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1.发明申请Methods and compositions for diagnosis and monitoring of atherosclerotic cardiovascular disease 审中-公开用于诊断和监测动脉粥样硬化性心血管疾病的方法和组成公开(公告)号：US20070099239A1
公开(公告)日：2007-05-03
申请号：US11473826
申请日：2006-06-23
申请人： Raymond Tabibiazar , Philip Tsao , Thomas Quertermous , Brit Turnbull , Richard Olshen , Evangelos Hytopoulos
发明人： Raymond Tabibiazar , Philip Tsao , Thomas Quertermous , Brit Turnbull , Richard Olshen , Evangelos Hytopoulos
CPC分类号： G01N33/6893 , G01N2800/60 , G16B40/00 , Y02A90/24 , Y02A90/26
摘要： The present invention identifies circulating proteins that are differentially expressed in atherosclerosis. Circulating levels of these proteins, particularly as a panel of proteins, can discriminate patients with acute myocardial infarction from those with stable exertional angina and from those with no history of atherosclerotic cardiovascular disease. Such levels can also predict cardiovascular events, determine the effectiveness of therapy, stage disease, and the like. For example, these markers are useful as surrogate biomarkers of clinical events needed for development of vascular specific pharmaceutical agents.
摘要翻译： 本发明鉴定在动脉粥样硬化中差异表达的循环蛋白质。 这些蛋白质的循环水平，特别是作为一组蛋白质，可以将急性心肌梗死患者与具有稳定的劳力性心绞痛的患者以及没有动脉粥样硬化性心血管疾病史的患者区分开来。 这些水平也可以预测心血管事件，确定治疗的有效性，疾病阶段等。 例如，这些标记物可用作开发血管特异性药剂所需的临床事件的替代生物标志物。
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2.发明申请TWO BIOMARKERS FOR DIAGNOSIS AND MONITORING OF ATHEROSCLEROTIC CARDIOVASCULAR DISEASE 审中-公开两个生物标记物用于诊断和监测甲状旁腺性心脏病公开(公告)号：US20080300797A1
公开(公告)日：2008-12-04
申请号：US11963673
申请日：2007-12-21
IPC分类号： G01N33/48
摘要： The present invention identifies two circulating proteins that have been newly identified as being differentially expressed in atherosclerosis. Circulating levels of these two proteins, particularly as a panel of proteins, can discriminate patients with acute myocardial infarction from those with stable exertional angina and from those with no history of atherosclerotic cardiovascular disease. Such levels can also predict cardiovascular events, determine the effectiveness of therapy, stage disease, and the like. For example, these markers are useful as surrogate biomarkers of clinical events needed for development of vascular specific pharmaceutical agents.
摘要翻译： 本发明鉴定了新鉴定为在动脉粥样硬化中差异表达的两种循环蛋白。 这两种蛋白质的循环水平，特别是作为一组蛋白质，可以将患有急性心肌梗死的患者与具有稳定的劳力性心绞痛的患者以及没有动脉粥样硬化性心血管疾病史的患者区分开来。 这些水平也可以预测心血管事件，确定治疗的有效性，疾病阶段等。 例如，这些标记物可用作开发血管特异性药剂所需的临床事件的替代生物标志物。
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3.发明申请公开(公告)号：US20090304769A1
公开(公告)日：2009-12-10
申请号：US12302756
申请日：2007-06-04
IPC分类号： A61F2/06 , A61K31/519 , A61K31/47 , A61K31/122 , A61K31/44 , A61K31/496 , A61K31/135 , A61K31/085 , A61P9/00
CPC分类号： C12Q1/02 , A61K31/13 , A61K31/135 , A61K31/4706 , A61K31/496 , A61K31/517 , A61K31/519 , A61K31/565 , A61K45/06 , A61L31/16 , G01N33/5061 , G01N33/5064 , G01N2800/323
摘要： Agents that inhibit or prevent restenosis are identified by assaying test agents in a battery of assays to measure the effect of the test agent on cell proliferation, thrombosis, tissue modeling, and inflammation. Treatment for restenosis is provided using compositions of the invention.
摘要翻译： 通过在一组测定中测定测试剂来测定抑制或预防再狭窄的药剂，以测量测试剂对细胞增殖，血栓形成，组织造型和炎症的影响。 使用本发明的组合物提供再狭窄的治疗。
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4.发明授权Methods for identifying agents and their use for the prevention of restenosis 有权识别药剂的方法及其用于预防再狭窄的用途公开(公告)号：US08697387B2
公开(公告)日：2014-04-15
申请号：US12302756
申请日：2007-06-04
CPC分类号： C12Q1/02 , A61K31/13 , A61K31/135 , A61K31/4706 , A61K31/496 , A61K31/517 , A61K31/519 , A61K31/565 , A61K45/06 , A61L31/16 , G01N33/5061 , G01N33/5064 , G01N2800/323
摘要： Agents that inhibit or prevent restenosis are identified by assaying test agents in a battery of assays to measure the effect of the test agent on cell proliferation, thrombosis, tissue modeling, and inflammation. Treatment for restenosis is provided using compositions of the invention.
摘要翻译： 通过在一组测定中测定测试剂来测定抑制或预防再狭窄的药剂，以测量测试剂对细胞增殖，血栓形成，组织造型和炎症的影响。 使用本发明的组合物提供再狭窄的治疗。
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5.发明申请BIOMARKER ASSAY FOR DIAGNOSIS AND CLASSIFICATION OF CARDIOVASCULAR DISEASE 审中-公开用于诊断和分类心血管疾病的生物标记物测定公开(公告)号：US20110144914A1
公开(公告)日：2011-06-16
申请号：US12964719
申请日：2010-12-09
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , C12Q2600/178 , G01N33/6893 , G01N2570/00 , G01N2800/32 , G01N2800/50 , G01N2800/60 , G16B20/00 , G16B40/00 , G16H50/20
摘要： The disclosed methods, assays and kits identify biomarkers, particularly miRNA and/or protein biomarkers, for assessing the cardiovascular health of a human. In certain embodiments, methods, assays and kits, circulating miRNA and/or protein biomarkers are identified for assessing the cardiovascular health of a human.
摘要翻译： 所公开的方法，测定和试剂盒鉴定用于评估人的心血管健康的生物标志物，特别是miRNA和/或蛋白质生物标志物。 在某些实施方案中，鉴定了用于评估人的心血管健康的方法，测定和试剂盒，循环的miRNA和/或蛋白质生物标志物。
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公开(公告)号：US20070135997A1
公开(公告)日：2007-06-14
申请号：US10553818
申请日：2004-04-23
申请人： Evangelos Hytopoulos
发明人： Evangelos Hytopoulos
CPC分类号： G01N33/5041 , G01N33/5023 , G16B5/00 , G16B20/00 , G16B25/00 , G16B40/00
摘要： Methods are provided for evaluating biological dataset profiles, where datasets comprising information for multiple cellular parameters are compared and identified. A typical dataset comprises readouts from multiple cellular parameters resulting from exposure of cells to biological factors in the absence or presence of a candidate agent. For analysis of multiple context-defined systems, the output data from multiple systems may be concatenated.
摘要翻译： 提供了用于评估生物数据集简档的方法，其中比较和识别包括多个细胞参数的信息的数据集。 典型的数据集包括在不存在或存在候选试剂的情况下将细胞暴露于生物因子引起的多种细胞参数的读数。 对于多个上下文定义的系统的分析，来自多个系统的输出数据可以被级联。
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