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    Optically active compound and method for producing same
    6.
    发明授权
    Optically active compound and method for producing same 失效
    光学活性化合物及其制备方法

    公开(公告)号：US06326520B1

    公开(公告)日：2001-12-04

    申请号：US09377688

    申请日：1999-08-20

    申请人： Akihiro Ishii ,  Koichi Mikami

    发明人： Akihiro Ishii ,  Koichi Mikami

    IPC分类号： C07C49213

    CPC分类号： C07F7/1892 ,  B01J31/223 ,  B01J2231/341 ,  B01J2531/0266 ,  B01J2531/46 ,  C07C43/1787 ,  C07C45/30 ,  C07C49/82

    摘要： The invention relates to a method for producing a novel optically active compound represented by the general formula [IV]. This method includes the step of reacting a vinyl ether with a halogenated acetaldehyde in the presence of an optically active binaphthol-titanium complex. With this, the novel optically active compound can be produced very easily. Furthermore, the novel optically active compound can easily be oxidized to a novel optically active &agr;,&bgr;-dihydrexyketone represented by the general formula [V]. These novel optically active compounds can each be used as useful intermediates. where R is a lower alkyl group or —Si(R3)3, where R3 is a lower alkyl group and three of R3 may be the same or different groups, R1 is a lower alkyl group or a substituted or unsubstituted phenyl group, R2 is hydrogen atom or a lower alkyl group or a substituted or unsubstituted phenyl group, or R1 and R2 are combined to form an alkylene group, and X is hydrogen, fluorine, chlorine or bromine with a proviso that three of said X may be the same or different atoms, but are not hydrogen at the same time.

    摘要翻译： 本发明涉及一种由通式[Ⅳ]表示的新的光学活性化合物的制备方法。 该方法包括在光学活性联萘酚钛络合物存在下使乙烯基醚与卤代乙醛反应的步骤。 由此，可以非常容易地制造新颖的光学活性化合物。 此外，新的光学活性化合物可以容易地被氧化成由通式[V]表示的新的光学活性α，β-二羟基酮。 这些新的光学活性化合物各自可用作有用的中间体。其中R是低级烷基或-Si（R3）3，其中R3是低级烷基，R3中的三个可以是相同或不同的基团，R1是 低级烷基或取代或未取代的苯基，R 2为氢原子或低级烷基或取代或未取代的苯基，或R 1和R 2结合形成亚烷基，X为氢，氟，氯或溴 条件是所述X中的三个可以是相同或不同的原子，但不是同时是氢。

    Methods for cross-metathesis of terminal olefins
    7.
    发明授权
    Methods for cross-metathesis of terminal olefins 有权
    端烯烃的交错复分解方法

    公开(公告)号：US06306988B1

    公开(公告)日：2001-10-23

    申请号：US09491800

    申请日：2000-01-26

    申请人： Robert H. Grubbs ,  Daniel J. O'Leary ,  Helen E. Blackwell

    发明人： Robert H. Grubbs ,  Daniel J. O'Leary ,  Helen E. Blackwell

    IPC分类号： C08F426

    CPC分类号： C07C269/06 ,  C07C41/30 ,  C07C67/475 ,  C07C69/78 ,  C07C69/007 ,  C07C69/16 ,  C07C43/166 ,  C07C43/1787

    摘要： A method for the cross-metathesis of terminal olefins is disclosed. The method describes making disubstituted internal olefin products by contacting a first terminal olefin with another first terminal olefin to form a dimer and then contacting the dimer with a second terminal olefin in the presence of a catalyst having the formula where M may be Os or Ru, R and R1 may be the same or different and may be hydrogen or a substitutent group selected from C1-C20 alkyl, C2-C20 alkenyl,C2-C20 alkynyl, aryl, C1-C20 carboxylate, C1-C20 alkoxy, C2-C20 alkenyloxy, C2-C20 alkynyloxy, aryloxy, C2-C20 alkoxycarbonyl, C1-C20 alkylthio, C1-C20 alkylsulfonyl, and C1-C20 alkylsulfinyl. X and X1 may be the same or different and may be any anionic ligand. L and L1 may be the same or different and may be any neutral electron donor.

    摘要翻译： 公开了一种用于末端烯烃交叉复分解的方法。 该方法描述了通过使第一末端烯烃与另一个第一末端烯烃接触以形成二聚体制备二取代的内烯烃产物，然后在具有式I的催化剂存在下使二聚体与第二末端烯烃接触，M可以是Os或Ru，R 并且R 1可以相同或不同，并且可以是氢或选自C 1 -C 20烷基，C 2 -C 20烯基，C 2 -C 20炔基，芳基，C 1 -C 20羧酸酯，C 1 -C 20烷氧基，C 2 -C 20链烯氧基， C 2 -C 20炔氧基，芳氧基，C 2 -C 20烷氧基羰基，C 1 -C 20烷硫基，C 1 -C 20烷基磺酰基和C 1 -C 20烷基亚磺酰基。 X和X 1可以相同或不同，并且可以是任何阴离子配体。 L和L1可以相同或不同，并且可以是任何中性电子给体。

    Control of molecular weight and end-group functionality of polymers
    8.
    发明授权
    Control of molecular weight and end-group functionality of polymers 失效
    控制聚合物的分子量和端基官能度

    公开(公告)号：US5385996A

    公开(公告)日：1995-01-31

    申请号：US72687

    申请日：1993-06-07

    申请人： Ezio Rizzardo ,  Gordon F. Meijs ,  San H. Thang

    发明人： Ezio Rizzardo ,  Gordon F. Meijs ,  San H. Thang

    IPC分类号： C07C43/176 ,  C07C43/178 ,  C07C43/215 ,  C07C323/25 ,  C07F7/18 ,  C07F9/40 ,  C08F2/38 ,  C08F246/00

    CPC分类号： C07C323/60 ,  C07C255/00 ,  C07C321/00 ,  C07C323/00 ,  C07C323/25 ,  C07C43/176 ,  C07C43/1787 ,  C07C43/215 ,  C07F7/1852 ,  C07F9/4015 ,  C08F246/00

    摘要： A process for the production of polymers by free radical polymerization, characterized in that there is added to the polymerization system one or more compounds of the general formula (A). ##STR1## where R.sup.1 is hydrogen or a group capable activating the vinylic carbon towards free radical addition;Y is OR.sup.2 or CH.sub.2 X(R.sup.2).sub.nwhere R.sup.2 is an optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, or optionally substituted saturated, unsaturated or aromatic, aromatic carbocyclic or heterocyclic ring;X is an element other than carbon selected from Groups IV, V, VI or VII of the Periodic Table or a group consisting of an element selected from Groups IV, V, or VI to which is attached one or more oxygen atoms; andn is a number from 0 to 3, such that the valency of the group X is satisfied and, when n is greater than 1, the groups represented by R.sup.2 may be identical or different.

    摘要翻译： 通过自由基聚合制备聚合物的方法，其特征在于向聚合体系中加入一种或多种通式（A）的化合物。 （A）其中R1是氢或能够将乙烯基碳活化成自由基添加的基团; Y是OR2或CH2X（R2）n，其中R2是任选取代的烷基，任选取代的烯基，任选取代的炔基或任选取代的饱和，不饱和或芳族芳族碳环或杂环; X是除了选自元素周期表第Ⅳ，Ⅴ，Ⅵ或Ⅶ族的碳以外的元素，或由选自附有一个或多个氧原子的第Ⅳ，Ⅴ或Ⅵ族元素组成的组元素; 并且n为0至3的数，使得满足基团X的化合价，并且当n大于1时，由R 2表示的基团可以相同或不同。

    A-Norsteroids
    9.
    发明授权
    A-Norsteroids 失效
    A类Norsteroids

    公开(公告)号：US4129599A

    公开(公告)日：1978-12-12

    申请号：US809237

    申请日：1977-06-23

    申请人： Sina Escher ,  Grant E. Dubois

    发明人： Sina Escher ,  Grant E. Dubois

    IPC分类号： C07C29/147 ,  C07C43/178 ,  C07C45/29 ,  C07C45/41 ,  C07C45/66 ,  C07C47/20 ,  C07C47/24 ,  C07C49/255 ,  C07C49/61

    CPC分类号： C07C29/147 ,  C07C43/1787 ,  C07C45/29 ,  C07C45/292 ,  C07C45/41 ,  C07C45/66 ,  C07C47/20 ,  C07C47/24 ,  C07C49/255 ,  C12C11/02 ,  C07C2101/10

    摘要： Method is provided for cyclization of polyunsaturated substituted acylic or monocarbocyclic initiator group containing compound having an endocyclic double bond with a chalcogen atom in the allylic position of the initiator group and having at least two sites of unconjugated aliphatic unsaturation in the side chain substituent on the ring. The polyunsaturated compound is cyclized in the presence of a strong acid in a protic solvent which is inert to the acid, preferably a hydroxylic solvent. Mild temperatures and varying times are employed. The products are useful primarily as intermediates for naturally occurring and synthetic steroids. By appropriate substitution of the side chain, the steroidial products are provided with the substituent at C-11, which upon cyclization results in the alpha-configuration. By resolution of the intermediates prior to cyclization, optically active steroids can be obtained.

    摘要翻译： 提供了用于在引发剂基团的烯丙基位置环化多不饱和取代的含酰基或单环引发剂基的含有内环双键的化合物与硫属化合物原子并且在环上的侧链取代基中具有至少两个未偶联的脂族不饱和位点 。 多不饱和化合物在强酸存在下，在对酸，优选羟基溶剂惰性的质子溶剂中环化。 采用温和的温度和变化的时间。 该产品主要用作天然存在和合成类固醇的中间体。 通过侧链的适当取代，在C-11处提供了具有取代基的类固醇产物，其在环化时产生α构型。 通过在环化前分解中间体，可以获得光学活性类固醇。