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    Method for removing phosphate from aqueous solutions
    1.
    发明申请
    Method for removing phosphate from aqueous solutions 审中-公开
    从水溶液中除去磷酸盐的方法

    公开(公告)号：US20080262285A1

    公开(公告)日：2008-10-23

    申请号：US12148627

    申请日：2008-04-21

    申请人： Richard Black ,  Lyn Hughes ,  Jose Antonio Trejo

    发明人： Richard Black ,  Lyn Hughes ,  Jose Antonio Trejo

    IPC分类号： A62D3/36

    CPC分类号： B01J41/04 ,  B01J45/00 ,  B01J47/016 ,  C02F1/42 ,  C02F2101/105

    摘要： A method for removing phosphate ion from an aqueous solution containing phosphate ion using a resin loaded with a hydrous oxide of an amphoteric metal ion. The resin loaded with a hydrous oxide of an amphoteric metal ion is produced by combining a resin with at least two bed volumes of an aqueous solution containing a salt of the amphoteric metal ion, and having a metal ion concentration of at least 5%, and then treating with an aqueous alkali metal hydroxide solution.

    摘要翻译： 使用负载有两性金属离子的含水氧化物的树脂从含有磷酸根离子的水溶液中除去磷酸根离子的方法。 负载两性金属离子的水合氧化物的树脂通过将树脂与至少两床体积的含有两性金属离子的盐并且具有至少5％的金属离子浓度的水溶液组合而制备，以及 然后用碱金属氢氧化物水溶液处理。

    Delivery device for dispensing pharmaceutical dosage forms into dissolution testing apparatus
    2.
    发明授权
    Delivery device for dispensing pharmaceutical dosage forms into dissolution testing apparatus 有权
    用于将药物剂型分配到溶出测试装置中的输送装置

    公开(公告)号：US08584539B2

    公开(公告)日：2013-11-19

    申请号：US13167812

    申请日：2011-06-24

    申请人： Daryl E Wright ,  Lyn Hughes ,  Donald F Wright

    发明人： Daryl E Wright ,  Lyn Hughes ,  Donald F Wright

    IPC分类号： G01N33/15

    CPC分类号： G01N33/15 ,  G01N2013/006

    摘要： The present invention provides a dissolution test cell having a chamber and slide valve for dispensing pharmaceutical dosage forms, such as tablets, capsules, and powders, into the chamber without having to open the cell and expose the chamber and its contents to the ambient environment. The present invention also facilitates removal of a partially dissolved or non-disintegrating dosage form from the chamber and cell entirely, without exposing the interior of the cell and chamber. Dissolution test apparatus comprising at least one dissolution test cell in accordance with the invention is also provided, as well as methods for its operation to obtain Level A IVIVC dissolution results which accurately correlate with in vivo dissolution results are also provided.

    摘要翻译： 本发明提供了一种具有腔室和滑阀的溶出测试电池，用于将药物剂型例如片剂，胶囊和粉末分配到腔室中，而不必打开电池并将腔室及其内容物暴露于周围环境。 本发明还有助于从室和细胞中完全去除部分溶解或非崩解剂型，而不暴露细胞和室的内部。 还提供了包含至少一种根据本发明的溶出性测试细胞的溶出度测试装置，以及其获得与体内溶出结果精确相关的A级IVIVC溶出结果的操作方法。

    DISSOLUTION TEST EQUIPMENT
    3.
    发明申请
    DISSOLUTION TEST EQUIPMENT 有权
    溶解测试设备

    公开(公告)号：US20120034704A1

    公开(公告)日：2012-02-09

    申请号：US13196184

    申请日：2011-08-02

    申请人： Lyn Hughes ,  Donald Frederick Wright

    发明人： Lyn Hughes ,  Donald Frederick Wright

    IPC分类号： G01N1/18

    CPC分类号： G01N33/15 ,  B01F13/1013 ,  G01N1/18 ,  G01N2013/006 ,  G01N2035/00198 ,  Y10T436/255

    摘要： Apparatus and method for dissolution testing of active substances in various dosage forms is provided. The apparatus has filtration cells equipped and configured to simulate bodily functions, operate continuously and facilitate testing various types of dosage forms including, but not limited to, tablets, capsules and those having non-disintegrating substrates.

    摘要翻译： 提供了各种剂型活性物质溶出试验的装置和方法。 该装置具有装配和配置以模拟身体功能并连续操作的过滤细胞，并且便于测试各种剂型，包括但不限于片剂，胶囊和具有非崩解底物的剂型。

    Dissolution test equipment and methods for testing having improved filtration system
    4.
    发明申请
    Dissolution test equipment and methods for testing having improved filtration system 审中-公开
    溶出度测试设备和测试方法具有改进的过滤系统

    公开(公告)号：US20070092404A1

    公开(公告)日：2007-04-26

    申请号：US11584161

    申请日：2006-10-20

    申请人： Lyn Hughes

    发明人： Lyn Hughes

    IPC分类号： G01N1/18

    CPC分类号： G01N13/00 ,  G01N33/15 ,  G01N2013/006 ,  G01N2035/00198 ,  Y10T436/255

    摘要： The present invention provides a dissolution test apparatus comprising, a first chamber 2 connected in series to at least a second chamber 10, wherein the first chamber 2 is capable of transferring solid test samples to the second chamber 10 and the second chamber 10 is capable of retaining the solid test samples. Further, the apparatus includes a first reservoir 21 and at least a second reservoir 22 for continuously supplying one or more media into the first chamber 2 and the second chamber 10, respectively, the chambers having stirrers 4, 11 for mixing the solid test samples and the media together. In addition, the second chamber 10 has a filter membrane 45 overlying a base 44 of the second chamber 10, the filter membrane 45 being supported by a filter support 46, the filter support 46 being provided between the filter membrane 45 and the base 44 of the second chamber 10 to prevent distortion of the filter membrane 45. Processors 5, 16, 20 for analyzing an effluent from the chambers are also provided.

    摘要翻译： 本发明提供了一种溶解试验装置，其包括：与至少第二室10串联连接的第一室2，其中第一室2能够将固体测试样品转移到第二室10，并且第二室10能够 保留固体试样。 此外，该装置包括第一储存器21和至少第二储存器22，用于将一个或多个介质分别连续地供应到第一室2和第二室10中，所述室具有用于混合固体测试样品的搅拌器4,11 媒体在一起。 此外，第二室10具有覆盖第二室10的基部44的过滤膜45，过滤膜45由过滤器支撑件46支撑，过滤器支撑件46设置在过滤膜45和基部44之间 第二室10以防止过滤膜45变形。还提供了用于分析来自室的流出物的处理器5,16,20。

    Pharmaceutical formulation including a resinate and an aversive agent
    6.
    发明授权
    Pharmaceutical formulation including a resinate and an aversive agent 有权
    包括树脂酸盐和厌恶剂的药物制剂

    公开(公告)号：US07655256B2

    公开(公告)日：2010-02-02

    申请号：US10679785

    申请日：2003-10-06

    申请人： Lyn Hughes

    发明人： Lyn Hughes

    IPC分类号： A61K9/48 ,  A61K9/20

    CPC分类号： A61K45/06 ,  A61K9/2013 ,  A61K9/2027 ,  A61K9/4858 ,  A61K9/5078 ,  A61K31/485

    摘要： The present invention provides a pharmaceutical that includes, in combination, a resinate and an aversive agent. The resinate includes an ion exchange resin and an drug. The drug is a controlled substance. In variants of the invention, both the aversive agent and the controlled substance are loaded onto the ion exchange resin; the aversive agent is loaded onto the ion exchange resin, and the controlled substance is not loaded onto the ion exchange resin; the controlled substance is loaded onto the ion exchange resin, and the aversive agent is not loaded onto the ion exchange resin; or, the controlled substance is loaded onto a first ion exchange resin, and the aversive agent is loaded onto an ion exchange resin different from the first ion exchange resin.

    摘要翻译： 本发明提供了一种组合包含树脂酸盐和厌食剂的药物。 树脂酸盐包括离子交换树脂和药物。 药物是受控物质。 在本发明的变体中，厌氧剂和受控物质都被加载到离子交换树脂上; 将厌恶剂加载到离子交换树脂上，将受控物质装载到离子交换树脂上; 受控物质被加载到离子交换树脂上，并且厌氧剂不被装载到离子交换树脂上; 或者将受控物质装载到第一离子交换树脂上，并将厌食剂负载到与第一离子交换树脂不同的离子交换树脂上。

    Method and composition for eliminating odors in ion exchange resins
    9.
    发明申请
    Method and composition for eliminating odors in ion exchange resins 审中-公开
    消除离子交换树脂中气味的方法和组成

    公开(公告)号：US20080058428A1

    公开(公告)日：2008-03-06

    申请号：US11890727

    申请日：2007-08-07

    申请人： Lyn Hughes

    发明人： Lyn Hughes

    IPC分类号： B01J41/12 ,  A61K47/30

    CPC分类号： B01J49/60 ,  B01J47/016 ,  B01J49/07

    摘要： A method for reducing undesirable odor of an anion exchange resins by preparing a composition comprising an admixture comprising an anion exchange resin having an undesirable odor and a cation exchange resin; and converting the mixture to form the composition.

    摘要翻译： 一种减少阴离子交换树脂的不良气味的方法，是通过制备包含含有不希望的气味的阴离子交换树脂和阳离子交换树脂的混合物的组合物; 并将混合物转化成组合物。

    DELIVERY DEVICE FOR DISPENSING PHARMACEUTICAL DOSAGE FORMS INTO DISSOLUTION TESTING APPARATUS
    10.
    发明申请
    DELIVERY DEVICE FOR DISPENSING PHARMACEUTICAL DOSAGE FORMS INTO DISSOLUTION TESTING APPARATUS 有权
    用于将药物剂量分配到溶解测试装置中的递送装置

    公开(公告)号：US20120000275A1

    公开(公告)日：2012-01-05

    申请号：US13167812

    申请日：2011-06-24

    申请人： Daryl E. Gilbert ,  Donald F. Wright ,  Lyn Hughes

    发明人： Daryl E. Gilbert ,  Donald F. Wright ,  Lyn Hughes

    IPC分类号： G01N33/00

    CPC分类号： G01N33/15 ,  G01N2013/006

    摘要： The present invention provides a dissolution test cell having a chamber and slide valve for dispensing pharmaceutical dosage forms, such as tablets, capsules, and powders, into the chamber without having to open the cell and expose the chamber and its contents to the ambient environment. The present invention also facilitates removal of a partially dissolved or non-disintegrating dosage form from the chamber and cell entirely, without exposing the interior of the cell and chamber. Dissolution test apparatus comprising at least one dissolution test cell in accordance with the invention is also provided, as well as methods for its operation to obtain Level A IVIVC dissolution results which accurately correlate with in vivo dissolution results are also provided.

    摘要翻译： 本发明提供了一种具有腔室和滑阀的溶出测试电池，用于将药物剂型例如片剂，胶囊和粉末分配到腔室中，而不必打开电池并将腔室及其内容物暴露于周围环境。 本发明还有助于从室和细胞中完全去除部分溶解或非崩解剂型，而不暴露细胞和室的内部。 还提供了包含至少一种根据本发明的溶出性测试细胞的溶出度测试装置，以及其获得与体内溶出结果精确相关的A级IVIVC溶出结果的操作方法。