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公开(公告)号：US06992194B2
公开(公告)日：2006-01-31
申请号：US10901845
申请日：2004-07-28
IPC分类号： C07D207/335
CPC分类号： C07D207/34 , A61K9/282 , A61K9/5021 , C07D405/06
摘要： The present invention provides novel forms of atorvastatin designated Forms VI, VIII, IX, X, XI and XII and novel processes for their preparation as well as processes for preparing atorvastatin Forms I, II, IV, V and amorphous atorvastatin.
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2.发明授权CRYSTAL FORMS III, IV, V, AND NOVEL AMORPHOUS FORM OF CLOPIDOGREL HYDROGENSULFATE, PROCESSES FOR THEIR PREPARATION, PROCESSES FOR THE PREPARATION OF FORM I, COMPOSITIONS CONTAINING THE NEW FORMS AND METHODS OF ADMINISTERING THE NEW FORMS 失效晶状体III，IV，V和新型非晶形态非晶形态，其制备方法，制备形式I的方法，包含新形式的组合物和管理新形式的方法公开(公告)号：US06767913B2
公开(公告)日：2004-07-27
申请号：US10074409
申请日：2002-02-12
申请人： Revital Lifshitz , Eti Kovalevski-Ishai , Shlomit Wizel , Sharon Avhar Maydan , Rami Lidor-Hadas
发明人： Revital Lifshitz , Eti Kovalevski-Ishai , Shlomit Wizel , Sharon Avhar Maydan , Rami Lidor-Hadas
IPC分类号： A61K3144
CPC分类号： C07D495/04
摘要： The present invention provides new crystalline Forms III, IV and V of clopidogrel hydrogensulfate and the amorphous form of clopidogrel hydrogensulfate, as well as their pharmaceutical compositions, and method of treatments with such compositions. The present invention also provides novel processes for preparation of clopidogrel hydrogensulfate Form I, Form III, Form IV, Form V and the amorphous form. The present invention further provides a novel process where the amorphous form is converted to Form I by contacting Form I with an ether.
摘要翻译： 本发明提供氯吡格雷硫酸氢盐和无定形形式的氯吡格雷硫酸氢盐的新结晶形式III，IV和V，以及它们的药物组合物，以及用这种组合物处理的方法。 本发明还提供了制备氯吡格雷硫酸氢盐形式I，形式III，形式IV，形式V和无定形形式的新方法。 本发明还提供了一种新的方法，其中通过使形式I与醚接触将无定形形式转化成晶型I.
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公开(公告)号：US20100016579A1
公开(公告)日：2010-01-21
申请号：US12455947
申请日：2009-06-08
申请人： Revital Lifshitz-Liron , Eti Kovalevski-Ishai , Ben-Zion Dolitzky , Shlomit Wizel , Rami Lidor-Hadas
发明人： Revital Lifshitz-Liron , Eti Kovalevski-Ishai , Ben-Zion Dolitzky , Shlomit Wizel , Rami Lidor-Hadas
IPC分类号： C07D417/04
CPC分类号： C07D281/16
摘要： The present invention relates to novel crystalline forms of quetiapine hemifumarate, denominated quetiapine hemifumarate form II and quetiapine hemifumarate form III. These novel crystalline forms of quetiapine hemifumarate have been characterized by methods including x-ray powder diffraction (XRD), Fourier transform IR spectroscopy (FTIR), differential scanning calorimetry (DSC), and thermal gravimetric analysis (TGA). Methods for preparation of the novel crystalline quetiapine hemifumarate form II as its chloroform solvate and its dichloromethane solvate, form III as its chloroform solvate, and form I are provided.
摘要翻译： 本发明涉及喹硫平半富马酸盐的新型结晶形式，称为喹喔啉半富马酸盐形式II和喹硫平半富马酸盐形式III。 已经通过X射线粉末衍射（XRD），傅立叶变换红外光谱（FTIR），差示扫描量热法（DSC）和热重分析（TGA）等方法对这些新型的喹硫平半富马酸盐结晶形态进行了表征。 提供了形成II型作为其氯仿溶剂合物的新型结晶喹硫平半富马酸盐及其二氯甲烷溶剂合物，形式III为其氯仿溶剂合物和形式I的方法。
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公开(公告)号：US07074928B2
公开(公告)日：2006-07-11
申请号：US10339008
申请日：2003-01-08
申请人： Revital Lifshitz-Liron , Eti Kovalevski-Ishai , Shlomit Wizel , Sharon Avhar-Maydan , Rami Lidor-Hadas
发明人： Revital Lifshitz-Liron , Eti Kovalevski-Ishai , Shlomit Wizel , Sharon Avhar-Maydan , Rami Lidor-Hadas
IPC分类号： C07D47/02
CPC分类号： C07D495/04
摘要： Provided are new crystalline Forms III, IV, V and VI of clopidogrel hydrogensulfate and the amorphous form of clopidogrel hydrogensulfate, as well as their pharmaceutical compositions, and method of treatments with such compositions. Also provided are novel processes for preparation of clopidogrel hydrogensulfate Form I, Form II, Form III, Form IV, Form V, Form VI and amorphous form.
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5.发明申请Novel Process For Making Bisphosphonic Acids Using Diluents Other Than Halogenated Hydrocarbons 审中-公开使用除卤代烃之外的稀释剂制备双膦酸的新方法公开(公告)号：US20090209763A1
公开(公告)日：2009-08-20
申请号：US12368805
申请日：2009-02-10
IPC分类号： C07F9/58 , C07F9/6506 , C07F9/38
CPC分类号： C07F9/3873 , C07F9/58 , C07F9/6506 , C07F9/6561
摘要： Provided is a novel method of making bisphosphonic acids, e.g. risedronic acid, including the step of combining a carboxylic acid, phosphorous acid, and a halophosphorous compound in the presence of a diluent that is an aromatic hydrocarbon or a silicone fluid. When the diluent is an aromatic hydrocarbon, an inert support or ortho-phosphoric acid codiluent is advantageously included.
摘要翻译： 提供制备双膦酸的新方法，例如 利塞膦酸，包括在作为芳族烃或硅氧烷流体的稀释剂存在下将羧酸，亚磷酸和卤代磷化合物组合的步骤。 当稀释剂是芳族烃时，有利地包括惰性载体或正磷酸共混物。
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6.发明申请Novel process for making bisphosphonic acids using diluents other than halogenated hydrocarbons 审中-公开使用除卤代烃以外的稀释剂制备二膦酸的新方法公开(公告)号：US20060128960A1
公开(公告)日：2006-06-15
申请号：US11350462
申请日：2006-02-08
IPC分类号： C07F9/28
CPC分类号： C07F9/3873 , C07F9/58 , C07F9/6506 , C07F9/6561
摘要： Provided is a novel method of making bisphosphonic acids, e.g. risedronic acid, including the step of combining a carboxylic acid, phoshorous acid, and a halophosphorous compound in the presence of a diluent that is an aromatic hydrocarbon or a silicone fluid. When the diluent is an aromatic hydrocarbon, a inert support or ortho-phosphoric acid codiluent is advantageously included.
摘要翻译： 提供制备双膦酸的新方法，例如 利塞膦酸，包括在作为芳族烃或硅氧烷流体的稀释剂的存在下组合羧酸，磷酸和卤代磷化合物的步骤。 当稀释剂是芳族烃时，有利地包括惰性载体或正磷酸共混物。
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公开(公告)号：US08999960B2
公开(公告)日：2015-04-07
申请号：US13122766
申请日：2009-10-01
申请人： Eyal Breitbart , Eti Kovalevski-Ishai , Erez Feige , Itzhak Mendel , Zeev Ziniuk , Gideon Halperin
发明人： Eyal Breitbart , Eti Kovalevski-Ishai , Erez Feige , Itzhak Mendel , Zeev Ziniuk , Gideon Halperin
IPC分类号： C07F9/10 , C07F9/165 , A61K31/661 , A61P37/06
CPC分类号： C07F9/10
摘要： Novel oxidized thiophospholipids are provided herein, as well as methods for producing same, and uses thereof in treating or preventing an inflammation associated with endogenous oxidized lipids and related conditions. Exemplary oxidized thiophospholipid according to embodiments described herein have the formula: wherein X1, X2, A1, A2, B′, B″, D′ and D″ are as described herein.
摘要翻译： 本文提供了新的氧化型硫代磷脂，以及其生产方法及其用于治疗或预防与内源性氧化脂质和相关病症相关的炎症的用途。 根据本文所述实施方案的示例性氧化硫磷脂具有下式：其中X1，X2，A1，A2，B'，B“，D'和D”如本文所述。
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公开(公告)号：US20110195937A1
公开(公告)日：2011-08-11
申请号：US13122766
申请日：2009-10-01
申请人： Eyal Breitbar , Eti Kovalevski-Ishai , Erez Feige , Itzhak Mendel , Zeev Ziniuk , Gideon Halperin
发明人： Eyal Breitbar , Eti Kovalevski-Ishai , Erez Feige , Itzhak Mendel , Zeev Ziniuk , Gideon Halperin
IPC分类号： A61K31/661 , C07F9/165 , A61P37/06
CPC分类号： C07F9/10
摘要： Novel oxidized thiophospholipids are provided herein, as well as methods for producing same, and uses thereof in treating or preventing an inflammation associated with endogenous oxidized lipids and related conditions. Exemplary oxidized thiophospholipid according to embodiments described herein have the formula: wherein X1, X2, A1, A2, B′, B″, D′ and D″ are as described herein.
摘要翻译： 本文提供了新的氧化型硫代磷脂，以及其生产方法及其用于治疗或预防与内源性氧化脂质和相关病症相关的炎症的用途。 根据本文所述实施方案的示例性氧化硫磷脂具有下式：其中X1，X2，A1，A2，B'，B“，D'和D”如本文所述。
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9.发明授权Oxidized lipids and uses thereof in the treatment of inflammatory diseases and disorders 有权氧化脂质及其在治疗炎性疾病和病症中的用途公开(公告)号：US07973023B2
公开(公告)日：2011-07-05
申请号：US12588371
申请日：2009-10-14
申请人： Dror Harats , Jacob George , Gideon Halperin , Itzhak Mendel , Niva Yacov , Eti Kovalevski-Ishai
发明人： Dror Harats , Jacob George , Gideon Halperin , Itzhak Mendel , Niva Yacov , Eti Kovalevski-Ishai
IPC分类号： A61K31/66
CPC分类号： C07F9/106 , A61K31/075 , A61K31/08 , A61K31/11 , A61K31/19 , A61K31/20 , A61K31/215 , A61K31/225 , A61K31/24 , A61K31/685 , C07C43/13 , C07C43/1785 , C07C43/1787 , C07F9/10 , Y02A50/411 , Y02A50/414
摘要： Novel synthetic oxidized lipids and methods utilizing oxidized lipids for treating and preventing an inflammation associated with an endogenous oxidized lipid are provided.
摘要翻译： 提供新型合成氧化脂质和利用氧化脂质治疗和预防与内源性氧化脂质相关的炎症的方法。
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10.发明申请METHODS EMPLOYING AND COMPOSITIONS CONTAINING DEFINED OXIDIZED PHOSPHOLIPIDS FOR PREVENTION AND TREATMENT OF ATHEROSCLEROSIS 有权含有定义氧化磷脂的方法和组合物用于预防和治疗甲状腺功能亢进公开(公告)号：US20110097350A1
公开(公告)日：2011-04-28
申请号：US12985365
申请日：2011-01-06
申请人： Dror HARATS , Jacob George , Gideon Halperin , Niva Yacov , Eti Kovalevski-Ishai
发明人： Dror HARATS , Jacob George , Gideon Halperin , Niva Yacov , Eti Kovalevski-Ishai
CPC分类号： C07F9/106 , A61K31/075 , A61K31/08 , A61K31/11 , A61K31/19 , A61K31/20 , A61K31/215 , A61K31/225 , A61K31/24 , A61K31/685 , C07C43/13 , C07C43/1785 , C07C43/1787 , C07F9/10 , Y02A50/411 , Y02A50/414
摘要： Novel synthetic forms of etherified oxidized phospholipids and methods of utilizing same for preventing and treating atherosclerosis and other related disorders, as well as inflammatory disorders, immune mediated diseases, autoimmune diseases and proliferative disorders, are provided. In addition, methods of synthesizing etherified and esterified oxidized phospholipids and of using same for preventing and treating atherosclerosis and other related disorders are also provided.
摘要翻译： 提供了醚化氧化磷脂的新型合成形式及其用于预防和治疗动脉粥样硬化和其它相关病症的方法，以及炎性疾病，免疫介导的疾病，自身免疫性疾病和增殖性疾病。 此外，还提供了合成醚化和酯化的氧化磷脂的方法以及用于预防和治疗动脉粥样硬化等相关疾病的方法。
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