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113 条记录 (耗时 0.031 秒)

    Piperidines promote release of growth hormone
    1.
    发明授权
    Piperidines promote release of growth hormone 失效
    皮质激素促进生长激素的释放

    公开(公告)号：US5965565A

    公开(公告)日：1999-10-12

    申请号：US988816

    申请日：1997-12-11

    申请人： Meng H. Chen ,  Zhijian Lu ,  Ravi Nargund ,  Arthur A. Patchett ,  James R. Tata ,  Lihu Yang ,  Mu Tsu Wu

    发明人： Meng H. Chen ,  Zhijian Lu ,  Ravi Nargund ,  Arthur A. Patchett ,  James R. Tata ,  Lihu Yang ,  Mu Tsu Wu

    IPC分类号： C07D401/06 ,  C07D413/14 ,  C07D471/10 ,  C07D495/10 ,  C07D209/04 ,  A61K31/445 ,  C07D211/00

    CPC分类号： C07D401/06 ,  C07D413/14 ,  C07D471/10 ,  C07D495/10

    摘要： The present invention is directed to certain piperidines, pyrrolidines, and hexahydro-1H-azepines of the general structural formula: ##STR1## wherein B is selected from: ##STR2## and R.sup.1, R.sup.1a, R.sup.2a, R.sup.3a, R.sup.3b, R.sup.4, R.sup.4a, R.sup.4b, R.sup.4c, R.sup.5, D, X, Y, n, x and y are as defined herein. These compounds promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to treat physiological or medical conditions characterized by a deficiency in growth hormone secretion, such as short stature in growth hormone deficient children, and to treat medical conditions which are improved by the anabolic effects of growth hormone. Growth hormone releasing compositions containing such compounds as the active ingredient thereof are also disclosed.

    摘要翻译： 本发明涉及一般结构式的某些哌啶，吡咯烷和六氢-1H-吖庚因：其中B选自：和R1，R1a，R2a，R3a，R3b，R4，R4a，R4b，R4c，R5， D，X，Y，n，x和y如本文所定义。 这些化合物促进人和动物中生长激素的释放。 这种性质可以用于促进食用动物的生长，使食用肉制品的生产更有效，并且在人类中，用于治疗以生长激素分泌不足为特征的生理或医学病症，例如生长激素缺乏的身材矮小 儿童，并且治疗通过生长激素的合成代谢作用改善的医疗状况。 还公开了含有这些化合物作为其活性成分的生长激素释放组合物。

    3-substituted piperidines promote release of growth hormone
    2.
    发明授权
    3-substituted piperidines promote release of growth hormone 失效
    3-取代的哌啶促进生长激素的释放

    公开(公告)号：US5559128A

    公开(公告)日：1996-09-24

    申请号：US424750

    申请日：1995-04-18

    申请人： Prasun K. Chakravarty ,  Ravi Nargund ,  Robert W. Marquis ,  Arthur A. Patchett ,  Lihu Yang

    发明人： Prasun K. Chakravarty ,  Ravi Nargund ,  Robert W. Marquis ,  Arthur A. Patchett ,  Lihu Yang

    IPC分类号： C07D211/56 ,  C07D401/06 ,  C07D401/14 ,  C07D413/14 ,  A61K31/445 ,  C07D209/04

    CPC分类号： C07D401/06 ,  C07D211/56 ,  C07D401/14 ,  C07D413/14

    摘要： The present invention is directed to certain novel compounds identified as 3-substituted piperidines of the general structural formula: ##STR1## wherein R.sup.1, R.sup.1a, R.sup.2a, R.sup.4, R.sup.5, A, X, and Y are as defined herein. These compounds promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to treat physiological or medical conditions characterized by a deficiency in growth hormone secretion, such as short stature in growth hormone deficient children, and to treat medical conditions which are improved by the anabolic effects of growth hormone. Growth hormone releasing compositions containing these compounds as the active ingredient thereof are also disclosed.

    摘要翻译： 本发明涉及鉴定为以下结构式的3-取代哌啶的某些新化合物：其中R1，R1a，R2a，R4，R5，A，X和Y如本文所定义。 这些化合物促进人和动物中生长激素的释放。 这种性质可以用于促进食用动物的生长，使食用肉制品的生产更有效，并且在人类中，用于治疗以生长激素分泌不足为特征的生理或医学病症，例如生长激素缺乏的身材矮小 儿童，并且治疗通过生长激素的合成代谢作用改善的医疗状况。 还公开了含有这些化合物作为其活性成分的生长激素释放组合物。

    Piperidine, pyrrolidine and hexahydro-1H-azepines promote release of growth hormone
    3.
    发明授权
    Piperidine, pyrrolidine and hexahydro-1H-azepines promote release of growth hormone 失效
    哌啶，吡咯烷和六氢-1H-吖庚因促进生长激素的释放

    公开(公告)号：US5492920A

    公开(公告)日：1996-02-20

    申请号：US323998

    申请日：1994-10-17

    申请人： Meng H. Chen ,  Ravi Nargund ,  Arthur A. Patchett ,  Lihu Yang

    发明人： Meng H. Chen ,  Ravi Nargund ,  Arthur A. Patchett ,  Lihu Yang

    IPC分类号： A61K38/00 ,  C07D401/06 ,  C07D401/14 ,  C07D453/02 ,  C07K5/02 ,  C07K5/06 ,  C07K5/083 ,  A61K31/445 ,  C07D209/04

    CPC分类号： C07D401/06 ,  C07D401/14 ,  C07D453/02 ,  C07K5/0202 ,  C07K5/021 ,  C07K5/06034 ,  C07K5/0808 ,  A61K38/00

    摘要： The present invention is directed to certain novel compounds identified as substituted piperidines, pyrrolidines and hexahydro-1H-azepines of the general structural formula: ##STR1## wherein R.sub.1, R.sub.4, R.sub.5, A, X, Y and n are as defined herein. These compounds promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to treat physiological or medical conditions characterized by a deficiency in growth hormone secretion, such as short stature in growth hormone deficient children, and to treat medical conditions which are improved by the anabolic effects of growth hormone. Growth hormone releasing compositions containing such compounds as the active ingredient thereof are also disclosed.

    摘要翻译： 本发明涉及鉴定为以下结构式的取代的哌啶，吡咯烷和六氢-1H-吖庚因的某些新化合物：其中R 1，R 4，R 5，A，X，Y和n如本文所定义。 这些化合物促进人和动物中生长激素的释放。 这种性质可以用于促进食用动物的生长，使食用肉制品的生产更有效，并且在人类中，用于治疗以生长激素分泌不足为特征的生理或医学病症，例如生长激素缺乏的身材矮小 儿童，并且治疗通过生长激素的合成代谢作用改善的医疗状况。 还公开了含有这些化合物作为其活性成分的生长激素释放组合物。

    4-Heterocyclic peperidines promote release of growth hormone
    5.
    发明授权
    4-Heterocyclic peperidines promote release of growth hormone 失效
    4-杂环peperidines促进生长激素的释放

    公开(公告)号：US5767118A

    公开(公告)日：1998-06-16

    申请号：US329357

    申请日：1994-10-26

    申请人： Ravi Nargund ,  Arthur A. Patchett ,  Lihu Yang

    发明人： Ravi Nargund ,  Arthur A. Patchett ,  Lihu Yang

    IPC分类号： A23K1/16 ,  A61K31/66 ,  A61K38/00 ,  A61K38/04 ,  A61K38/27 ,  A61P3/04 ,  A61P5/00 ,  A61P17/00 ,  A61P35/00 ,  A61P37/00 ,  A61P43/00 ,  C07D401/04 ,  C07D401/14 ,  C07D413/14 ,  C07K5/06 ,  A61K31/535 ,  A01N43/40 ,  A01N43/54 ,  A61K31/54 ,  C07D211/36 ,  C07D211/68 ,  C07D401/00 ,  C07D409/00

    CPC分类号： C07D401/04 ,  C07D401/14 ,  C07D413/14

    摘要： The present invention is directed to certain novel compounds identified as 4-heterocycle substituted piperidines of the general structural formula: ##STR1## wherein R.sup.1, R.sup.4, R.sup.5, A, R.sup.3 and the dashed line are as defined herein. These compounds promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to treat physiological or medical conditions characterized by a deficiency in growth hormone secretion, such as short stature in growth hormone deficient children, and to treat medical conditions which are improved by the anabolic effects of growth hormone. Growth hormone releasing compositions containing such compounds as the active ingredient thereof are also disclosed.

    摘要翻译： 本发明涉及鉴定为以下结构式的4-杂环取代的哌啶的某些新化合物：其中R1，R4，R5，A，R3和虚线如本文所定义。 这些化合物促进人和动物中生长激素的释放。 这种性质可以用于促进食用动物的生长，使食用肉制品的生产更有效，并且在人类中，用于治疗以生长激素分泌不足为特征的生理或医学病症，例如生长激素缺乏的身材矮小 儿童，并且治疗通过生长激素的合成代谢作用改善的医疗状况。 还公开了含有这些化合物作为其活性成分的生长激素释放组合物。

    Piperidines, pyrrolidines and hexahydro-1H-azepines promote release of growth hormone
    8.
    发明授权
    Piperidines, pyrrolidines and hexahydro-1H-azepines promote release of growth hormone 失效
    哌啶，吡咯烷和六氢-1H-吖庚因促进生长激素的释放

    公开(公告)号：US5804578A

    公开(公告)日：1998-09-08

    申请号：US828606

    申请日：1997-03-31

    申请人： Prasun K. Chakravarty ,  Meng H. Chen ,  Ravi Nargund ,  Arthur A. Patchett ,  James R. Tata ,  Mu Tsu Wu ,  Lihu Yang

    发明人： Prasun K. Chakravarty ,  Meng H. Chen ,  Ravi Nargund ,  Arthur A. Patchett ,  James R. Tata ,  Mu Tsu Wu ,  Lihu Yang

    IPC分类号： A61K38/00 ,  C07K5/02 ,  C07K5/08 ,  C07K5/083 ,  A01N43/54 ,  C07D215/00 ,  C07D413/00 ,  C07D453/02

    CPC分类号： C07K5/0802 ,  C07K5/021 ,  C07K5/0806 ,  A61K38/00

    摘要： The present invention is directed to certain piperidines, pyrrolidines, and hexahydro-1H-azepines of the general structural formula: ##STR1## wherein B is selected from: ##STR2## and R.sup.1, R.sup.1a, R.sup.2a, R.sup.3a, R.sup.3b, R.sup.4, R.sup.4a, R.sup.4b, R.sup.4c, R.sup.5, D, X, Y, n, x and y are as defined herein. These compounds promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to treat physiological or medical conditions characterized by a deficiency in growth hormone secretion, such as short stature in growth hormone deficient children, and to treat medical conditions which are improved by the anabolic effects of growth hormone. Growth hormone releasing compositions containing such compounds as the active ingredient thereof are also disclosed.

    摘要翻译： 本发明涉及以下通式结构式的某些哌啶，吡咯烷和六氢-1H-吖庚因：其中B选自：其中R 1，R 1a，R 2a，R 3a，R 3b，R 4，R 4a， R4b，R4c，R5，D，X，Y，n，x和y如本文所定义。 这些化合物促进人和动物中生长激素的释放。 这种性质可以用于促进食用动物的生长，使食用肉制品的生产更有效，并且在人类中，用于治疗以生长激素分泌不足为特征的生理或医学病症，例如生长激素缺乏的身材矮小 儿童，并且治疗通过生长激素的合成代谢作用改善的医疗状况。 还公开了含有这些化合物作为其活性成分的生长激素释放组合物。

    Piperidine, pyrrolidine and hexahydro-1H-azepines promote release of growth hormone
    9.
    发明授权
    Piperidine, pyrrolidine and hexahydro-1H-azepines promote release of growth hormone 失效
    哌啶，吡咯烷和六氢-1H-吖庚因促进生长激素的释放

    公开(公告)号：US5721251A

    公开(公告)日：1998-02-24

    申请号：US600912

    申请日：1996-02-13

    申请人： Meng H. Chen ,  Ravi Nargund ,  Arthur A. Patchett ,  Lihu Yang

    发明人： Meng H. Chen ,  Ravi Nargund ,  Arthur A. Patchett ,  Lihu Yang

    IPC分类号： A61K38/00 ,  C07D401/06 ,  C07D401/14 ,  C07D453/02 ,  C07K5/02 ,  C07K5/06 ,  C07K5/083 ,  A61K31/445 ,  C07D401/02 ,  C07D409/02

    CPC分类号： C07D401/06 ,  C07D401/14 ,  C07D453/02 ,  C07K5/0202 ,  C07K5/021 ,  C07K5/06034 ,  C07K5/06139 ,  C07K5/0808 ,  A61K38/00

    摘要： The present invention is directed to certain novel compounds identified as substituted piperidines, pyrrolidines and hexahydro-1H-azepines of the general structural formula: ##STR1## wherein R.sub.1, R.sub.4, R.sub.5, A, X, Y and n are as defined herein. These compounds promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to treat physiological or medical conditions characterized by a deficiency in growth hormone secretion, such as short stature in growth hormone deficient children, and to treat medical conditions which are improved by growth hormone. Growth hormone releasing compositions containing such compounds as the active ingredient thereof are also disclosed.

    摘要翻译： 本发明涉及鉴定为以下结构式的取代的哌啶，吡咯烷和六氢-1H-吖庚因的某些新化合物：其中R 1，R 4，R 5，A，X，Y和n如本文所定义。 这些化合物促进人和动物中生长激素的释放。 这种性质可以用于促进食用动物的生长，使食用肉制品的生产更有效，并且在人类中，用于治疗以生长激素分泌不足为特征的生理或医学病症，例如生长激素缺乏的身材矮小 儿童，并治疗由生长激素改善的医疗状况。 还公开了含有这些化合物作为其活性成分的生长激素释放组合物。