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公开(公告)号：US5721108A
公开(公告)日：1998-02-24
申请号：US471984
申请日：1995-06-06
IPC分类号： G01N33/53 , A61K38/00 , A61K39/395 , A61K47/48 , C07K1/22 , C07K14/00 , C07K14/705 , C07K16/00 , C07K16/28 , C07K16/46 , C07K19/00 , C12N1/19 , C12N15/09 , C12P21/08 , C12R1/91 , C07K16/30 , G01N33/574
CPC分类号： C07K16/2887 , A61K47/48561 , A61K47/48669 , C07K16/2896 , C07K16/462 , A61K2039/505 , A61K38/00 , C07K2317/24 , C07K2317/732 , C07K2317/734 , C07K2319/00 , C07K2319/02 , C07K2319/30 , C07K2319/40
摘要： The present invention relates to a chimeric antibody molecule comprising two heavy chains and two light chains, each of the chains comprising a variable region and a human constant region, said antibody having specificity for the antigen bound by the 2H7 murine monoclonal antibody. The invention is also related to methods of use for such antibody.
摘要翻译： 本发明涉及包含两条重链和两条轻链的嵌合抗体分子，每条链包含可变区和人恒定区，所述抗体对由2H7鼠单克隆抗体结合的抗原具有特异性。 本发明也涉及这种抗体的使用方法。
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公开(公告)号：US5677180A
公开(公告)日：1997-10-14
申请号：US469916
申请日：1995-06-06
IPC分类号： G01N33/53 , A61K38/00 , A61K39/395 , A61K47/48 , C07K1/22 , C07K14/00 , C07K14/705 , C07K16/00 , C07K16/28 , C07K16/46 , C07K19/00 , C12N1/19 , C12N15/09 , C12P21/08 , C12R1/91 , C12N5/20 , C12N15/13
CPC分类号： C07K16/2887 , A61K47/48561 , A61K47/48669 , C07K16/2896 , C07K16/462 , A61K2039/505 , A61K38/00 , C07K2317/24 , C07K2317/732 , C07K2317/734 , C07K2319/00 , C07K2319/02 , C07K2319/30 , C07K2319/40
摘要： The present invention relates to a eukaryotic host cell that contains DNA encoding a chimeric antibody molecule comprising two heavy chains and two light chains, each of the chains comprising a variable region and a human constant region, said antibody having specificity for the antigen bound by the 2H7 murine monoclonal antibody. The invention is also related to methods of producing the antibody.
摘要翻译： 本发明涉及包含编码嵌合抗体分子的DNA的真核宿主细胞，其包含两条重链和两条轻链，每条链包含可变区和人恒定区，所述抗体对由 2H7鼠单克隆抗体。 本发明还涉及产生抗体的方法。
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公开(公告)号：US5500362A
公开(公告)日：1996-03-19
申请号：US665939
申请日：1991-03-05
IPC分类号： G01N33/53 , A61K38/00 , A61K39/395 , A61K47/48 , C07K1/22 , C07K14/00 , C07K14/705 , C07K16/00 , C07K16/28 , C07K16/46 , C07K19/00 , C12N1/19 , C12N15/09 , C12P21/08 , C12R1/91 , C07K16/30 , G01N33/574
CPC分类号： C07K16/2887 , A61K47/48561 , A61K47/48669 , C07K16/2896 , C07K16/462 , A61K2039/505 , A61K38/00 , C07K2317/24 , C07K2317/732 , C07K2317/734 , C07K2319/00 , C07K2319/02 , C07K2319/30 , C07K2319/40
摘要： The present invention relates to a chimeric IgG1 antibody molecule comprising two heavy chains and two light chains, each of the chains comprising a human constant region and a variable region, said antibody having specificity for the antigen bound by the 2H7 murine monoclonal antibody. The invention also relates to the increased ADCC and CDC cytolytic activities of the chimeric antibody, methods of production by recombinant DNA techniques, and uses.
摘要翻译： 本发明涉及包含两条重链和两条轻链的嵌合IgG1抗体分子，每条链包含人恒定区和可变区，所述抗体对由2H7鼠单克隆抗体结合的抗原具有特异性。 本发明还涉及嵌合抗体的增加的ADCC和CDC细胞溶解活性，通过重组DNA技术生产的方法和用途。
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公开(公告)号：US06893625B1
公开(公告)日：2005-05-17
申请号：US09630198
申请日：2000-08-01
CPC分类号： C07K16/2887 , A61K38/00 , A61K47/6849 , A61K47/6877 , A61K2039/505 , C07K16/462 , C07K2317/24 , C07K2317/732 , C07K2317/734 , C07K2319/00 , C07K2319/02 , C07K2319/30 , C07K2319/40
摘要： A chimeric antibody with human constant region and murine variable region, having specificity to a 35 kDA polypeptide (Bp35(CD20)) expressed on the surface of human B cells, methods of production, and uses.
摘要翻译： 具有人恒定区和鼠可变区的嵌合抗体，对人B细胞表面表达的35kDa多肽（Bp35（CD20））具有特异性，生产方法和用途。
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公开(公告)号：US06652852B1
公开(公告)日：2003-11-25
申请号：US09724138
申请日：2000-11-28
IPC分类号： A61K39395
CPC分类号： C07K16/2887 , A61K38/00 , A61K47/6849 , A61K47/6877 , A61K2039/505 , C07K16/462 , C07K2317/24 , C07K2317/732 , C07K2317/734 , C07K2319/00 , C07K2319/02 , C07K2319/30 , C07K2319/40
摘要： A chimeric antibody with human constant region and murine variable region, having specificity to a 35 kDA polypeptide (Bp35(CD20)) expressed on the surface of human B cells, methods of production, and uses.
摘要翻译： 具有人恒定区和鼠可变区的嵌合抗体，对人B细胞表面表达的35kDa多肽（Bp35（CD20））具有特异性，生产方法和用途。
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公开(公告)号：US6120767A
公开(公告)日：2000-09-19
申请号：US21934
申请日：1998-02-12
IPC分类号： G01N33/53 , A61K38/00 , A61K39/395 , A61K47/48 , C07K1/22 , C07K14/00 , C07K14/705 , C07K16/00 , C07K16/28 , C07K16/46 , C07K19/00 , C12N1/19 , C12N15/09 , C12P21/08 , C12R1/91 , C07K16/30
CPC分类号： C07K16/2887 , A61K47/48561 , A61K47/48669 , C07K16/2896 , C07K16/462 , A61K2039/505 , A61K38/00 , C07K2317/24 , C07K2317/732 , C07K2317/734 , C07K2319/00 , C07K2319/02 , C07K2319/30 , C07K2319/40
摘要： A chimeric antibody with human constant region and murine variable region, having specificity to a 35 kDA polypeptide (Bp35(CD20)) expressed on the surface of human B cells, methods of production, and uses.
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公开(公告)号：US09090712B2
公开(公告)日：2015-07-28
申请号：US12536975
申请日：2009-08-06
IPC分类号： C07K14/435 , C07K19/00 , C07K14/81 , C07K16/18 , C07K16/30 , C07K16/40 , G01N33/574 , G01N33/53 , A61K39/00
CPC分类号： G01N33/57449 , A61K2039/505 , C07K14/811 , C07K16/18 , C07K16/30 , C07K16/3069 , C07K16/40 , C07K2319/00 , C07K2319/30 , G01N33/57488 , G01N2333/705
摘要： The invention is directed to compositions and methods for the detection of a malignant condition, and relates to the discovery of soluble and cell surface forms of HE4a polypeptides, including HE4a that is overexpressed in ovarian carcinomas. In particular the invention provides a nucleic acid sequence encoding HE4a, and also provides a method of screening for the presence of a malignant condition in a subject by detecting reactivity of an antibody specific for a HE4a polypeptide with a molecule naturally occurring in soluble and/or cell surface form in a sample from such a subject, and by hybridization screening using an HE4a nucleotide sequence, as well as other related advantages.
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公开(公告)号：US08197810B2
公开(公告)日：2012-06-12
申请号：US12901297
申请日：2010-10-08
IPC分类号： A61K39/395
CPC分类号： C07K16/46 , A61K2039/505 , C07K16/2809 , C07K16/2818 , C07K16/2878 , C07K16/2896 , C07K16/462 , C07K2317/22 , C07K2317/24 , C07K2317/53 , C07K2317/622 , C07K2317/64 , C07K2317/732 , C07K2317/734 , C07K2319/00 , C07K2319/30
摘要： The invention relates to novel binding domain-immunoglobulin fusion proteins that feature a binding domain for a cognate structure such as an antigen, a counterreceptor or the like, a hinge region polypeptide having either zero or one cysteine residue, and immunoglobulin CH2 and CH3 domains, and that are capable of ADCC and/or CDC while occurring predominantly as monomeric polypeptides. The fusion proteins can be recombinantly produced at high expression levels. Also provided are related compositions and methods, including immunotherapeutic applications.
摘要翻译： 本发明涉及新颖的结合域 - 免疫球蛋白融合蛋白，其特征在于同源结构如结合抗原，反式受体等的结合结构域，具有零个或一个半胱氨酸残基的铰链区多肽和免疫球蛋白CH2和CH3结构域， 并且其能够主要以单体多肽的形式存在于ADCC和/或CDC。 可以以高表达水平重组产生融合蛋白。 还提供了相关的组合物和方法，包括免疫治疗应用。
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公开(公告)号：US20120034245A9
公开(公告)日：2012-02-09
申请号：US12304562
申请日：2007-06-12
申请人： Peter Armstrong Thompson , Jeffrey A. Ledbetter , Martha Susan Hayden-Ledbetter , Laura Sue Grosmaire , Robert Bader , William Brady
发明人： Peter Armstrong Thompson , Jeffrey A. Ledbetter , Martha Susan Hayden-Ledbetter , Laura Sue Grosmaire , Robert Bader , William Brady
IPC分类号： A61K39/395 , C07K16/46 , C07H21/00 , C12N15/63 , C12N5/10 , A61P37/06 , A61P29/00 , A61P3/10 , A61P19/02 , A61P11/06 , A61P25/00 , A61P17/06 , C07K19/00 , A61P35/00
CPC分类号： C07K16/28 , A61K2039/505 , A61K2039/507 , C07K16/18 , C07K16/2803 , C07K16/2809 , C07K16/2818 , C07K16/2827 , C07K16/2833 , C07K16/2851 , C07K16/2875 , C07K16/2878 , C07K16/2887 , C07K16/2896 , C07K16/30 , C07K16/46 , C07K16/468 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/52 , C07K2317/53 , C07K2317/622 , C07K2317/64 , C07K2317/732 , C07K2317/734 , C07K2319/30
摘要： Multivalent binding peptides, including bi-specific binding peptides, having immunoglobulin effector function are provided, along with encoding nucleic acids, vectors and host cells as well as methods for making such peptides and methods for using such peptides to treat or prevent a variety of diseases, disorders or conditions, as well as to ameliorate at least one symptom associated with such a disease, disorder or condition.
摘要翻译： 提供具有免疫球蛋白效应子功能的多价结合肽，包括双特异性结合肽，以及编码核酸，载体和宿主细胞以及制备这些肽的方法和使用这些肽治疗或预防各种疾病的方法 ，疾病或病症，以及改善与这种疾病，病症或病症相关的至少一种症状。
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公开(公告)号：US20100203052A1
公开(公告)日：2010-08-12
申请号：US12724333
申请日：2010-03-15
IPC分类号： A61K39/395 , A61P29/00 , A61P3/10 , A61P17/06 , A61P1/04
CPC分类号： C07K16/3061 , A61K38/00 , A61K39/0011 , A61K2039/505 , A61K2039/5152 , A61K2039/5156 , A61K2039/5158 , C07K16/2809 , C07K16/2818 , C07K16/2878 , C07K16/2896 , C07K16/462 , C07K2317/22 , C07K2317/24 , C07K2317/53 , C07K2317/622 , C07K2317/64 , C07K2317/732 , C07K2317/734 , C07K2319/00 , C07K2319/30 , C12N5/0636 , C12N2501/23 , C12N2501/51 , C12N2501/515 , C12N2501/52 , C12N2502/11 , C12N2510/00
摘要： The invention relates to novel binding domain-immunoglobulin fusion proteins that feature a binding domain for a cognate structure such as an antigen, a counterreceptor or the like, a wild-type IgG1, IGA or IgE hinge region polypeptide or a mutant IgG1 hinge region polypeptide having either zero, one or two cysteine residues, and immunoglobulin CH2 and CH3 domains, and that are capable of ADCC and/or CDC while occurring predominantly as polypeptides that are compromised in their ability to form disulfide-linked multimers. The fusion proteins can be recombinantly produced at high express levels. Also provided are related compositions and methods, including cell surface forms of the fusion proteins and immunotherapeutic applications of the fusion proteins and of polynucleotides encoding such fusion proteins.
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