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公开(公告)号：US20060121437A1
公开(公告)日：2006-06-08
申请号：US11003808
申请日：2004-12-03
申请人： Ramon Poo , Camillo Ricordi
发明人： Ramon Poo , Camillo Ricordi
CPC分类号： A01N1/02 , A01N1/0263
摘要： An organ preservation container includes a gas impermeable housing for containing an organ. At least two liquids having different densities and forming a liquid-liquid interface are also contained in the housing. A closure for hermetically sealing the housing is provided. A structure is provided within the housing for engaging the organ and for maintaining a portion of the organ at the liquid-liquid interface such that the organ will be maintained partially in both of the liquids. A method for preserving the organ is also described.
摘要翻译： 器官保存容器包括用于容纳器官的不透气壳体。 至少两种具有不同密度并形成液 - 液界面的液体也包含在壳体中。 提供用于密封壳体的封闭件。 在壳体内设置有用于接合器官并用于将器官的一部分保持在液 - 液界面处的结构，使得器官部分地保持在两液体中。 还描述了保存器官的方法。
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公开(公告)号：US20060213802A1
公开(公告)日：2006-09-28
申请号：US11283951
申请日：2005-11-21
申请人： Ramon Poo , Camillo Ricordi
发明人： Ramon Poo , Camillo Ricordi
IPC分类号： B65D81/20
CPC分类号： B65D81/20 , Y10S435/809
摘要： A container for shipping items in an aircraft includes a shipping compartment and an expandable chamber for receiving gas from the shipping compartment. At least one conduit connects the expandable chamber to the shipping department so as to permit the flow of gas therebetween. A method for shipping items in an aircraft is also disclosed.
摘要翻译： 用于在飞行器中运输物品的容器包括运输舱和用于从运输隔间接收气体的可扩张室。 至少一个管道将可膨胀室连接到运输部门，以便允许其间的气体流动。 还公开了一种用于在飞行器中运送物品的方法。
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公开(公告)号：US20050239190A1
公开(公告)日：2005-10-27
申请号：US10829752
申请日：2004-04-22
申请人： Ramon Poo , Camillo Ricordi
发明人： Ramon Poo , Camillo Ricordi
CPC分类号： B65D81/20 , Y10S435/809
摘要： A container for shipping items in an aircraft includes a shipping compartment and an expandable chamber for receiving gas from the shipping compartment. At least one conduit connects the expandable chamber to the shipping department so as to permit the flow of gas therebetween. A method for shipping items in an aircraft is also disclosed.
摘要翻译： 用于在飞行器中运输物品的容器包括运输舱和用于从运输隔间接收气体的可扩张室。 至少一个管道将可膨胀室连接到运输部门，以便允许其间的气体流动。 还公开了一种用于在飞行器中运送物品的方法。
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公开(公告)号：US20050142532A1
公开(公告)日：2005-06-30
申请号：US11057994
申请日：2005-02-15
申请人： Ramon Poo , Camillo Ricordi
发明人： Ramon Poo , Camillo Ricordi
CPC分类号： A01N1/0263 , A01N1/02
摘要： A method for storing organs, cells, and tissues, includes the steps of providing a gas impermeable container; providing a preservation solution containing dissolved oxygen; placing the preservation solution into the container with the organ, cell or tissue; and hermetically closing said container. A system for storing organs, cells, and tissue includes a gas impermeable organ container for the organs, cells and tissue. A hermetically sealable solution container is provided for storing a preservation solution. The preservation solution contains dissolved oxygen. A dispensing structure is provided for placing the solution into the organ container. The preservation solution can include an oxygen-carrier solution and UW solution. The oxygen-carrier solution can be perfluorocarbon.
摘要翻译： 用于储存器官，细胞和组织的方法包括提供不透气容器的步骤; 提供含有溶解氧的保存溶液; 将保存液置于器皿，细胞或组织的容器中; 并密封所述容器。 用于储存器官，细胞和组织的系统包括用于器官，细胞和组织的不透气器官容器。 提供一种用于储存保存溶液的气密密封的溶液容器。 保存液含有溶解氧。 提供了用于将溶液置于器官容器中的分配结构。 保存溶液可以包括氧载体溶液和UW溶液。 氧载体溶液可以是全氟化碳。
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5.发明授权公开(公告)号：US11466255B2
公开(公告)日：2022-10-11
申请号：US15573870
申请日：2016-05-02
摘要： Compositions and methods are provided for generating islet-like cell clusters. The methods include culturing a whole non-islet pancreatic cell discard or cells sorted therefrom with an effective amount of a molecule having Bone Morphogenetic Protein (BMP) activity (e.g., a BMP polypeptide). The effective amount of said molecule having BMP activity (e.g., BMP polypeptide) is sufficient to induce the formation of islet-like cell clusters. The methods further include treating or attenuating insulin-deficiency disorders, including type 1 diabetes. In one non-limiting embodiment, an insulin-deficiency disorder in a subject is treated or attenuated by culturing a whole non-islet pancreatic cell discard or cells sorted therefrom with an effective amount of a molecule having BMP activity (e.g., a BMP polypeptide) such that tho formation of islet-like cell clusters occurs. A therapeutically effective amount of the islet-like cell clusters which produce insulin are then transplanted into a subject in need to treat the insulin-deficiency disorder.
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公开(公告)号：US07790437B2
公开(公告)日：2010-09-07
申请号：US11610913
申请日：2006-12-14
申请人： Ramon E. Poo , Camillo Ricordi
发明人： Ramon E. Poo , Camillo Ricordi
CPC分类号： A01N1/02 , A01N1/0273
摘要： An organ transportation device includes a fluid-tight organ container and structure within the organ container for engaging an organ within the organ container. A base assembly is provided, and structure for rotating the organ engaging structure and the organ relative to the base assembly. The base assembly can have a motor and a battery to provide for rotation of the organ container during shipping.
摘要翻译： 器官输送装置包括在器官容器内的流体密封的器官容器和结构，用于与器官容器内的器官接合。 提供基座组件，以及用于相对于基座组件旋转器官接合结构和器官的结构。 基座组件可以具有马达和电池以在运输期间提供器官容器的旋转。
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公开(公告)号：US20080166992A1
公开(公告)日：2008-07-10
申请号：US11938057
申请日：2007-11-09
CPC分类号： H04M11/04 , A61B5/0002 , A61B5/021 , A61B5/024 , A61B5/14532 , A61B5/1455 , G08B21/0269 , G08B21/0283 , G08B21/0453 , G08B25/002 , G08B25/005 , G08B25/006 , G08B25/08 , H04M1/72538
摘要： A health-related emergency mobile alert system to facilitate communication, care and intervention during critical events. The system communicates with medical monitors, which measure and collect a subject's physiological data and vital signs information. A service provider maintains a database with the subject's medical records and an emergency contact list. When a critical event is detected, a two-way mobile communication device that is configured to communicate with the medical monitor transmits the physiological data and location coordinates of the subject to the service provider, and a conference call with members of the emergency contact list is initiated to help facilitate aid to the subject. The two-way mobile communication device may include a speaker and GPS technology. It may also include self-activating features wherein pre-recorded messages conveying potential dangers are transmitted to the subject when the subject's physiological data and vital signs reflect precarious levels.
摘要翻译： 健康相关的紧急移动警报系统，以促进关键事件期间的沟通，关怀和干预。 系统与医疗监护仪进行通信，医疗监护仪可测量和收集受试者的生理数据和生命体征信息。 服务提供商维护与受试者的医疗记录和紧急联系人列表的数据库。 当检测到关键事件时，被配置为与医疗监视器通信的双向移动通信设备将该对象的生理数据和位置坐标发送给服务提供商，并且与紧急联系人列表的成员的电话会议是 开始帮助促进对该问题的援助。 双向移动通信设备可以包括扬声器和GPS技术。 它还可以包括自我激活特征，其中当被摄体的生理数据和生命体征反映不稳定的水平时，传达潜在危险的预先记录的信息被传送给受检者。
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公开(公告)号：US20080145833A1
公开(公告)日：2008-06-19
申请号：US11610913
申请日：2006-12-14
申请人： RAMON E. POO , Camillo Ricordi
发明人： RAMON E. POO , Camillo Ricordi
CPC分类号： A01N1/02 , A01N1/0273
摘要： An organ transportation device includes a fluid-tight organ container and structure within the organ container for engaging an organ within the organ container. A base assembly is provided, and structure for rotating the organ engaging structure and the organ relative to the base assembly. The base assembly can have a motor and a battery to provide for rotation of the organ container during shipping.
摘要翻译： 器官输送装置包括在器官容器内的流体密封的器官容器和结构，用于与器官容器内的器官接合。 提供基座组件，以及用于相对于基座组件旋转器官接合结构和器官的结构。 基座组件可以具有马达和电池以在运输期间提供器官容器的旋转。
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公开(公告)号：US20060024276A1
公开(公告)日：2006-02-02
申请号：US11185011
申请日：2005-07-20
申请人： Camillo Ricordi
发明人： Camillo Ricordi
IPC分类号： A61K9/22
CPC分类号： A61M5/14244 , A61M5/14276 , A61M2202/097
摘要： A device for receiving implanted biological material includes a porous outer wall defining an inner space, a fluid manifold assembly for selectively infusing at least one of immunosuppressive and growth factor media to said space, and a pump structure operatively coupled to the manifold assembly. The device may comprise an additional plunger body for being disposed in said space and so as to define a peripheral gap between the plunger and the perforated wall of the device.
摘要翻译： 用于接收植入的生物材料的装置包括限定内部空间的多孔外壁，用于选择性地将免疫抑制和生长因子介质中的至少一种介入所述空间的流体歧管组件，以及可操作地联接到歧管组件的泵结构。 该装置可以包括附加的柱塞体，用于设置在所述空间中并且限定柱塞与装置的穿孔壁之间的周边间隙。
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公开(公告)号：US20130040324A1
公开(公告)日：2013-02-14
申请号：US13595697
申请日：2012-08-27
IPC分类号： C12M1/36 , C12Q1/54 , G01N33/566 , C12Q1/02
摘要： A perifusion device includes at least one sample container for cells, the sample container having an inlet and an outlet. The container receives test liquid through the inlet and discharges the liquid through the outlet. A manifold having a plurality of liquid inlets, control valves, and liquid outlets can be provided. A receptacle housing has a plurality of receptacles. A drive is connected to the receptacle housing for moving the receptacle housing. A programmable controller can be provided to control movement of the receptacle housing. The test liquid includes at least one stimuli for the cells. The liquid collected in the receptacles is analyzed to determine the response of the cells to the stimuli.
摘要翻译： 渗出装置包括用于细胞的至少一个样品容器，样品容器具有入口和出口。 容器通过入口接收测试液体，并通过出口排出液体。 可以提供具有多个液体入口，控制阀和液体出口的歧管。 插座壳体具有多个插座。 驱动器连接到插座壳体以移动插座壳体。 可以提供可编程控制器来控制插座壳体的运动。 测试液体包括用于细胞的至少一种刺激物。 分析收集在容器中的液体以确定细胞对刺激的反应。
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