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7 条记录 (耗时 0.02 秒)

    Method for treating unstable angina pectoris
    5.
    发明授权
    Method for treating unstable angina pectoris 有权
    治疗不稳定性心绞痛的方法

    公开(公告)号：US07053049B2

    公开(公告)日：2006-05-30

    申请号：US10333212

    申请日：2001-07-20

    申请人： Thomas Luescher ,  Georg Noll ,  Peter Lerch

    发明人： Thomas Luescher ,  Georg Noll ,  Peter Lerch

    IPC分类号： A61K38/17

    CPC分类号： A61K38/1709

    摘要： The invention relates to the use of reconstituted HDL for improving the endothelial function in patients suffering from hypercholesterolaemia and for treating or preventing acute coronary diseases such as unstable angina pectoris.

    摘要翻译： 本发明涉及重建HDL用于改善患有高胆固醇血症的患者的内皮功能以及用于治疗或预防急性冠状动脉疾病如不稳定型心绞痛的用途。

    Method of producing reconstituted lipoproteins
    6.
    发明授权
    Method of producing reconstituted lipoproteins 失效
    生产重构脂蛋白的方法

    公开(公告)号：US5652339A

    公开(公告)日：1997-07-29

    申请号：US361132

    申请日：1994-12-21

    申请人： Peter Lerch ,  Gerhard Hodler ,  Vreni Fortsch

    发明人： Peter Lerch ,  Gerhard Hodler ,  Vreni Fortsch

    IPC分类号： A61K38/00 ,  A61K9/127 ,  A61P3/06 ,  C07K1/22 ,  C07K14/775 ,  C07K1/00 ,  C07K14/00

    CPC分类号： C07K14/775 ,  A61K9/1275

    摘要： Reconstituted high density lipoproteins (rHDL) are produced from apolipoproteins and lipids in that an aqueous apolipoprotein solution with a concentration of 1-40 g protein/l is mixed with an aqueous lipid-detergent solution without mandatory addition of organic solvents, the molar ratio of lipid to detergent being 1:0.5 to 1:4 and the weight ratio of lipid to detergent being 1:1.5 to 1:5, the resultant apolipoprotein-lipid-detergent mixture then being incubated at a temperature in the range of the phase change temperature of the lipid in water .+-.10.degree. C., and the detergent being at least partially removed.The rHDL are useful for various prophylactic and therapeutic treatments of diseases that have a connection with lipids and lipidoidal substances. This method is especially suitable for technical and industrial production.

    摘要翻译： 重组的高密度脂蛋白（rHDL）由载脂蛋白和脂质产生，因为浓度为1-40g蛋白/ l的载脂蛋白溶液溶液与水性脂质 - 洗涤剂溶液混合，而不必强制加入有机溶剂，摩尔比 脂类与洗涤剂的比例为1:0.5至1:4，脂质与洗涤剂的重量比为1:1.5至1:5，然后将所得载脂蛋白脂质洗涤剂混合物在相变温度范围内的温度 的脂质在水中+/- 10℃，并且洗涤剂被至少部分去除。 rHDL可用于与脂质和脂质物质有关联的疾病的各种预防和治疗性治疗。 这种方法特别适用于技术和工业生产。

    Method of producing an anti-D immunoglobulin concentrate and a pharmaceutical preparation
    7.
    发明授权
    Method of producing an anti-D immunoglobulin concentrate and a pharmaceutical preparation 失效
    制备抗D免疫球蛋白浓缩物和药物制剂的方法

    公开(公告)号：US5593675A

    公开(公告)日：1997-01-14

    申请号：US360334

    申请日：1994-12-21

    申请人： Gerhard Hodler ,  Peter Lerch ,  Martin Stucki

    发明人： Gerhard Hodler ,  Peter Lerch ,  Martin Stucki

    IPC分类号： A61K9/08 ,  A61K39/395 ,  A61K47/02 ,  A61K47/18 ,  A61K47/26 ,  C07K1/18 ,  C07K16/00 ,  C07K16/06 ,  C07K16/34 ,  C07K1/14 ,  C07K16/46

    CPC分类号： C07K16/065 ,  C07K16/34

    摘要： An anti-D immunoglobulin G-preparation is produced in high-yield from human plasma containing anti-D IgG, or a plasma fraction containing an anti-D IgG, in which (A) the plasma, or the plasma fraction, with a pH in the range of pH 3.5 to 6.5 and a conductivity value in the range of 2 to 4 mS/cm, is subjected to ion exchange chromatography with an adsorbent which has carboxymethyl groups as functional groups, the anti-D IgG being bound to the adsorbent, (B) the adsorbent with the bound anti-D IgG is first rinsed with a wash solution at a pH in the range of 5 to 8 and a conductivity value in the range of 2 to 4 mS/cm, and the anti-D IgG is subsequently eluted, and further (C) the eluted anti-D IgG at a pH in the range of 6 to 8 and a conductivity value in the range of 2 to 4 mS/cm is treated with an alkaline adsorbent with ion-exchange characteristics in order to bind undesired components, and finally, the anti-D IgG is concentrated. The non-infectious anti-D concentrate thus obtained possesses a high specific activity of more than 1% anti-D IgG per gram of total IgG.

    摘要翻译： 抗-D免疫球蛋白G制剂以含有抗-D IgG的人血浆的高产率或含有抗-DIgG的血浆级分产生，其中（A）血浆或血浆级分具有pH 在pH 3.5〜6.5的范围内，电导率值在2〜4mS / cm的范围内，用具有羧甲基作为官能团的吸附剂进行离子交换层析，抗D IgG与吸附剂结合 ，（B）具有结合的抗-D IgG的吸附剂首先用pH为5〜8，电导率值为2〜4mS / cm的洗涤溶液冲洗，反-D 随后洗脱IgG，并且进一步（C）在6至8范围内的pH值和2至4mS / cm 2范围内的电导率值下洗脱的抗-D IgG用离子交换的碱性吸附剂处理 特性以便结合不合需要的组分，最后浓缩抗D IgG。 由此获得的非感染性抗-D浓缩物具有高于每克总IgG超过1％抗-D IgG的比活性。