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公开(公告)号：US20160311890A1
公开(公告)日：2016-10-27
申请号：US15208924
申请日：2016-07-13
CPC分类号： C07K16/1009 , C07K14/70503 , C12N2740/16011 , G01N33/56988 , G01N33/576 , G01N33/6863 , G01N33/6866 , G01N2333/525 , G01N2333/57 , G01N2800/52 , G01N2800/56
摘要： The application relates to methods of treating chronic viral infection by modulating Tim-3 activity. In addition, the present application relates to methods of diagnosing or monitoring immune system activity or function, chronic viral infection and inflammatory disease using Tim-3 expression.
摘要翻译： 本申请涉及通过调节Tim-3活性来治疗慢性病毒感染的方法。 此外，本申请涉及使用Tim-3表达来诊断或监测免疫系统活性或功能，慢性病毒感染和炎性疾病的方法。
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2.发明授权Methods of inhibiting viral replication and improving T cell function employing soluble Tim-3 inhibitors 有权使用可溶性Tim-3抑制剂抑制病毒复制和改善T细胞功能的方法公开(公告)号：US09416165B2
公开(公告)日：2016-08-16
申请号：US12739639
申请日：2008-10-27
IPC分类号： C07K14/705 , G01N33/569 , G01N33/576
CPC分类号： C07K16/1009 , C07K14/70503 , C12N2740/16011 , G01N33/56988 , G01N33/576 , G01N33/6863 , G01N33/6866 , G01N2333/525 , G01N2333/57 , G01N2800/52 , G01N2800/56
摘要： The application relates to methods of treating a chronic viral infection, such as HIV (Human Immunodeficiency Virus), by modulating Tim-3 activity, whereby blocking the action of Tim-3 on a T cell enhances the immunity to the virus.
摘要翻译： 本申请涉及通过调节Tim-3活性来治疗慢性病毒感染（例如HIV（人类免疫缺陷病毒））的方法，由此阻断Tim-3对T细胞的作用增强了对病毒的免疫力。
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公开(公告)号：US20100247521A1
公开(公告)日：2010-09-30
申请号：US12739639
申请日：2008-10-27
IPC分类号： A61K39/395 , A61K39/21 , A61P37/04 , C12Q1/02
CPC分类号： C07K16/1009 , C07K14/70503 , C12N2740/16011 , G01N33/56988 , G01N33/576 , G01N33/6863 , G01N33/6866 , G01N2333/525 , G01N2333/57 , G01N2800/52 , G01N2800/56
摘要： The application relates to methods of treating chronic viral infection by modulating Tim-3 activity. In addition, the present application relates to methods of diagnosing or monitoring immune system activity or function, chronic viral infection and inflammatory disease using Tim-3 expression.
摘要翻译： 本申请涉及通过调节Tim-3活性来治疗慢性病毒感染的方法。 此外，本申请涉及使用Tim-3表达来诊断或监测免疫系统活性或功能，慢性病毒感染和炎性疾病的方法。
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公开(公告)号：US11261231B2
公开(公告)日：2022-03-01
申请号：US15208924
申请日：2016-07-13
IPC分类号： C07K14/705 , C07K16/28 , G01N33/68 , G01N33/569 , G01N33/576 , C07K16/10
摘要： The application relates to methods of treating chronic viral infection by modulating Tim-3 activity. In addition, the present application relates to methods of diagnosing or monitoring immune system activity or function, chronic viral infection and inflammatory disease using Tim-3 expression.
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公开(公告)号：US20050142574A1
公开(公告)日：2005-06-30
申请号：US10866526
申请日：2004-06-10
申请人： Steve Bryson , Dale Cumming , Alessandro Datti , James Rini , Sawako Takeshita , Roderick Tse , April Lew
发明人： Steve Bryson , Dale Cumming , Alessandro Datti , James Rini , Sawako Takeshita , Roderick Tse , April Lew
CPC分类号： C12N9/1051
摘要： This invention provides novel mutant Core 2 GlcNAcT nucleic acids, polypeptides encoded by the nucleic acids, and uses of the nucleic acids and polypeptides
摘要翻译： 本发明提供新的突变核心2 GlcNAcT核酸，由核酸编码的多肽，以及核酸和多肽的用途
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