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    Transgenic mice carrying functional single nucleotide polymorphisms in brain-specific tryptophan hydroxylase
    5.
    发明授权
    Transgenic mice carrying functional single nucleotide polymorphisms in brain-specific tryptophan hydroxylase 失效
    在脑特异性色氨酸羟化酶中携带功能单核苷酸多态性的转基因小鼠

    公开(公告)号：US08124831B2

    公开(公告)日：2012-02-28

    申请号：US11825202

    申请日：2007-07-05

    申请人： Marc G. Caron ,  Xiaodong Zhang ,  Martin Beaulieu ,  Raul R. Gainetdinov ,  Tatyana D. Sotnikova

    发明人： Marc G. Caron ,  Xiaodong Zhang ,  Martin Beaulieu ,  Raul R. Gainetdinov ,  Tatyana D. Sotnikova

    IPC分类号： A01K67/027 ,  G01N33/00

    CPC分类号： A01K67/0276 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/0356 ,  C12N9/0071 ,  C12N15/8509 ,  C12N2800/30

    摘要： Recombinant or transgenic non-human mammals are described having a mutant tryptophan hydroxylase 2 (Tph2) gene resulting in altered synthesis of 5-hydroxytryptophan and serotonin in the brain. In some embodiments the mutant tryptophan hydroxylase 2 gene contains mouse R439H and/or P447R functional mutations, or their corresponding mutations in other species. Congenic non-human mammals having mutant tryptophan hydroxylase 2 genes are also provided. Methods of screening a compound for serotonergic activity or activity in treating a serotonergic neurotransmission dysregulation disorder are provided, which include administering a test compound to a recombinant non-human mammal and then detecting the presence or absence of serotonergic activity, or activity in treating a serotonergic neurotransmission dysregulation disorder, in the mammal. A cell such as a nerve cell (e.g., a central nervous system neuron) isolated from a transgenic or congenic mammal is also disclosed, along with cell cultures containing these cells.

    摘要翻译： 描述了具有突变色氨酸羟化酶2（Tph2）基因的重组或转基因非人哺乳动物，导致脑中5-羟色胺和5-羟色胺的合成改变。 在一些实施方案中，突变色氨酸羟化酶2基因含有小鼠R439H和/或P447R功能性突变或其他物种中相应的突变。 还提供了具有突变色氨酸羟化酶2基因的同种非人哺乳动物。 提供了筛选化合物用于治疗血清素能神经递质调节障碍的5-羟色胺能活性或活性的方法，其包括向重组非人哺乳动物施用测试化合物，然后检测血清素能活性的存在或不存在或治疗血清素能的活性 神经传递异常调节障碍。 还公开了从转基因或同基因哺乳动物分离的细胞例如分离自转基因或同种哺乳动物的神经细胞（例如中枢神经系统神经元）以及含有这些细胞的细胞培养物。

    Mammals carrying functional single nucleotide polymorphisms in brain-specific tryptophan hydroxylase
    6.
    发明申请
    Mammals carrying functional single nucleotide polymorphisms in brain-specific tryptophan hydroxylase 失效
    在脑特异性色氨酸羟化酶中携带功能性单核苷酸多态性的哺乳动物

    公开(公告)号：US20080010692A1

    公开(公告)日：2008-01-10

    申请号：US11825202

    申请日：2007-07-05

    申请人： Marc Caron ,  Xiaodong Zhang ,  Martin Beaulieu ,  Raul Gainetdinov ,  Tatyana Sotnikova

    发明人： Marc Caron ,  Xiaodong Zhang ,  Martin Beaulieu ,  Raul Gainetdinov ,  Tatyana Sotnikova

    IPC分类号： G01N33/00 ,  A01K67/00 ,  C12N5/00

    CPC分类号： A01K67/0276 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/0356 ,  C12N9/0071 ,  C12N15/8509 ,  C12N2800/30

    摘要： Recombinant or transgenic non-human mammals are described having a mutant tryptophan hydroxylase 2 (Tph2) gene resulting in altered synthesis of 5-hydroxytryptophan and serotonin in the brain. In some embodiments the mutant tryptophan hydroxylase 2 gene contains mouse R439H and/or P447R functional mutations, or their corresponding mutations in other species. Congenic non-human mammals having mutant tryptophan hydroxylase 2 genes are also provided. Methods of screening a compound for serotonergic activity or activity in treating a serotonergic neurotransmission dysregulation disorder are provided, which include administering a test compound to a recombinant non-human mammal and then detecting the presence or absence of serotonergic activity, or activity in treating a serotonergic neurotransmission dysregulation disorder, in the mammal. A cell such as a nerve cell (e.g., a central nervous system neuron) isolated from a transgenic or congenic mammal is also disclosed, along with cell cultures containing these cells. Such mammals and cells and cell cultures are useful in vitro for screening the activity of candidate compounds for their effect on serotonergic neurotransmission and for their activity in treating serotonergic neurotransmission dysregulation disorders.

    摘要翻译： 描述了具有突变色氨酸羟化酶2（Tph2）基因的重组或转基因非人哺乳动物，导致脑中5-羟色胺和5-羟色胺的合成改变。 在一些实施方案中，突变色氨酸羟化酶2基因含有小鼠R439H和/或P447R功能性突变或其他物种中相应的突变。 还提供了具有突变色氨酸羟化酶2基因的同种非人哺乳动物。 提供了筛选化合物用于治疗血清素能神经递质调节障碍的5-羟色胺能活性或活性的方法，其包括向重组非人哺乳动物施用测试化合物，然后检测血清素能活性的存在或不存在或治疗血清素能的活性 神经传递异常调节障碍。 还公开了从转基因或同基因哺乳动物分离的细胞例如分离自转基因或同种哺乳动物的神经细胞（例如中枢神经系统神经元）以及含有这些细胞的细胞培养物。 这样的哺乳动物和细胞和细胞培养物在体外可用于筛选候选化合物对5-羟色胺能神经传递的作用及其在治疗5-羟色胺能神经传递失调调节障碍中的活性。

    POLYPEPTIDE DRUG AGAINST HEPATITIS B VIRUS PROTEIN
    9.
    发明申请
    POLYPEPTIDE DRUG AGAINST HEPATITIS B VIRUS PROTEIN 有权

    公开(公告)号：US20210113685A1

    公开(公告)日：2021-04-22

    申请号：US14004613

    申请日：2012-03-15

    申请人： Xiaodong Zhang ,  Lihong Ye

    发明人： Xiaodong Zhang ,  Lihong Ye

    IPC分类号： A61K39/29 ,  C12N15/79

    摘要： Provided are polypeptides having the effects of inhibiting hepatitis B virus x protein (HBx) and polynucleotides encoding the peptides. Also provided are peptidomimetics, functional fragments and functional variants thereof, as well as the encoding genes thereof. The polypeptides and peptidomimetics can be used for the treatment and prevention of liver diseases resulted from hepatitis B virus infection, including hepatitis, cirrhosis and liver cancer.

    Smart card simultaneously having two read/write mode matrixes and method for producing same
    10.
    发明授权
    Smart card simultaneously having two read/write mode matrixes and method for producing same 有权
    智能卡同时具有两个读/写模式矩阵及其制造方法

    公开(公告)号：US09342779B2

    公开(公告)日：2016-05-17

    申请号：US14355398

    申请日：2012-01-06

    申请人： Xiaodong Zhang

    发明人： Xiaodong Zhang

    IPC分类号： G06K19/06 ,  G06K19/077 ,  G06K19/07

    CPC分类号： G06K19/07754 ,  G06K19/0723 ,  Y10T29/49018

    摘要： A smart card with two read-write modes includes antenna layer, and an antenna and a chip module circuits on the antenna layer, wherein the antenna and the chip module circuit are electrically connected via an elastic conductive device. The invention also provides a manufacturing method of the aforesaid smart card with two read-write modes, which includes steps of: embedding an antenna on a back side or a front side of an antenna layer; after completing embedding on the antenna layer, add bedding sheets, printed sheets and protection films respectively above and underneath the antenna layer, then laminating to obtain a card base carrier; cutting card from the treated whole-sheet card base carrier to obtain a card base, and milling slots on the obtained card base, then finally encapsulating.

    摘要翻译： 具有两个读写模式的智能卡包括天线层，天线层上的天线和芯片模块电路，其中天线和芯片模块电路通过弹性导电装置电连接。 本发明还提供了具有两种读写模式的上述智能卡的制造方法，包括以下步骤：在天线层的背面或前侧嵌入天线; 完成嵌入天线层后，分别在天线层的上方和下方添加寝具，印刷片和保护膜，然后层叠以获得卡片基底; 从经处理的整张卡片基座上取出卡片，以获得卡片基座，并在获得的卡座上铣削槽，然后最终封装。