公开(公告)号：US09636353B2

公开(公告)日：2017-05-02

申请号：US13880092

申请日：2011-10-19

申请人： Ravindra Mittal ,  Sunilendu Bhushan Roy ,  Jay Shantilal Kothari ,  Shafiq Sheikh ,  Jitendra Dasharathlal Patel ,  Jinesh Suresh Pancholi

发明人： Ravindra Mittal ,  Sunilendu Bhushan Roy ,  Jay Shantilal Kothari ,  Shafiq Sheikh ,  Jitendra Dasharathlal Patel ,  Jinesh Suresh Pancholi

IPC分类号： A61K31/7056 ,  A61K31/192

CPC分类号： A61K31/7056 ,  A61K31/192 ,  A61K2300/00

摘要： The present invention relates to a method for treating, reducing or preventing acne. In particular, the present invention relates to methods for reducing the total number, incidence and severity of acne lesions on the skin which includes both inflammatory and non-inflammatory lesions. Further, the invention relates to reducing the incidence and severity of adverse events resulting from topical application of anti-acne agents resulting in improvement of skin tone. The method includes administering a novel and stable topical anti-acne pharmaceutical composition.

公开(公告)号：US10028972B2

公开(公告)日：2018-07-24

申请号：US13880187

申请日：2011-10-19

申请人： Sunilendu Bhushan Roy ,  Jay Shantilal Kothari ,  Shafiq Sheikh ,  Jinesh Suresh Pancholi ,  Jitendra Dasharathlal Patel ,  Ravindra Mittal

发明人： Sunilendu Bhushan Roy ,  Jay Shantilal Kothari ,  Shafiq Sheikh ,  Jinesh Suresh Pancholi ,  Jitendra Dasharathlal Patel ,  Ravindra Mittal

IPC分类号： A61K9/107 ,  A61K31/7056 ,  A61K9/00 ,  A61K9/06 ,  A61K31/192 ,  A61K45/06 ,  A61K47/32 ,  A61K47/44

摘要： The present invention relates to pharmaceutical compositions for treatment of acne. In particular, the present invention relates to stable pharmaceutical compositions for treatment of acne along with other pharmaceutically acceptable excipients. These compositions exhibit excellent stability, greater permeability, and enhanced therapeutic efficacy. The invention also relates to processes for the preparation of such compositions.

公开(公告)号：US09254257B2

公开(公告)日：2016-02-09

申请号：US13880107

申请日：2011-10-18

申请人： Ravindra Mittal ,  Sunilendu Bhushan Roy ,  Jay Shantilal Kothari ,  Shafiq Sheikh ,  Jitendra Dasharathlal Patel ,  Jinesh Suresh Pancholi

发明人： Ravindra Mittal ,  Sunilendu Bhushan Roy ,  Jay Shantilal Kothari ,  Shafiq Sheikh ,  Jitendra Dasharathlal Patel ,  Jinesh Suresh Pancholi

IPC分类号： A61K9/00 ,  A61K9/107 ,  A61K31/7056 ,  A61K8/49 ,  A61Q19/00

CPC分类号： A61K9/0014 ,  A61K8/49 ,  A61K9/1075 ,  A61K31/7056 ,  A61K2800/412 ,  A61Q19/00 ,  A61Q19/005 ,  A61Q19/007

摘要： The present invention relates to a method for treating, reducing or preventing acne. In particular, the present invention relates to methods for reducing the total number, incidence and severity of acne lesions on the skin which includes both inflammatory and non-inflammatory lesions. Further, the invention relates to reducing the incidence and severity of adverse events resulting from topical application of anti-acne agents resulting in improvement of skin tone. The method includes administering a novel and stable topical anti-acne pharmaceutical composition.

摘要翻译： 本发明涉及一种治疗，减少或预防痤疮的方法。 特别地，本发明涉及减少包括炎性和非炎性损害在内的皮肤上的痤疮损伤的总数，发病率和严重程度的方法。 此外，本发明涉及减少局部施用抗痤疮剂导致皮肤色调改善所引起的不良事件的发生率和严重程度。 该方法包括施用新颖且稳定的局部抗痤疮药物组合物。

公开(公告)号：US20130337016A1

公开(公告)日：2013-12-19

申请号：US13880092

申请日：2011-10-19

申请人： Ravindra Mittal ,  Sunilendu Bhushan Roy ,  Jay Shantilal Kothari ,  Shafiq Sheikh ,  Jitendra Dasharathlal Patel ,  Jinesh Suresh Pancholi

发明人： Ravindra Mittal ,  Sunilendu Bhushan Roy ,  Jay Shantilal Kothari ,  Shafiq Sheikh ,  Jitendra Dasharathlal Patel ,  Jinesh Suresh Pancholi

IPC分类号： A61K31/7056 ,  A61K31/192

CPC分类号： A61K31/7056 ,  A61K31/192 ,  A61K2300/00

摘要： The present invention relates to a method for treating, reducing or preventing acne. In particular, the present invention relates to methods for reducing the total number, incidence and severity of acne lesions on the skin which includes both inflammatory and non-inflammatory lesions. Further, the invention relates to reducing the incidence and severity of adverse events resulting from topical application of anti-acne agents resulting in improvement of skin tone. The method includes administering a novel and stable topical anti-acne pharmaceutical composition.

摘要翻译： 本发明涉及一种治疗，减少或预防痤疮的方法。 特别地，本发明涉及减少包括炎性和非炎性损害在内的皮肤上的痤疮损伤的总数，发病率和严重程度的方法。 此外，本发明涉及减少局部施用抗痤疮剂导致皮肤色调改善所引起的不良事件的发生率和严重程度。 该方法包括施用新颖且稳定的局部抗痤疮药物组合物。

公开(公告)号：US20130280308A1

公开(公告)日：2013-10-24

申请号：US13880187

申请日：2011-10-19

申请人： Sunilendu Bhushan Roy ,  Jay Shantilal Kothari ,  Shafiq Sheikh ,  Jinesh Suresh Pancholi ,  Jitendra Dasharathlal Patel ,  Ravindra Mittal

发明人： Sunilendu Bhushan Roy ,  Jay Shantilal Kothari ,  Shafiq Sheikh ,  Jinesh Suresh Pancholi ,  Jitendra Dasharathlal Patel ,  Ravindra Mittal

IPC分类号： A61K31/7056 ,  A61K31/192

CPC分类号： A61K31/7056 ,  A61K9/0014 ,  A61K9/06 ,  A61K9/1075 ,  A61K31/192 ,  A61K45/06 ,  A61K47/32 ,  A61K47/44 ,  Y10T428/2982 ,  A61K2300/00

摘要： The present invention relates to pharmaceutical compositions for treatment of acne. In particular, the present invention relates to stable pharmaceutical compositions for treatment of acne along with other pharmaceutically acceptable excipients. These compositions exhibit excellent stability, greater permeability, and enhanced therapeutic efficacy. The invention also relates to processes for the preparation of such compositions.

摘要翻译： 本发明涉及治疗痤疮的药物组合物。 特别地，本发明涉及用于治疗痤疮以及其它药学上可接受的赋形剂的稳定的药物组合物。 这些组合物表现出优异的稳定性，更高的渗透性和增强的治疗功效。 本发明还涉及制备这种组合物的方法。

公开(公告)号：US20130266654A1

公开(公告)日：2013-10-10

申请号：US13880107

申请日：2011-10-18

申请人： Ravindra Mittal ,  Sunilendu Bhushan Roy ,  Jay Shantilal Kothari ,  Shafiq Sheikh ,  Jitendra Dasharathlal Patel ,  Jinesh Suresh Pancholi

发明人： Ravindra Mittal ,  Sunilendu Bhushan Roy ,  Jay Shantilal Kothari ,  Shafiq Sheikh ,  Jitendra Dasharathlal Patel ,  Jinesh Suresh Pancholi

IPC分类号： A61K9/00

CPC分类号： A61K9/0014 ,  A61K8/49 ,  A61K9/1075 ,  A61K31/7056 ,  A61K2800/412 ,  A61Q19/00 ,  A61Q19/005 ,  A61Q19/007

摘要： The present invention relates to a method for treating, reducing or preventing acne. In particular, the present invention relates to methods for reducing the total number, incidence and severity of acne lesions on the skin which includes both inflammatory and non-inflammatory lesions. Further, the invention relates to reducing the incidence and severity of adverse events resulting from topical application of anti-acne agents resulting in improvement of skin tone. The method includes administering a novel and stable topical anti-acne pharmaceutical composition.

摘要翻译： 本发明涉及一种治疗，减少或预防痤疮的方法。 特别地，本发明涉及减少包括炎性和非炎性损害在内的皮肤上的痤疮损伤的总数，发病率和严重程度的方法。 此外，本发明涉及减少局部施用抗痤疮剂导致皮肤色调改善所引起的不良事件的发生率和严重程度。 该方法包括施用新颖且稳定的局部抗痤疮药物组合物。

公开(公告)号：US20130287825A1

公开(公告)日：2013-10-31

申请号：US13880342

申请日：2011-10-18

申请人： Sunilendu Bhushan Roy ,  Jay Shantilal Kothari ,  Shafiq Sheikh ,  Jitendra Dasharathlal Patel ,  Jinesh Suresh Pancholi

发明人： Sunilendu Bhushan Roy ,  Jay Shantilal Kothari ,  Shafiq Sheikh ,  Jitendra Dasharathlal Patel ,  Jinesh Suresh Pancholi

IPC分类号： A61K8/06 ,  A61K8/49 ,  A61K8/63 ,  A61K8/34 ,  A61K8/36

CPC分类号： A61K8/06 ,  A61K8/347 ,  A61K8/355 ,  A61K8/361 ,  A61K8/362 ,  A61K8/365 ,  A61K8/4946 ,  A61K8/4973 ,  A61K8/63 ,  A61K8/671 ,  A61K8/675 ,  A61K2800/20 ,  A61K2800/21 ,  A61K2800/413 ,  A61Q19/02 ,  Y10S977/773 ,  Y10S977/906

摘要： The present invention relates to pharmaceutical compositions comprising mono size droplets of skin whitening agents or salts thereof. In particular, the present invention relates to a stable pharmaceutical composition comprising skin whitening agents or salts thereof along with other pharmaceutically acceptable excipients which possess substantially improved skin whitening effects and also exhibits greater skin permeability. The invention also relates to processes for the preparation of such compositions.

摘要翻译： 本发明涉及包含皮肤增白剂或其盐的单大小滴的药物组合物。 特别地，本发明涉及稳定的药物组合物，其包含皮肤增白剂或其盐以及具有显着改善的皮肤美白效果并且还具有更高的皮肤渗透性的其它药学上可接受的赋形剂。 本发明还涉及制备这种组合物的方法。

公开(公告)号：US08992994B2

公开(公告)日：2015-03-31

申请号：US13880519

申请日：2011-10-18

申请人： Sunilendu Bhushan Roy ,  Jay Shantilal Kothari ,  Shafiq Sheikh ,  Jitendra Dasharathlal Patel ,  Jinesh Suresh Pancholi

发明人： Sunilendu Bhushan Roy ,  Jay Shantilal Kothari ,  Shafiq Sheikh ,  Jitendra Dasharathlal Patel ,  Jinesh Suresh Pancholi

IPC分类号： A61K9/107 ,  A61K31/60 ,  A61K31/573 ,  A61K9/00 ,  A61K47/44 ,  B82Y5/00

CPC分类号： A61K9/107 ,  A61K9/0014 ,  A61K9/1075 ,  A61K31/573 ,  A61K31/60 ,  A61K47/44 ,  B82Y5/00 ,  A61K2300/00

摘要： The present invention relates to stable topical pharmaceutical compositions for the treatment of psoriasis. Disclosed are in particular nonoemulsions comprising nano size droplets of one or more anti-psoriasis agents, e.g. clobetasol and/or salicylic acid. These compositions exhibit greater permeability, and improved bioavailability. The invention also relates to processes for the preparation of such compositions.

摘要翻译： 本发明涉及用于治疗牛皮癣的稳定的局部药物组合物。 公开了特别是包含一种或多种抗牛皮癣药剂的纳米尺寸液滴的非乳液，例如。 氯倍他索和/或水杨酸。 这些组合物表现出更大的渗透性和改善的生物利用度。 本发明还涉及制备这种组合物的方法。

公开(公告)号：US20130295145A1

公开(公告)日：2013-11-07

申请号：US13880302

申请日：2011-10-18

申请人： Sunilendu Bhushan Roy ,  Jay Shantilal Kothari ,  Shafiq Sheikh ,  Jitendra Dasharathlal Patel ,  Jinesh Suresh Pancholi

发明人： Sunilendu Bhushan Roy ,  Jay Shantilal Kothari ,  Shafiq Sheikh ,  Jitendra Dasharathlal Patel ,  Jinesh Suresh Pancholi

IPC分类号： A61K9/06 ,  A61K31/618 ,  A61K31/407

CPC分类号： A61K9/06 ,  A61K9/0014 ,  A61K9/1075 ,  A61K31/407 ,  A61K31/618 ,  A61K47/06 ,  A61K47/32 ,  A61K47/44

摘要： The present invention relates to stable pharmaceutical compositions comprising nano size droplets of etodolac or salts thereof along with other pharmaceutically acceptable excipients. These compositions exhibit greater permeability, and improved bioavailability leading to enhanced therapeutic activity. The invention also relates to processes for the preparation of such compositions.

摘要翻译： 本发明涉及稳定的药物组合物，其包含依托托卡酸的纳米尺寸液滴或其盐与其它药学上可接受的赋形剂。 这些组合物显示出更大的渗透性，并且改善了生物利用度，导致增强的治疗活性。 本发明还涉及制备这种组合物的方法。

公开(公告)号：US09629785B2

公开(公告)日：2017-04-25

申请号：US13880342

申请日：2011-10-18

申请人： Sunilendu Bhushan Roy ,  Jay Shantilal Kothari ,  Shafiq Sheikh ,  Jitendra Dasharathlal Patel ,  Jinesh Suresh Pancholi

发明人： Sunilendu Bhushan Roy ,  Jay Shantilal Kothari ,  Shafiq Sheikh ,  Jitendra Dasharathlal Patel ,  Jinesh Suresh Pancholi

IPC分类号： A61Q9/02 ,  A61K8/06 ,  A61K8/34 ,  A61K8/35 ,  A61K8/362 ,  A61K8/365 ,  A61K8/49 ,  A61K8/63 ,  A61K8/67 ,  A61Q19/02 ,  A61K8/36

CPC分类号： A61K8/06 ,  A61K8/347 ,  A61K8/355 ,  A61K8/361 ,  A61K8/362 ,  A61K8/365 ,  A61K8/4946 ,  A61K8/4973 ,  A61K8/63 ,  A61K8/671 ,  A61K8/675 ,  A61K2800/20 ,  A61K2800/21 ,  A61K2800/413 ,  A61Q19/02 ,  Y10S977/773 ,  Y10S977/906

摘要： The present invention relates to pharmaceutical compositions comprising mono size droplets of skin whitening agents or salts thereof. In particular, the present invention relates to a stable pharmaceutical composition comprising skin whitening agents or salts thereof along with other pharmaceutically acceptable excipients which possess substantially improved skin whitening effects and also exhibits greater skin permeability. The invention also relates to processes for the preparation of such compositions.