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公开(公告)号：US07424321B2
公开(公告)日：2008-09-09
申请号：US11135985
申请日：2005-05-24
IPC分类号： A61B5/04 , A61B5/025 , A61B5/0225
摘要： A system to monitor heart sounds, such as to detect a worsening condition of heart failure decompensation. The system comprises a medical device that includes an implantable multi-axis heart sound sensor, operable to produce, for each of at least two nonparallel axes, an electrical signal representative of at least one heart sound, the heart sound associated with mechanical activity of a patient's heart. The device further includes a controller circuit coupled to the heart sound sensor. The controller circuit measures components of the heart sound that respectively correspond to each of the axes.
摘要翻译： 监测心脏声音的系统，例如检测心力衰竭代偿失调的恶化情况。 该系统包括医疗装置，其包括可植入的多轴心音传感器，可操作以针对至少两个不平行的轴中的每一个产生代表至少一个心脏声音的电信号，所述心脏声音与 病人的心。 该装置还包括耦合到心脏声音传感器的控制器电路。 控制器电路测量分别对应于每个轴的心音的分量。
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2.发明申请SENSING RATE OF CHANGE OF PRESSURE IN THE LEFT VENTRICLE WITH AN IMPLANTED DEVICE 有权在具有嵌入式装置的左心室中的压力变化率的感测率公开(公告)号：US20120330174A1
公开(公告)日：2012-12-27
申请号：US13605397
申请日：2012-09-06
CPC分类号： A61B5/021 , A61N1/36564 , A61N1/36578 , A61N1/375
摘要： An implantable device and method for monitoring S1 heart sounds with a remotely located accelerometer. The device includes a transducer that converts heart sounds into an electrical signal. A control circuit is coupled to the transducer. The control circuit is configured to receive the electrical signal, identify an S1 heart sound, and to convert the S1 heart sound into electrical information. The control circuit also generates morphological data from the electrical information. The morphological data relates to a hemodynamic metric, such as left ventricular contractility. A housing may enclose the control circuit. The housing defines a volume coextensive with an outer surface of the housing. The transducer is in or on the volume defined by the housing.
摘要翻译： 一种用远程位置加速度计监测S1心音的可植入装置和方法。 该装置包括将心音转换为电信号的换能器。 控制电路耦合到换能器。 控制电路被配置为接收电信号，识别S1心音，并将S1心音转换为电信息。 控制电路还从电信息生成形态数据。 形态学数据涉及血流动力学指标，如左心室收缩力。 壳体可以包围控制电路。 壳体限定与壳体的外表面共同延伸的体积。 传感器位于由外壳限定的体积中。
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3.发明申请MANAGING PRELOAD RESERVE BY TRACKING THE VENTRICULAR OPERATING POINT WITH HEART SOUNDS 有权通过用心脏声音追踪心室操作点来管理前端保留公开(公告)号：US20120203116A1
公开(公告)日：2012-08-09
申请号：US13447506
申请日：2012-04-16
IPC分类号： A61N1/365 , A61B5/0205 , A61B5/021
CPC分类号： A61N1/36585 , A61B5/021 , A61B5/0452 , A61B7/04 , A61M5/1723 , A61N1/37
摘要： A system and method for managing preload reserve and tracking the inotropic state of a patient's heart. The S1 heart sound is measured as a proxy for direct measurement of stroke volume. The S3 heart sound may be measured as a proxy for direct measurement of preload level. The S1-S3 pair yield a point on a Frank Starling type of curve, and reveal information regarding the patient's ventricular operating point and inotropic state. As an alternative, or in addition to, measurement of the S3 heart sound, the S4 heart sound may be measured or a direct pressure measurement may be made for the sake of determining the patient's preload level. The aforementioned measurements may be made by a cardiac rhythm management device, such as a pacemaker or implantable defibrillator.
摘要翻译： 一种用于管理预负荷储备并跟踪患者心脏的变力状态的系统和方法。 测量S1心音作为直接测量行程体积的代理。 可以将S3心音测量为用于直接测量预载水平的代理。 S1-S3对在Frank Starling曲线上产生一个点，并显示关于患者的心室手术点和变力状态的信息。 作为S3心音的测量或除了测量S3心音之外，也可以测量S4心音，或者为了确定患者的预压水平可以进行直接的压力测量。 上述测量可以由诸如起搏器或可植入除颤器的心律管理装置进行。
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4.发明申请SENSING RATE OF CHANGE OF PRESSURE IN THE LEFT VENTRICLE WITH AN IMPLANTED DEVICE 有权在具有嵌入式装置的左心室中的压力变化率的感测率公开(公告)号：US20100145403A1
公开(公告)日：2010-06-10
申请号：US12703533
申请日：2010-02-10
CPC分类号： A61B5/021 , A61N1/36564 , A61N1/36578 , A61N1/375
摘要： An implantable device and method for monitoring S1 heart sounds with a remotely located accelerometer. The device includes a transducer that converts heart sounds into an electrical signal. A control circuit is coupled to the transducer. The control circuit is configured to receive the electrical signal, identify an S1 heart sound, and to convert the S1 heart sound into electrical information. The control circuit also generates morphological data from the electrical information. The morphological data relates to a hemodynamic metric, such as left ventricular contractility. A housing may enclose the control circuit. The housing defines a volume coextensive with an outer surface of the housing. The transducer is in or on the volume defined by the housing.
摘要翻译： 一种用远程位置加速度计监测S1心音的可植入装置和方法。 该装置包括将心音转换为电信号的换能器。 控制电路耦合到换能器。 控制电路被配置为接收电信号，识别S1心音，并将S1心音转换为电信息。 控制电路还从电信息生成形态数据。 形态学数据涉及血流动力学指标，如左心室收缩力。 壳体可以包围控制电路。 壳体限定与壳体的外表面共同延伸的体积。 传感器位于由外壳限定的体积中。
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公开(公告)号：US08579828B2
公开(公告)日：2013-11-12
申请号：US13447506
申请日：2012-04-16
IPC分类号： A61B5/021 , A61B5/0225
CPC分类号： A61N1/36585 , A61B5/021 , A61B5/0452 , A61B7/04 , A61M5/1723 , A61N1/37
摘要： A system and method for managing preload reserve and tracking the inotropic state of a patient's heart. The S1 heart sound is measured as a proxy for direct measurement of stroke volume. The S3 heart sound may be measured as a proxy for direct measurement of preload level. The S1-S3 pair yield a point on a Frank Starling type of curve, and reveal information regarding the patient's ventricular operating point and inotropic state. As an alternative, or in addition to, measurement of the S3 heart sound, the S4 heart sound may be measured or a direct pressure measurement may be made for the sake of determining the patient's preload level. The aforementioned measurements may be made by a cardiac rhythm management device, such as a pacemaker or implantable defibrillator.
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6.发明授权Managing preload reserve by tracking the ventricular operating point with heart sounds 有权通过用心脏声音跟踪心室手术点来管理预负荷储备公开(公告)号：US08162844B2
公开(公告)日：2012-04-24
申请号：US12547207
申请日：2009-08-25
IPC分类号： A61B5/021 , A61B5/0225
CPC分类号： A61N1/36585 , A61B5/021 , A61B5/0452 , A61B7/04 , A61M5/1723 , A61N1/37
摘要： A system and method for managing preload reserve and tracking the inotropic state of a patient's heart. The S1 heart sound is measured as a proxy for direct measurement of stroke volume. The S3 heart sound may be measured as a proxy for direct measurement of preload level. The S1-S3 pair yield a point on a Frank Starling type of curve, and reveal information regarding the patient's ventricular operating point and inotropic state. As an alternative, or in addition to, measurement of the S3 heart sound, the S4 heart sound may be measured or a direct pressure measurement may be made for the sake of determining the patient's preload level. The aforementioned measurements may be made by a cardiac rhythm management device, such as a pacemaker or implantable defibrillator.
摘要翻译： 一种用于管理预负荷储备并跟踪患者心脏的变力状态的系统和方法。 测量S1心音作为直接测量行程体积的代理。 可以将S3心音测量为用于直接测量预载水平的代理。 S1-S3对在Frank Starling曲线上产生一个点，并显示关于患者的心室手术点和变力状态的信息。 作为S3心音的测量或除了测量S3心音之外，也可以测量S4心音，或者为了确定患者的预压水平可以进行直接的压力测量。 上述测量可以由诸如起搏器或可植入除颤器的心律管理装置进行。
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7.发明申请SENSING RATE OF CHANGE OF PRESSURE IN THE LEFT VENTRICLE WITH AN IMPLANTED DEVICE 有权在具有嵌入式装置的左心室中的压力变化率的感测率公开(公告)号：US20110263988A1
公开(公告)日：2011-10-27
申请号：US13178945
申请日：2011-07-08
IPC分类号： A61B5/0205 , A61N1/365 , A61M5/168 , A61B5/02
CPC分类号： A61B5/021 , A61N1/36564 , A61N1/36578 , A61N1/375
摘要： An implantable device and method for monitoring S1 heart sounds with a remotely located accelerometer. The device includes a transducer that converts heart sounds into an electrical signal. A control circuit is coupled to the transducer. The control circuit is configured to receive the electrical signal, identify an S1 heart sound, and to convert the S1 heart sound into electrical information. The control circuit also generates morphological data from the electrical information. The morphological data relates to a hemodynamic metric, such as left ventricular contractility. A housing may enclose the control circuit. The housing defines a volume coextensive with an outer surface of the housing. The transducer is in or on the volume defined by the housing.
摘要翻译： 一种用远程位置加速度计监测S1心音的可植入装置和方法。 该装置包括将心音转换为电信号的换能器。 控制电路耦合到换能器。 控制电路被配置为接收电信号，识别S1心音，并将S1心音转换为电信息。 控制电路还从电信息生成形态数据。 形态学数据涉及血流动力学指标，如左心室收缩力。 壳体可以包围控制电路。 壳体限定与壳体的外表面共同延伸的体积。 传感器位于由外壳限定的体积中。
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8.发明申请MANAGING PRELOAD RESERVE BY TRACKING THE VENTRICULAR OPERATING POINT WITH HEART SOUNDS 有权通过用心脏声音追踪心室操作点来管理前端保留公开(公告)号：US20090312659A1
公开(公告)日：2009-12-17
申请号：US12547207
申请日：2009-08-25
IPC分类号： A61B5/02
CPC分类号： A61N1/36585 , A61B5/021 , A61B5/0452 , A61B7/04 , A61M5/1723 , A61N1/37
摘要： A system and method for managing preload reserve and tracking the inotropic state of a patient's heart. The S1 heart sound is measured as a proxy for direct measurement of stroke volume. The S3 heart sound may be measured as a proxy for direct measurement of preload level. The S1-S3 pair yield a point on a Frank Starling type of curve, and reveal information regarding the patient's ventricular operating point and inotropic state. As an alternative, or in addition to, measurement of the S3 heart sound, the S4 heart sound may be measured or a direct pressure measurement may be made for the sake of determining the patient's preload level. The aforementioned measurements may be made by a cardiac rhythm management device, such as a pacemaker or implantable defibrillator.
摘要翻译： 一种用于管理预负荷储备并跟踪患者心脏的变力状态的系统和方法。 测量S1心音作为直接测量行程体积的代理。 可以将S3心音测量为用于直接测量预载水平的代理。 S1-S3对在Frank Starling曲线上产生一个点，并显示关于患者的心室手术点和变力状态的信息。 作为S3心音的测量或除了测量S3心音之外，也可以测量S4心音，或者为了确定患者的预压水平可以进行直接的压力测量。 上述测量可以由诸如起搏器或可植入除颤器的心律管理装置进行。
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9.发明授权公开(公告)号：US08277389B2
公开(公告)日：2012-10-02
申请号：US13178945
申请日：2011-07-08
IPC分类号： A61B5/02
CPC分类号： A61B5/021 , A61N1/36564 , A61N1/36578 , A61N1/375
摘要： An implantable device and method for monitoring S1 heart sounds with a remotely located accelerometer. The device includes a transducer that converts heart sounds into an electrical signal. A control circuit is coupled to the transducer. The control circuit is configured to receive the electrical signal, identify an S1 heart sound, and to convert the S1 heart sound into electrical information. The control circuit also generates morphological data from the electrical information. The morphological data relates to a hemodynamic metric, such as left ventricular contractility. A housing may enclose the control circuit. The housing defines a volume coextensive with an outer surface of the housing. The transducer is in or on the volume defined by the housing.
摘要翻译： 一种用远程位置加速度计监测S1心音的可植入装置和方法。 该装置包括将心音转换为电信号的换能器。 控制电路耦合到换能器。 控制电路被配置为接收电信号，识别S1心音，并将S1心音转换为电信息。 控制电路还从电信息生成形态数据。 形态学数据涉及血流动力学指标，如左心室收缩力。 壳体可以包围控制电路。 壳体限定与壳体的外表面共同延伸的体积。 传感器位于由外壳限定的体积中。
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10.发明授权公开(公告)号：US07670298B2
公开(公告)日：2010-03-02
申请号：US11142851
申请日：2005-06-01
CPC分类号： A61B5/021 , A61N1/36564 , A61N1/36578 , A61N1/375
摘要： An implantable device and method for monitoring S1 heart sounds with a remotely located accelerometer. The device includes a transducer that converts heart sounds into an electrical signal. A control circuit is coupled to the transducer. The control circuit is configured to receive the electrical signal, identify an S1 heart sound, and to convert the S1 heart sound into electrical information. The control circuit also generates morphological data from the electrical information. The morphological data relates to a hemodynamic metric, such as left ventricular contractility. A housing may enclose the control circuit. The housing defines a volume coextensive with an outer surface of the housing. The transducer is in or on the volume defined by the housing.
摘要翻译： 一种用远程位置加速度计监测S1心音的可植入装置和方法。 该装置包括将心音转换为电信号的换能器。 控制电路耦合到换能器。 控制电路被配置为接收电信号，识别S1心音，并将S1心音转换为电信息。 控制电路还从电信息生成形态数据。 形态学数据涉及血流动力学指标，如左心室收缩力。 壳体可以包围控制电路。 壳体限定与壳体的外表面共同延伸的体积。 传感器位于由外壳限定的体积中。
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