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    TRANSDERMAL THERAPEUTIC SYSTEM HAVING STABILIZED MEMBRANE
    3.
    发明申请
    TRANSDERMAL THERAPEUTIC SYSTEM HAVING STABILIZED MEMBRANE 有权
    具有稳定性膜的透皮治疗系统

    公开(公告)号：US20120245537A1

    公开(公告)日：2012-09-27

    申请号：US12921988

    申请日：2009-02-28

    申请人： Michael Horstmann ,  Patrick Mohr ,  Mohammad Sameti

    发明人： Michael Horstmann ,  Patrick Mohr ,  Mohammad Sameti

    IPC分类号： A61M35/00 ,  B05D1/36

    CPC分类号： A61K9/7084 ,  A61K9/0014

    摘要： The invention relates to a transdermal therapeutic system made of the following layers: a carrier layer (T), an active ingredient layer (R), a membrane layer (M) and optionally an adhesive layer (K), wherein the carrier layer (T) is impenetrable to the active substance and to water, the active substance layer (R) comprises as an active substance component the salt of an alkali reactive active substance, such as a CNS-active amine in combination with at least one alkali reactive further component, and a polymer component (P1), wherein the active substance is released from the active substance layer (R) only by the moisture entering from the exterior through the membrane layer (M), and the membrane layer (M) is made of a polymer component (P2), allowing a uniform delivery of basic active substances to the skin.

    摘要翻译： 本发明涉及由以下层构成的透皮治疗系统：载体层（T），活性成分层（R），膜层（M）和任选的粘合剂层（K），其中载体层 ）对于活性物质和水是不可穿透的，活性物质层（R）包含作为活性成分的碱反应性活性物质的盐，例如CNS-活性胺与至少一种碱反应性进一步组分 和聚合物组分（P1），其中活性物质仅通过从外部通过膜层（M）进入的水分从活性物质层（R）释放，并且膜层（M）由 聚合物组分（P2），允许将基本活性物质均匀地递送至皮肤。

    Transdermal therapeutic system having stabilized membrane
    5.
    发明授权
    Transdermal therapeutic system having stabilized membrane 有权
    透皮治疗系统具有稳定的膜

    公开(公告)号：US08882729B2

    公开(公告)日：2014-11-11

    申请号：US12921988

    申请日：2009-02-28

    申请人： Michael Horstmann ,  Patrick Mohr ,  Mohammad Sameti

    发明人： Michael Horstmann ,  Patrick Mohr ,  Mohammad Sameti

    IPC分类号： A61M35/00 ,  A61K9/00 ,  A61K9/70

    CPC分类号： A61K9/7084 ,  A61K9/0014

    摘要： The invention relates to a transdermal therapeutic system made of the following layers: a carrier layer (T), an active ingredient layer (R), a membrane layer (M) and optionally an adhesive layer (K), wherein the carrier layer (T) is impenetrable to the active substance and to water, the active substance layer (R) comprises as an active substance component the salt of an alkali reactive active substance, such as a CNS-active amine in combination with at least one alkali reactive further component, and a polymer component (P1), wherein the active substance is released from the active substance layer (R) only by the moisture entering from the exterior through the membrane layer (M), and the membrane layer (M) is made of a polymer component (P2), allowing a uniform delivery of basic active substances to the skin.

    摘要翻译： 本发明涉及由以下层构成的透皮治疗系统：载体层（T），活性成分层（R），膜层（M）和任选的粘合剂层（K），其中载体层 ）对于活性物质和水是不可穿透的，活性物质层（R）包含作为活性成分的碱反应性活性物质的盐，例如CNS-活性胺与至少一种碱反应性进一步组分 和聚合物组分（P1），其中活性物质仅通过从外部通过膜层（M）进入的水分从活性物质层（R）释放，并且膜层（M）由 聚合物组分（P2），允许将基本活性物质均匀地递送至皮肤。

    Transdermal Therapeutic System for the Administration of Peptides
    8.
    发明申请
    Transdermal Therapeutic System for the Administration of Peptides 审中-公开
    经皮给药治疗系统

    公开(公告)号：US20120245538A1

    公开(公告)日：2012-09-27

    申请号：US13512403

    申请日：2010-12-02

    申请人： Michael Horstmann ,  Horst Dzekan ,  Sandra Wiedersberg

    发明人： Michael Horstmann ,  Horst Dzekan ,  Sandra Wiedersberg

    IPC分类号： A61M35/00 ,  B32B37/12

    摘要： The invention relates to a transdermal therapeutic system (TTS) which is suited for the administration of a peptide to a patient through skin treated with ablation. The transdermal therapeutic system incorporates a back layer and an active substance-containing layer that includes at least one peptide and a carrier substance.

    摘要翻译： 本发明涉及一种透皮治疗系统（TTS），其适于通过用消融治疗的皮肤向患者施用肽。 透皮治疗系统包含背层和含有至少一种肽和载体物质的含活性物质的层。

    Pharmaceutical preparation adhering to the skin, in particular a transdermal therapeutic system for the release of 17-&bgr;-estradiol to the human organism
    10.
    发明授权
    Pharmaceutical preparation adhering to the skin, in particular a transdermal therapeutic system for the release of 17-&bgr;-estradiol to the human organism 失效
    粘附于皮肤的药物制剂，特别是用于将17-β-雌二醇释放至人体的透皮治疗系统

    公开(公告)号：US06623763B2

    公开(公告)日：2003-09-23

    申请号：US09885132

    申请日：2001-06-19

    申请人： Bodo Asmussen ,  Michael Horstmann

    发明人： Bodo Asmussen ,  Michael Horstmann

    IPC分类号： A61F1302

    CPC分类号： A61K9/7053 ,  A61K9/7061 ,  A61K9/7069 ,  A61K31/565

    摘要： A pharmaceutical preparation adhering to the skin, in particular a transdermal therapeutic system, for the release of the active substance 17-&bgr;-estradiol, contained therein in dissolved form being between its saturation concentration in equilibrium with a gas phase of less than 10% relative air humidity and its saturation concentration in equilibrium with a gas phase of more than 90% relative air humidity, in all matrix levels and, if present, also in an adhesive layer, characterized in that the estradiol quantity contained in in the preparation amounts to at least three times the saturation solubility measured at 95% relative air humidity, and that the air enclosed in the package is adjusted to a relative air humidity between 5% and below 0.5%.

    摘要翻译： 粘附于皮肤的药物制剂，特别是透皮治疗系统，用于释放其中溶解形式的活性物质17-β-雌二醇，其平衡中的饱和浓度与小于10％相对的气相 空气湿度及其饱和浓度与所有基质水平中超过90％相对空气湿度的气相平衡，并且如果存在，也在粘合剂层中，其特征在于，制剂中所含的雌二醇量等于 在95％相对空气湿度下测量的饱和溶解度至少为三倍，并且将封装在包装中的空气调节至5％至0.5％以下的相对空气湿度。