay M. Matthews , James J. McNally , Laura M. Reaney , Ronald K. Russell , Ning Qin , Christopher Teleha , Kenneth M. Wells , Scott C. Youells , Mark A. Youngman
IPC分类号： C07D419/12 , C07D417/12 , C07D413/12 , C07D409/04 , C07D409/12 , C07D333/66 , A61K31/5377 , A61K31/496 , A61K31/4535 , A61K31/433 , A61K31/4245 , A61K31/422 , A61K31/4196 , A61K31/4192 , A61K31/4178 , A61K31/4025 , A61K31/381
CPC分类号： C07D333/66 , C07D333/36 , C07D409/12 , C07D409/14 , C07D417/12 , C07D495/04
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein A, B, G, Y, R1, R2, R3, and R4 are defined herein.
摘要翻译： 公开了用于治疗各种疾病，综合征，病症和障碍（包括疼痛）的化合物，组合物和方法。 这样的化合物由式I表示如下：其中A，B，G，Y，R 1，R 2，R 3和R 4在本文中定义。
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公开(公告)号：US08148422B2
公开(公告)日：2012-04-03
申请号：US12638550
申请日：2009-12-15
申请人： Mark J. Macielag , James J. McNally
发明人： Mark J. Macielag , James J. McNally
IPC分类号： A61K31/551 , A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/535 , A61K31/54 , A61K31/4725 , A61K31/472 , A61K31/4535 , A61K31/445 , A61K31/4025 , A61K31/381 , A61K31/18 , C07D417/12 , C07D413/12 , C07D401/12 , C07D403/12 , C07D333/66 , C07D295/088 , C07D241/04 , C07D217/04 , C07D211/14 , C07D207/06 , C07D205/04 , C07C311/08 , C07C311/07
CPC分类号： C07D333/66 , C07C311/32 , C07D205/04 , C07D211/14 , C07D217/04 , C07D295/10 , C07D295/18 , C07D409/12 , C07D413/12 , C07D417/12
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) and Formula (II) as follows: wherein Y, R1, R2, R3, R4, RA, and RB are defined herein.
摘要翻译： 公开了用于治疗各种疾病，综合征，病症和障碍（包括疼痛）的化合物，组合物和方法。 这样的化合物由式（I）和式（II）表示如下：其中Y，R 1，R 2，R 3，R 4，RA和RB在本文中定义。
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公开(公告)号：US20100160289A1
公开(公告)日：2010-06-24
申请号：US12638550
申请日：2009-12-15
申请人： Mark J. Macielag , James J. McNally
发明人： Mark J. Macielag , James J. McNally
IPC分类号： A61K31/381 , C07D333/66 , A61K31/4535 , C07D409/12 , A61K31/496 , A61K31/541 , C07D417/12 , A61K31/4025 , A61K31/551 , C07D413/12 , A61K31/5377 , A61K31/397 , A61K31/4725 , C07C311/32 , A61K31/18 , A61K31/5375 , C07D295/16 , A61K31/54 , C07D211/30 , A61K31/451 , A61K31/472 , C07D217/04 , C07D205/04 , A61K31/495 , A61P29/00
CPC分类号： C07D333/66 , C07C311/32 , C07D205/04 , C07D211/14 , C07D217/04 , C07D295/10 , C07D295/18 , C07D409/12 , C07D413/12 , C07D417/12
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) and Formula (II) as follows: wherein Y, R1, R2, R3, R4, RA, and RB are defined herein.
摘要翻译： 公开了用于治疗各种疾病，综合征，病症和障碍（包括疼痛）的化合物，组合物和方法。 这样的化合物由式（I）和式（II）表示如下：其中Y，R 1，R 2，R 3，R 4，RA和RB在本文中定义。
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公开(公告)号：US20090264474A1
公开(公告)日：2009-10-22
申请号：US12175740
申请日：2008-07-18
申请人： Shawn T. Branum , Raymond W. Colburn , Scott L. Dax , Christopher M. Flores , Michele C. Jetter , Yi Liu , Donald Ludovici , Mark J. Macielag , Jay M. Matthews , James J. McNally , Laura M. Reaney , Ronald K. Russell , Ning Qin , Christopher Teleha , Kenneth M. Wells , Scott C. Youells , Mark A. Youngman
发明人： Shawn T. Branum , Raymond W. Colburn , Scott L. Dax , Christopher M. Flores , Michele C. Jetter , Yi Liu , Donald Ludovici , Mark J. Macielag , Jay M. Matthews , James J. McNally , Laura M. Reaney , Ronald K. Russell , Ning Qin , Christopher Teleha , Kenneth M. Wells , Scott C. Youells , Mark A. Youngman
IPC分类号： A61K31/4439 , C07D333/66 , A61K31/381 , C07D417/12 , C07D409/12 , A61K31/4196 , A61K31/427 , C07D401/14
CPC分类号： C07D333/66 , C07D333/36 , C07D409/12 , C07D409/14 , C07D417/12 , C07D495/04
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein A, B, G, Y, R1, R2, R3, and R4 are defined herein.
摘要翻译： 公开了用于治疗各种疾病，综合征，病症和障碍（包括疼痛）的化合物，组合物和方法。 这样的化合物由式I表示如下：其中A，B，G，Y，R 1，R 2，R 3和R 4在本文中定义。
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9.发明授权Oxopiperazine-azetidine amides and oxodiazepine-azetidine amides as monoacylglycerol lipase inhibitors 失效氧基哌嗪 - 氮杂环丁烷酰胺和氧代二氮杂吖啶啶酰胺作为单酰基甘油脂肪酶抑制剂公开(公告)号：US08637498B2
公开(公告)日：2014-01-28
申请号：US13246232
申请日：2011-09-27
IPC分类号： A61K31/496 , A61K31/506 , A61K31/551 , C07D403/04 , C07D403/14 , C07D409/14 , C07D417/14
CPC分类号： C07D403/14 , C07D403/04 , C07D409/14 , C07D417/14
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds, and enantiomers, diastereomers, and pharmaceutically acceptable salts thereof, are represented by Formula (Ia) and Formula (Ib) as follows: wherein Y, Z, and n are defined herein; and wherein Yb and Zb are as defined herein.
摘要翻译： 公开了用于治疗各种疾病，综合征，病症和障碍（包括疼痛）的化合物，组合物和方法。 这样的化合物和对映体，非对映异构体及其药学上可接受的盐由式（Ia）和式（Ib）表示如下：其中Y，Z和n如本文所定义; 并且其中Yb和Zb如本文所定义。
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10.发明申请PIPERIDIN-4-YL-AZETIDINE DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS 有权哌可啶-4-Y-AZETIDINE DIAMIDES作为单羟乙基脂肪酶抑制剂公开(公告)号：US20130102584A1
公开(公告)日：2013-04-25
申请号：US13277702
申请日：2011-10-20
申请人： Peter J. Connolly , Haiyan Bian , Xun Li , Li Liu , Mark J. Macielag , Mark E. McDonnell
发明人： Peter J. Connolly , Haiyan Bian , Xun Li , Li Liu , Mark J. Macielag , Mark E. McDonnell
IPC分类号： A61K31/454 , A61P25/00 , A61P25/06 , C07D417/14
CPC分类号： C07D417/14
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds, and enantiomers, diastereomers, and pharmaceutically acceptable salts thereof, are represented by Formula (I) as follows: wherein Y, Z, and R are defined herein.
摘要翻译： 公开了用于治疗各种疾病，综合征，病症和障碍（包括疼痛）的化合物，组合物和方法。 这样的化合物和对映体，非对映异构体及其药学上可接受的盐由式（I）表示如下：其中Y，Z和R在本文中定义。
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