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1.发明授权Methods of inhibiting viral replication and improving T cell function employing soluble Tim-3 inhibitors 有权使用可溶性Tim-3抑制剂抑制病毒复制和改善T细胞功能的方法公开(公告)号：US09416165B2
公开(公告)日：2016-08-16
申请号：US12739639
申请日：2008-10-27
IPC分类号： C07K14/705 , G01N33/569 , G01N33/576
CPC分类号： C07K16/1009 , C07K14/70503 , C12N2740/16011 , G01N33/56988 , G01N33/576 , G01N33/6863 , G01N33/6866 , G01N2333/525 , G01N2333/57 , G01N2800/52 , G01N2800/56
摘要： The application relates to methods of treating a chronic viral infection, such as HIV (Human Immunodeficiency Virus), by modulating Tim-3 activity, whereby blocking the action of Tim-3 on a T cell enhances the immunity to the virus.
摘要翻译： 本申请涉及通过调节Tim-3活性来治疗慢性病毒感染（例如HIV（人类免疫缺陷病毒））的方法，由此阻断Tim-3对T细胞的作用增强了对病毒的免疫力。
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公开(公告)号：US20100247521A1
公开(公告)日：2010-09-30
申请号：US12739639
申请日：2008-10-27
IPC分类号： A61K39/395 , A61K39/21 , A61P37/04 , C12Q1/02
CPC分类号： C07K16/1009 , C07K14/70503 , C12N2740/16011 , G01N33/56988 , G01N33/576 , G01N33/6863 , G01N33/6866 , G01N2333/525 , G01N2333/57 , G01N2800/52 , G01N2800/56
摘要： The application relates to methods of treating chronic viral infection by modulating Tim-3 activity. In addition, the present application relates to methods of diagnosing or monitoring immune system activity or function, chronic viral infection and inflammatory disease using Tim-3 expression.
摘要翻译： 本申请涉及通过调节Tim-3活性来治疗慢性病毒感染的方法。 此外，本申请涉及使用Tim-3表达来诊断或监测免疫系统活性或功能，慢性病毒感染和炎性疾病的方法。
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公开(公告)号：US20160311890A1
公开(公告)日：2016-10-27
申请号：US15208924
申请日：2016-07-13
CPC分类号： C07K16/1009 , C07K14/70503 , C12N2740/16011 , G01N33/56988 , G01N33/576 , G01N33/6863 , G01N33/6866 , G01N2333/525 , G01N2333/57 , G01N2800/52 , G01N2800/56
摘要： The application relates to methods of treating chronic viral infection by modulating Tim-3 activity. In addition, the present application relates to methods of diagnosing or monitoring immune system activity or function, chronic viral infection and inflammatory disease using Tim-3 expression.
摘要翻译： 本申请涉及通过调节Tim-3活性来治疗慢性病毒感染的方法。 此外，本申请涉及使用Tim-3表达来诊断或监测免疫系统活性或功能，慢性病毒感染和炎性疾病的方法。
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公开(公告)号：US08417480B2
公开(公告)日：2013-04-09
申请号：US13195988
申请日：2011-08-02
IPC分类号： G06F17/18
CPC分类号： G06Q10/0633 , G06Q10/06 , G06Q10/06393 , Y02P90/82 , Y02P90/84
摘要： A system and method is provided for determining the variability induced on a process output. The method includes the analysis of input variable values to determine the total variability. A series of processes may be analyzed and ranked so that a process owner may gain an understanding of how a target process performs relative to the processes of other process owners. The method includes the generation of graphical process comparisons and advice regarding asset performance. The method also includes the estimation of cost impacts due to changes in induced variability.
摘要翻译： 提供了一种用于确定在过程输出上引起的可变性的系统和方法。 该方法包括输入变量值的分析以确定总变异性。 可以分析和排列一系列过程，以便流程所有者可以了解目标进程如何相对于其他进程所有者的进程执行。 该方法包括生成关于资产绩效的图形过程比较和建议。 该方法还包括由诱发变异性变化引起的成本影响的估计。
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公开(公告)号：US20120278110A1
公开(公告)日：2012-11-01
申请号：US13458456
申请日：2012-04-27
IPC分类号： G06Q40/08
摘要： In the present invention, an insurance product, rating system and method generally relates to a rating and pricing system for quantifying the risk that the annual savings will not fall below specified levels associated with implementing and maintaining economic improvements. The product, system and method can be applied to various industries, including, power generation, petro-chemical, manufacturing and refining facilities. Various embodiments disclosed herein relate to systems and methods for determining optimal risk acceptance values associated with implementing an economic improvement plan for a facility.
摘要翻译： 在本发明中，保险产品，评级系统和方法通常涉及用于量化每年节省不会低于与实施和维持经济改进相关的指定水平的风险的评级和定价系统。 产品，系统和方法可应用于发电，石油化工，制造和炼油设备等行业。 本文公开的各种实施例涉及用于确定与实施设施的经济改进计划相关联的最佳风险接受值的系统和方法。
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公开(公告)号：US07991577B2
公开(公告)日：2011-08-02
申请号：US11933128
申请日：2007-10-31
IPC分类号： G06F17/18
CPC分类号： G06Q10/0633 , G06Q10/06 , G06Q10/06393 , Y02P90/82 , Y02P90/84
摘要： A system and method is provided for determining the variability induced on a process output. The method includes the analysis of input variable values to determine the total variability. A series of processes may be analyzed and ranked so that a process owner may gain an understanding of how a target process performs relative to the processes of other process owners. The method includes the generation of graphical process comparisons and advice regarding asset performance. The method also includes the estimation of cost impacts due to changes in induced variability.
摘要翻译： 提供了一种用于确定在过程输出上引起的可变性的系统和方法。 该方法包括输入变量值的分析以确定总变异性。 可以分析和排列一系列过程，以便流程所有者可以了解目标进程如何相对于其他进程所有者的进程执行。 该方法包括生成关于资产绩效的图形过程比较和建议。 该方法还包括由诱发变异性变化引起的成本影响的估计。
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公开(公告)号：US20070265804A1
公开(公告)日：2007-11-15
申请号：US11801221
申请日：2007-05-09
CPC分类号： G06Q10/06 , G06Q10/063 , G06Q10/0639 , G06Q50/06 , H02J3/00 , Y04S10/54
摘要： A system and method is described herein that includes a software-based functionality to assess the relationship between reliability, operational, maintenance and plant betterment activities and to determine the frontier of efficient spending and other measures of performance to achieve a level of reliability that is based on data from units of similar design and performance.
摘要翻译： 本文描述了一种系统和方法，其包括基于软件的功能，以评估可靠性，操作，维护和工厂改进活动之间的关系，并确定有效支出的前沿和其他性能测量，以达到基于的可靠性水平 来自相似设计和性能单位的数据。
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公开(公告)号：US4793043A
公开(公告)日：1988-12-27
申请号：US70386
申请日：1987-07-07
申请人： Will W. Mathews , Richard B. Jones
发明人： Will W. Mathews , Richard B. Jones
CPC分类号： B23P6/00 , F02M59/48 , F02B3/06 , Y10T29/49238 , Y10T29/49726 , Y10T29/49746
摘要： A method of rebuilding fuel injection pumps which have become inoperative due to excessive wear or other damage. Damaged surfaces of parts of the fuel distribution assembly, e.g., head and rotor assemblies used in rotary distributor type diesel fuel injection pumps, as well as plunger and barrel assemblies of inline diesel injection distributor pumps, are restored by a method involving disassembling of the distributor assemblies, inspecting and categorizing of damaged surface areas, machining of the parts to return them to their proper degree of roundness and surface finish with selected areas of the rotor or plunger being plated with a hard material such as chrome.
摘要翻译： 一种重建燃油喷射泵的方法，由于过度的磨损或其他损坏而使其不起作用。 燃料分配组件的部件的损坏的表面，例如用于旋转分配器型柴油喷射泵中的头部和转子组件，以及在线柴油喷射分配器泵的柱塞和筒组件，通过一种方法来恢复，该方法包括拆卸分配器 组件，检查和分类损坏的表面区域，加工零件以使其恢复到适当的圆度和表面光洁度，转子或柱塞的选定区域镀有诸如铬的硬质材料。
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公开(公告)号：US4362573A
公开(公告)日：1982-12-07
申请号：US172974
申请日：1980-07-28
CPC分类号： C23G5/0288 , C07C17/42
摘要： A solvent composition comprising 1,1,1-trichloroethane and a stabilizing amount of an epoxide of formula ##STR1## wherein R.sub.1 and R.sub.2 are hydrogen, alkyl of 1 to 4 carbon atoms, phenyl or benzyl,R.sub.3 is hydrogen or alkyl of 1 to 4 carbon atoms,R.sub.4 is alkyl of 1 to 4 carbon atomsand n is 0 or 1.Preferably the or each alkyl group contains 1 or 2 carbon atoms; examples of useful epoxides are ethyl trans-2,3-epoxybutyrate, ethyl 3,4-epoxy-3-methylvalerate and ethyl beta-methyl-beta-phenylglycidate.
摘要翻译： 包含1,1,1-三氯乙烷和稳定量的式（I）的环氧化物的溶剂组合物，其中R 1和R 2是氢，1至4个碳原子的烷基，苯基或苄基，R 3是氢或1至 4个碳原子，R4是1至4个碳原子的烷基，n是0或1.优选地，每个烷基含有1或2个碳原子; 有用的环氧化物的实例是反式-2,3-环氧丁酸乙酯，3,4-环氧-3-甲基戊酸乙酯和β-甲基-β-苯基缩水甘油乙酯。
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公开(公告)号：US4187767A
公开(公告)日：1980-02-12
申请号：US833497
申请日：1977-09-15
摘要： A cylinder head and liner assembly for use in a diesel engine wherein the inner end of the cylinder liner is accurately and positively adjusted within the bore in the diesel engine block for maximum efficiency in alignment of the liner relative to the piston reciprocating therein, the adjustment being accomplished through a series of manually movable adjustable wedges that are circumferentially spaced around the liner and provide inclined surfaces cooperating with the liner exterior surface and the internal surface of the bore in the crankcase.
摘要翻译： 一种用于柴油发动机的气缸盖和衬套组件，其中气缸套的内端在柴油发动机缸体的孔内被精确和积极地调节，以使衬套相对于在其中往复运动的活塞对准地获得最大的效率， 通过一系列手动可移动的可调楔形件实现，该楔形件围绕衬套周向隔开并提供与衬套外表面和曲轴箱内孔表面配合的倾斜表面。
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