摘要:
Novel 3′-deoxy-3′-acylaminospectinomycin compounds are described. Also described are methods of using the 3′-deoxy-3-acylaminospectinomycin compounds and other spectinomycin analogs in treating tuberculosis and in treating microbial infections.
摘要:
Novel 3′-deoxy-3′-acylaminospectinomycin compounds are described. Also described are methods of using the 3′-deoxy-3-acylaminospectinomycin compounds and other spectinomycin analogs in treating tuberculosis and in treating microbial infections.
摘要:
In particular, the compound is effective to inhibit Dxr in Mycobacterium tuberculosis (Mtb). The present invention relates to compounds having general formula (I) or (II) where X is an acidic group, such as carboxylate, phosphonate, sulfate, and tetrazole; Ar is a substituted or unsubstituted aromatic or heteroaromatic group; and n is 0, 1, 2, 3, or 4, preferably 2, 3, or 4. The compounds inhibits 1-deoxy-D-xylulose-5-phosphate reductoisomerase (Dxr), particularly Dxr in Mycobacterium tuberculosis (Mtb).
摘要:
Disclosed is a method, system, and information bearing medium for associating attribute information with symbols. A command is processed associating user specified attribute information with a symbol definition or reference. The user specified attribute information is added to an object file including the symbol definition or reference. The attribute information may then be used to determine compatibility when resolving references to the symbol. Further, the user specified attribute information may also be associated with an address constant.
摘要:
In particular, the compound is effective to inhibit Dxr in Mycobacterium tuberculosis (Mtb). The present invention relates to compounds having general formula (I) or (II) where X is an acidic group, such as carboxylate, phosphonate, sulfate, and tetrazole; Ar is a substituted or unsubstituted aromatic or heteroaromatic group; and n is 0, 1, 2, 3, or 4, preferably 2, 3, or 4. The compounds inhibits 1-deoxy-D-xylulose-5-phosphate reductoisomerase (Dxr), particularly Dxr in Mycobacterium tuberculosis (Mtb).
摘要:
A new format of executable program is provided which is flexible and open-ended to provide a means for storing heterogeneous program data in an executable program. In a computer system having a central processing unit, memory, and a storage device, a system and method of executing a computer program is provided for converting one or more source programs into an executable program. The data from the object modules are arranged according to a set of predefined classes. Each class of data is written out to memory keeping data from the same class stored together. Only the data in classes needed for running the program are loaded into memory. As data is required to continue running the program, it is read into memory. A directory is maintained of where each class is stored on the storage device.
摘要:
A method, apparatus, and article of manufacture for the inclusion of extended relocation types and operations performed thereon in a relocation directory within an object module or load module. The relocation directory includes a field to describe the referenced item relocated into the address constant location within the text, which may be a numerical value, symbol, address, set of data or instructions or symbol. The relocation directory further includes a field to describe the operation performed on the referenced item and the present contents of the address constant, which includes operations such as subtraction, addition, division, multiplication, logical AND, logical OR, shifting, logical XOR, and moving. The result of the operation performed on the referenced item and the content of the address constant is relocated into the address constant location.