公开(公告)号：US20120203530A1

公开(公告)日：2012-08-09

申请号：US13366677

申请日：2012-02-06

申请人： Puneet Sharma ,  Tommaso Mansi ,  Viorel Mihalef ,  Jingdan Zhang ,  David Liu ,  Shaohua Kevin Zhou ,  Bogdan Georgescu ,  Dorin Comaniciu

发明人： Puneet Sharma ,  Tommaso Mansi ,  Viorel Mihalef ,  Jingdan Zhang ,  David Liu ,  Shaohua Kevin Zhou ,  Bogdan Georgescu ,  Dorin Comaniciu

IPC分类号： G06G7/60

CPC分类号： G06F19/3437 ,  G06F19/00 ,  G16H50/50

摘要： A method and system for patient-specific computational modeling and simulation for coupled hemodynamic analysis of cerebral vessels is disclosed. An anatomical model of a cerebral vessel is extracted from 3D medical image data. The anatomical model of the cerebral vessel includes an inner wall and an outer wall of the cerebral vessel. Blood flow in the cerebral vessel and deformation of the cerebral vessel wall are simulated using coupled computational fluid dynamics (CFD) and computational solid mechanics (CSM) simulations based on the anatomical model of the cerebral vessel.

摘要翻译： 公开了一种用于脑血管耦合血流动力学分析的患者特异性计算建模和模拟方法和系统。 从3D医学图像数据中提取脑血管的解剖模型。 脑血管的解剖模型包括脑血管的内壁和外壁。 基于脑血管解剖模型，使用耦合计算流体动力学（CFD）和计算固体力学（CSM）模拟模拟脑血管中的血流和脑血管壁的变形。

公开(公告)号：US09141763B2

公开(公告)日：2015-09-22

申请号：US13366677

申请日：2012-02-06

申请人： Puneet Sharma ,  Tommaso Mansi ,  Viorel Mihalef ,  Jingdan Zhang ,  David Liu ,  Shaohua Kevin Zhou ,  Bogdan Georgescu ,  Dorin Comaniciu

发明人： Puneet Sharma ,  Tommaso Mansi ,  Viorel Mihalef ,  Jingdan Zhang ,  David Liu ,  Shaohua Kevin Zhou ,  Bogdan Georgescu ,  Dorin Comaniciu

IPC分类号： G06G7/48 ,  G06G7/50 ,  G06F19/00

CPC分类号： G06F19/3437 ,  G06F19/00 ,  G16H50/50

摘要： A method and system for patient-specific computational modeling and simulation for coupled hemodynamic analysis of cerebral vessels is disclosed. An anatomical model of a cerebral vessel is extracted from 3D medical image data. The anatomical model of the cerebral vessel includes an inner wall and an outer wall of the cerebral vessel. Blood flow in the cerebral vessel and deformation of the cerebral vessel wall are simulated using coupled computational fluid dynamics (CFD) and computational solid mechanics (CSM) simulations based on the anatomical model of the cerebral vessel.

摘要翻译： 公开了一种用于脑血管耦合血流动力学分析的患者特异性计算建模和模拟方法及系统。 从3D医学图像数据中提取脑血管的解剖模型。 脑血管的解剖模型包括脑血管的内壁和外壁。 基于脑血管解剖模型，使用耦合计算流体动力学（CFD）和计算固体力学（CSM）模拟模拟脑血管中的血流和脑血管壁的变形。

公开(公告)号：US08682626B2

公开(公告)日：2014-03-25

申请号：US13091076

申请日：2011-04-20

申请人： Razvan Ioan Ionasec ,  Ingmar Voigt ,  Viorel Mihalef ,  Sasa Grbic ,  Dime Vitanovski ,  Yang Wang ,  Yefeng Zheng ,  Bogdan Georgescu ,  Dorin Comaniciu ,  Puneet Sharma ,  Tommaso Mansi

发明人： Razvan Ioan Ionasec ,  Ingmar Voigt ,  Viorel Mihalef ,  Sasa Grbic ,  Dime Vitanovski ,  Yang Wang ,  Yefeng Zheng ,  Bogdan Georgescu ,  Dorin Comaniciu ,  Puneet Sharma ,  Tommaso Mansi

IPC分类号： G06G7/48

CPC分类号： G06T13/20 ,  G06F19/321 ,  G06T2210/24 ,  G06T2210/41 ,  G16H50/50

摘要： A method and system for patient-specific modeling of the whole heart anatomy, dynamics, hemodynamics, and fluid structure interaction from 4D medical image data is disclosed. The anatomy and dynamics of the heart are determined by estimating patient-specific parameters of a physiological model of the heart from the 4D medical image data for a patient. The patient-specific anatomy and dynamics are used as input to a 3D Navier-Stokes solver that derives realistic hemodynamics, constrained by the local anatomy, along the entire heart cycle. Fluid structure interactions are determined iteratively over the heart cycle by simulating the blood flow at a given time step and calculating the deformation of the heart structure based on the simulated blood flow, such that the deformation of the heart structure is used in the simulation of the blood flow at the next time step. The comprehensive patient-specific model of the heart representing anatomy, dynamics, hemodynamics, and fluid structure interaction can be used for non-invasive assessment and diagnosis of the heart, as well as virtual therapy planning and cardiovascular disease management. Parameters of the comprehensive patient-specific model are changed or perturbed to simulate various conditions or treatment options, and then the patient specific model is recalculated to predict the effect of the conditions or treatment options.

摘要翻译： 公开了一种用于针对4D医学图像数据的整个心脏解剖结构，动力学，血流动力学和流体结构相互作用的患者特异性建模的方法和系统。 通过从患者的4D医学图像数据估计心脏的生理模型的患者特异性参数来确定心脏的解剖学和动力学。 患者特异性解剖学和动力学被用作3D Navier-Stokes求解器的输入，该解算器在整个心脏周期中导出由局部解剖结构约束的现实血液动力学。 流体结构相互作用是通过在给定的时间步长模拟血液流动而在心脏周期上迭代地确定的，并且基于模拟的血液流量计算心脏结构的变形，使得心脏结构的变形用于模拟 血液流动在下一个时间步。 代表解剖学，动力学，血液动力学和流体结构相互作用的心脏综合患者特异性模型可用于心脏的非侵入性评估和诊断，以及虚拟治疗计划和心血管疾病管理。 全面的患者特异性模型的参数被改变或扰动以模拟各种条件或治疗选择，然后重新计算患者特异性模型以预测条件或治疗选择的影响。

公开(公告)号：US09129053B2

公开(公告)日：2015-09-08

申请号：US13757517

申请日：2013-02-01

申请人： Tommaso Mansi ,  Viorel Mihalef ,  Xudong Zheng ,  Bogdan Georgescu ,  Saikiran Rapaka ,  Puneet Sharma ,  Ali Kamen ,  Dorin Comaniciu

发明人： Tommaso Mansi ,  Viorel Mihalef ,  Xudong Zheng ,  Bogdan Georgescu ,  Saikiran Rapaka ,  Puneet Sharma ,  Ali Kamen ,  Dorin Comaniciu

IPC分类号： G06F19/00 ,  G06T19/00

CPC分类号： G06F19/3437 ,  G06F19/00 ,  G06T19/00 ,  G06T2210/41 ,  G16H50/50

摘要： Method and system for computation of advanced heart measurements from medical images and data; and therapy planning using a patient-specific multi-physics fluid-solid heart model is disclosed. A patient-specific anatomical model of the left and right ventricles is generated from medical image patient data. A patient-specific computational heart model is generated based on the patient-specific anatomical model of the left and right ventricles and patient-specific clinical data. The computational model includes biomechanics, electrophysiology and hemodynamics. To generate the patient-specific computational heart model, initial patient-specific parameters of an electrophysiology model, initial patient-specific parameters of a biomechanics model, and initial patient-specific computational fluid dynamics (CFD) boundary conditions are marginally estimated. A coupled fluid-structure interaction (FSI) simulation is performed using the initial patient-specific parameters, and the initial patient-specific parameters are refined based on the coupled FSI simulation. The estimated model parameters then constitute new advanced measurements that can be used for decision making.

摘要翻译： 用于从医学图像和数据计算先进心脏测量的方法和系统; 并且公开了使用患者特定的多物理流体 - 固体心脏模型的治疗计划。 从医学图像患者数据生成左心室和右心室的患者特异性解剖模型。 基于左心室和右心室的患者特异性解剖模型和患者特异性临床数据生成患者特异性计算心脏模型。 计算模型包括生物力学，电生理学和血液动力学。 为了产生患者特异性计算心脏模型，电生理模型的初始患者特异性参数，生物力学模型的初始患者特异性参数和初始患者特异性计算流体动力学（CFD）边界条件被轻微估计。 使用初始患者特异性参数进行耦合的流体结构相互作用（FSI）模拟，并且基于耦合的FSI模拟来改进初始的患者特异性参数。 估计的模型参数然后构成可用于决策的新的高级测量。

公开(公告)号：US20130197884A1

公开(公告)日：2013-08-01

申请号：US13757517

申请日：2013-02-01

申请人： Tommaso Mansi ,  Viorel Mihalef ,  Xudong Zheng ,  Bogdan Georgescu ,  Saikiran Rapaka ,  Puneet Sharma ,  Ali Kamen ,  Dorin Comaniciu

发明人： Tommaso Mansi ,  Viorel Mihalef ,  Xudong Zheng ,  Bogdan Georgescu ,  Saikiran Rapaka ,  Puneet Sharma ,  Ali Kamen ,  Dorin Comaniciu

IPC分类号： G06F19/00

CPC分类号： G06F19/3437 ,  G06F19/00 ,  G06T19/00 ,  G06T2210/41 ,  G16H50/50

摘要： Method and system for computation of advanced heart measurements from medical images and data; and therapy planning using a patient-specific multi-physics fluid-solid heart model is disclosed. A patient-specific anatomical model of the left and right ventricles is generated from medical image patient data. A patient-specific computational heart model is generated based on the patient-specific anatomical model of the left and right ventricles and patient-specific clinical data. The computational model includes biomechanics, electrophysiology and hemodynamics. To generate the patient-specific computational heart model, initial patient-specific parameters of an electrophysiology model, initial patient-specific parameters of a biomechanics model, and initial patient-specific computational fluid dynamics (CFD) boundary conditions are marginally estimated. A coupled fluid-structure interaction (FSI) simulation is performed using the initial patient-specific parameters, and the initial patient-specific parameters are refined based on the coupled FSI simulation. The estimated model parameters then constitute new advanced measurements that can be used for decision making.

摘要翻译： 用于从医学图像和数据计算先进心脏测量的方法和系统; 并且公开了使用患者特定的多物理流体 - 固体心脏模型的治疗计划。 从医学图像患者数据生成左心室和右心室的患者特异性解剖模型。 基于左心室和右心室的患者特异性解剖模型和患者特异性临床数据生成患者特异性计算心脏模型。 计算模型包括生物力学，电生理学和血液动力学。 为了产生患者特异性计算心脏模型，电生理模型的初始患者特异性参数，生物力学模型的初始患者特异性参数和初始患者特异性计算流体动力学（CFD）边界条件被轻微估计。 使用初始患者特异性参数进行耦合的流体结构相互作用（FSI）模拟，并且基于耦合的FSI模拟来改进初始的患者特异性参数。 估计的模型参数然后构成可用于决策的新的高级测量。

公开(公告)号：US20120022843A1

公开(公告)日：2012-01-26

申请号：US13091076

申请日：2011-04-20

申请人： Razvan Ioan Ionasec ,  Ingmar Voigt ,  Viorel Mihalef ,  Sasa Grbic ,  Dime Vitanovski ,  Yang Wang ,  Yefeng Zheng ,  Bogdan Georgescu ,  Dorin Comaniciu ,  Puneet Sharma ,  Tommaso Mansi

发明人： Razvan Ioan Ionasec ,  Ingmar Voigt ,  Viorel Mihalef ,  Sasa Grbic ,  Dime Vitanovski ,  Yang Wang ,  Yefeng Zheng ,  Bogdan Georgescu ,  Dorin Comaniciu ,  Puneet Sharma ,  Tommaso Mansi

IPC分类号： G06G7/60 ,  G06G7/57

CPC分类号： G06T13/20 ,  G06F19/321 ,  G06T2210/24 ,  G06T2210/41 ,  G16H50/50

摘要： A method and system for patient-specific modeling of the whole heart anatomy, dynamics, hemodynamics, and fluid structure interaction from 4D medical image data is disclosed. The anatomy and dynamics of the heart are determined by estimating patient-specific parameters of a physiological model of the heart from the 4D medical image data for a patient. The patient-specific anatomy and dynamics are used as input to a 3D Navier-Stokes solver that derives realistic hemodynamics, constrained by the local anatomy, along the entire heart cycle. Fluid structure interactions are determined iteratively over the heart cycle by simulating the blood flow at a given time step and calculating the deformation of the heart structure based on the simulated blood flow, such that the deformation of the heart structure is used in the simulation of the blood flow at the next time step. The comprehensive patient-specific model of the heart representing anatomy, dynamics, hemodynamics, and fluid structure interaction can be used for non-invasive assessment and diagnosis of the heart, as well as virtual therapy planning and cardiovascular disease management. Parameters of the comprehensive patient-specific model are changed or perturbed to simulate various conditions or treatment options, and then the patient specific model is recalculated to predict the effect of the conditions or treatment options.

摘要翻译： 公开了一种用于针对4D医学图像数据的整个心脏解剖结构，动力学，血流动力学和流体结构相互作用的患者特异性建模的方法和系统。 通过从患者的4D医学图像数据估计心脏的生理模型的患者特异性参数来确定心脏的解剖学和动力学。 患者特异性解剖学和动力学被用作3D Navier-Stokes求解器的输入，该解算器在整个心脏周期中导出由局部解剖结构约束的现实血液动力学。 流体结构相互作用是通过在给定的时间步长模拟血液流动而在心脏周期上迭代地确定的，并且基于模拟的血液流量计算心脏结构的变形，使得心脏结构的变形用于模拟 血液流动在下一个时间步。 代表解剖学，动力学，血液动力学和流体结构相互作用的心脏综合患者特异性模型可用于心脏的非侵入性评估和诊断，以及虚拟治疗计划和心血管疾病管理。 全面的患者特异性模型的参数被改变或扰动以模拟各种条件或治疗选择，然后重新计算患者特异性模型以预测条件或治疗选择的影响。

公开(公告)号：US09462952B2

公开(公告)日：2016-10-11

申请号：US14455500

申请日：2014-08-08

申请人： Dorin Comaniciu ,  Bogdan Georgescu ,  Ali Kamen ,  Tommaso Mansi ,  Viorel Mihalef

发明人： Dorin Comaniciu ,  Bogdan Georgescu ,  Ali Kamen ,  Tommaso Mansi ,  Viorel Mihalef

IPC分类号： A61B5/02 ,  A61B5/026 ,  A61B8/04 ,  A61B5/00 ,  A61B8/08 ,  A61B6/03 ,  A61B6/00 ,  A61B5/029 ,  A61B5/021 ,  A61B8/06 ,  G06T7/00 ,  A61B5/055

CPC分类号： A61B5/02007 ,  A61B5/0037 ,  A61B5/0044 ,  A61B5/02125 ,  A61B5/0263 ,  A61B5/029 ,  A61B5/055 ,  A61B6/503 ,  A61B6/5217 ,  A61B8/065 ,  G06T7/0016 ,  G06T7/11 ,  G06T2207/30101 ,  G06T2207/30104

摘要： A method and system for estimating arterial compliance and resistance based on medical image data and pressure measurements is disclosed. An arterial inflow estimate over a plurality of time points is determined based on medical image data of a patient. An arterial pressure measurement of the patient is received. At least one cardiac cycle of the arterial pressure measurement is synchronized with at least one cardiac cycle of the arterial inflow measurement. Arterial compliance and resistance of the patient is estimated based on the arterial inflow estimate and the synchronized arterial pressure measurement.

摘要翻译： 公开了一种基于医学图像数据和压力测量来估计动脉顺应性和阻力的方法和系统。 基于患者的医学图像数据确定多个时间点的动脉流入估计。 接受患者的动脉压测量。 动脉压测量的至少一个心动周期与动脉流入测量的至少一个心动周期同步。 基于动脉血流量估计和同步动脉压测量来估计患者的动脉顺应性和抵抗力。

公开(公告)号：US20150045644A1

公开(公告)日：2015-02-12

申请号：US14455500

申请日：2014-08-08

申请人： Dorin Comaniciu ,  Bogdan Georgescu ,  Ali Kamen ,  Tommaso Mansi ,  Viorel Mihalef

发明人： Dorin Comaniciu ,  Bogdan Georgescu ,  Ali Kamen ,  Tommaso Mansi ,  Viorel Mihalef

IPC分类号： A61B5/02 ,  A61B5/026 ,  A61B8/04 ,  A61B5/00 ,  A61B8/08 ,  A61B6/03 ,  A61B6/00 ,  A61B5/029 ,  A61B5/021 ,  A61B8/06

CPC分类号： A61B5/02007 ,  A61B5/0037 ,  A61B5/0044 ,  A61B5/02125 ,  A61B5/0263 ,  A61B5/029 ,  A61B5/055 ,  A61B6/503 ,  A61B6/5217 ,  A61B8/065 ,  G06T7/0016 ,  G06T7/11 ,  G06T2207/30101 ,  G06T2207/30104

摘要： A method and system for estimating arterial compliance and resistance based on medical image data and pressure measurements is disclosed. An arterial inflow estimate over a plurality of time points is determined based on medical image data of a patient. An arterial pressure measurement of the patient is received. At least one cardiac cycle of the arterial pressure measurement is synchronized with at least one cardiac cycle of the arterial inflow measurement. Arterial compliance and resistance of the patient is estimated based on the arterial inflow estimate and the synchronized arterial pressure measurement.

摘要翻译： 公开了一种基于医学图像数据和压力测量来估计动脉顺应性和阻力的方法和系统。 基于患者的医学图像数据确定多个时间点的动脉流入估计。 接受患者的动脉压测量。 动脉压测量的至少一个心动周期与动脉流入测量的至少一个心动周期同步。 基于动脉血流量估计和同步动脉压测量来估计患者的动脉顺应性和抵抗力。

公开(公告)号：US09846765B2

公开(公告)日：2017-12-19

申请号：US14071688

申请日：2013-11-05

申请人： Chloe Audigier ,  Tommaso Mansi ,  Viorel Mihalef ,  Ali Kamen ,  Dorin Comaniciu ,  Puneet Sharma ,  Saikiran Rapaka ,  Herve Delingette ,  Nicholas Ayache

发明人： Chloe Audigier ,  Tommaso Mansi ,  Viorel Mihalef ,  Ali Kamen ,  Dorin Comaniciu ,  Puneet Sharma ,  Saikiran Rapaka ,  Herve Delingette ,  Nicholas Ayache

IPC分类号： G06F19/00 ,  G06F19/10 ,  G09B23/30

CPC分类号： G16H50/50 ,  G06F19/00 ,  G06F19/3481 ,  G09B23/30

摘要： A method and system for tumor ablation planning and guidance based on a patient-specific model of liver tumor ablation is disclosed. A patient-specific anatomical model of the liver and circulatory system of the liver is estimated from 3D medical image data of a patient. Blood flow in the liver and the circulatory system of the liver is simulated based on the patient-specific anatomical model. Heat diffusion due to ablation is simulated based on a virtual ablation probe position and the simulated blood flow in the liver and the venous system of the liver. Cellular necrosis in the liver is simulated based on the simulated heat diffusion. A visualization of a simulated necrosis region is generated and displayed to the user for decision making and optimal therapy planning and guidance.

公开(公告)号：US20140296842A1

公开(公告)日：2014-10-02

申请号：US13854991

申请日：2013-04-02

申请人： Tommaso Mansi ,  Puneet Sharma ,  Viorel Mihalef ,  Ali Kamen ,  Saikiran Rapaka ,  Dorin Comaniciu

发明人： Tommaso Mansi ,  Puneet Sharma ,  Viorel Mihalef ,  Ali Kamen ,  Saikiran Rapaka ,  Dorin Comaniciu

IPC分类号： A61B19/00 ,  G06F17/50 ,  A61B18/12

CPC分类号： A61B19/50 ,  A61B18/1233 ,  A61B34/10 ,  A61B2018/00577 ,  A61B2034/104 ,  A61B2034/105

摘要： Patient specific temperature distribution in organs, due to an ablative device, is simulated. The effects of ablation are modeled. The modeling is patient specific. The vessel structure for a given patient, segmented from medical images, is accounted for as a heat sink in the model of biological heat transfer. A temperature map is generated to show the effects of ablation in a pre-operative analysis. Temperature maps resulting from different ablation currents and ablation device positions may be used to determine a more optimal location of the ablative device for a given patient. Other models may be included, such as accounting for the tissue damage during the ablation.

摘要翻译： 模拟了器官中由于消融装置而导致的患者特异性温度分布。 模拟消融的效果。 建模是患者特异性的。 从医学图像分割的给定患者的血管结构在生物传热模型中被认为是散热器。 生成温度图以显示术前分析中消融的效果。 可以使用由不同烧蚀电流和消融装置位置产生的温度图来确定给定患者的烧蚀装置的更优选的位置。 可能包括其他模型，例如消融期间的组织损伤。